Serveur d'exploration sur les dispositifs haptiques

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis

Identifieur interne : 004015 ( Ncbi/Merge ); précédent : 004014; suivant : 004016

Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis

Auteurs : Yanlai Sun [République populaire de Chine] ; Huirong Xu [République populaire de Chine] ; Zengjun Li [République populaire de Chine] ; Jianjun Han [République populaire de Chine] ; Wentao Song [République populaire de Chine] ; Junwei Wang [République populaire de Chine] ; Zhongfa Xu [République populaire de Chine]

Source :

RBID : PMC:4772524

Abstract

Background

The objective of this meta-analysis was to compare the clinical and oncologic outcomes of robotic low anterior resection (R-LAR) with conventional laparoscopic low anterior resection (L-LAR).

Methods

A search in the MEDLINE, Embase, and Ovid databases was performed for studies published before July 2014 that compared the clinical and oncologic outcomes of R-LAR and L-LAR. The methodological quality of the selected studies was assessed. Depending on statistical heterogeneity, a fixed or random effects model was used for the meta-analysis. The clinical and oncologic outcomes evaluated included operative time, estimated blood loss, length of hospital stay, rate of conversion to open surgery, post-operative complications, circumferential margin status, and number of lymph nodes collected.

Results

Eight studies, including 324 R-LAR cases and 268 conventional L-LAR cases, were analyzed. The meta-analysis showed that R-LAR was associated with a shorter hospital stay (mean difference (MD) = −1.03; 95 % confidence interval (CI) = −1.78, −0.28; P = 0.007), lower conversion rate (odds ratio (OR) = 0.08; 95 % CI = 0.02, 0.31; P = 0.0002), lower rate of circumferential margin involvement (OR = 0.5; 95 % CI = 0.25, 1.01; P = 0.05), and lower overall complication rate (MD = 0.65; 95 % CI = 0.43, 0.99; P = 0.04) compared with L-LAR. There was no difference in operative time (MD = 28.4; 95 % CI = −3.48, 60.27; P = 0.08), the number of lymph nodes removed (MD = −0.63; 95 % CI = −0.78, 2.05; P = 0.38), and days to return of bowel function (MD = −0.15; 95 % CI = −0.37, 0.06; P = 0.17).

Conclusions

R-LAR was shown to be associated with a shorter hospital stay, lower conversion rate, lower rate of circumferential margin involvement, and lower overall complication rate compared with L-LAR. There were no differences in operative time, the number of lymph nodes removed, and days to return of bowel function.


Url:
DOI: 10.1186/s12957-016-0816-6
PubMed: 26928124
PubMed Central: 4772524

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:4772524

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis</title>
<author>
<name sortKey="Sun, Yanlai" sort="Sun, Yanlai" uniqKey="Sun Y" first="Yanlai" last="Sun">Yanlai Sun</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Xu, Huirong" sort="Xu, Huirong" uniqKey="Xu H" first="Huirong" last="Xu">Huirong Xu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Li, Zengjun" sort="Li, Zengjun" uniqKey="Li Z" first="Zengjun" last="Li">Zengjun Li</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Han, Jianjun" sort="Han, Jianjun" uniqKey="Han J" first="Jianjun" last="Han">Jianjun Han</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Song, Wentao" sort="Song, Wentao" uniqKey="Song W" first="Wentao" last="Song">Wentao Song</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wang, Junwei" sort="Wang, Junwei" uniqKey="Wang J" first="Junwei" last="Wang">Junwei Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Xu, Zhongfa" sort="Xu, Zhongfa" uniqKey="Xu Z" first="Zhongfa" last="Xu">Zhongfa Xu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">26928124</idno>
<idno type="pmc">4772524</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772524</idno>
<idno type="RBID">PMC:4772524</idno>
<idno type="doi">10.1186/s12957-016-0816-6</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000896</idno>
<idno type="wicri:Area/Pmc/Curation">000896</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000050</idno>
<idno type="wicri:Area/Ncbi/Merge">004015</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis</title>
<author>
<name sortKey="Sun, Yanlai" sort="Sun, Yanlai" uniqKey="Sun Y" first="Yanlai" last="Sun">Yanlai Sun</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Xu, Huirong" sort="Xu, Huirong" uniqKey="Xu H" first="Huirong" last="Xu">Huirong Xu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Li, Zengjun" sort="Li, Zengjun" uniqKey="Li Z" first="Zengjun" last="Li">Zengjun Li</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Han, Jianjun" sort="Han, Jianjun" uniqKey="Han J" first="Jianjun" last="Han">Jianjun Han</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Song, Wentao" sort="Song, Wentao" uniqKey="Song W" first="Wentao" last="Song">Wentao Song</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wang, Junwei" sort="Wang, Junwei" uniqKey="Wang J" first="Junwei" last="Wang">Junwei Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Xu, Zhongfa" sort="Xu, Zhongfa" uniqKey="Xu Z" first="Zhongfa" last="Xu">Zhongfa Xu</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan</wicri:regionArea>
<wicri:noRegion>Jinan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">World Journal of Surgical Oncology</title>
<idno type="eISSN">1477-7819</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>The objective of this meta-analysis was to compare the clinical and oncologic outcomes of robotic low anterior resection (R-LAR) with conventional laparoscopic low anterior resection (L-LAR).</p>
</sec>
<sec>
<title>Methods</title>
<p>A search in the MEDLINE, Embase, and Ovid databases was performed for studies published before July 2014 that compared the clinical and oncologic outcomes of R-LAR and L-LAR. The methodological quality of the selected studies was assessed. Depending on statistical heterogeneity, a fixed or random effects model was used for the meta-analysis. The clinical and oncologic outcomes evaluated included operative time, estimated blood loss, length of hospital stay, rate of conversion to open surgery, post-operative complications, circumferential margin status, and number of lymph nodes collected.</p>
</sec>
<sec>
<title>Results</title>
<p>Eight studies, including 324 R-LAR cases and 268 conventional L-LAR cases, were analyzed. The meta-analysis showed that R-LAR was associated with a shorter hospital stay (mean difference (MD) = −1.03; 95 % confidence interval (CI) = −1.78, −0.28;
<italic>P</italic>
 = 0.007), lower conversion rate (odds ratio (OR) = 0.08; 95 % CI = 0.02, 0.31;
<italic>P</italic>
 = 0.0002), lower rate of circumferential margin involvement (OR = 0.5; 95 % CI = 0.25, 1.01;
<italic>P</italic>
 = 0.05), and lower overall complication rate (MD = 0.65; 95 % CI = 0.43, 0.99;
<italic>P</italic>
 = 0.04) compared with L-LAR. There was no difference in operative time (MD = 28.4; 95 % CI = −3.48, 60.27;
<italic>P</italic>
 = 0.08), the number of lymph nodes removed (MD = −0.63; 95 % CI = −0.78, 2.05;
<italic>P</italic>
 = 0.38), and days to return of bowel function (MD = −0.15; 95 % CI = −0.37, 0.06;
<italic>P</italic>
 = 0.17).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>R-LAR was shown to be associated with a shorter hospital stay, lower conversion rate, lower rate of circumferential margin involvement, and lower overall complication rate compared with L-LAR. There were no differences in operative time, the number of lymph nodes removed, and days to return of bowel function.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Veldkamp, R" uniqKey="Veldkamp R">R Veldkamp</name>
</author>
<author>
<name sortKey="Kuhry, E" uniqKey="Kuhry E">E Kuhry</name>
</author>
<author>
<name sortKey="Hop, Wc" uniqKey="Hop W">WC Hop</name>
</author>
<author>
<name sortKey="Jeekel, J" uniqKey="Jeekel J">J Jeekel</name>
</author>
<author>
<name sortKey="Kazemier, G" uniqKey="Kazemier G">G Kazemier</name>
</author>
<author>
<name sortKey="Bonjer, Hj" uniqKey="Bonjer H">HJ Bonjer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Guillou, Pj" uniqKey="Guillou P">PJ Guillou</name>
</author>
<author>
<name sortKey="Quirke, P" uniqKey="Quirke P">P Quirke</name>
</author>
<author>
<name sortKey="Thorpe, H" uniqKey="Thorpe H">H Thorpe</name>
</author>
<author>
<name sortKey="Walker, J" uniqKey="Walker J">J Walker</name>
</author>
<author>
<name sortKey="Jayne, Dg" uniqKey="Jayne D">DG Jayne</name>
</author>
<author>
<name sortKey="Smith, Am" uniqKey="Smith A">AM Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cadiere, Gb" uniqKey="Cadiere G">GB Cadière</name>
</author>
<author>
<name sortKey="Himpens, J" uniqKey="Himpens J">J Himpens</name>
</author>
<author>
<name sortKey="Germay, O" uniqKey="Germay O">O Germay</name>
</author>
<author>
<name sortKey="Izizaw, R" uniqKey="Izizaw R">R Izizaw</name>
</author>
<author>
<name sortKey="Degueldre, M" uniqKey="Degueldre M">M Degueldre</name>
</author>
<author>
<name sortKey="Vandromme, J" uniqKey="Vandromme J">J Vandromme</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ng, Kh" uniqKey="Ng K">KH Ng</name>
</author>
<author>
<name sortKey="Lim, Yk" uniqKey="Lim Y">YK Lim</name>
</author>
<author>
<name sortKey="Ho, Ks" uniqKey="Ho K">KS Ho</name>
</author>
<author>
<name sortKey="Ooi, Bs" uniqKey="Ooi B">BS Ooi</name>
</author>
<author>
<name sortKey="Eu, Kw" uniqKey="Eu K">KW Eu</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Baek, Sj" uniqKey="Baek S">SJ Baek</name>
</author>
<author>
<name sortKey="Al Asari, S" uniqKey="Al Asari S">S Al-Asari</name>
</author>
<author>
<name sortKey="Jeong, Dh" uniqKey="Jeong D">DH Jeong</name>
</author>
<author>
<name sortKey="Hur, H" uniqKey="Hur H">H Hur</name>
</author>
<author>
<name sortKey="Min, Bs" uniqKey="Min B">BS Min</name>
</author>
<author>
<name sortKey="Baik, Sh" uniqKey="Baik S">SH Baik</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Bianchi, Pp" uniqKey="Bianchi P">PP Bianchi</name>
</author>
<author>
<name sortKey="Ceriani, C" uniqKey="Ceriani C">C Ceriani</name>
</author>
<author>
<name sortKey="Locatelli, A" uniqKey="Locatelli A">A Locatelli</name>
</author>
<author>
<name sortKey="Spinoglio, G" uniqKey="Spinoglio G">G Spinoglio</name>
</author>
<author>
<name sortKey="Zampino, Mg" uniqKey="Zampino M">MG Zampino</name>
</author>
<author>
<name sortKey="Sonzogni, A" uniqKey="Sonzogni A">A Sonzogni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Fernandez, R" uniqKey="Fernandez R">R Fernandez</name>
</author>
<author>
<name sortKey="Anaya, Da" uniqKey="Anaya D">DA Anaya</name>
</author>
<author>
<name sortKey="Li, Lt" uniqKey="Li L">LT Li</name>
</author>
<author>
<name sortKey="Orcutt, St" uniqKey="Orcutt S">ST Orcutt</name>
</author>
<author>
<name sortKey="Balentine, Cj" uniqKey="Balentine C">CJ Balentine</name>
</author>
<author>
<name sortKey="Awad, Sa" uniqKey="Awad S">SA Awad</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Clark, Hd" uniqKey="Clark H">HD Clark</name>
</author>
<author>
<name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name>
</author>
<author>
<name sortKey="Huet, C" uniqKey="Huet C">C Huët</name>
</author>
<author>
<name sortKey="Mcalister, Fa" uniqKey="Mcalister F">FA McAlister</name>
</author>
<author>
<name sortKey="Salmi, Lr" uniqKey="Salmi L">LR Salmi</name>
</author>
<author>
<name sortKey="Fergusson, D" uniqKey="Fergusson D">D Fergusson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Slim, K" uniqKey="Slim K">K Slim</name>
</author>
<author>
<name sortKey="Nini, E" uniqKey="Nini E">E Nini</name>
</author>
<author>
<name sortKey="Forestier, D" uniqKey="Forestier D">D Forestier</name>
</author>
<author>
<name sortKey="Kwiatkowski, F" uniqKey="Kwiatkowski F">F Kwiatkowski</name>
</author>
<author>
<name sortKey="Panis, Y" uniqKey="Panis Y">Y Panis</name>
</author>
<author>
<name sortKey="Chipponi, J" uniqKey="Chipponi J">J Chipponi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hozo, Sp" uniqKey="Hozo S">SP Hozo</name>
</author>
<author>
<name sortKey="Djulbegovic, B" uniqKey="Djulbegovic B">B Djulbegovic</name>
</author>
<author>
<name sortKey="Hozo, I" uniqKey="Hozo I">I Hozo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Park, Ej" uniqKey="Park E">EJ Park</name>
</author>
<author>
<name sortKey="Cho, Ms" uniqKey="Cho M">MS Cho</name>
</author>
<author>
<name sortKey="Baek, Sj" uniqKey="Baek S">SJ Baek</name>
</author>
<author>
<name sortKey="Hur, H" uniqKey="Hur H">H Hur</name>
</author>
<author>
<name sortKey="Min, Bs" uniqKey="Min B">BS Min</name>
</author>
<author>
<name sortKey="Baik, Sh" uniqKey="Baik S">SH Baik</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Pigazzi, A" uniqKey="Pigazzi A">A Pigazzi</name>
</author>
<author>
<name sortKey="Ellenhorn, Jd" uniqKey="Ellenhorn J">JD Ellenhorn</name>
</author>
<author>
<name sortKey="Ballantyne, Gh" uniqKey="Ballantyne G">GH Ballantyne</name>
</author>
<author>
<name sortKey="Paz, Ib" uniqKey="Paz I">IB Paz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Baik, Sh" uniqKey="Baik S">SH Baik</name>
</author>
<author>
<name sortKey="Ko, Yt" uniqKey="Ko Y">YT Ko</name>
</author>
<author>
<name sortKey="Kang, Cm" uniqKey="Kang C">CM Kang</name>
</author>
<author>
<name sortKey="Lee, Wj" uniqKey="Lee W">WJ Lee</name>
</author>
<author>
<name sortKey="Kim, Nk" uniqKey="Kim N">NK Kim</name>
</author>
<author>
<name sortKey="Sohn, Sk" uniqKey="Sohn S">SK Sohn</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Baik, Sh" uniqKey="Baik S">SH Baik</name>
</author>
<author>
<name sortKey="Kwon, Hy" uniqKey="Kwon H">HY Kwon</name>
</author>
<author>
<name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name>
</author>
<author>
<name sortKey="Hur, H" uniqKey="Hur H">H Hur</name>
</author>
<author>
<name sortKey="Sohn, Sk" uniqKey="Sohn S">SK Sohn</name>
</author>
<author>
<name sortKey="Cho, Ch" uniqKey="Cho C">CH Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="D Nnibale, A" uniqKey="D Nnibale A">A D’Annibale</name>
</author>
<author>
<name sortKey="Pernazza, G" uniqKey="Pernazza G">G Pernazza</name>
</author>
<author>
<name sortKey="Monsellato, I" uniqKey="Monsellato I">I Monsellato</name>
</author>
<author>
<name sortKey="Pende, V" uniqKey="Pende V">V Pende</name>
</author>
<author>
<name sortKey="Lucandri, G" uniqKey="Lucandri G">G Lucandri</name>
</author>
<author>
<name sortKey="Mazzocchi, P" uniqKey="Mazzocchi P">P Mazzocchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Erguner, I" uniqKey="Erguner I">I Erguner</name>
</author>
<author>
<name sortKey="Aytac, E" uniqKey="Aytac E">E Aytac</name>
</author>
<author>
<name sortKey="Boler, De" uniqKey="Boler D">DE Boler</name>
</author>
<author>
<name sortKey="Atalar, B" uniqKey="Atalar B">B Atalar</name>
</author>
<author>
<name sortKey="Baca, B" uniqKey="Baca B">B Baca</name>
</author>
<author>
<name sortKey="Karahasanoglu, T" uniqKey="Karahasanoglu T">T Karahasanoglu</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marecik, S" uniqKey="Marecik S">S Marecik</name>
</author>
<author>
<name sortKey="Zawadzki, M" uniqKey="Zawadzki M">M Zawadzki</name>
</author>
<author>
<name sortKey="Velchuru, Vr" uniqKey="Velchuru V">VR Velchuru</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Shin, Jy" uniqKey="Shin J">JY Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jacobs, M" uniqKey="Jacobs M">M Jacobs</name>
</author>
<author>
<name sortKey="Verdeja, Jc" uniqKey="Verdeja J">JC Verdeja</name>
</author>
<author>
<name sortKey="Goldstein, Hs" uniqKey="Goldstein H">HS Goldstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Fleshman, J" uniqKey="Fleshman J">J Fleshman</name>
</author>
<author>
<name sortKey="Sargent, Dj" uniqKey="Sargent D">DJ Sargent</name>
</author>
<author>
<name sortKey="Green, E" uniqKey="Green E">E Green</name>
</author>
<author>
<name sortKey="Anvari, M" uniqKey="Anvari M">M Anvari</name>
</author>
<author>
<name sortKey="Stryker, Sj" uniqKey="Stryker S">SJ Stryker</name>
</author>
<author>
<name sortKey="Beart, Rw" uniqKey="Beart R">RW Beart</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jayne, Dg" uniqKey="Jayne D">DG Jayne</name>
</author>
<author>
<name sortKey="Guillou, Pj" uniqKey="Guillou P">PJ Guillou</name>
</author>
<author>
<name sortKey="Thorpe, H" uniqKey="Thorpe H">H Thorpe</name>
</author>
<author>
<name sortKey="Quirke, P" uniqKey="Quirke P">P Quirke</name>
</author>
<author>
<name sortKey="Copeland, J" uniqKey="Copeland J">J Copeland</name>
</author>
<author>
<name sortKey="Smith, Am" uniqKey="Smith A">AM Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kuhry, E" uniqKey="Kuhry E">E Kuhry</name>
</author>
<author>
<name sortKey="Schwenk, Wf" uniqKey="Schwenk W">WF Schwenk</name>
</author>
<author>
<name sortKey="Gaupset, R" uniqKey="Gaupset R">R Gaupset</name>
</author>
<author>
<name sortKey="Romild, U" uniqKey="Romild U">U Romild</name>
</author>
<author>
<name sortKey="Bonjer, Hj" uniqKey="Bonjer H">HJ Bonjer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Trastulli, S" uniqKey="Trastulli S">S Trastulli</name>
</author>
<author>
<name sortKey="Cirocchi, R" uniqKey="Cirocchi R">R Cirocchi</name>
</author>
<author>
<name sortKey="Listorti, C" uniqKey="Listorti C">C Listorti</name>
</author>
<author>
<name sortKey="Cavaliere, D" uniqKey="Cavaliere D">D Cavaliere</name>
</author>
<author>
<name sortKey="Avenia, N" uniqKey="Avenia N">N Avenia</name>
</author>
<author>
<name sortKey="Gulla, N" uniqKey="Gulla N">N Gullà</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Choi, Dj" uniqKey="Choi D">DJ Choi</name>
</author>
<author>
<name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author>
<name sortKey="Lee, Pj" uniqKey="Lee P">PJ Lee</name>
</author>
<author>
<name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author>
<name sortKey="Woo, Su" uniqKey="Woo S">SU Woo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kim, Nk" uniqKey="Kim N">NK Kim</name>
</author>
<author>
<name sortKey="Kang, J" uniqKey="Kang J">J Kang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kwak, Jm" uniqKey="Kwak J">JM Kwak</name>
</author>
<author>
<name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author>
<name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author>
<name sortKey="Son, Dn" uniqKey="Son D">DN Son</name>
</author>
<author>
<name sortKey="Baek, Sj" uniqKey="Baek S">SJ Baek</name>
</author>
<author>
<name sortKey="Cho, Js" uniqKey="Cho J">JS Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Patriti, A" uniqKey="Patriti A">A Patriti</name>
</author>
<author>
<name sortKey="Ceccarelli, G" uniqKey="Ceccarelli G">G Ceccarelli</name>
</author>
<author>
<name sortKey="Bartoli, A" uniqKey="Bartoli A">A Bartoli</name>
</author>
<author>
<name sortKey="Spaziani, A" uniqKey="Spaziani A">A Spaziani</name>
</author>
<author>
<name sortKey="Biancafarina, A" uniqKey="Biancafarina A">A Biancafarina</name>
</author>
<author>
<name sortKey="Casciola, L" uniqKey="Casciola L">L Casciola</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Broholm, M" uniqKey="Broholm M">M Broholm</name>
</author>
<author>
<name sortKey="Pommergaard, Hc" uniqKey="Pommergaard H">HC Pommergaard</name>
</author>
<author>
<name sortKey="Gogenur, I" uniqKey="Gogenur I">I Gögenür</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rencuzogullari, A" uniqKey="Rencuzogullari A">A Rencuzogullari</name>
</author>
<author>
<name sortKey="Gorgun, E" uniqKey="Gorgun E">E Gorgun</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="D Nnibale, A" uniqKey="D Nnibale A">A D’Annibale</name>
</author>
<author>
<name sortKey="Pernazza, G" uniqKey="Pernazza G">G Pernazza</name>
</author>
<author>
<name sortKey="Morpurgo, E" uniqKey="Morpurgo E">E Morpurgo</name>
</author>
<author>
<name sortKey="Monsellato, I" uniqKey="Monsellato I">I Monsellato</name>
</author>
<author>
<name sortKey="Pende, V" uniqKey="Pende V">V Pende</name>
</author>
<author>
<name sortKey="Lucandri, G" uniqKey="Lucandri G">G Lucandri</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Nagtegaal, Id" uniqKey="Nagtegaal I">ID Nagtegaal</name>
</author>
<author>
<name sortKey="Quirke, P" uniqKey="Quirke P">P Quirke</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hottenrott, C" uniqKey="Hottenrott C">C Hottenrott</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Maclehose, Rr" uniqKey="Maclehose R">RR MacLehose</name>
</author>
<author>
<name sortKey="Reeves, Bc" uniqKey="Reeves B">BC Reeves</name>
</author>
<author>
<name sortKey="Harvey, Im" uniqKey="Harvey I">IM Harvey</name>
</author>
<author>
<name sortKey="Sheldon, Ta" uniqKey="Sheldon T">TA Sheldon</name>
</author>
<author>
<name sortKey="Russell, It" uniqKey="Russell I">IT Russell</name>
</author>
<author>
<name sortKey="Black, Am" uniqKey="Black A">AM Black</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">World J Surg Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">World J Surg Oncol</journal-id>
<journal-title-group>
<journal-title>World Journal of Surgical Oncology</journal-title>
</journal-title-group>
<issn pub-type="epub">1477-7819</issn>
<publisher>
<publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">26928124</article-id>
<article-id pub-id-type="pmc">4772524</article-id>
<article-id pub-id-type="publisher-id">816</article-id>
<article-id pub-id-type="doi">10.1186/s12957-016-0816-6</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Sun</surname>
<given-names>Yanlai</given-names>
</name>
<address>
<email>sunyanlai@126.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Xu</surname>
<given-names>Huirong</given-names>
</name>
<address>
<email>xuhuirong676@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Li</surname>
<given-names>Zengjun</given-names>
</name>
<address>
<phone>86-531-67626830</phone>
<email>lizengjun676@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Han</surname>
<given-names>Jianjun</given-names>
</name>
<address>
<email>handoctor@139.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Song</surname>
<given-names>Wentao</given-names>
</name>
<address>
<email>songwentao676@126.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wang</surname>
<given-names>Junwei</given-names>
</name>
<address>
<email>wangjunwei676@126.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Xu</surname>
<given-names>Zhongfa</given-names>
</name>
<address>
<phone>86-531-67626830</phone>
<email>xzfa2216@163.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1">Department of Colorectal Cancer Surgery, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan, 250117 China</aff>
</contrib-group>
<pub-date pub-type="epub">
<day>1</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>1</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection">
<year>2016</year>
</pub-date>
<volume>14</volume>
<elocation-id>61</elocation-id>
<history>
<date date-type="received">
<day>21</day>
<month>11</month>
<year>2015</year>
</date>
<date date-type="accepted">
<day>19</day>
<month>2</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>© Sun et al. 2016</copyright-statement>
<license license-type="OpenAccess">
<license-p>
<bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1">
<sec>
<title>Background</title>
<p>The objective of this meta-analysis was to compare the clinical and oncologic outcomes of robotic low anterior resection (R-LAR) with conventional laparoscopic low anterior resection (L-LAR).</p>
</sec>
<sec>
<title>Methods</title>
<p>A search in the MEDLINE, Embase, and Ovid databases was performed for studies published before July 2014 that compared the clinical and oncologic outcomes of R-LAR and L-LAR. The methodological quality of the selected studies was assessed. Depending on statistical heterogeneity, a fixed or random effects model was used for the meta-analysis. The clinical and oncologic outcomes evaluated included operative time, estimated blood loss, length of hospital stay, rate of conversion to open surgery, post-operative complications, circumferential margin status, and number of lymph nodes collected.</p>
</sec>
<sec>
<title>Results</title>
<p>Eight studies, including 324 R-LAR cases and 268 conventional L-LAR cases, were analyzed. The meta-analysis showed that R-LAR was associated with a shorter hospital stay (mean difference (MD) = −1.03; 95 % confidence interval (CI) = −1.78, −0.28;
<italic>P</italic>
 = 0.007), lower conversion rate (odds ratio (OR) = 0.08; 95 % CI = 0.02, 0.31;
<italic>P</italic>
 = 0.0002), lower rate of circumferential margin involvement (OR = 0.5; 95 % CI = 0.25, 1.01;
<italic>P</italic>
 = 0.05), and lower overall complication rate (MD = 0.65; 95 % CI = 0.43, 0.99;
<italic>P</italic>
 = 0.04) compared with L-LAR. There was no difference in operative time (MD = 28.4; 95 % CI = −3.48, 60.27;
<italic>P</italic>
 = 0.08), the number of lymph nodes removed (MD = −0.63; 95 % CI = −0.78, 2.05;
<italic>P</italic>
 = 0.38), and days to return of bowel function (MD = −0.15; 95 % CI = −0.37, 0.06;
<italic>P</italic>
 = 0.17).</p>
</sec>
<sec>
<title>Conclusions</title>
<p>R-LAR was shown to be associated with a shorter hospital stay, lower conversion rate, lower rate of circumferential margin involvement, and lower overall complication rate compared with L-LAR. There were no differences in operative time, the number of lymph nodes removed, and days to return of bowel function.</p>
</sec>
</abstract>
<kwd-group xml:lang="en">
<title>Keywords</title>
<kwd>Rectal cancer</kwd>
<kwd>da Vinci Surgical System</kwd>
<kwd>Laparoscopic surgery</kwd>
<kwd>Low anterior resection</kwd>
<kwd>Meta-analysis</kwd>
</kwd-group>
<custom-meta-group>
<custom-meta>
<meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec id="Sec1" sec-type="introduction">
<title>Background</title>
<p>Laparoscopic colorectal resection has been popularized due to its associated short length of hospital stay, reduced post-operative pain, and early return to normal bowel function [
<xref ref-type="bibr" rid="CR1">1</xref>
,
<xref ref-type="bibr" rid="CR2">2</xref>
]; however, the laparoscopic colorectal technique has several drawbacks, such as a two-dimensional view and the limited dexterity of instruments due to the fixed instrument tips [
<xref ref-type="bibr" rid="CR3">3</xref>
]. The da Vinci Surgical System was first used by colorectal surgeons in 2002 and was shown to overcome the drawbacks of conventional laparoscopic surgery. The da Vinci Surgical System allows for improved dexterity of movement, 3D and magnified vision, and tremor filtering [
<xref ref-type="bibr" rid="CR4">4</xref>
]. Both laparoscopic and robotic surgeries for rectal cancer have been proven to be safe and effective. Thus far, there have been several studies comparing the clinical and oncologic outcomes of robotic versus laparoscopic surgery for rectal cancer [
<xref ref-type="bibr" rid="CR5">5</xref>
<xref ref-type="bibr" rid="CR7">7</xref>
], but few studies and no meta-analyses have been conducted comparing the outcomes of robotic (R-LAR) versus laparoscopic low anterior resection (L-LAR).</p>
</sec>
<sec id="Sec2" sec-type="materials|methods">
<title>Methods</title>
<sec id="Sec3">
<title>Information sources and search</title>
<p>A search in the MEDLINE, Embase, and Ovid databases was performed for studies published before July 2014 comparing clinical or oncologic outcomes of R-LAR and L-LAR. In addition, the abstracts published at major international conferences were manually searched. The following search terms were used: “robotic/robotic-assisted,” “low anterior resection,” “robotic⁄robotic-assisted versus laparoscopic rectal resection,” and “robotic/robotic-assisted versus laparoscopic low anterior resection.”</p>
</sec>
<sec id="Sec4">
<title>Study selection and quality assessment</title>
<p>Two authors (SYL and XHR) obtained full-text articles of relevant studies and independently determined the criteria for inclusion. Disagreements between the two authors were resolved by discussion and consensus. If the negotiation failed, a third independent author (XZF) provided an opinion. The quality of RCTs was evaluated using the Cochrane Reviewer’s Handbook Jadad scale [
<xref ref-type="bibr" rid="CR8">8</xref>
], and the quality of the NRCTs was evaluated by the “Methodological Items for Non-randomized Studies” [
<xref ref-type="bibr" rid="CR9">9</xref>
].</p>
</sec>
<sec id="Sec5">
<title>Criteria for inclusion and exclusion</title>
<p>The following inclusive criteria were required: (1) randomized or non-randomized studies comparing the clinical and oncologic outcomes of R-LAR and L-LAR; (2) if the same institution and/or authors reported more than one study, the higher quality study was included; (3) studies reported at least one of seven outcomes (operative time, estimated blood loss, length of hospital stay, conversion rate to open surgery, post-operative complications, circumferential margin status, and number of lymph nodes collected); and (4) the definition of the rectal cancer level should be below the peritoneal reflection.</p>
<p>The exclusion criteria were as follows: (1) the clinical and oncologic outcomes were not reported clearly; (2) studies reporting proctectomy for rectal cancer that was not a low anterior resection, such as an abdominoperineal resection and Hartman procedure; (3) overlaps between authors or institutions in the published literature; and (4) studies that lacked control arms.</p>
</sec>
<sec id="Sec6">
<title>Statistical analysis</title>
<p>Review Manager software (RevMan, version 5.2) provided by the Cochrane Collaboration was used to perform the meta-analysis. Continuous variables were pooled using the mean difference (MD) with a 95 % confidence interval (CI), and dichotomous variables were pooled using the odds ratio (OR) with a 95 % CI. If continuous variables were reported as the median with range, we calculated the means and standard deviations according to Hozo [
<xref ref-type="bibr" rid="CR10">10</xref>
]. Statistical heterogeneity was evaluated by
<italic>I</italic>
<sup>2</sup>
, and heterogeneity was considered high if the
<italic>I</italic>
<sup>2</sup>
statistic was >50 %. The fixed effects model was used for studies with low or moderate statistical heterogeneity, and the random effects model was used for studies with high statistical heterogeneity. Sensitivity analysis was performed by repeating the meta-analysis on the studies that were excluded.</p>
</sec>
</sec>
<sec id="Sec7" sec-type="results">
<title>Results</title>
<sec id="Sec8">
<title>Eligible studies</title>
<p>Using the search terms, we initially retrieved 168 publications. After carefully browsing the abstracts and full texts, eight comparative studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR18">18</xref>
] met all of the inclusion criteria and were eligible for meta-analysis. One comparative study [
<xref ref-type="bibr" rid="CR18">18</xref>
] was excluded because it did not include patient characteristics, thus leaving seven suitable studies for the meta-analysis (Fig. 
<xref rid="Fig1" ref-type="fig">1</xref>
). The seven studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR17">17</xref>
] involved a total of 592 patients (324 in the R-LAR group and 268 in the L-LAR group) (Table 
<xref rid="Tab1" ref-type="table">1</xref>
). The seven studies included six non-randomized controlled trials (NRCTs) and one randomized controlled trial (RCT). The characteristics of these seven studies are listed in Table 
<xref rid="Tab1" ref-type="table">1</xref>
. Of all the studies, two were conducted in the USA [
<xref ref-type="bibr" rid="CR12">12</xref>
,
<xref ref-type="bibr" rid="CR17">17</xref>
], three in Korea [
<xref ref-type="bibr" rid="CR11">11</xref>
,
<xref ref-type="bibr" rid="CR13">13</xref>
,
<xref ref-type="bibr" rid="CR14">14</xref>
], one in Italy [
<xref ref-type="bibr" rid="CR15">15</xref>
], and one in Turkey [
<xref ref-type="bibr" rid="CR16">16</xref>
]. The quality of all the studies was satisfactory. The results showed that R-LAR had longer operative times, lower estimated blood loss, shorter hospital stays, lower overall post-operative complications, and a significantly faster recovery of bowel function.
<fig id="Fig1">
<label>Fig. 1</label>
<caption>
<p>Flow diagram of study selection for meta-analysis</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig1_HTML" id="MO1"></graphic>
</fig>
<table-wrap id="Tab1">
<label>Table 1</label>
<caption>
<p>Characteristics of the eight selected studies included in the meta-analysis</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2">Study</th>
<th rowspan="2">Country</th>
<th rowspan="2">Group</th>
<th rowspan="2">Patients</th>
<th>Mean</th>
<th>Mean</th>
<th>Sex</th>
<th>CRT</th>
<th>Study</th>
<th>Anastomosis</th>
</tr>
<tr>
<th>Age</th>
<th>BMI</th>
<th>M/F</th>
<th>(%)</th>
<th>Type</th>
<th>Technique</th>
</tr>
</thead>
<tbody>
<tr>
<td rowspan="2">Park (2015) [
<xref ref-type="bibr" rid="CR11">11</xref>
] </td>
<td rowspan="2">Korea</td>
<td>RCC</td>
<td>133</td>
<td char="." align="char">59.2</td>
<td char="." align="char">23.1</td>
<td>86:47</td>
<td>11.3</td>
<td rowspan="2">R</td>
<td rowspan="2">Hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>84</td>
<td char="." align="char">63.5</td>
<td char="." align="char">22.9</td>
<td>60:24</td>
<td>11.9</td>
</tr>
<tr>
<td rowspan="2">Pigazzi (2006) [
<xref ref-type="bibr" rid="CR12">12</xref>
] </td>
<td rowspan="2">USA</td>
<td>RCC</td>
<td>6</td>
<td char="." align="char">60.0</td>
<td char="." align="char">31.0</td>
<td>2:4</td>
<td>33.0</td>
<td rowspan="2">PNR</td>
<td rowspan="2">Total/hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>6</td>
<td char="." align="char">70.0</td>
<td char="." align="char">27.0</td>
<td>4:2</td>
<td>33.0</td>
</tr>
<tr>
<td rowspan="2">Baik (2008) [
<xref ref-type="bibr" rid="CR13">13</xref>
]</td>
<td rowspan="2">Korea</td>
<td>RCC</td>
<td>18</td>
<td char="." align="char">57.3</td>
<td char="." align="char">22.8</td>
<td>14:4</td>
<td>NS</td>
<td rowspan="2">RCT</td>
<td rowspan="2">Hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>18</td>
<td char="." align="char">62.0</td>
<td char="." align="char">24.0</td>
<td>14:4</td>
<td>NS</td>
</tr>
<tr>
<td rowspan="2">Baik (2009) [
<xref ref-type="bibr" rid="CR14">14</xref>
]</td>
<td rowspan="2">Korea</td>
<td>RCC</td>
<td>56</td>
<td char="." align="char">60.3</td>
<td char="." align="char">23.4</td>
<td>37:19</td>
<td>8.9</td>
<td rowspan="2">PNR</td>
<td rowspan="2">Hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>57</td>
<td char="." align="char">63.2</td>
<td char="." align="char">23.2</td>
<td>34:23</td>
<td>12.3</td>
</tr>
<tr>
<td rowspan="2">Annibale (2013) [
<xref ref-type="bibr" rid="CR15">15</xref>
] </td>
<td rowspan="2">Italy</td>
<td>RCC</td>
<td>50</td>
<td char="." align="char">66.0</td>
<td char="." align="char">NS</td>
<td>30:20</td>
<td>68.0</td>
<td rowspan="2">PNR</td>
<td rowspan="2">Total</td>
</tr>
<tr>
<td>LRC</td>
<td>50</td>
<td char="." align="char">65.7</td>
<td char="." align="char">NS</td>
<td>30:20</td>
<td>56.0</td>
</tr>
<tr>
<td rowspan="2">Erguner (2013) [
<xref ref-type="bibr" rid="CR16">16</xref>
]</td>
<td rowspan="2">Turkey</td>
<td>RCC</td>
<td>27</td>
<td char="." align="char">54.0</td>
<td char="." align="char">28.3</td>
<td>14:13</td>
<td>14.8</td>
<td rowspan="2">R</td>
<td rowspan="2">Total</td>
</tr>
<tr>
<td>LRC</td>
<td>37</td>
<td char="." align="char">61.5</td>
<td char="." align="char">26.7</td>
<td>20:17</td>
<td>8.0</td>
</tr>
<tr>
<td rowspan="2">Marecik (2011) [
<xref ref-type="bibr" rid="CR17">17</xref>
]</td>
<td rowspan="2">USA</td>
<td>RCC</td>
<td>34</td>
<td char="." align="char">60.0</td>
<td char="." align="char">28.5</td>
<td>20:14</td>
<td>58.8</td>
<td rowspan="2">PNR</td>
<td rowspan="2">Hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>24</td>
<td char="." align="char">64.0</td>
<td char="." align="char">25.9</td>
<td>14:10</td>
<td>41.7</td>
</tr>
<tr>
<td rowspan="2">Shin (2012) [
<xref ref-type="bibr" rid="CR18">18</xref>
]</td>
<td rowspan="2">Korea</td>
<td>RCC</td>
<td>30</td>
<td char="." align="char">58.1</td>
<td char="." align="char">22.0</td>
<td>18:12</td>
<td>NS</td>
<td rowspan="2">PNR</td>
<td rowspan="2">Total/hybrid</td>
</tr>
<tr>
<td>LRC</td>
<td>30</td>
<td char="." align="char">63.3</td>
<td char="." align="char">20.0</td>
<td>18:12</td>
<td>NS</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
</sec>
<sec id="Sec9">
<title>Operative time</title>
<p>All of the studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR17">17</xref>
] reported operative times; the meta-analysis showed no significant difference between the two techniques (MD = 28.4; 95 % CI = −3.48, 60.27;
<italic>P</italic>
 = 0.08). The random effects model was used because of the high heterogeneity among studies (
<italic>I</italic>
<sup>2</sup>
 = 93 %) (Fig. 
<xref rid="Fig2" ref-type="fig">2</xref>
).
<fig id="Fig2">
<label>Fig. 2</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: operative time</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig2_HTML" id="MO2"></graphic>
</fig>
</p>
</sec>
<sec id="Sec10">
<title>Length of hospital stay</title>
<p>All of the studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR17">17</xref>
] reported the length of hospital stay. The meta-analysis showed that R-LAR required a shorter hospital stay compared with L-LAR (MD = −1.03; 95 % CI = −1.78, −0.28;
<italic>P</italic>
 = 0.007). The heterogeneity was high; therefore, a random effects model was utilized (
<italic>I</italic>
<sup>2</sup>
 = 78 %) (Fig. 
<xref rid="Fig3" ref-type="fig">3</xref>
).
<fig id="Fig3">
<label>Fig. 3</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: length of hospital stay</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig3_HTML" id="MO3"></graphic>
</fig>
</p>
</sec>
<sec id="Sec11">
<title>Conversion to open surgery</title>
<p>Six studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR16">16</xref>
] reported the rate of conversion to open surgery. The meta-analysis showed that R-LAR had a lower conversion rate compared with L-LAR (OR = 0.07; 95 % CI = 0.02, 0.31;
<italic>P</italic>
 = 0.0004) with no observed heterogeneity (
<italic>I</italic>
<sup>2</sup>
 = 0 %) (Fig. 
<xref rid="Fig4" ref-type="fig">4</xref>
).
<fig id="Fig4">
<label>Fig. 4</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: length of hospital stay</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig4_HTML" id="MO4"></graphic>
</fig>
</p>
</sec>
<sec id="Sec12">
<title>Number of harvested lymph nodes</title>
<p>Six studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR16">16</xref>
] reported the number of harvested lymph nodes. The meta-analysis showed no significant difference between the two techniques (MD = −0.63; 95 % CI = −0.78, 2.05;
<italic>P</italic>
 = 0.38) with no observed heterogeneity (
<italic>I</italic>
<sup>2</sup>
 = 0 %) (Fig. 
<xref rid="Fig5" ref-type="fig">5</xref>
).
<fig id="Fig5">
<label>Fig. 5</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: number of harvested lymph nodes</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig5_HTML" id="MO5"></graphic>
</fig>
</p>
</sec>
<sec id="Sec13">
<title>Positive circumferential resection margin involvement</title>
<p>Four studies [
<xref ref-type="bibr" rid="CR11">11</xref>
,
<xref ref-type="bibr" rid="CR14">14</xref>
,
<xref ref-type="bibr" rid="CR15">15</xref>
,
<xref ref-type="bibr" rid="CR17">17</xref>
] reported the status of the circumferential resection margin (CRM). Circumferential resection margin involvement was found to be significantly lower in the R-LAR group than in the L-LAR group (OR = 0.5; 95 % CI = 0.25, 1.01;
<italic>P</italic>
 = 0.05) with low heterogeneity (
<italic>I</italic>
<sup>2</sup>
 = 39 %) (Fig. 
<xref rid="Fig6" ref-type="fig">6</xref>
).
<fig id="Fig6">
<label>Fig. 6</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: positive circumferential resection margin involvement</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig6_HTML" id="MO6"></graphic>
</fig>
</p>
</sec>
<sec id="Sec14">
<title>Post-operative complications</title>
<p>All of the studies [
<xref ref-type="bibr" rid="CR11">11</xref>
<xref ref-type="bibr" rid="CR17">17</xref>
] reported the overall post-operative complication rate. The result of the meta-analysis showed that the overall complication rate was significantly lower in the RRC group (MD = 0.65; 95 % CI = 0.43, 0.99;
<italic>P</italic>
 = 0.04) with no heterogeneity (
<italic>I</italic>
<sup>2</sup>
 = 0 %) (Fig. 
<xref rid="Fig7" ref-type="fig">7</xref>
).
<fig id="Fig7">
<label>Fig. 7</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: post-operative overall complications</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig7_HTML" id="MO7"></graphic>
</fig>
</p>
</sec>
<sec id="Sec15">
<title>Days to return of bowel function</title>
<p>Three studies [
<xref ref-type="bibr" rid="CR11">11</xref>
,
<xref ref-type="bibr" rid="CR13">13</xref>
,
<xref ref-type="bibr" rid="CR14">14</xref>
] reported the number of days to passing flatus. The meta-analysis showed no significant difference between the two techniques (MD = −0.15; 95 % CI = −0.37, 0.06;
<italic>P</italic>
 = 0.17) with no observed heterogeneity (
<italic>I</italic>
<sup>2</sup>
 = 23 %) (Fig. 
<xref rid="Fig8" ref-type="fig">8</xref>
).
<fig id="Fig8">
<label>Fig. 8</label>
<caption>
<p>Robotic compared with laparoscopic low anterior resection for cancer: days to return of bowel function</p>
</caption>
<graphic xlink:href="12957_2016_816_Fig8_HTML" id="MO8"></graphic>
</fig>
</p>
</sec>
</sec>
<sec id="Sec16" sec-type="discussion">
<title>Discussion</title>
<p>Laparoscopic colorectal surgery was first reported by Jacobs in 1991 [
<xref ref-type="bibr" rid="CR19">19</xref>
] and has increasingly become a popular approach for colorectal procedures. The long-term outcomes of laparoscopic colorectal surgery have been shown to be similar to open techniques; however, laparoscopy offers better short-term outcomes [
<xref ref-type="bibr" rid="CR20">20</xref>
,
<xref ref-type="bibr" rid="CR21">21</xref>
]. Some of the advantages of the laparoscopic colorectal technique over the open procedures include smaller incisions, reduction in post-operative pain and duration of ileus, quicker post-operative recovery, and earlier return to normal activity [
<xref ref-type="bibr" rid="CR22">22</xref>
]. The new meta-analysis indicates that laparoscopy benefits rectal cancer patients with a shorter hospital stay, earlier return of bowel function, reduced blood loss and number of blood transfusions and lower rates of abdominal post-operative bleeding, late intestinal adhesion obstruction, and other late morbidities [
<xref ref-type="bibr" rid="CR23">23</xref>
]. The laparoscopic technique still has several limitations, such as tremor, loss of three-dimensional view, poor ergonomics, and limited dexterity of movement due to the fixed instrument tips [
<xref ref-type="bibr" rid="CR24">24</xref>
]. The da Vinci Surgical System has overcome these limitations and provides a three-dimensional, high-definition operative field, the steady “traction and counter-traction,” reduces the physiologic tremor, and enables three extra degrees of movement using articulated instruments. However, the da Vinci Surgical System also has drawbacks, such as the loss of haptic feedback, limited range of movement of the robotic arms, time-consuming, and high cost of the system. Several studies [
<xref ref-type="bibr" rid="CR11">11</xref>
,
<xref ref-type="bibr" rid="CR25">25</xref>
<xref ref-type="bibr" rid="CR27">27</xref>
] have compared the clinical and oncologic safety and efficacy of robotic resection and laparoscopic rectal resection for cancer, but no meta-analyses have compared R-LAR with conventional L-LAR. Indeed, this is the first meta-analysis comparing the two approaches.</p>
<p>Although it is better to use RCTs to perform a meta-analysis, randomization is difficult to carry out in surgery. Therefore, NRCTs represent an acceptable alternative when performing a meta-analysis comparing two surgical techniques. We selected studies that we deemed to be of the highest methodological quality; however, selection bias may have existed because most of the studies were non-randomized and pre-operative baseline characteristics were not equal in the included studies. High heterogeneity for some outcomes may have influenced the effect of the meta-analysis; however, the significant impact of factors other than the surgical method affects these outcomes.</p>
<p>The heterogeneity of the length of hospital stay variable was high between studies (
<italic>I</italic>
<sup>2</sup>
 = 78 %). The reason for the high heterogeneity between the groups may be differences in discharge criteria from hospital or different post-operative complications. The three-dimensional, high-definition field of view and augmented dexterity offered by the robotic approach minimizes the risk of injury of tissue and small blood vessels and leads to fewer complications, which may be related to the shorter length of hospital stay. Recently, a systematic review and meta-analysis about possible benefits of robotic surgery regarding urinary and sexual dysfunctions was reported [
<xref ref-type="bibr" rid="CR28">28</xref>
], although there were few data and no randomized controlled trials support the results. Looking forward to the future randomized controlled trials could compare this area.</p>
<p>Operative time is considered to be long in robotic colorectal surgery because of additional set-up time, additional docking time, and the steep learning curve associated with this technique [
<xref ref-type="bibr" rid="CR29">29</xref>
]. This meta-analysis showed no significant difference in operative time between the two surgical approaches. The heterogeneity in operative time between the two methods was very high (
<italic>I</italic>
<sup>2</sup>
 = 93 %). The set-up time was excluded in all of the studies. The reasons for high heterogeneity of operative time are as follows. (1) Some studies adopt hybrid robotic approaches, while some studies adopt full robotic approaches. (2) Specimen-retrieval techniques (natural orifice or mini-laparotomy) are different. (3) The learning curve in R-LAR is less steep than that in L-LAR procedures, and surgeons are relatively unskilled in the R-LAR technique [
<xref ref-type="bibr" rid="CR30">30</xref>
]. As surgeons become more and more adept with the technique, the operative time for R-LAR will decrease.</p>
<p>Local recurrence of rectal cancer after surgery is common and influences survival, and most studies involving CRM focus on local recurrence [
<xref ref-type="bibr" rid="CR31">31</xref>
]. The CRM is a powerful prognostic factor for rectal cancer resection. In our study, R-LAR was associated with a lower conversion rate, lower rate of circumferential margin involvement, and lower overall complication rate. These findings may be explained by the advantages of the robotic surgical system, including the three-dimensional operative field, reduction of the physiologic tremor, and the three extra degrees of freedom in movement. In combination, these features may minimize the risk of tissue and vascular injuries. Local recurrence rate, incision recurrence rate, and overall recurrence rate are the key to the success or failure of surgery. In our meta-analysis, few studies focus on the comparison of post-operative recurrence, and it was difficult to perform subgroup analyses. We hope that more randomized controlled studies will be able to compare the post-operative recurrence rate in the future.</p>
<p>The major drawback of robotic surgery for rectal cancer is the cost. Initial purchasing costs, maintenance costs, and equipment costs contribute to the high price. We cannot carry out a comparative analysis of cost because few studies provide related data. A cost-effectiveness analysis should be performed before this approach is widely implemented. Hottenrott [
<xref ref-type="bibr" rid="CR32">32</xref>
] reported that the cost may be reduced by increasing productivity and competition. Therefore, this drawback may be overcome as the robotic approach becomes more widely used.</p>
<p>Our meta-analysis had some limitations. First, the meta-analysis only included one RCT and six NRCTs. The latter can bias the interpretation of the results, although the quality of the studies was deemed satisfactory [
<xref ref-type="bibr" rid="CR33">33</xref>
]. Second, the number of studies and patients was relatively small, making it difficult to perform a subgroup analysis. Finally, matching patient characteristics is difficult in all of the studies, thus there is still some heterogeneity in the two groups.</p>
</sec>
<sec id="Sec17" sec-type="conclusion">
<title>Conclusions</title>
<p>This meta-analysis suggests that R-LAR is associated with a shorter hospital stay, lower conversion rate, lower rate of circumferential margin involvement, and lower overall complication rate than L-LAR. There were no differences in operative time, the number of lymph nodes removed, and the number of days to return of bowel function. At present, there are larger randomized controlled trials (trial ROLARR) comparing robotic versus laparoscopic rectal resection, and we hope to have more randomized controlled studies comparing robotic and laparoscopic low anterior resection.</p>
</sec>
</body>
<back>
<glossary>
<title>Abbreviations</title>
<def-list>
<def-item>
<term>BMI</term>
<def>
<p>body mass index</p>
</def>
</def-item>
<def-item>
<term>CRM</term>
<def>
<p>circumferential resection margin</p>
</def>
</def-item>
<def-item>
<term>L-LAR</term>
<def>
<p>laparoscopic low anterior resection</p>
</def>
</def-item>
<def-item>
<term>MD</term>
<def>
<p>mean difference</p>
</def>
</def-item>
<def-item>
<term>MeSH</term>
<def>
<p>medical subject headings</p>
</def>
</def-item>
<def-item>
<term>NRCTs</term>
<def>
<p>non-randomized controlled trials</p>
</def>
</def-item>
<def-item>
<term>OR</term>
<def>
<p>odds ratio</p>
</def>
</def-item>
<def-item>
<term>RCT</term>
<def>
<p>randomized controlled trial</p>
</def>
</def-item>
<def-item>
<term>R-LAR</term>
<def>
<p>robotic low anterior resection</p>
</def>
</def-item>
</def-list>
</glossary>
<fn-group>
<fn>
<p>
<bold>Competing interests</bold>
</p>
<p>The authors declare that they have no competing interests.</p>
</fn>
<fn>
<p>
<bold>Authors’ contributions</bold>
</p>
<p>SYL and XZF designed the research; SYL, XZF, and XHR performed the research. LZJ, HJJ, and SWT analyzed the data. SYL, Xu HR, and WJW wrote the paper. Sun YL and Xu HR equally contributed to this paper. All authors read and approved the final manuscript.</p>
</fn>
</fn-group>
<ack>
<title>Acknowledgements</title>
<p>This work was supported by Grants from medical and health technology development program foundation of Shandong Province, NO. 2015WS0149 and NO. 2015WS0197; Science and Technology development plan of Jinan, NO. 201401253; and The Natural Science Foundation of Shandong Province, NO. ZR2013HL047.</p>
</ack>
<ref-list id="Bib1">
<title>References</title>
<ref id="CR1">
<label>1.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Veldkamp</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Kuhry</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Hop</surname>
<given-names>WC</given-names>
</name>
<name>
<surname>Jeekel</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Kazemier</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Bonjer</surname>
<given-names>HJ</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial</article-title>
<source>Lancet Oncol</source>
<year>2005</year>
<volume>6</volume>
<fpage>477</fpage>
<lpage>484</lpage>
<pub-id pub-id-type="doi">10.1016/S1470-2045(05)70221-7</pub-id>
<pub-id pub-id-type="pmid">15992696</pub-id>
</element-citation>
</ref>
<ref id="CR2">
<label>2.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Guillou</surname>
<given-names>PJ</given-names>
</name>
<name>
<surname>Quirke</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Thorpe</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Walker</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Jayne</surname>
<given-names>DG</given-names>
</name>
<name>
<surname>Smith</surname>
<given-names>AM</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial</article-title>
<source>Lancet</source>
<year>2005</year>
<volume>365</volume>
<fpage>1718</fpage>
<lpage>1726</lpage>
<pub-id pub-id-type="doi">10.1016/S0140-6736(05)66545-2</pub-id>
<pub-id pub-id-type="pmid">15894098</pub-id>
</element-citation>
</ref>
<ref id="CR3">
<label>3.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Cadière</surname>
<given-names>GB</given-names>
</name>
<name>
<surname>Himpens</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Germay</surname>
<given-names>O</given-names>
</name>
<name>
<surname>Izizaw</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Degueldre</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Vandromme</surname>
<given-names>J</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Feasibility of robotic laparoscopic surgery: 146 cases</article-title>
<source>World J Surg</source>
<year>2001</year>
<volume>25</volume>
<fpage>1467</fpage>
<lpage>1477</lpage>
<pub-id pub-id-type="pmid">11760751</pub-id>
</element-citation>
</ref>
<ref id="CR4">
<label>4.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ng</surname>
<given-names>KH</given-names>
</name>
<name>
<surname>Lim</surname>
<given-names>YK</given-names>
</name>
<name>
<surname>Ho</surname>
<given-names>KS</given-names>
</name>
<name>
<surname>Ooi</surname>
<given-names>BS</given-names>
</name>
<name>
<surname>Eu</surname>
<given-names>KW</given-names>
</name>
</person-group>
<article-title>Robotic-assisted surgery for low rectal dissection: from better views to better outcome</article-title>
<source>Singapore Med J</source>
<year>2009</year>
<volume>50</volume>
<fpage>763</fpage>
<lpage>767</lpage>
<pub-id pub-id-type="pmid">19710972</pub-id>
</element-citation>
</ref>
<ref id="CR5">
<label>5.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Baek</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Al-Asari</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Jeong</surname>
<given-names>DH</given-names>
</name>
<name>
<surname>Hur</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Min</surname>
<given-names>BS</given-names>
</name>
<name>
<surname>Baik</surname>
<given-names>SH</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Robotic versus laparoscopic coloanal anastomosis with or without intersphincteric resection for rectal cancer</article-title>
<source>Surg Endosc</source>
<year>2013</year>
<volume>27</volume>
<fpage>4157</fpage>
<lpage>4163</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-013-3014-4</pub-id>
<pub-id pub-id-type="pmid">23708725</pub-id>
</element-citation>
</ref>
<ref id="CR6">
<label>6.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bianchi</surname>
<given-names>PP</given-names>
</name>
<name>
<surname>Ceriani</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Locatelli</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Spinoglio</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Zampino</surname>
<given-names>MG</given-names>
</name>
<name>
<surname>Sonzogni</surname>
<given-names>A</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Robotic versus laparoscopic total mesorectal excision for rectal cancer: a comparative analysis of oncological safety and short-term outcomes</article-title>
<source>Surg Endosc</source>
<year>2010</year>
<volume>24</volume>
<fpage>2888</fpage>
<lpage>2894</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-010-1134-7</pub-id>
<pub-id pub-id-type="pmid">20526623</pub-id>
</element-citation>
</ref>
<ref id="CR7">
<label>7.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Fernandez</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Anaya</surname>
<given-names>DA</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>LT</given-names>
</name>
<name>
<surname>Orcutt</surname>
<given-names>ST</given-names>
</name>
<name>
<surname>Balentine</surname>
<given-names>CJ</given-names>
</name>
<name>
<surname>Awad</surname>
<given-names>SA</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Laparoscopic versus robotic rectal resection for rectal cancer in a veteran population</article-title>
<source>Am J Surg</source>
<year>2013</year>
<volume>206</volume>
<fpage>509</fpage>
<lpage>517</lpage>
<pub-id pub-id-type="doi">10.1016/j.amjsurg.2013.01.036</pub-id>
<pub-id pub-id-type="pmid">23809672</pub-id>
</element-citation>
</ref>
<ref id="CR8">
<label>8.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Clark</surname>
<given-names>HD</given-names>
</name>
<name>
<surname>Wells</surname>
<given-names>GA</given-names>
</name>
<name>
<surname>Huët</surname>
<given-names>C</given-names>
</name>
<name>
<surname>McAlister</surname>
<given-names>FA</given-names>
</name>
<name>
<surname>Salmi</surname>
<given-names>LR</given-names>
</name>
<name>
<surname>Fergusson</surname>
<given-names>D</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Assessing the quality of randomized trials: reliability of the Jadad scale</article-title>
<source>Control Clin Trials</source>
<year>1999</year>
<volume>20</volume>
<fpage>448</fpage>
<lpage>452</lpage>
<pub-id pub-id-type="doi">10.1016/S0197-2456(99)00026-4</pub-id>
<pub-id pub-id-type="pmid">10503804</pub-id>
</element-citation>
</ref>
<ref id="CR9">
<label>9.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Slim</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Nini</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Forestier</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Kwiatkowski</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Panis</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Chipponi</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Methodological index for non-randomized studies (minors): development and validation of a new instrument</article-title>
<source>ANZ J Surg</source>
<year>2003</year>
<volume>73</volume>
<fpage>712</fpage>
<lpage>716</lpage>
<pub-id pub-id-type="doi">10.1046/j.1445-2197.2003.02748.x</pub-id>
<pub-id pub-id-type="pmid">12956787</pub-id>
</element-citation>
</ref>
<ref id="CR10">
<label>10.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Hozo</surname>
<given-names>SP</given-names>
</name>
<name>
<surname>Djulbegovic</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Hozo</surname>
<given-names>I</given-names>
</name>
</person-group>
<article-title>Estimating the mean and variance from the median, range, and the size of a sample</article-title>
<source>BMC Med Res Methodol</source>
<year>2005</year>
<volume>5</volume>
<fpage>13</fpage>
<pub-id pub-id-type="doi">10.1186/1471-2288-5-13</pub-id>
<pub-id pub-id-type="pmid">15840177</pub-id>
</element-citation>
</ref>
<ref id="CR11">
<label>11.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Park</surname>
<given-names>EJ</given-names>
</name>
<name>
<surname>Cho</surname>
<given-names>MS</given-names>
</name>
<name>
<surname>Baek</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Hur</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Min</surname>
<given-names>BS</given-names>
</name>
<name>
<surname>Baik</surname>
<given-names>SH</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Long-term oncologic outcomes of robotic low anterior resection for rectal cancer: a comparative study with laparoscopic surgery</article-title>
<source>Ann Surg</source>
<year>2015</year>
<volume>261</volume>
<fpage>129</fpage>
<lpage>137</lpage>
<pub-id pub-id-type="doi">10.1097/SLA.0000000000000613</pub-id>
<pub-id pub-id-type="pmid">24662411</pub-id>
</element-citation>
</ref>
<ref id="CR12">
<label>12.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Pigazzi</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Ellenhorn</surname>
<given-names>JD</given-names>
</name>
<name>
<surname>Ballantyne</surname>
<given-names>GH</given-names>
</name>
<name>
<surname>Paz</surname>
<given-names>IB</given-names>
</name>
</person-group>
<article-title>Robotic-assisted laparoscopic low anterior resection with total mesorectal excision for rectal cancer</article-title>
<source>Surg Endosc</source>
<year>2006</year>
<volume>20</volume>
<fpage>1521</fpage>
<lpage>1525</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-005-0855-5</pub-id>
<pub-id pub-id-type="pmid">16897284</pub-id>
</element-citation>
</ref>
<ref id="CR13">
<label>13.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Baik</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Ko</surname>
<given-names>YT</given-names>
</name>
<name>
<surname>Kang</surname>
<given-names>CM</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>WJ</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>NK</given-names>
</name>
<name>
<surname>Sohn</surname>
<given-names>SK</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Robotic tumor-specific mesorectal excision of rectal cancer: short-term outcome of a pilot randomized trial</article-title>
<source>Surg Endosc</source>
<year>2008</year>
<volume>22</volume>
<fpage>1601</fpage>
<lpage>1608</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-008-9752-z</pub-id>
<pub-id pub-id-type="pmid">18270772</pub-id>
</element-citation>
</ref>
<ref id="CR14">
<label>14.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Baik</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Kwon</surname>
<given-names>HY</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>JS</given-names>
</name>
<name>
<surname>Hur</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Sohn</surname>
<given-names>SK</given-names>
</name>
<name>
<surname>Cho</surname>
<given-names>CH</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Robotic versus laparoscopic low anterior resection of rectal cancer: short-term outcome of a prospective comparative study</article-title>
<source>Ann Surg Oncol</source>
<year>2009</year>
<volume>16</volume>
<fpage>1480</fpage>
<lpage>1487</lpage>
<pub-id pub-id-type="doi">10.1245/s10434-009-0435-3</pub-id>
<pub-id pub-id-type="pmid">19290486</pub-id>
</element-citation>
</ref>
<ref id="CR15">
<label>15.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>D’Annibale</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Pernazza</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Monsellato</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Pende</surname>
<given-names>V</given-names>
</name>
<name>
<surname>Lucandri</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Mazzocchi</surname>
<given-names>P</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Total mesorectal excision: a comparison of oncological and functional outcomes between robotic and laparoscopic surgery for rectal cancer</article-title>
<source>Surg Endosc</source>
<year>2013</year>
<volume>27</volume>
<fpage>1887</fpage>
<lpage>1895</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-012-2731-4</pub-id>
<pub-id pub-id-type="pmid">23292566</pub-id>
</element-citation>
</ref>
<ref id="CR16">
<label>16.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Erguner</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Aytac</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Boler</surname>
<given-names>DE</given-names>
</name>
<name>
<surname>Atalar</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Baca</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Karahasanoglu</surname>
<given-names>T</given-names>
</name>
<etal></etal>
</person-group>
<article-title>What have we gained by performing robotic rectal resection? Evaluation of 64 consecutive patients who underwent laparoscopic or robotic low anterior resection for rectal adenocarcinoma</article-title>
<source>Surg Laparosc Endosc Percutan Tech</source>
<year>2013</year>
<volume>23</volume>
<fpage>316</fpage>
<lpage>319</lpage>
<pub-id pub-id-type="doi">10.1097/SLE.0b013e31828e3697</pub-id>
<pub-id pub-id-type="pmid">23752000</pub-id>
</element-citation>
</ref>
<ref id="CR17">
<label>17.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Marecik</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Zawadzki</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Velchuru</surname>
<given-names>VR</given-names>
</name>
</person-group>
<article-title>Cost comparison of robot-assisted versus hand assisted laparoscopic anterior resections for rectal cancer</article-title>
<source>Colorectal Dis</source>
<year>2011</year>
<volume>6</volume>
<fpage>16</fpage>
<lpage>27</lpage>
</element-citation>
</ref>
<ref id="CR18">
<label>18.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Shin</surname>
<given-names>JY</given-names>
</name>
</person-group>
<article-title>Comparison of short-term surgical outcomes between a robotic colectomy and a laparoscopic colectomy during early experience</article-title>
<source>J Korean Soc Coloproctol</source>
<year>2012</year>
<volume>28</volume>
<fpage>19</fpage>
<lpage>26</lpage>
<pub-id pub-id-type="doi">10.3393/jksc.2012.28.1.19</pub-id>
<pub-id pub-id-type="pmid">22413078</pub-id>
</element-citation>
</ref>
<ref id="CR19">
<label>19.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Jacobs</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Verdeja</surname>
<given-names>JC</given-names>
</name>
<name>
<surname>Goldstein</surname>
<given-names>HS</given-names>
</name>
</person-group>
<article-title>Minimally invasive colon resection (laparoscopic colectomy)</article-title>
<source>Surg Laparosc Endosc</source>
<year>1991</year>
<volume>1</volume>
<fpage>144</fpage>
<lpage>150</lpage>
<pub-id pub-id-type="pmid">1688289</pub-id>
</element-citation>
</ref>
<ref id="CR20">
<label>20.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Fleshman</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Sargent</surname>
<given-names>DJ</given-names>
</name>
<name>
<surname>Green</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Anvari</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Stryker</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Beart</surname>
<given-names>RW</given-names>
<suffix>Jr</suffix>
</name>
<etal></etal>
</person-group>
<article-title>Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial</article-title>
<source>Ann Surg.</source>
<year>2007</year>
<volume>246</volume>
<fpage>655</fpage>
<lpage>62</lpage>
<pub-id pub-id-type="doi">10.1097/SLA.0b013e318155a762</pub-id>
<pub-id pub-id-type="pmid">17893502</pub-id>
</element-citation>
</ref>
<ref id="CR21">
<label>21.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Jayne</surname>
<given-names>DG</given-names>
</name>
<name>
<surname>Guillou</surname>
<given-names>PJ</given-names>
</name>
<name>
<surname>Thorpe</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Quirke</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Copeland</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Smith</surname>
<given-names>AM</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group</article-title>
<source>J Clin Oncol</source>
<year>2007</year>
<volume>25</volume>
<fpage>3061</fpage>
<lpage>3068</lpage>
<pub-id pub-id-type="doi">10.1200/JCO.2006.09.7758</pub-id>
<pub-id pub-id-type="pmid">17634484</pub-id>
</element-citation>
</ref>
<ref id="CR22">
<label>22.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kuhry</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Schwenk</surname>
<given-names>WF</given-names>
</name>
<name>
<surname>Gaupset</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Romild</surname>
<given-names>U</given-names>
</name>
<name>
<surname>Bonjer</surname>
<given-names>HJ</given-names>
</name>
</person-group>
<article-title>Long-term results of laparoscopic colorectal cancer resection</article-title>
<source>Cochrane Database Syst Rev</source>
<year>2008</year>
<volume>16</volume>
<issue>2</issue>
<fpage>CD003432</fpage>
<pub-id pub-id-type="pmid">18425886</pub-id>
</element-citation>
</ref>
<ref id="CR23">
<label>23.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Trastulli</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Cirocchi</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Listorti</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Cavaliere</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Avenia</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Gullà</surname>
<given-names>N</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Laparoscopic vs open resection for rectal cancer: a meta-analysis of randomized clinical trials</article-title>
<source>Colorectal Dis</source>
<year>2012</year>
<volume>14</volume>
<fpage>e277</fpage>
<lpage>e296</lpage>
<pub-id pub-id-type="doi">10.1111/j.1463-1318.2012.02985.x</pub-id>
<pub-id pub-id-type="pmid">22330061</pub-id>
</element-citation>
</ref>
<ref id="CR24">
<label>24.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Choi</surname>
<given-names>DJ</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>PJ</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Woo</surname>
<given-names>SU</given-names>
</name>
</person-group>
<article-title>Single-stage totally robotic dissection for rectal cancer surgery: technique and short-term outcome in 50 consecutive patients</article-title>
<source>Dis Colon Rectum</source>
<year>2009</year>
<volume>52</volume>
<fpage>1824</fpage>
<lpage>1830</lpage>
<pub-id pub-id-type="doi">10.1007/DCR.0b013e3181b13536</pub-id>
<pub-id pub-id-type="pmid">19966627</pub-id>
</element-citation>
</ref>
<ref id="CR25">
<label>25.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kim</surname>
<given-names>NK</given-names>
</name>
<name>
<surname>Kang</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Optimal total mesorectal excision for rectal cancer: the role of robotic surgery from an expert’s view</article-title>
<source>J Korean Soc Coloproctol</source>
<year>2010</year>
<volume>26</volume>
<fpage>377</fpage>
<lpage>387</lpage>
<pub-id pub-id-type="doi">10.3393/jksc.2010.26.6.377</pub-id>
<pub-id pub-id-type="pmid">21221237</pub-id>
</element-citation>
</ref>
<ref id="CR26">
<label>26.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kwak</surname>
<given-names>JM</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Son</surname>
<given-names>DN</given-names>
</name>
<name>
<surname>Baek</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Cho</surname>
<given-names>JS</given-names>
</name>
</person-group>
<article-title>Robotic vs laparoscopic resection of rectal cancer: short-term outcomes of a case–control study</article-title>
<source>Dis Colon Rectum</source>
<year>2011</year>
<volume>54</volume>
<fpage>151</fpage>
<lpage>156</lpage>
<pub-id pub-id-type="doi">10.1007/DCR.0b013e3181fec4fd</pub-id>
<pub-id pub-id-type="pmid">21228661</pub-id>
</element-citation>
</ref>
<ref id="CR27">
<label>27.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Patriti</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Ceccarelli</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Bartoli</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Spaziani</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Biancafarina</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Casciola</surname>
<given-names>L</given-names>
</name>
</person-group>
<article-title>Short- and medium-term outcome of robot-assisted and traditional laparoscopic rectal resection</article-title>
<source>JSLS</source>
<year>2009</year>
<volume>13</volume>
<fpage>176</fpage>
<lpage>183</lpage>
<pub-id pub-id-type="pmid">19660212</pub-id>
</element-citation>
</ref>
<ref id="CR28">
<label>28.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Broholm</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Pommergaard</surname>
<given-names>HC</given-names>
</name>
<name>
<surname>Gögenür</surname>
<given-names>I</given-names>
</name>
</person-group>
<article-title>Possible benefits of robot-assisted rectal cancer surgery regarding urological and sexual dysfunction: a systematic review and meta-analysis</article-title>
<source>Colorectal Dis</source>
<year>2015</year>
<volume>17</volume>
<fpage>375</fpage>
<lpage>381</lpage>
<pub-id pub-id-type="doi">10.1111/codi.12872</pub-id>
<pub-id pub-id-type="pmid">25515638</pub-id>
</element-citation>
</ref>
<ref id="CR29">
<label>29.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rencuzogullari</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Gorgun</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>Robotic rectal surgery</article-title>
<source>J Surg Oncol</source>
<year>2015</year>
<volume>112</volume>
<fpage>326</fpage>
<lpage>331</lpage>
<pub-id pub-id-type="doi">10.1002/jso.23956</pub-id>
<pub-id pub-id-type="pmid">26390286</pub-id>
</element-citation>
</ref>
<ref id="CR30">
<label>30.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>D’Annibale</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Pernazza</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Morpurgo</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Monsellato</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Pende</surname>
<given-names>V</given-names>
</name>
<name>
<surname>Lucandri</surname>
<given-names>G</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Robotic right colon resection: evaluation of first 50 consecutive cases for malignant disease</article-title>
<source>Ann Surg Oncol</source>
<year>2010</year>
<volume>17</volume>
<fpage>2856</fpage>
<lpage>2862</lpage>
<pub-id pub-id-type="doi">10.1245/s10434-010-1175-0</pub-id>
<pub-id pub-id-type="pmid">20567918</pub-id>
</element-citation>
</ref>
<ref id="CR31">
<label>31.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Nagtegaal</surname>
<given-names>ID</given-names>
</name>
<name>
<surname>Quirke</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>What is the role for the circumferential margin in the modern treatment of rectal cancer?</article-title>
<source>J Clin Oncol</source>
<year>2008</year>
<volume>26</volume>
<fpage>303</fpage>
<lpage>312</lpage>
<pub-id pub-id-type="doi">10.1200/JCO.2007.12.7027</pub-id>
<pub-id pub-id-type="pmid">18182672</pub-id>
</element-citation>
</ref>
<ref id="CR32">
<label>32.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Hottenrott</surname>
<given-names>C</given-names>
</name>
</person-group>
<article-title>Robotic versus laparoscopic surgery for rectal cancer and cost-effectiveness analysis</article-title>
<source>Surg Endosc</source>
<year>2011</year>
<volume>25</volume>
<fpage>3954</fpage>
<lpage>3956</lpage>
<pub-id pub-id-type="doi">10.1007/s00464-011-1808-9</pub-id>
<pub-id pub-id-type="pmid">21695585</pub-id>
</element-citation>
</ref>
<ref id="CR33">
<label>33.</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>MacLehose</surname>
<given-names>RR</given-names>
</name>
<name>
<surname>Reeves</surname>
<given-names>BC</given-names>
</name>
<name>
<surname>Harvey</surname>
<given-names>IM</given-names>
</name>
<name>
<surname>Sheldon</surname>
<given-names>TA</given-names>
</name>
<name>
<surname>Russell</surname>
<given-names>IT</given-names>
</name>
<name>
<surname>Black</surname>
<given-names>AM</given-names>
</name>
</person-group>
<article-title>A systematic review of comparisons of effect sizes derived from randomised and non-randomised studies</article-title>
<source>Health Technol Assess</source>
<year>2000</year>
<volume>4</volume>
<fpage>1</fpage>
<lpage>154</lpage>
<pub-id pub-id-type="pmid">11134917</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
</pmc>
<affiliations>
<list>
<country>
<li>République populaire de Chine</li>
</country>
</list>
<tree>
<country name="République populaire de Chine">
<noRegion>
<name sortKey="Sun, Yanlai" sort="Sun, Yanlai" uniqKey="Sun Y" first="Yanlai" last="Sun">Yanlai Sun</name>
</noRegion>
<name sortKey="Han, Jianjun" sort="Han, Jianjun" uniqKey="Han J" first="Jianjun" last="Han">Jianjun Han</name>
<name sortKey="Li, Zengjun" sort="Li, Zengjun" uniqKey="Li Z" first="Zengjun" last="Li">Zengjun Li</name>
<name sortKey="Song, Wentao" sort="Song, Wentao" uniqKey="Song W" first="Wentao" last="Song">Wentao Song</name>
<name sortKey="Wang, Junwei" sort="Wang, Junwei" uniqKey="Wang J" first="Junwei" last="Wang">Junwei Wang</name>
<name sortKey="Xu, Huirong" sort="Xu, Huirong" uniqKey="Xu H" first="Huirong" last="Xu">Huirong Xu</name>
<name sortKey="Xu, Zhongfa" sort="Xu, Zhongfa" uniqKey="Xu Z" first="Zhongfa" last="Xu">Zhongfa Xu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004015 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 004015 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    HapticV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:4772524
   |texte=   Robotic versus laparoscopic low anterior resection for rectal cancer: a meta-analysis
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:26928124" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a HapticV1 

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Mon Jun 13 01:09:46 2016. Site generation: Wed Mar 6 09:54:07 2024