Electrical Tongue Stimulation Normalizes Activity Within the Motion-Sensitive Brain Network in Balance-Impaired Subjects as Revealed by Group Independent Component Analysis
Identifieur interne : 001B61 ( Pmc/Checkpoint ); précédent : 001B60; suivant : 001B62Electrical Tongue Stimulation Normalizes Activity Within the Motion-Sensitive Brain Network in Balance-Impaired Subjects as Revealed by Group Independent Component Analysis
Auteurs : Joseph C. Wildenberg ; Mitchell E. Tyler ; Yuri P. Danilov ; Kurt A. Kaczmarek ; Mary E. MeyerandSource :
- Brain Connectivity [ 2158-0014 ] ; 2011.
Abstract
Multivariate analysis of functional magnetic resonance imaging (fMRI) data allows investigations into network behavior beyond simple activations of individual regions. We apply group independent component analysis to fMRI data collected in a previous study looking at the sustained neuromodulatory effects of electrical tongue stimulation in balance-impaired individuals. Twelve subjects with balance disorders viewed optic flow in an fMRI scanner before and after 5 days of electrical tongue stimulation. Nine healthy controls also viewed the visual stimuli but did not receive any stimulation. Multiple regression of the 47 estimated components found two that were modulated by the visual stimuli. Component 7, comprised primarily of the primary visual cortex (V1), responded to all visual stimuli and showed no difference in task-related activity between the healthy controls and the balance-impaired subjects before or after stimulation. Component 11 responded only to motion in the visual field and contained multiple cortical and subcortical regions involved in processing information pertinent to balance. Two-sample
Url:
DOI: 10.1089/brain.2011.0029
PubMed: 22433053
PubMed Central: 3621307
Affiliations:
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<series><title level="j">Brain Connectivity</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Multivariate analysis of functional magnetic resonance imaging (fMRI) data allows investigations into network behavior beyond simple activations of individual regions. We apply group independent component analysis to fMRI data collected in a previous study looking at the sustained neuromodulatory effects of electrical tongue stimulation in balance-impaired individuals. Twelve subjects with balance disorders viewed optic flow in an fMRI scanner before and after 5 days of electrical tongue stimulation. Nine healthy controls also viewed the visual stimuli but did not receive any stimulation. Multiple regression of the 47 estimated components found two that were modulated by the visual stimuli. Component 7, comprised primarily of the primary visual cortex (V1), responded to all visual stimuli and showed no difference in task-related activity between the healthy controls and the balance-impaired subjects before or after stimulation. Component 11 responded only to motion in the visual field and contained multiple cortical and subcortical regions involved in processing information pertinent to balance. Two-sample <italic>t</italic>
-tests of the calculated signal change revealed that the task-related activity of this network is greater in balance-impaired subjects compared with controls before stimulation (<italic>p</italic>
=0.02), but that this network hypersensitivity decreases after electrical tongue stimulation (<italic>p</italic>
=0.001).</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain Connect</journal-id>
<journal-id journal-id-type="iso-abbrev">Brain Connect</journal-id>
<journal-id journal-id-type="publisher-id">brain</journal-id>
<journal-title-group><journal-title>Brain Connectivity</journal-title>
</journal-title-group>
<issn pub-type="ppub">2158-0014</issn>
<issn pub-type="epub">2158-0022</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22433053</article-id>
<article-id pub-id-type="pmc">3621307</article-id>
<article-id pub-id-type="publisher-id">10.1089/brain.2011.0029</article-id>
<article-id pub-id-type="doi">10.1089/brain.2011.0029</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Electrical Tongue Stimulation Normalizes Activity Within the Motion-Sensitive Brain Network in Balance-Impaired Subjects as Revealed by Group Independent Component Analysis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Wildenberg</surname>
<given-names>Joseph C.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tyler</surname>
<given-names>Mitchell E.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Danilov</surname>
<given-names>Yuri P.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaczmarek</surname>
<given-names>Kurt A.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meyerand</surname>
<given-names>Mary E.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Neuroscience Training Program,<institution>University of Wisconsin</institution>
, Madison, Wisconsin.</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
Medical Scientist Training Program,<institution>University of Wisconsin</institution>
, Madison, Wisconsin.</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Department of Biomedical Engineering,<institution>University of Wisconsin</institution>
, Madison, Wisconsin.</aff>
<aff id="aff4"><label><sup>4</sup>
</label>
Department of Medical Physics,<institution>University of Wisconsin</institution>
, Madison, Wisconsin.</aff>
</contrib-group>
<author-notes><corresp>Address correspondence to: <italic>Joseph C. Wildenberg, Neuroscience Training Program, University of Wisconsin, 1122o Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705. E-mail:</italic>
<email xlink:href="mailto:jcwildenberg@wisc.edu">jcwildenberg@wisc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2011</year>
<pmc-comment>string-date: 2011</pmc-comment>
</pub-date>
<volume>1</volume>
<issue>3</issue>
<fpage>255</fpage>
<lpage>265</lpage>
<permissions><copyright-statement>Copyright 2011, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:type="simple" xlink:href="brain.2011.0029.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>Multivariate analysis of functional magnetic resonance imaging (fMRI) data allows investigations into network behavior beyond simple activations of individual regions. We apply group independent component analysis to fMRI data collected in a previous study looking at the sustained neuromodulatory effects of electrical tongue stimulation in balance-impaired individuals. Twelve subjects with balance disorders viewed optic flow in an fMRI scanner before and after 5 days of electrical tongue stimulation. Nine healthy controls also viewed the visual stimuli but did not receive any stimulation. Multiple regression of the 47 estimated components found two that were modulated by the visual stimuli. Component 7, comprised primarily of the primary visual cortex (V1), responded to all visual stimuli and showed no difference in task-related activity between the healthy controls and the balance-impaired subjects before or after stimulation. Component 11 responded only to motion in the visual field and contained multiple cortical and subcortical regions involved in processing information pertinent to balance. Two-sample <italic>t</italic>
-tests of the calculated signal change revealed that the task-related activity of this network is greater in balance-impaired subjects compared with controls before stimulation (<italic>p</italic>
=0.02), but that this network hypersensitivity decreases after electrical tongue stimulation (<italic>p</italic>
=0.001).</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Key words</title>
<kwd>brain plasticity</kwd>
<kwd>CN-NINM</kwd>
<kwd>ICA</kwd>
<kwd>movement disorders</kwd>
<kwd>tongue</kwd>
<kwd>visual system</kwd>
</kwd-group>
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<ref-count count="69"></ref-count>
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</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Danilov, Yuri P" sort="Danilov, Yuri P" uniqKey="Danilov Y" first="Yuri P." last="Danilov">Yuri P. Danilov</name>
<name sortKey="Kaczmarek, Kurt A" sort="Kaczmarek, Kurt A" uniqKey="Kaczmarek K" first="Kurt A." last="Kaczmarek">Kurt A. Kaczmarek</name>
<name sortKey="Meyerand, Mary E" sort="Meyerand, Mary E" uniqKey="Meyerand M" first="Mary E." last="Meyerand">Mary E. Meyerand</name>
<name sortKey="Tyler, Mitchell E" sort="Tyler, Mitchell E" uniqKey="Tyler M" first="Mitchell E." last="Tyler">Mitchell E. Tyler</name>
<name sortKey="Wildenberg, Joseph C" sort="Wildenberg, Joseph C" uniqKey="Wildenberg J" first="Joseph C." last="Wildenberg">Joseph C. Wildenberg</name>
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