Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain
Identifieur interne : 003F91 ( Ncbi/Merge ); précédent : 003F90; suivant : 003F92Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain
Auteurs : Nina Linde Reislev [Danemark] ; Tim Bj Rn Dyrby [Danemark] ; Hartwig Roman Siebner [Danemark] ; Ron Kupers [Danemark] ; Maurice Ptito [Danemark, Canada]Source :
- Neural Plasticity [ 2090-5904 ] ; 2016.
Abstract
Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness.
Url:
DOI: 10.1155/2016/6029241
PubMed: 26881120
PubMed Central: 4736370
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<front><div type="abstract" xml:lang="en"><p>Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness. </p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bavelier, D" uniqKey="Bavelier D">D. Bavelier</name>
</author>
<author><name sortKey="Neville, H J" uniqKey="Neville H">H. J. Neville</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renier, L" uniqKey="Renier L">L. Renier</name>
</author>
<author><name sortKey="De Volder, A G" uniqKey="De Volder A">A. G. De Volder</name>
</author>
<author><name sortKey="Rauschecker, J P" uniqKey="Rauschecker J">J. P. Rauschecker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desgent, S" uniqKey="Desgent S">S. Desgent</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merabet, L B" uniqKey="Merabet L">L. B. Merabet</name>
</author>
<author><name sortKey="Pascual Leone, A" uniqKey="Pascual Leone A">A. Pascual-Leone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Voss, P" uniqKey="Voss P">P. Voss</name>
</author>
<author><name sortKey="Pike, B G" uniqKey="Pike B">B. G. Pike</name>
</author>
<author><name sortKey="Zatorre, R J" uniqKey="Zatorre R">R. J. Zatorre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedny, M" uniqKey="Bedny M">M. Bedny</name>
</author>
<author><name sortKey="Pascual Leone, A" uniqKey="Pascual Leone A">A. Pascual-Leone</name>
</author>
<author><name sortKey="Dodell Feder, D" uniqKey="Dodell Feder D">D. Dodell-Feder</name>
</author>
<author><name sortKey="Fedorenko, E" uniqKey="Fedorenko E">E. Fedorenko</name>
</author>
<author><name sortKey="Saxe, R" uniqKey="Saxe R">R. Saxe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collignon, O" uniqKey="Collignon O">O. Collignon</name>
</author>
<author><name sortKey="Vandewalle, G" uniqKey="Vandewalle G">G. Vandewalle</name>
</author>
<author><name sortKey="Voss, P" uniqKey="Voss P">P. Voss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watkins, K E" uniqKey="Watkins K">K. E. Watkins</name>
</author>
<author><name sortKey="Shakespeare, T J" uniqKey="Shakespeare T">T. J. Shakespeare</name>
</author>
<author><name sortKey="O Donoghue M Clare, M C" uniqKey="O Donoghue M Clare M">M. C. O'Donoghue M. Clare</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hotting, K" uniqKey="Hotting K">K. Hötting</name>
</author>
<author><name sortKey="Roder, B" uniqKey="Roder B">B. Röder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagnon, L" uniqKey="Gagnon L">L. Gagnon</name>
</author>
<author><name sortKey="Schneider, F C" uniqKey="Schneider F">F. C. Schneider</name>
</author>
<author><name sortKey="Siebner, H R" uniqKey="Siebner H">H. R. Siebner</name>
</author>
<author><name sortKey="Paulson, O B" uniqKey="Paulson O">O. B. Paulson</name>
</author>
<author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matteau, I" uniqKey="Matteau I">I. Matteau</name>
</author>
<author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Ricciardi, E" uniqKey="Ricciardi E">E. Ricciardi</name>
</author>
<author><name sortKey="Pietrini, P" uniqKey="Pietrini P">P. Pietrini</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sadato, N" uniqKey="Sadato N">N. Sadato</name>
</author>
<author><name sortKey="Pascual Leone, A" uniqKey="Pascual Leone A">A. Pascual-Leone</name>
</author>
<author><name sortKey="Grafman, J" uniqKey="Grafman J">J. Grafman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Theoret, H" uniqKey="Theoret H">H. Théoret</name>
</author>
<author><name sortKey="Merabet, L" uniqKey="Merabet L">L. Merabet</name>
</author>
<author><name sortKey="Pascual Leone, A" uniqKey="Pascual Leone A">A. Pascual-Leone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Beaulieu Lefebvre, M" uniqKey="Beaulieu Lefebvre M">M. Beaulieu-Lefebvre</name>
</author>
<author><name sortKey="Schneider, F C" uniqKey="Schneider F">F. C. Schneider</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noppeney, U" uniqKey="Noppeney U">U. Noppeney</name>
</author>
<author><name sortKey="Friston, K J" uniqKey="Friston K">K. J. Friston</name>
</author>
<author><name sortKey="Ashburner, J" uniqKey="Ashburner J">J. Ashburner</name>
</author>
<author><name sortKey="Frackowiak, R" uniqKey="Frackowiak R">R. Frackowiak</name>
</author>
<author><name sortKey="Price, C J" uniqKey="Price C">C. J. Price</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
<author><name sortKey="Schneider, F C G" uniqKey="Schneider F">F. C. G. Schneider</name>
</author>
<author><name sortKey="Paulson, O B" uniqKey="Paulson O">O. B. Paulson</name>
</author>
<author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaulieu, C" uniqKey="Beaulieu C">C. Beaulieu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basser, P J" uniqKey="Basser P">P. J. Basser</name>
</author>
<author><name sortKey="Mattiello, J" uniqKey="Mattiello J">J. Mattiello</name>
</author>
<author><name sortKey="Lebihan, D" uniqKey="Lebihan D">D. LeBihan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pierpaoli, C" uniqKey="Pierpaoli C">C. Pierpaoli</name>
</author>
<author><name sortKey="Jezzard, P" uniqKey="Jezzard P">P. Jezzard</name>
</author>
<author><name sortKey="Basser, P J" uniqKey="Basser P">P. J. Basser</name>
</author>
<author><name sortKey="Barnett, A" uniqKey="Barnett A">A. Barnett</name>
</author>
<author><name sortKey="Di Chiro, G" uniqKey="Di Chiro G">G. Di Chiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le Bihan, D" uniqKey="Le Bihan D">D. Le Bihan</name>
</author>
<author><name sortKey="Mangin, J F" uniqKey="Mangin J">J.-F. Mangin</name>
</author>
<author><name sortKey="Poupon, C" uniqKey="Poupon C">C. Poupon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimony, J S" uniqKey="Shimony J">J. S. Shimony</name>
</author>
<author><name sortKey="Burton, H" uniqKey="Burton H">H. Burton</name>
</author>
<author><name sortKey="Epstein, A A" uniqKey="Epstein A">A. A. Epstein</name>
</author>
<author><name sortKey="Mclaren, D G" uniqKey="Mclaren D">D. G. McLaren</name>
</author>
<author><name sortKey="Sun, S W" uniqKey="Sun S">S. W. Sun</name>
</author>
<author><name sortKey="Snyder, A Z" uniqKey="Snyder A">A. Z. Snyder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Qin, W" uniqKey="Qin W">W. Qin</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
<author><name sortKey="Shu, N" uniqKey="Shu N">N. Shu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Qin, W" uniqKey="Qin W">W. Qin</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bridge, H" uniqKey="Bridge H">H. Bridge</name>
</author>
<author><name sortKey="Cowey, A" uniqKey="Cowey A">A. Cowey</name>
</author>
<author><name sortKey="Ragge, N" uniqKey="Ragge N">N. Ragge</name>
</author>
<author><name sortKey="Watkins, K" uniqKey="Watkins K">K. Watkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shu, N" uniqKey="Shu N">N. Shu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K. Li</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shu, N" uniqKey="Shu N">N. Shu</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Qin, W" uniqKey="Qin W">W. Qin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qin, W" uniqKey="Qin W">W. Qin</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burton, H" uniqKey="Burton H">H. Burton</name>
</author>
<author><name sortKey="Snyder, A Z" uniqKey="Snyder A">A. Z. Snyder</name>
</author>
<author><name sortKey="Conturo, T E" uniqKey="Conturo T">T. E. Conturo</name>
</author>
<author><name sortKey="Akbudak, E" uniqKey="Akbudak E">E. Akbudak</name>
</author>
<author><name sortKey="Ollinger, J M" uniqKey="Ollinger J">J. M. Ollinger</name>
</author>
<author><name sortKey="Raichle, M E" uniqKey="Raichle M">M. E. Raichle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burton, H" uniqKey="Burton H">H. Burton</name>
</author>
<author><name sortKey="Snyder, A Z" uniqKey="Snyder A">A. Z. Snyder</name>
</author>
<author><name sortKey="Raichle, M E" uniqKey="Raichle M">M. E. Raichle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bedny, M" uniqKey="Bedny M">M. Bedny</name>
</author>
<author><name sortKey="Konkle, T" uniqKey="Konkle T">T. Konkle</name>
</author>
<author><name sortKey="Pelphrey, K" uniqKey="Pelphrey K">K. Pelphrey</name>
</author>
<author><name sortKey="Saxe, R" uniqKey="Saxe R">R. Saxe</name>
</author>
<author><name sortKey="Pascual Leone, A" uniqKey="Pascual Leone A">A. Pascual-Leone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bozzali, M" uniqKey="Bozzali M">M. Bozzali</name>
</author>
<author><name sortKey="Parker, G J M" uniqKey="Parker G">G. J. M. Parker</name>
</author>
<author><name sortKey="Serra, L" uniqKey="Serra L">L. Serra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cercignani, M" uniqKey="Cercignani M">M. Cercignani</name>
</author>
<author><name sortKey="Embleton, K" uniqKey="Embleton K">K. Embleton</name>
</author>
<author><name sortKey="Parker, G J M" uniqKey="Parker G">G. J. M. Parker</name>
</author>
<author><name sortKey="Bozzali, M" uniqKey="Bozzali M">M. Bozzali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lyksborg, M" uniqKey="Lyksborg M">M. Lyksborg</name>
</author>
<author><name sortKey="Siebner, H R" uniqKey="Siebner H">H. R. Siebner</name>
</author>
<author><name sortKey="S Rensen, P S" uniqKey="S Rensen P">P. S. Sørensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reislev, N L" uniqKey="Reislev N">N. L. Reislev</name>
</author>
<author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
<author><name sortKey="Siebner, H R" uniqKey="Siebner H">H. R. Siebner</name>
</author>
<author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
<author><name sortKey="Dyrby, T B" uniqKey="Dyrby T">T. B. Dyrby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reese, T G" uniqKey="Reese T">T. G. Reese</name>
</author>
<author><name sortKey="Heid, O" uniqKey="Heid O">O. Heid</name>
</author>
<author><name sortKey="Weisskoff, R M" uniqKey="Weisskoff R">R. M. Weisskoff</name>
</author>
<author><name sortKey="Wedeen, V J" uniqKey="Wedeen V">V. J. Wedeen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersson, J L R" uniqKey="Andersson J">J. L. R. Andersson</name>
</author>
<author><name sortKey="Skare, S" uniqKey="Skare S">S. Skare</name>
</author>
<author><name sortKey="Ashburner, J" uniqKey="Ashburner J">J. Ashburner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, S M" uniqKey="Smith S">S. M. Smith</name>
</author>
<author><name sortKey="Jenkinson, M" uniqKey="Jenkinson M">M. Jenkinson</name>
</author>
<author><name sortKey="Woolrich, M W" uniqKey="Woolrich M">M. W. Woolrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alexander, D C" uniqKey="Alexander D">D. C. Alexander</name>
</author>
<author><name sortKey="Pierpaoli, C" uniqKey="Pierpaoli C">C. Pierpaoli</name>
</author>
<author><name sortKey="Basser, P J" uniqKey="Basser P">P. J. Basser</name>
</author>
<author><name sortKey="Gee, J C" uniqKey="Gee J">J. C. Gee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jovicich, J" uniqKey="Jovicich J">J. Jovicich</name>
</author>
<author><name sortKey="Czanner, S" uniqKey="Czanner S">S. Czanner</name>
</author>
<author><name sortKey="Greve, D" uniqKey="Greve D">D. Greve</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, D K" uniqKey="Jones D">D. K. Jones</name>
</author>
<author><name sortKey="Basser, P J" uniqKey="Basser P">P. J. Basser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cook, P A" uniqKey="Cook P">P. A. Cook</name>
</author>
<author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name>
</author>
<author><name sortKey="Seunarine, K K" uniqKey="Seunarine K">K. K. Seunarine</name>
</author>
<author><name sortKey="Hall, M G" uniqKey="Hall M">M. G. Hall</name>
</author>
<author><name sortKey="Parker, G J" uniqKey="Parker G">G. J. Parker</name>
</author>
<author><name sortKey="Alexander, D C" uniqKey="Alexander D">D. C. Alexander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Behrens, T E J" uniqKey="Behrens T">T. E. J. Behrens</name>
</author>
<author><name sortKey="Woolrich, M W" uniqKey="Woolrich M">M. W. Woolrich</name>
</author>
<author><name sortKey="Jenkinson, M" uniqKey="Jenkinson M">M. Jenkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Behrens, T E J" uniqKey="Behrens T">T. E. J. Behrens</name>
</author>
<author><name sortKey="Berg, H J" uniqKey="Berg H">H. J. Berg</name>
</author>
<author><name sortKey="Jbabdi, S" uniqKey="Jbabdi S">S. Jbabdi</name>
</author>
<author><name sortKey="Rushworth, M F S" uniqKey="Rushworth M">M. F. S. Rushworth</name>
</author>
<author><name sortKey="Woolrich, M W" uniqKey="Woolrich M">M. W. Woolrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liptrot, M G" uniqKey="Liptrot M">M. G. Liptrot</name>
</author>
<author><name sortKey="Sidaros, K" uniqKey="Sidaros K">K. Sidaros</name>
</author>
<author><name sortKey="Dyrby, T B" uniqKey="Dyrby T">T. B. Dyrby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jenkinson, M" uniqKey="Jenkinson M">M. Jenkinson</name>
</author>
<author><name sortKey="Smith, S" uniqKey="Smith S">S. Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jenkinson, M" uniqKey="Jenkinson M">M. Jenkinson</name>
</author>
<author><name sortKey="Bannister, P" uniqKey="Bannister P">P. Bannister</name>
</author>
<author><name sortKey="Brady, M" uniqKey="Brady M">M. Brady</name>
</author>
<author><name sortKey="Smith, S" uniqKey="Smith S">S. Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersson, J L R" uniqKey="Andersson J">J. L. R. Andersson</name>
</author>
<author><name sortKey="Jenkinson, M" uniqKey="Jenkinson M">M. Jenkinson</name>
</author>
<author><name sortKey="Smith, S" uniqKey="Smith S">S. Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lilliefors, H W" uniqKey="Lilliefors H">H. W. Lilliefors</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, S M" uniqKey="Smith S">S. M. Smith</name>
</author>
<author><name sortKey="Nichols, T E" uniqKey="Nichols T">T. E. Nichols</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Winkler, A M" uniqKey="Winkler A">A. M. Winkler</name>
</author>
<author><name sortKey="Ridgway, G R" uniqKey="Ridgway G">G. R. Ridgway</name>
</author>
<author><name sortKey="Webster, M A" uniqKey="Webster M">M. A. Webster</name>
</author>
<author><name sortKey="Smith, S M" uniqKey="Smith S">S. M. Smith</name>
</author>
<author><name sortKey="Nichols, T E" uniqKey="Nichols T">T. E. Nichols</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, S" uniqKey="Mori S">S. Mori</name>
</author>
<author><name sortKey="Wakana, S" uniqKey="Wakana S">S. Wakana</name>
</author>
<author><name sortKey="Nagae Poetscher, L M" uniqKey="Nagae Poetscher L">L. M. Nagae-Poetscher</name>
</author>
<author><name sortKey="Van Zijl, P C M" uniqKey="Van Zijl P">P. C. M. van Zijl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Catani, M" uniqKey="Catani M">M. Catani</name>
</author>
<author><name sortKey="Thiebaut De Schotten, M" uniqKey="Thiebaut De Schotten M">M. Thiebaut de Schotten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Innocenti, G M" uniqKey="Innocenti G">G. M. Innocenti</name>
</author>
<author><name sortKey="Price, D J" uniqKey="Price D">D. J. Price</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Innocenti, G M" uniqKey="Innocenti G">G. M. Innocenti</name>
</author>
<author><name sortKey="Frost, D O" uniqKey="Frost D">D. O. Frost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Innocenti, G M" uniqKey="Innocenti G">G. M. Innocenti</name>
</author>
<author><name sortKey="Frost, D O" uniqKey="Frost D">D. O. Frost</name>
</author>
<author><name sortKey="Illes, J" uniqKey="Illes J">J. Illes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bock, A S" uniqKey="Bock A">A. S. Bock</name>
</author>
<author><name sortKey="Saenz, M" uniqKey="Saenz M">M. Saenz</name>
</author>
<author><name sortKey="Tungaraza, R" uniqKey="Tungaraza R">R. Tungaraza</name>
</author>
<author><name sortKey="Boynton, G M" uniqKey="Boynton G">G. M. Boynton</name>
</author>
<author><name sortKey="Bridge, H" uniqKey="Bridge H">H. Bridge</name>
</author>
<author><name sortKey="Fine, I" uniqKey="Fine I">I. Fine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
<author><name sortKey="Liang, M" uniqKey="Liang M">M. Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lepore, N" uniqKey="Lepore N">N. Leporé</name>
</author>
<author><name sortKey="Voss, P" uniqKey="Voss P">P. Voss</name>
</author>
<author><name sortKey="Lepore, F" uniqKey="Lepore F">F. Lepore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tomaiuolo, F" uniqKey="Tomaiuolo F">F. Tomaiuolo</name>
</author>
<author><name sortKey="Campana, S" uniqKey="Campana S">S. Campana</name>
</author>
<author><name sortKey="Collins, D L" uniqKey="Collins D">D. L. Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caminiti, R" uniqKey="Caminiti R">R. Caminiti</name>
</author>
<author><name sortKey="Carducci, F" uniqKey="Carducci F">F. Carducci</name>
</author>
<author><name sortKey="Piervincenzi, C" uniqKey="Piervincenzi C">C. Piervincenzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, K C" uniqKey="Chan K">K. C. Chan</name>
</author>
<author><name sortKey="Cheng, J S" uniqKey="Cheng J">J. S. Cheng</name>
</author>
<author><name sortKey="Fan, S" uniqKey="Fan S">S. Fan</name>
</author>
<author><name sortKey="Zhou, I Y" uniqKey="Zhou I">I. Y. Zhou</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Wu, E X" uniqKey="Wu E">E. X. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amedi, A" uniqKey="Amedi A">A. Amedi</name>
</author>
<author><name sortKey="Malach, R" uniqKey="Malach R">R. Malach</name>
</author>
<author><name sortKey="Hendler, T" uniqKey="Hendler T">T. Hendler</name>
</author>
<author><name sortKey="Peled, S" uniqKey="Peled S">S. Peled</name>
</author>
<author><name sortKey="Zohary, E" uniqKey="Zohary E">E. Zohary</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pietrini, P" uniqKey="Pietrini P">P. Pietrini</name>
</author>
<author><name sortKey="Furey, M L" uniqKey="Furey M">M. L. Furey</name>
</author>
<author><name sortKey="Ricciardi, E" uniqKey="Ricciardi E">E. Ricciardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poirier, C" uniqKey="Poirier C">C. Poirier</name>
</author>
<author><name sortKey="Collignon, O" uniqKey="Collignon O">O. Collignon</name>
</author>
<author><name sortKey="Scheiber, C" uniqKey="Scheiber C">C. Scheiber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ptito, M" uniqKey="Ptito M">M. Ptito</name>
</author>
<author><name sortKey="Matteau, I" uniqKey="Matteau I">I. Matteau</name>
</author>
<author><name sortKey="Gjedde, A" uniqKey="Gjedde A">A. Gjedde</name>
</author>
<author><name sortKey="Kupers, R" uniqKey="Kupers R">R. Kupers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renier, L A" uniqKey="Renier L">L. A. Renier</name>
</author>
<author><name sortKey="Anurova, I" uniqKey="Anurova I">I. Anurova</name>
</author>
<author><name sortKey="De Volder, A G" uniqKey="De Volder A">A. G. De Volder</name>
</author>
<author><name sortKey="Carlson, S" uniqKey="Carlson S">S. Carlson</name>
</author>
<author><name sortKey="Vanmeter, J" uniqKey="Vanmeter J">J. VanMeter</name>
</author>
<author><name sortKey="Rauschecker, J P" uniqKey="Rauschecker J">J. P. Rauschecker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collignon, O" uniqKey="Collignon O">O. Collignon</name>
</author>
<author><name sortKey="Dormal, G" uniqKey="Dormal G">G. Dormal</name>
</author>
<author><name sortKey="Albouy, G" uniqKey="Albouy G">G. Albouy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lasi, S" uniqKey="Lasi S">S. Lasič</name>
</author>
<author><name sortKey="Szczepankiewicz, F" uniqKey="Szczepankiewicz F">F. Szczepankiewicz</name>
</author>
<author><name sortKey="Eriksson, S" uniqKey="Eriksson S">S. Eriksson</name>
</author>
<author><name sortKey="Nilsson, M" uniqKey="Nilsson M">M. Nilsson</name>
</author>
<author><name sortKey="Topgaard, D" uniqKey="Topgaard D">D. Topgaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szczepankiewicz, F" uniqKey="Szczepankiewicz F">F. Szczepankiewicz</name>
</author>
<author><name sortKey="Lasi, S" uniqKey="Lasi S">S. Lasič</name>
</author>
<author><name sortKey="Van Westen, D" uniqKey="Van Westen D">D. van Westen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jespersen, S N" uniqKey="Jespersen S">S. N. Jespersen</name>
</author>
<author><name sortKey="Lundell, H" uniqKey="Lundell H">H. Lundell</name>
</author>
<author><name sortKey="S Nderby, C K" uniqKey="S Nderby C">C. K. Sønderby</name>
</author>
<author><name sortKey="Dyrby, T B" uniqKey="Dyrby T">T. B. Dyrby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vos, S B" uniqKey="Vos S">S. B. Vos</name>
</author>
<author><name sortKey="Jones, D K" uniqKey="Jones D">D. K. Jones</name>
</author>
<author><name sortKey="Viergever, M A" uniqKey="Viergever M">M. A. Viergever</name>
</author>
<author><name sortKey="Leemans, A" uniqKey="Leemans A">A. Leemans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Qin, W" uniqKey="Qin W">W. Qin</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Yu, C" uniqKey="Yu C">C. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watkins, K E" uniqKey="Watkins K">K. E. Watkins</name>
</author>
<author><name sortKey="Cowey, A" uniqKey="Cowey A">A. Cowey</name>
</author>
<author><name sortKey="Alexander, I" uniqKey="Alexander I">I. Alexander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heine, L" uniqKey="Heine L">L. Heine</name>
</author>
<author><name sortKey="Bahri, M A" uniqKey="Bahri M">M. A. Bahri</name>
</author>
<author><name sortKey="Cavaliere, C" uniqKey="Cavaliere C">C. Cavaliere</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saygin, Z M" uniqKey="Saygin Z">Z. M. Saygin</name>
</author>
<author><name sortKey="Osher, D E" uniqKey="Osher D">D. E. Osher</name>
</author>
<author><name sortKey="Koldewyn, K" uniqKey="Koldewyn K">K. Koldewyn</name>
</author>
<author><name sortKey="Reynolds, G" uniqKey="Reynolds G">G. Reynolds</name>
</author>
<author><name sortKey="Gabrieli, J D E" uniqKey="Gabrieli J">J. D. E. Gabrieli</name>
</author>
<author><name sortKey="Saxe, R R" uniqKey="Saxe R">R. R. Saxe</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neural Plast</journal-id>
<journal-id journal-id-type="iso-abbrev">Neural Plast</journal-id>
<journal-id journal-id-type="publisher-id">NP</journal-id>
<journal-title-group><journal-title>Neural Plasticity</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-5904</issn>
<issn pub-type="epub">1687-5443</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26881120</article-id>
<article-id pub-id-type="pmc">4736370</article-id>
<article-id pub-id-type="doi">10.1155/2016/6029241</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Reislev</surname>
<given-names>Nina Linde</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dyrby</surname>
<given-names>Tim Bjørn</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siebner</surname>
<given-names>Hartwig Roman</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="I3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kupers</surname>
<given-names>Ron</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ptito</surname>
<given-names>Maurice</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="I4"><sup>4</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, Denmark</aff>
<aff id="I2"><sup>2</sup>
BRAINlab and Neuropsychiatry Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark</aff>
<aff id="I3"><sup>3</sup>
Department of Neurology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark</aff>
<aff id="I4"><sup>4</sup>
University of Montreal, School of Optometry, Montréal, QC, Canada H3C 3J7</aff>
<author-notes><corresp id="cor1">*Nina Linde Reislev: <email>ninar@drcmr.dk</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: James M. Wyss</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>5</day>
<month>1</month>
<year>2016</year>
</pub-date>
<volume>2016</volume>
<elocation-id>6029241</elocation-id>
<history><date date-type="received"><day>13</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>28</day>
<month>10</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2016 Nina Linde Reislev et al.</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness. </p>
</abstract>
</article-meta>
</front>
<body><sec id="sec1"><title>1. Introduction</title>
<p>Structural and functional alterations in the brain related to visual deprivation have been widely studied in both animals and humans to unravel the underlying plastic mechanisms [<xref rid="B1" ref-type="bibr">1</xref>
–<xref rid="B3" ref-type="bibr">3</xref>
]. These lines of research have identified cross-modal compensatory plasticity and impaired brain maturation as two concepts directly related to lack of visual input [<xref rid="B4" ref-type="bibr">4</xref>
–<xref rid="B6" ref-type="bibr">6</xref>
]. Cross-modal plasticity refers to the ability of the blind brain to functionally recruit the visual cortex to process a variety of nonvisual tasks such as audition and language [<xref rid="B7" ref-type="bibr">7</xref>
–<xref rid="B10" ref-type="bibr">10</xref>
], tactile discrimination and spatial navigation [<xref rid="B11" ref-type="bibr">11</xref>
–<xref rid="B14" ref-type="bibr">14</xref>
], and even olfaction [<xref rid="B15" ref-type="bibr">15</xref>
] (for review see Kupers and Ptito [<xref rid="B6" ref-type="bibr">6</xref>
, <xref rid="B79" ref-type="bibr">16</xref>
]). This raises the question of whether the functional recruitment of the visual cortex during nonvisual tasks involves plastic changes in the anatomical connections. This question can be studied noninvasively with functional and structural MRI relating changes in functional connectivity to changes in structural connectivity. Yet connectivity analyses provide no information about the regional structural changes driving the connectivity differences, for instance, local microstructural changes in specific tract-systems. Linking such regional microstructural changes in white matter (WM) tracts to the altered patterns of brain connectivity can hold important information on the rewiring of the blind brain.</p>
<p>Volumetry based on T1-weighted structural MRI has previously been used to show regional WM and grey matter (GM) decreases in congenital and early blindness [<xref rid="B17" ref-type="bibr">17</xref>
, <xref rid="B18" ref-type="bibr">18</xref>
], mainly in the primary visual pathway and the visual cortex. While volumetry indicates a deprivation-induced regional brain atrophy, diffusion MRI provides complementary information about local microstructural features in specific WM pathways [<xref rid="B19" ref-type="bibr">19</xref>
]. Diffusion tensor imaging (DTI) employs a diffusion tensor model to characterise regional tissue properties based on well-established measures such as mean and radial diffusivity and fractional anisotropy [<xref rid="B20" ref-type="bibr">20</xref>
–<xref rid="B22" ref-type="bibr">22</xref>
]. Several DTI studies identified a decrease in FA in the primary visual pathway in both the early and late blind [<xref rid="B23" ref-type="bibr">23</xref>
–<xref rid="B27" ref-type="bibr">27</xref>
]. These regional voxel-based measures provide important information about local microstructural alterations in the blind brain but do not reflect connectivity properties of the brain. Shu and Li [<xref rid="B28" ref-type="bibr">28</xref>
, <xref rid="B29" ref-type="bibr">29</xref>
] studied network properties in congenitally and early blind individuals, based on graph theory and diffusion tensor tractography. They reported a decreased degree of connectivity in occipital and inferior frontal areas, while regions involved in motor and somatosensory function (precentral gyrus, supplementary motor area) and memory (hippocampus) showed an increased degree of connectivity.</p>
<p>Only a few studies have related changes in regional brain structure to changes in brain connectivity. For instance, Qin et al. [<xref rid="B30" ref-type="bibr">30</xref>
] found that congenitally blind individuals showed increased thickness of the primary visual cortex, but not the secondary visual areas, and related this local structural change to decreased resting-state functional MRI (rs-fMRI) in the early visual areas. The local properties within the WM pathways leading to the observed differences of the cortical areas in the blind brain remain to be clarified. The aim of our study was to examine the structural differences that underlie the functional plastic adaptations described by others [<xref rid="B7" ref-type="bibr">7</xref>
, <xref rid="B31" ref-type="bibr">31</xref>
–<xref rid="B33" ref-type="bibr">33</xref>
]. Brain imaging studies of the blind brain should not only establish a link between structure and function, but should also examine how the various methods relate to each other and which information is given by which measure. This gap of knowledge motivated this study in which we simultaneously assessed anatomical connectivity and microstructure in the blind brain from the same diffusion MRI dataset. Microstructural properties of the tissue were assessed based on voxel-wise DTI indices, while anatomical connectivity was assessed with anatomical connectivity mapping (ACM) [<xref rid="B34" ref-type="bibr">34</xref>
–<xref rid="B36" ref-type="bibr">36</xref>
] using whole-brain probabilistic tractography in congenitally and late blind participants. ACM probes how much each voxel in the WM is connected with all other WM voxels in the brain and thus can detect local alterations in whole-brain anatomical connectivity in the WM.</p>
</sec>
<sec id="sec2"><title>2. Materials and Methods</title>
<sec id="sec2.1"><title>2.1. Subjects</title>
<p>Forty-eight subjects were included in the study, as previously used in Reislev et al. [<xref rid="B37" ref-type="bibr">37</xref>
]. The subjects were subdivided into 12 congenitally blind (CB) participants (mean age 42 ± 13 years), 15 late blind (LB) participants (mean age 52 ± 15 years; mean onset of blindness 16.6 ± 8.9 years), and 15 normally sighted (NS) controls (mean age 46 ± 13 years) matched for gender, age, education, and handedness. The inclusion criteria of blind subjects were constrained to blindness caused by pathology of peripheral origin. The congenitally blind subjects were classified as such based on self-reports of medical history and aetiology of the subjects. Since several (9 of 12) of the CB subjects suffered from blindness due to retinopathy of prematurity, an extra control group of six subjects born 6–12 weeks prematurely (PT) (mean age 28 ± 6 years) but with normal vision was included to control for the effect of prematurity. The ethics committee for the city of Copenhagen and Frederiksberg (Denmark) approved the experimental procedures (ethics protocol number (KF) 01 328 723).</p>
</sec>
<sec id="sec2.2"><title>2.2. MRI Acquisition</title>
<p>Diffusion-weighted images (DWIs) of the whole brain were acquired with a 32-channel head coil on a 3.0 Tesla Siemens Verio MRI system (Siemens, Erlangen, Germany). We used a twice-refocused spin-echo sequence [<xref rid="B38" ref-type="bibr">38</xref>
] to acquire DWI at 2.3<sup>3</sup>
mm<sup>3</sup>
isotropic resolution in 61 noncollinear directions (<italic>b</italic>
-value of 1500 s/mm<sup>2</sup>
) and 10 non-diffusion-weighted images (<italic>b</italic>
= 0 s/mm<sup>2</sup>
), as previously described in [<xref rid="B37" ref-type="bibr">37</xref>
]. A set of reversed phase encoded <italic>b</italic>
= 0 images was acquired for preprocessing purposes. Additionally, two T1-weighted MPRAGE image volumes were acquired (TE = 2.32 ms, TR = 1900 ms, flip angle = 9, and isotropic 0.9<sup>3</sup>
mm<sup>3</sup>
voxels).</p>
</sec>
<sec id="sec2.3"><title>2.3. Data Processing and Analyses</title>
<sec id="sec2.3.1"><title>2.3.1. Preprocessing</title>
<p>The data were similarly processed as described by Reislev et al. [<xref rid="B37" ref-type="bibr">37</xref>
] and briefly listed in the following. Geometric distortions related to susceptibility artefacts were minimised in the DWIs with the application of a voxel displacement map (VDM) estimated from the two reversed phase encoded images [<xref rid="B39" ref-type="bibr">39</xref>
, <xref rid="B40" ref-type="bibr">40</xref>
]. Combined correction for motion and eddy currents was obtained by applying a full affine transformation of the DWIs to the mean of the<italic> b</italic>
0-images, using normalised mutual information (SPM8, Wellcome Trust Centre for Neuroimaging, UCL, London, UK). The images were finally resliced to native DWI resolution using 3rd-order B-spline interpolation. The 61 noncollinear directions were reoriented according to the rotation of the applied transformations [<xref rid="B41" ref-type="bibr">41</xref>
]. The T1-weighted image volumes were intensity corrected for gradient nonlinearities of the scanner [<xref rid="B42" ref-type="bibr">42</xref>
].</p>
</sec>
<sec id="sec2.3.2"><title>2.3.2. Microstructural Indices with DTI</title>
<p>The diffusion tensor model [<xref rid="B20" ref-type="bibr">20</xref>
] was fitted to the preprocessed DWI dataset using nonlinear model estimation [<xref rid="B43" ref-type="bibr">43</xref>
]. DTI indices, that is, fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD), were calculated using Camino (<ext-link ext-link-type="uri" xlink:href="http://cmic.cs.ucl.ac.uk/camino/">http://cmic.cs.ucl.ac.uk/camino/</ext-link>
) [<xref rid="B44" ref-type="bibr">44</xref>
].</p>
</sec>
<sec id="sec2.3.3"><title>2.3.3. Anatomical Connectivity Mapping (ACM)</title>
<p>ACM summarises whole-brain probabilistic tractography information into a scalar map reflecting the relative connectivity of each voxel within the whole-brain network [<xref rid="B34" ref-type="bibr">34</xref>
, <xref rid="B36" ref-type="bibr">36</xref>
]. The ACM is generated by performing whole-brain tractography, where all voxels within a brain mask are used as seeds. Hereafter, counting the number of streamlines that project through each voxel within the brain mask then generates a voxel-wise reflection of the connectedness with the rest of the brain. Hence, ACM generates a voxel-wise connectedness map which has the capability to capture the accumulation of global effects represented within pathway systems of the brain, as opposed to FA that represents voxel-wise local effects. For instance, we recently showed that ACM offers increased sensitivity and provides additional information on specific WM alterations in multiple sclerosis as compared to FA maps [<xref rid="B36" ref-type="bibr">36</xref>
].</p>
</sec>
<sec id="sec2.3.4"><title>2.3.4. Individual Brain Mask</title>
<p>In each individual subject, a brain mask including the whole GM and WM of the brain was used as seed and target mask for the tractography in native space. The brain mask was obtained by performing a cortical reconstruction process of the two averaged T1-weighted images within each subject (FreeSurfer v. 5.3.0, <ext-link ext-link-type="uri" xlink:href="http://surfer.nmr.mgh.harvard.edu/">http://surfer.nmr.mgh.harvard.edu/</ext-link>
).</p>
</sec>
<sec id="sec2.3.5"><title>2.3.5. Probabilistic Tractography in Native Space</title>
<p>We used the probabilistic tractography method as implemented in FSL [<xref rid="B45" ref-type="bibr">45</xref>
, <xref rid="B46" ref-type="bibr">46</xref>
], based on the Bayesian modelling of crossing fibres in each voxel. Default settings were applied for most tracking parameters (2000 steps per streamline, step length = 0.5, curvature threshold = 0.2). Based on a priori analysis on the stability of the ACM as a function of how many streamlines to initiate from each voxel, we chose to use 500 streamlines for the whole-brain tractography per voxel. Due to the nature of ACM, where every voxel in the brain mask is used as seed, fewer numbers of streamlines are needed per voxel to ensure statistically robust results compared with tractography using a single seed ROI [<xref rid="B36" ref-type="bibr">36</xref>
, <xref rid="B47" ref-type="bibr">47</xref>
].</p>
</sec>
<sec id="sec2.3.6"><title>2.3.6. Group-Based Analysis</title>
<p>For group-based comparisons individual ACM, FA, RD, AD, and MD maps were spatially normalised to the MNI standard space by defining a warp field between the individual FA map and the FMRIB58_FA_2 mm atlas in standard space [<xref rid="B40" ref-type="bibr">40</xref>
]. The warp field was obtained using FSL's linear and nonlinear registration tools flirt and fnirt [<xref rid="B48" ref-type="bibr">48</xref>
–<xref rid="B50" ref-type="bibr">50</xref>
]. Finally, the ACM and DTI indices maps in standard space were smoothed with a 4 mm<sup>3</sup>
full-width half-maximum Gaussian filter, as in Lyksborg et al. [<xref rid="B36" ref-type="bibr">36</xref>
].</p>
</sec>
</sec>
<sec id="sec2.4"><title>2.4. Group-Based Statistics</title>
<p>A general linear model (GLM) was set up for voxel-wise comparison of the ACM and DTI indices between groups. Because exploration of the residuals by histogram inspection and the Lilliefors test [<xref rid="B51" ref-type="bibr">51</xref>
] revealed nonnormality, a nonparametric approach was used (FSL randomise, <ext-link ext-link-type="uri" xlink:href="http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise">http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise</ext-link>
), including group as the main factor, and age, gender, and number of voxels in the brain mask in native space as covariates. The permutation testing was performed with 5000 permutations and threshold-free cluster enhancement (TFCE) applied [<xref rid="B52" ref-type="bibr">52</xref>
]. FSL randomise allows inference using the setup of a standard general linear model [<xref rid="B53" ref-type="bibr">53</xref>
] and thus an initial <italic>F</italic>
-test examined for group differences in the ACM and DTI indices FA, RD, AD, and MD at <italic>p</italic>
< 0.05, family-wise error (FWE) corrected. This was followed by post hoc one-tailed two-sample <italic>t</italic>
-tests to test for specific whole-brain differences between NS, CB, LB, and PT individuals. Using tract-specific small volume correction (SVC), we further investigated specific pathways involved in visual processing for altered local structural connectivity and microstructure. The SVC was based on the JHU-ICBM-DTI-81 [<xref rid="B54" ref-type="bibr">54</xref>
] atlas available in FSL. The pathways investigated included the primary visual pathway (the posterior thalamic radiation including the optic radiation), the ventral (inferior longitudinal fasciculus and inferior frontooccipital fasciculus) and dorsal (superior longitudinal fasciculus) stream and the splenium, midbody, and genu of corpus callosum, and the corticospinal tract. Values were considered significant at the FWE level of <italic>p</italic>
< 0.05.</p>
<p>The ACM is generated from whole-brain probabilistic tractography and therefore variation in intracranial tissue volume (ICV) or brain size, that is, different number of voxels between seeded voxels, may bias group analysis [<xref rid="B34" ref-type="bibr">34</xref>
, <xref rid="B36" ref-type="bibr">36</xref>
]. We have previously reported atrophy of the primary visual pathway related to blindness [<xref rid="B18" ref-type="bibr">18</xref>
] and therefore investigated if global brain atrophy via the ICV had a linear correlation between the different groups biasing the ACM analysis.</p>
</sec>
</sec>
<sec id="sec3"><title>3. Results</title>
<sec id="sec3.1"><title>3.1. Altered Anatomical Connectivity and Microstructure in the Blind Brain</title>
<sec id="sec3.1.1"><title>3.1.1. Differences in Anatomical Connectivity between CB and NS Individuals</title>
<p><xref ref-type="fig" rid="fig1">Figure 1</xref>
shows the TFCE-based FWE corrected <italic>t</italic>
-statistical values for whole-brain group differences in anatomical connectivity, assessed with ACM. Decreased regional ACM was found only in the CB group compared with the NS group (<italic>p</italic>
< 0.05). This decrease was located primarily in the corpus callosum (white arrow, <xref ref-type="fig" rid="fig1">Figure 1</xref>
). A tendency of decreased ACM was also found in the optic radiations. No significant differences were found in the whole-brain ACM between NS and LB group, but LB group differed from CB group (<italic>p</italic>
< 0.05), suggesting that only CB individuals are affected in terms of brain connectivity. Also, ACM did not reveal significant differences in anatomical connectivity between the PT and NS individuals. In line with the observed difference between CB and NS group, CB individuals also showed decreased ACM when compared to PT individuals (<italic>p</italic>
< 0.05). This indicates that congenital blindness and not prematurity is the cause of the reported differences.</p>
</sec>
<sec id="sec3.1.2"><title>3.1.2. Differences in DTI Microstructural Features between CB, LB, and NS Individuals</title>
<p><xref ref-type="fig" rid="fig2">Figure 2</xref>
shows voxel-wise whole-brain microstructural differences evidenced by a decreased FA in both CB (a) and LB (b) individuals compared to the NS group (<italic>p</italic>
< 0.001). The between-group differences in FA were mainly located within the primary visual pathway (white arrows, <xref ref-type="fig" rid="fig2">Figure 2</xref>
) and the ventral visual processing stream. The reduction in FA was driven by increased radial diffusivity relatively to the axial diffusivity, and increased mean diffusivity, as illustrated in <xref ref-type="fig" rid="fig3">Figure 3</xref>
. Also here, no significant difference was found in FA between PT and NS individuals, but compared with CB individuals, the PT individuals showed higher FA-values (<italic>p</italic>
< 0.001). This confirms that the effects are related to blindness and not prematurity.</p>
</sec>
</sec>
<sec id="sec3.2"><title>3.2. Tract-Specific Statistics</title>
<p>Differences in anatomical connectivity and microstructure between CB, LB, and NS individuals were investigated within tract-specific ROIs obtained from JHU-ICBM-DTI-81 atlas, namely, the corticospinal tract, corpus callosum, optic radiations, and ventral and dorsal visual streams.</p>
<sec id="sec3.2.1"><title>3.2.1. Regional Decreases in Anatomical Connectivity in Congenitally Blind Individuals</title>
<p>The results of the tract-specific statistics of the ACM are shown in <xref ref-type="table" rid="tab1">Table 1</xref>
. Anatomical connectivity was primarily decreased in the splenium and midbody of corpus callosum in CB individuals compared to the NS group (<xref ref-type="fig" rid="fig4">Figure 4</xref>
). No between-group differences were found in the dorsal and ventral streams or the corticospinal tract. No significant differences in anatomical connectivity were found between the LB and NS group.</p>
</sec>
<sec id="sec3.2.2"><title>3.2.2. Regional Decreases in FA Associated with Blindness</title>
<p><xref ref-type="table" rid="tab2">Table 2</xref>
and <xref ref-type="fig" rid="fig5">Figure 5</xref>
illustrate the WM regions with significantly decreased FA in the CB and LB group compared to the NS group. The largest FA decreases were found in the optic radiations and the ventral stream. The right dorsal visual processing stream showed few voxels with decreased FA-values, yet the MNI-coordinates revealed overlap with the WM of the optic radiation. While the splenium of corpus callosum showed clearly reduced regional FA in CB individuals, FA-values were normal in LB subjects. Also the corticospinal tract showed a bilateral decrease in FA, primarily in the CB group.</p>
</sec>
<sec id="sec3.2.3"><title>3.2.3. Congruency of Regional Differences in Connectivity and Regional Microstructure</title>
<p>The tractography-derived measures of anatomical connectivity and microstructure associated with blindness showed only limited spatial overlap. Although anatomical connectivity and FA differences coincided in some tract ROI, for example, the splenium, ACM differences between CB and NS subjects were more pronounced in the midbody of corpus callosum, where FA reductions were less evident. Conversely, large effects in FA were seen in the optic radiations and ventral stream, where little or no effects were highlighted with ACM. This suggests that the two measures complement each other and that ACM captures changes in brain connectivity along the tract-systems that are spatially distinct from regional changes in microstructure as reflected by FA.</p>
</sec>
</sec>
<sec id="sec3.3"><title>3.3. Effect of the Intracranial Tissue Volume (ICV)</title>
<p>No significant difference was found in the ICV between CB and NS individuals (<italic>p</italic>
= 0.06), whereas LB individuals showed a significantly decreased ICV (<italic>p</italic>
= 0.01). Linear correlation was used to assess whether ACM depended linearly on the ICV for the specific ROIs and thereby could drive the differences in anatomical connectivity between CB and NS individuals. The correlation between ICV and ACM was restricted to the tract ROIs of splenium and midbody of corpus callosum, being the tract-systems where the largest ACM differences were found between CB and NS individuals. No significant correlation was found for either NS or CB individuals in the splenium ROI (NS: <italic>r</italic>
= −0.5, <italic>p</italic>
= 0.1; CB: <italic>r</italic>
= −0.4, <italic>p</italic>
= 0.2) or midbody (NS: <italic>r</italic>
= −0.4, <italic>p</italic>
= 0.2; CB: <italic>r</italic>
= −0.3, <italic>p</italic>
= 0.4). This means that the ICV is not the driving factor for the decreased ACM in CB individuals compared to NS. This is also supported by the finding of no significant differences in anatomical connectivity in the LB individuals, even though the ICV differ between the LB and NS individuals.</p>
</sec>
</sec>
<sec id="sec4"><title>4. Discussion</title>
<p>Our results demonstrate that by combining ACM, expressing global connectivity, and FA, expressing local microstructure, we gain additional contrast on structural brain plasticity of the blind brain. We find that regional differences of ACM and FA in specific WM pathways depend differently on a blindness onset. We show here that anatomical connectivity is widely decreased in the callosal fibres of the splenium and midbody of corpus callosum in the congenitally blind only. In contrast, both the congenitally and late blind showed reductions in FA mainly in the optic radiations and bilaterally in the ventral stream. Thus loss of vision at an early stage of life prior to visual experience gives rise to decreased anatomical connectivity of the callosal fibres, but we found no evidence of increased FA or increased ACM as a marker of compensatory plasticity in either CB or LB individuals. ACM and DTI do not directly reflect the biological features of the tracts but help gain additional contrast on brain plastic processes. Similar to other studies in human blind subjects, the present results are based on moderately large sample sizes due to difficulties in recruiting homogenous groups of blind subjects. The results should preferably be confirmed in an independent larger population sample.</p>
<sec id="sec4.1"><title>4.1. Decreased ACM in Corpus Callosum in CB Individuals</title>
<p>We find significantly decreased connectedness with ACM in subregions of the corpus callosum, that is, the splenium, and extending into the midbody in CB compared to NS individuals. The splenium mainly connects visual cortical areas through the forceps major, whereas the midbody connects both sensory and motor related cortical areas [<xref rid="B55" ref-type="bibr">55</xref>
]. The corpus callosum has an initial exuberance in the connectivity connecting the two hemispheres. During development with normal sensory input, a phase of axonal pruning is necessary for the maturation of the callosal connections [<xref rid="B56" ref-type="bibr">56</xref>
]. Innocenti and Frost [<xref rid="B57" ref-type="bibr">57</xref>
] showed in a study on bilaterally enucleated kittens a 50% loss of callosal neurons projecting to visual Brodmann areas 17 and 18, caused by the lack of postnatal visual experience. The same effect could not be established after just a short period of postnatal visual stimulation [<xref rid="B58" ref-type="bibr">58</xref>
]. This supports our results of decreased callosal ACM in CB but not LB individuals and emphasises the presence of a critical period of development in humans also. Decreased ACM in the splenium is also supported by decreased FA in the CB individuals, which is not seen in LB individuals. Decreased FA in the splenium was also reported by Yu et al. [<xref rid="B25" ref-type="bibr">25</xref>
] in early blind subjects, whereas Bridge and Bock [<xref rid="B26" ref-type="bibr">26</xref>
, <xref rid="B59" ref-type="bibr">59</xref>
] reported no differences in congenital and early blindness. We suggest that the observed combined regional ACM and DTI WM differences in the splenium could be an underlying factor of previously reported decreased functional [<xref rid="B60" ref-type="bibr">60</xref>
] and structural [<xref rid="B29" ref-type="bibr">29</xref>
] interhemispheric network connectivity of the occipital cortex.</p>
<p>Interestingly, also the midbody showed decreased ACM; however decreased FA did not support this region to the same extent as in the splenium. Thus the decreased ACM in the midbody might be related to more widespread structural connectivity changes than those related to the visual cortex. We did not expect a direct relationship between measures of FA and ACM. Although FA and ACM are both voxel-wise measures, ACM supplies tract-specific information by seeding tractography streamlines in every voxel within a tract [<xref rid="B47" ref-type="bibr">47</xref>
]. In a study on multiple sclerosis, Lyksborg et al. [<xref rid="B36" ref-type="bibr">36</xref>
] showed that ACM accumulated effects along the fibre pathways that were not detectable with FA. Such effects might explain the observed differences in the WM fibres within the midbody. DTI on the other hand is a very sensitive measure to local changes in microstructure. We have previously shown a general decreased GM and WM volume in the early blind [<xref rid="B18" ref-type="bibr">18</xref>
], based on conventional structural T1-weighted MRI, which might now be explained by the observed decreased ACM and FA in the large interhemispheric callosal fibre bundle. Also Leporé et al. [<xref rid="B61" ref-type="bibr">61</xref>
] reported T1-based volume decreases in both splenium and isthmus of corpus callosum and a tendency of increased volume of the genu of corpus callosum. More recently, Tomaiuolo et al. [<xref rid="B62" ref-type="bibr">62</xref>
] measured the surface of callosal subregions in a large group of congenitally blind individuals and confirmed a significant decrease in the surface of the splenium whereas the isthmus and the posterior part of the midbody showed increases. Only Bock et al. [<xref rid="B59" ref-type="bibr">59</xref>
] reported no differences between early blind, anophthalmic, and sighted subjects in the T1-weighted volume measure of the splenium as well as overall volume of the corpus callosum. As also discussed in [<xref rid="B59" ref-type="bibr">59</xref>
], these discrepancies in the effects within the splenium of corpus callosum might be due to differences in the group analysis methodology. We used a group comparison of ACM and FA based on voxel-based analyses and atlas-based predefined ROIs of the splenium, midbody, and genu. Our ROI of the splenium might therefore include a larger area of the corpus callosum than if it had been defined individually in each subject. This explanation seems however unlikely, as also [<xref rid="B25" ref-type="bibr">25</xref>
] reported similar decreased FA in CB individuals within individually defined splenium ROI.</p>
<p>If ACM is decreased in the splenium and midbody of corpus callosum, one might expect the genu to show increased ACM. For example, training-induced plasticity should have an effect on auditory and somatosensory connectivity, since CB subjects depend more on the two senses, although recent studies have indicated also superior smell abilities in congenital blind subjects [<xref rid="B6" ref-type="bibr">6</xref>
, <xref rid="B15" ref-type="bibr">15</xref>
]. We do not find any increase in the ACM in the genu and also no evidence of increased FA as a marker of compensatory plasticity in either CB or LB individuals. However, increased functionality is not necessarily coupled to increased ACM or increased FA, since these measures do not directly reflect the conduction speed of the axonal bundles, coupled to axonal length and diameter [<xref rid="B63" ref-type="bibr">63</xref>
]. During development, the brain connectivity becomes specialised by pruning of the axons, optimising the functionality. Such similar structural mechanisms might also support cross-modal plasticity.</p>
</sec>
<sec id="sec4.2"><title>4.2. Decreased Microstructural Features in CB and LB Individuals</title>
<p>DTI is sensitive to the local microstructural tissue environment, and we find that mainly the primary visual pathway is largely affected by visual loss, expressed as decreased FA driven by increased RD, in CB and LB individuals compared to NS. Our findings of widespread microstructural WM differences of the primary visual system are in concordance with previous reports in both animals [<xref rid="B64" ref-type="bibr">64</xref>
] and humans [<xref rid="B23" ref-type="bibr">23</xref>
, <xref rid="B24" ref-type="bibr">24</xref>
, <xref rid="B26" ref-type="bibr">26</xref>
]. We find that FA is decreased in both CB and LB individuals, which suggests that these differences might reflect degenerative effects in the primary visual pathways related to the onset of a visual loss. Our results also supported previous findings from our group of decreased FA bilaterally in the ventral stream that projects to higher order visual areas from the visual cortex [<xref rid="B37" ref-type="bibr">37</xref>
]. Although we found no differences in FA in the dorsal stream, some rs-fMRI studies report a decreased functional connectivity for both streams [<xref rid="B60" ref-type="bibr">60</xref>
]. However, changes in WM structure do not need to be directly linked with function as measured by rs-fMRI. Also, several groups have shown that blind individuals can perform motion or shape discrimination tasks by recruiting the dorsal and ventral visual pathways [<xref rid="B12" ref-type="bibr">12</xref>
, <xref rid="B65" ref-type="bibr">65</xref>
–<xref rid="B70" ref-type="bibr">70</xref>
]. Interestingly, only CB individuals showed decreased FA in the corpus callosum compared to NS, mainly in the splenium connecting the two occipital lobes. Few studies have examined specific structural differences related to blindness in nonvisual pathways, for example, the corticospinal tract. Yu et al. [<xref rid="B25" ref-type="bibr">25</xref>
] reported an increased FA in the corticospinal tract of early blind men. We were not able to replicate this finding of increased FA in the corticospinal tract but rather found a discrete region of the tract with a decreased FA in CB individuals.</p>
</sec>
<sec id="sec4.3"><title>4.3. Combining Tract-Specific ACM, DTI Measures, and Network Analyses</title>
<p>We here used the two measures of ACM, expressing brain connectedness, and DTI indices, expressing regional WM microstructural features, which both provide information on specific tract-systems of interest but capture two different effects, however, indirectly coupled [<xref rid="B36" ref-type="bibr">36</xref>
]. ACM is a new measure that gives insight into voxel-wise connectedness for a voxel within a related pathway, providing supplementary information to DTI and structural network analyses. DTI is very sensitive to voxel-wise difference in microstructural features, which at a group level need to be clustered to show a significant effect. But DTI is also heavily affected by macrostructural effects such as fibre crossing, dispersion, and undulating fibres [<xref rid="B71" ref-type="bibr">71</xref>
–<xref rid="B73" ref-type="bibr">73</xref>
] which means that differences in FA might be driven not only by microstructure but also by differences in axonal projections or simply by partial volume contamination from macroscopic effects and volume of the structure of interest [<xref rid="B74" ref-type="bibr">74</xref>
].</p>
<p>Structural network analyses give information about whether two or more cortical regions are connected through WM fibre tracts. Thus information is obtained about whether a connection exists or not and how probable this connection is. In comparison, ACM measures the local connectivity effects along a tract-system and can thereby provide insight into the mechanisms behind the structural networks. A general decreased degree of connectivity with occipital and frontal areas was found in a structural network analysis by Shu et al. [<xref rid="B28" ref-type="bibr">28</xref>
]. The same group later reported that the decreased degree of connectivity in the structural network of the occipital cortex was only found in congenital and early blindness but not late-onset blindness [<xref rid="B29" ref-type="bibr">29</xref>
]. This agrees with our finding that tract-specific differences in ACM are confined to CB individuals. The observed decreased FA in the corpus callosum in CB individuals only might also reflect reduced density of fibres connecting occipital and parietal areas across the two hemispheres. However, also increased connectivity has been reported in functional brain networks of visual and language-related frontal areas [<xref rid="B32" ref-type="bibr">32</xref>
, <xref rid="B60" ref-type="bibr">60</xref>
, <xref rid="B75" ref-type="bibr">75</xref>
–<xref rid="B77" ref-type="bibr">77</xref>
] as measured by rs-fMRI and structural networks of motor, somatosensory, and memory areas [<xref rid="B28" ref-type="bibr">28</xref>
, <xref rid="B29" ref-type="bibr">29</xref>
]. In this study, we do not find increased ACM to support the previously reported increased functional connectivity. The structural and functional network studies are somewhat contradictory, and challenges exist in comparing the different methodologies. In perspective, the understanding of the mechanisms relating functional and structural connectivity in the blind brain would benefit from a study combining functional and structural network analyses in the same group. For example, Saygin et al. [<xref rid="B78" ref-type="bibr">78</xref>
] showed a very reliable prediction of functional activation of the fusiform gyrus in face recognition, by the anatomical connection probability with other brain areas.</p>
</sec>
</sec>
<sec id="sec5"><title>5. Conclusion</title>
<p>The present study showed how ACM can be used to give complementary information to DTI indices and connectivity-based structural network analyses about the mechanisms of the plastic processes in the brain of congenitally and late-onset blind individuals. ACM identified reduced anatomical connectivity in the tract-systems of mainly the splenium and midbody of corpus callosum in congenitally blind but not late-onset blind individuals, compared to normal sighted controls. Regional voxel-based DTI revealed lower FA in the primary visual and the ventral visual stream regardless of the blindness onset, but also the splenium of corpus callosum in the congenitally blind. No region with increased anatomical connectivity or higher FA-values was observed in any of the two blind groups. This study highlights how the two different voxel-wise measures of tract-based anatomical connectivity and regional microstructure provide different information on the nature of the alterations produced by visual deprivation. They clearly provide complementary data that support a generalized model of plastic mechanisms that depend upon the onset of blindness. A future combination of all three methods of ACM, DTI, and connectivity-based structural network analyses in the same blind subject group based on the same DWI acquisition would be able to shed further light on the structural plasticity of the blind brain.</p>
</sec>
</body>
<back><ack><title>Acknowledgments</title>
<p>The authors would like to thank the participants for taking part in the experiments. The work was supported by grants from the Lundbeck Foundation (3156-50-28667 to Ron Kupers), Excellence on Mapping, Modulation & Modelling the Control of Actions (R59 A5399 to Hartwig Roman Siebner), and The Danish Council for Independent Research, Medical Sciences (09-063392, 0602-01340B to Maurice Ptito).</p>
</ack>
<glossary><title>Abbreviations</title>
<def-list><def-item><term>ACM:</term>
<def><p>Anatomical connectivity mapping</p>
</def>
</def-item>
<def-item><term>DTI:</term>
<def><p>Diffusion tensor imaging</p>
</def>
</def-item>
<def-item><term>FA:</term>
<def><p>Fractional anisotropy</p>
</def>
</def-item>
<def-item><term>CB:</term>
<def><p>Congenitally blind</p>
</def>
</def-item>
<def-item><term>LB:</term>
<def><p>Late blind</p>
</def>
</def-item>
<def-item><term>NS:</term>
<def><p>Normal sighted control</p>
</def>
</def-item>
<def-item><term>WM:</term>
<def><p>White matter</p>
</def>
</def-item>
<def-item><term>GM:</term>
<def><p>Grey matter.</p>
</def>
</def-item>
</def-list>
</glossary>
<sec sec-type="conflict"><title>Conflict of Interests</title>
<p>The authors declare that there is no conflict of interests regarding the publication of this paper.</p>
</sec>
<ref-list><ref id="B1"><label>1</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bavelier</surname>
<given-names>D.</given-names>
</name>
<name><surname>Neville</surname>
<given-names>H. J.</given-names>
</name>
</person-group>
<article-title>Cross-modal plasticity: where and how?</article-title>
<source><italic>Nature Reviews Neuroscience</italic>
</source>
<year>2002</year>
<volume>3</volume>
<issue>6</issue>
<fpage>443</fpage>
<lpage>452</lpage>
<pub-id pub-id-type="other">2-s2.0-0036598391</pub-id>
<pub-id pub-id-type="pmid">12042879</pub-id>
</element-citation>
</ref>
<ref id="B2"><label>2</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renier</surname>
<given-names>L.</given-names>
</name>
<name><surname>De Volder</surname>
<given-names>A. G.</given-names>
</name>
<name><surname>Rauschecker</surname>
<given-names>J. P.</given-names>
</name>
</person-group>
<article-title>Cortical plasticity and preserved function in early blindness</article-title>
<source><italic>Neuroscience and Biobehavioral Reviews</italic>
</source>
<year>2014</year>
<volume>41</volume>
<fpage>53</fpage>
<lpage>63</lpage>
<pub-id pub-id-type="doi">10.1016/j.neubiorev.2013.01.025</pub-id>
<pub-id pub-id-type="other">2-s2.0-84898905282</pub-id>
<pub-id pub-id-type="pmid">23453908</pub-id>
</element-citation>
</ref>
<ref id="B3"><label>3</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Desgent</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Cortical GABAergic interneurons in cross-modal plasticity following early blindness</article-title>
<source><italic>Neural Plasticity</italic>
</source>
<year>2012</year>
<volume>2012</volume>
<fpage>20</fpage>
<pub-id pub-id-type="publisher-id">590725</pub-id>
<pub-id pub-id-type="doi">10.1155/2012/590725</pub-id>
<pub-id pub-id-type="other">2-s2.0-84863763937</pub-id>
</element-citation>
</ref>
<ref id="B4"><label>4</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Merabet</surname>
<given-names>L. B.</given-names>
</name>
<name><surname>Pascual-Leone</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Neural reorganization following sensory loss: the opportunity of change</article-title>
<source><italic>Nature Reviews Neuroscience</italic>
</source>
<year>2010</year>
<volume>11</volume>
<issue>1</issue>
<fpage>44</fpage>
<lpage>52</lpage>
<pub-id pub-id-type="doi">10.1038/nrn2758</pub-id>
<pub-id pub-id-type="other">2-s2.0-72849146595</pub-id>
<pub-id pub-id-type="pmid">19935836</pub-id>
</element-citation>
</ref>
<ref id="B5"><label>5</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Voss</surname>
<given-names>P.</given-names>
</name>
<name><surname>Pike</surname>
<given-names>B. G.</given-names>
</name>
<name><surname>Zatorre</surname>
<given-names>R. J.</given-names>
</name>
</person-group>
<article-title>Evidence for both compensatory plastic and disuse atrophy-related neuroanatomical changes in the blind</article-title>
<source><italic>Brain</italic>
</source>
<year>2014</year>
<volume>137</volume>
<issue>4</issue>
<fpage>1224</fpage>
<lpage>1240</lpage>
<pub-id pub-id-type="doi">10.1093/brain/awu030</pub-id>
<pub-id pub-id-type="other">2-s2.0-84897891899</pub-id>
<pub-id pub-id-type="pmid">24648057</pub-id>
</element-citation>
</ref>
<ref id="B6"><label>6</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Compensatory plasticity and cross-modal reorganization following early visual deprivation</article-title>
<source><italic>Neuroscience and Biobehavioral Reviews</italic>
</source>
<year>2014</year>
<volume>41</volume>
<fpage>36</fpage>
<lpage>52</lpage>
<pub-id pub-id-type="doi">10.1016/j.neubiorev.2013.08.001</pub-id>
<pub-id pub-id-type="other">2-s2.0-84898902312</pub-id>
<pub-id pub-id-type="pmid">23954750</pub-id>
</element-citation>
</ref>
<ref id="B7"><label>7</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bedny</surname>
<given-names>M.</given-names>
</name>
<name><surname>Pascual-Leone</surname>
<given-names>A.</given-names>
</name>
<name><surname>Dodell-Feder</surname>
<given-names>D.</given-names>
</name>
<name><surname>Fedorenko</surname>
<given-names>E.</given-names>
</name>
<name><surname>Saxe</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>Language processing in the occipital cortex of congenitally blind adults</article-title>
<source><italic>Proceedings of the National Academy of Sciences of the United States of America</italic>
</source>
<year>2011</year>
<volume>108</volume>
<issue>11</issue>
<fpage>4429</fpage>
<lpage>4434</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.1014818108</pub-id>
<pub-id pub-id-type="other">2-s2.0-79952717230</pub-id>
<pub-id pub-id-type="pmid">21368161</pub-id>
</element-citation>
</ref>
<ref id="B8"><label>8</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Collignon</surname>
<given-names>O.</given-names>
</name>
<name><surname>Vandewalle</surname>
<given-names>G.</given-names>
</name>
<name><surname>Voss</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Functional specialization for auditory-spatial processing in the occipital cortex of congenitally blind humans</article-title>
<source><italic>Proceedings of the National Academy of Sciences of the United States of America</italic>
</source>
<year>2011</year>
<volume>108</volume>
<issue>11</issue>
<fpage>4435</fpage>
<lpage>4440</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.1013928108</pub-id>
<pub-id pub-id-type="other">2-s2.0-79952734019</pub-id>
<pub-id pub-id-type="pmid">21368198</pub-id>
</element-citation>
</ref>
<ref id="B9"><label>9</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Watkins</surname>
<given-names>K. E.</given-names>
</name>
<name><surname>Shakespeare</surname>
<given-names>T. J.</given-names>
</name>
<name><surname>O'Donoghue M. Clare</surname>
<given-names>M. C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Early auditory processing in area V5/MT+ of the congenitally blind brain</article-title>
<source><italic>Journal of Neuroscience</italic>
</source>
<year>2013</year>
<volume>33</volume>
<issue>46</issue>
<fpage>18242</fpage>
<lpage>18246</lpage>
<pub-id pub-id-type="doi">10.1523/jneurosci.2546-13.2013</pub-id>
<pub-id pub-id-type="other">2-s2.0-84887347208</pub-id>
<pub-id pub-id-type="pmid">24227733</pub-id>
</element-citation>
</ref>
<ref id="B10"><label>10</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hötting</surname>
<given-names>K.</given-names>
</name>
<name><surname>Röder</surname>
<given-names>B.</given-names>
</name>
</person-group>
<article-title>Auditory and auditory-tactile processing in congenitally blind humans</article-title>
<source><italic>Hearing Research</italic>
</source>
<year>2009</year>
<volume>258</volume>
<issue>1-2</issue>
<fpage>165</fpage>
<lpage>174</lpage>
<pub-id pub-id-type="doi">10.1016/j.heares.2009.07.012</pub-id>
<pub-id pub-id-type="other">2-s2.0-70449637695</pub-id>
<pub-id pub-id-type="pmid">19651199</pub-id>
</element-citation>
</ref>
<ref id="B11"><label>11</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gagnon</surname>
<given-names>L.</given-names>
</name>
<name><surname>Schneider</surname>
<given-names>F. C.</given-names>
</name>
<name><surname>Siebner</surname>
<given-names>H. R.</given-names>
</name>
<name><surname>Paulson</surname>
<given-names>O. B.</given-names>
</name>
<name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Activation of the hippocampal complex during tactile maze solving in congenitally blind subjects</article-title>
<source><italic>Neuropsychologia</italic>
</source>
<year>2012</year>
<volume>50</volume>
<issue>7</issue>
<fpage>1663</fpage>
<lpage>1671</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuropsychologia.2012.03.022</pub-id>
<pub-id pub-id-type="other">2-s2.0-84861223883</pub-id>
<pub-id pub-id-type="pmid">22483742</pub-id>
</element-citation>
</ref>
<ref id="B12"><label>12</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matteau</surname>
<given-names>I.</given-names>
</name>
<name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Ricciardi</surname>
<given-names>E.</given-names>
</name>
<name><surname>Pietrini</surname>
<given-names>P.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Beyond visual, aural and haptic movement perception: hMT+ is activated by electrotactile motion stimulation of the tongue in sighted and in congenitally blind individuals</article-title>
<source><italic>Brain Research Bulletin</italic>
</source>
<year>2010</year>
<volume>82</volume>
<issue>5-6</issue>
<fpage>264</fpage>
<lpage>270</lpage>
<pub-id pub-id-type="doi">10.1016/j.brainresbull.2010.05.001</pub-id>
<pub-id pub-id-type="other">2-s2.0-77955088448</pub-id>
<pub-id pub-id-type="pmid">20466041</pub-id>
</element-citation>
</ref>
<ref id="B13"><label>13</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sadato</surname>
<given-names>N.</given-names>
</name>
<name><surname>Pascual-Leone</surname>
<given-names>A.</given-names>
</name>
<name><surname>Grafman</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Activation of the primary visual cortex by braille reading in blind subjects</article-title>
<source><italic>Nature</italic>
</source>
<year>1996</year>
<volume>380</volume>
<issue>6574</issue>
<fpage>526</fpage>
<lpage>528</lpage>
<pub-id pub-id-type="doi">10.1038/380526a0</pub-id>
<pub-id pub-id-type="other">2-s2.0-0029914588</pub-id>
<pub-id pub-id-type="pmid">8606771</pub-id>
</element-citation>
</ref>
<ref id="B14"><label>14</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Théoret</surname>
<given-names>H.</given-names>
</name>
<name><surname>Merabet</surname>
<given-names>L.</given-names>
</name>
<name><surname>Pascual-Leone</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Behavioral and neuroplastic changes in the blind: evidence for functionally relevant cross-modal interactions</article-title>
<source><italic>Journal of Physiology Paris</italic>
</source>
<year>2004</year>
<volume>98</volume>
<issue>1–3</issue>
<fpage>221</fpage>
<lpage>233</lpage>
<pub-id pub-id-type="doi">10.1016/j.jphysparis.2004.03.009</pub-id>
<pub-id pub-id-type="other">2-s2.0-5144230883</pub-id>
</element-citation>
</ref>
<ref id="B15"><label>15</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Beaulieu-Lefebvre</surname>
<given-names>M.</given-names>
</name>
<name><surname>Schneider</surname>
<given-names>F. C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Neural correlates of olfactory processing in congenital blindness</article-title>
<source><italic>Neuropsychologia</italic>
</source>
<year>2011</year>
<volume>49</volume>
<issue>7</issue>
<fpage>2037</fpage>
<lpage>2044</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuropsychologia.2011.03.033</pub-id>
<pub-id pub-id-type="other">2-s2.0-79956073501</pub-id>
<pub-id pub-id-type="pmid">21458471</pub-id>
</element-citation>
</ref>
<ref id="B79"><label>16</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Insights from darkness: what the study of blindness has taught us about brain structure and function</article-title>
<source><italic>Progress in Brain Research</italic>
</source>
<year>2011</year>
<volume>192</volume>
<fpage>17</fpage>
<lpage>31</lpage>
<pub-id pub-id-type="doi">10.1016/b978-0-444-53355-5.00002-6</pub-id>
<pub-id pub-id-type="other">2-s2.0-79960202494</pub-id>
<pub-id pub-id-type="pmid">21763516</pub-id>
</element-citation>
</ref>
<ref id="B17"><label>17</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Noppeney</surname>
<given-names>U.</given-names>
</name>
<name><surname>Friston</surname>
<given-names>K. J.</given-names>
</name>
<name><surname>Ashburner</surname>
<given-names>J.</given-names>
</name>
<name><surname>Frackowiak</surname>
<given-names>R.</given-names>
</name>
<name><surname>Price</surname>
<given-names>C. J.</given-names>
</name>
</person-group>
<article-title>Early visual deprivation induces structural plasticity in gray and white matter</article-title>
<source><italic>Current Biology</italic>
</source>
<year>2005</year>
<volume>15</volume>
<issue>13</issue>
<fpage>R488</fpage>
<lpage>R490</lpage>
<pub-id pub-id-type="doi">10.1016/j.cub.2005.06.053</pub-id>
<pub-id pub-id-type="other">2-s2.0-21844479303</pub-id>
<pub-id pub-id-type="pmid">16005276</pub-id>
</element-citation>
</ref>
<ref id="B18"><label>18</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
<name><surname>Schneider</surname>
<given-names>F. C. G.</given-names>
</name>
<name><surname>Paulson</surname>
<given-names>O. B.</given-names>
</name>
<name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>Alterations of the visual pathways in congenital blindness</article-title>
<source><italic>Experimental Brain Research</italic>
</source>
<year>2008</year>
<volume>187</volume>
<issue>1</issue>
<fpage>41</fpage>
<lpage>49</lpage>
<pub-id pub-id-type="doi">10.1007/s00221-008-1273-4</pub-id>
<pub-id pub-id-type="other">2-s2.0-42449083698</pub-id>
<pub-id pub-id-type="pmid">18224306</pub-id>
</element-citation>
</ref>
<ref id="B19"><label>19</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beaulieu</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>The basis of anisotropic water diffusion in the nervous system—a technical review</article-title>
<source><italic>NMR in Biomedicine</italic>
</source>
<year>2002</year>
<volume>15</volume>
<issue>7-8</issue>
<fpage>435</fpage>
<lpage>455</lpage>
<pub-id pub-id-type="doi">10.1002/nbm.782</pub-id>
<pub-id pub-id-type="other">2-s2.0-0036868692</pub-id>
<pub-id pub-id-type="pmid">12489094</pub-id>
</element-citation>
</ref>
<ref id="B20"><label>20</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Basser</surname>
<given-names>P. J.</given-names>
</name>
<name><surname>Mattiello</surname>
<given-names>J.</given-names>
</name>
<name><surname>LeBihan</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>MR diffusion tensor spectroscopy and imaging</article-title>
<source><italic>Biophysical Journal</italic>
</source>
<year>1994</year>
<volume>66</volume>
<issue>1</issue>
<fpage>259</fpage>
<lpage>267</lpage>
<pub-id pub-id-type="doi">10.1016/S0006-3495(94)80775-1</pub-id>
<pub-id pub-id-type="other">2-s2.0-0028154030</pub-id>
<pub-id pub-id-type="pmid">8130344</pub-id>
</element-citation>
</ref>
<ref id="B21"><label>21</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pierpaoli</surname>
<given-names>C.</given-names>
</name>
<name><surname>Jezzard</surname>
<given-names>P.</given-names>
</name>
<name><surname>Basser</surname>
<given-names>P. J.</given-names>
</name>
<name><surname>Barnett</surname>
<given-names>A.</given-names>
</name>
<name><surname>Di Chiro</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Diffusion tensor MR imaging of the human brain</article-title>
<source><italic>Radiology</italic>
</source>
<year>1996</year>
<volume>201</volume>
<issue>3</issue>
<fpage>637</fpage>
<lpage>648</lpage>
<pub-id pub-id-type="doi">10.1148/radiology.201.3.8939209</pub-id>
<pub-id pub-id-type="other">2-s2.0-0029828575</pub-id>
<pub-id pub-id-type="pmid">8939209</pub-id>
</element-citation>
</ref>
<ref id="B22"><label>22</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Le Bihan</surname>
<given-names>D.</given-names>
</name>
<name><surname>Mangin</surname>
<given-names>J.-F.</given-names>
</name>
<name><surname>Poupon</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Diffusion tensor imaging: concepts and applications</article-title>
<source><italic>Journal of Magnetic Resonance Imaging</italic>
</source>
<year>2001</year>
<volume>13</volume>
<issue>4</issue>
<fpage>534</fpage>
<lpage>546</lpage>
<pub-id pub-id-type="doi">10.1002/jmri.1076</pub-id>
<pub-id pub-id-type="other">2-s2.0-0035080580</pub-id>
<pub-id pub-id-type="pmid">11276097</pub-id>
</element-citation>
</ref>
<ref id="B23"><label>23</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shimony</surname>
<given-names>J. S.</given-names>
</name>
<name><surname>Burton</surname>
<given-names>H.</given-names>
</name>
<name><surname>Epstein</surname>
<given-names>A. A.</given-names>
</name>
<name><surname>McLaren</surname>
<given-names>D. G.</given-names>
</name>
<name><surname>Sun</surname>
<given-names>S. W.</given-names>
</name>
<name><surname>Snyder</surname>
<given-names>A. Z.</given-names>
</name>
</person-group>
<article-title>Diffusion tensor imaging reveals white matter reorganization in early blind humans</article-title>
<source><italic>Cerebral Cortex</italic>
</source>
<year>2006</year>
<volume>16</volume>
<issue>11</issue>
<fpage>1653</fpage>
<lpage>1661</lpage>
<pub-id pub-id-type="doi">10.1093/cercor/bhj102</pub-id>
<pub-id pub-id-type="other">2-s2.0-33749528497</pub-id>
<pub-id pub-id-type="pmid">16400157</pub-id>
</element-citation>
</ref>
<ref id="B24"><label>24</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>D.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>W.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Altered white matter integrity in the congenital and late blind people</article-title>
<source><italic>Neural Plasticity</italic>
</source>
<year>2013</year>
<volume>2013</volume>
<fpage>8</fpage>
<pub-id pub-id-type="publisher-id">128236</pub-id>
<pub-id pub-id-type="doi">10.1155/2013/128236</pub-id>
<pub-id pub-id-type="other">2-s2.0-84877290912</pub-id>
</element-citation>
</ref>
<ref id="B25"><label>25</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
<name><surname>Shu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>W.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Li</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>Plasticity of the corticospinal tract in early blindness revealed by quantitative analysis of fractional anisotropy based on diffusion tensor tractography</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2007</year>
<volume>36</volume>
<issue>2</issue>
<fpage>411</fpage>
<lpage>417</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2007.03.003</pub-id>
<pub-id pub-id-type="other">2-s2.0-34248175143</pub-id>
<pub-id pub-id-type="pmid">17442594</pub-id>
</element-citation>
</ref>
<ref id="B26"><label>26</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bridge</surname>
<given-names>H.</given-names>
</name>
<name><surname>Cowey</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ragge</surname>
<given-names>N.</given-names>
</name>
<name><surname>Watkins</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>Imaging studies in congenital anophthalmia reveal preservation of brain architecture in ‘visual’ cortex</article-title>
<source><italic>Brain</italic>
</source>
<year>2009</year>
<volume>132</volume>
<issue>12</issue>
<fpage>3467</fpage>
<lpage>3480</lpage>
<pub-id pub-id-type="doi">10.1093/brain/awp279</pub-id>
<pub-id pub-id-type="other">2-s2.0-72649100212</pub-id>
<pub-id pub-id-type="pmid">19892766</pub-id>
</element-citation>
</ref>
<ref id="B27"><label>27</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Li</surname>
<given-names>K.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>Abnormal diffusion of cerebral white matter in early blindness</article-title>
<source><italic>Human Brain Mapping</italic>
</source>
<year>2009</year>
<volume>30</volume>
<issue>1</issue>
<fpage>220</fpage>
<lpage>227</lpage>
<pub-id pub-id-type="doi">10.1002/hbm.20507</pub-id>
<pub-id pub-id-type="other">2-s2.0-58149348715</pub-id>
<pub-id pub-id-type="pmid">18072278</pub-id>
</element-citation>
</ref>
<ref id="B28"><label>28</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Li</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>Altered anatomical network in early blindness revealed by diffusion tensor tractography</article-title>
<source><italic>PLoS ONE</italic>
</source>
<year>2009</year>
<volume>4</volume>
<issue>9</issue>
<pub-id pub-id-type="publisher-id">e7228</pub-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0007228</pub-id>
<pub-id pub-id-type="other">2-s2.0-70349667285</pub-id>
</element-citation>
</ref>
<ref id="B29"><label>29</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>W.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Age of onset of blindness affects brain anatomical networks constructed using diffusion tensor tractography</article-title>
<source><italic>Cerebral Cortex</italic>
</source>
<year>2013</year>
<volume>23</volume>
<issue>3</issue>
<fpage>542</fpage>
<lpage>551</lpage>
<pub-id pub-id-type="doi">10.1093/cercor/bhs034</pub-id>
<pub-id pub-id-type="other">2-s2.0-84873678480</pub-id>
<pub-id pub-id-type="pmid">22371309</pub-id>
</element-citation>
</ref>
<ref id="B30"><label>30</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qin</surname>
<given-names>W.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>The development of visual areas depends differently on visual experience</article-title>
<source><italic>PLoS ONE</italic>
</source>
<year>2013</year>
<volume>8</volume>
<issue>1</issue>
<pub-id pub-id-type="publisher-id">e53784</pub-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0053784</pub-id>
<pub-id pub-id-type="other">2-s2.0-84872154418</pub-id>
</element-citation>
</ref>
<ref id="B31"><label>31</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burton</surname>
<given-names>H.</given-names>
</name>
<name><surname>Snyder</surname>
<given-names>A. Z.</given-names>
</name>
<name><surname>Conturo</surname>
<given-names>T. E.</given-names>
</name>
<name><surname>Akbudak</surname>
<given-names>E.</given-names>
</name>
<name><surname>Ollinger</surname>
<given-names>J. M.</given-names>
</name>
<name><surname>Raichle</surname>
<given-names>M. E.</given-names>
</name>
</person-group>
<article-title>Adaptive changes in early and late blind: a fMRI study of Braille reading</article-title>
<source><italic>Journal of Neurophysiology</italic>
</source>
<year>2001</year>
<volume>87</volume>
<issue>1</issue>
<fpage>589</fpage>
<lpage>607</lpage>
<pub-id pub-id-type="other">2-s2.0-0036089903</pub-id>
<pub-id pub-id-type="pmid">11784773</pub-id>
</element-citation>
</ref>
<ref id="B32"><label>32</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burton</surname>
<given-names>H.</given-names>
</name>
<name><surname>Snyder</surname>
<given-names>A. Z.</given-names>
</name>
<name><surname>Raichle</surname>
<given-names>M. E.</given-names>
</name>
</person-group>
<article-title>Resting state functional connectivity in early blind humans</article-title>
<source><italic>Frontiers in Systems Neuroscience</italic>
</source>
<year>2014</year>
<volume>8</volume>
<issue>1, article 51</issue>
<pub-id pub-id-type="doi">10.3389/fnsys.2014.00051</pub-id>
<pub-id pub-id-type="other">2-s2.0-84898739329</pub-id>
</element-citation>
</ref>
<ref id="B33"><label>33</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bedny</surname>
<given-names>M.</given-names>
</name>
<name><surname>Konkle</surname>
<given-names>T.</given-names>
</name>
<name><surname>Pelphrey</surname>
<given-names>K.</given-names>
</name>
<name><surname>Saxe</surname>
<given-names>R.</given-names>
</name>
<name><surname>Pascual-Leone</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Sensitive period for a multimodal response in human visual motion area MT/MST</article-title>
<source><italic>Current Biology</italic>
</source>
<year>2010</year>
<volume>20</volume>
<issue>21</issue>
<fpage>1900</fpage>
<lpage>1906</lpage>
<pub-id pub-id-type="doi">10.1016/j.cub.2010.09.044</pub-id>
<pub-id pub-id-type="other">2-s2.0-78149292225</pub-id>
<pub-id pub-id-type="pmid">20970337</pub-id>
</element-citation>
</ref>
<ref id="B34"><label>34</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bozzali</surname>
<given-names>M.</given-names>
</name>
<name><surname>Parker</surname>
<given-names>G. J. M.</given-names>
</name>
<name><surname>Serra</surname>
<given-names>L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Anatomical connectivity mapping: a new tool to assess brain disconnection in Alzheimer's disease</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2011</year>
<volume>54</volume>
<issue>3</issue>
<fpage>2045</fpage>
<lpage>2051</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2010.08.069</pub-id>
<pub-id pub-id-type="other">2-s2.0-78650207640</pub-id>
<pub-id pub-id-type="pmid">20828625</pub-id>
</element-citation>
</ref>
<ref id="B35"><label>35</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cercignani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Embleton</surname>
<given-names>K.</given-names>
</name>
<name><surname>Parker</surname>
<given-names>G. J. M.</given-names>
</name>
<name><surname>Bozzali</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Group-averaged anatomical connectivity mapping for improved human white matter pathway visualisation</article-title>
<source><italic>NMR in Biomedicine</italic>
</source>
<year>2012</year>
<volume>25</volume>
<issue>11</issue>
<fpage>1224</fpage>
<lpage>1233</lpage>
<pub-id pub-id-type="doi">10.1002/nbm.2793</pub-id>
<pub-id pub-id-type="other">2-s2.0-84868159750</pub-id>
<pub-id pub-id-type="pmid">22438202</pub-id>
</element-citation>
</ref>
<ref id="B36"><label>36</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lyksborg</surname>
<given-names>M.</given-names>
</name>
<name><surname>Siebner</surname>
<given-names>H. R.</given-names>
</name>
<name><surname>Sørensen</surname>
<given-names>P. S.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity</article-title>
<source><italic>PLoS ONE</italic>
</source>
<year>2014</year>
<volume>9</volume>
<issue>4</issue>
<pub-id pub-id-type="publisher-id">e95540</pub-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0095540</pub-id>
<pub-id pub-id-type="other">2-s2.0-84899703394</pub-id>
</element-citation>
</ref>
<ref id="B37"><label>37</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reislev</surname>
<given-names>N. L.</given-names>
</name>
<name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
<name><surname>Siebner</surname>
<given-names>H. R.</given-names>
</name>
<name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
<name><surname>Dyrby</surname>
<given-names>T. B.</given-names>
</name>
</person-group>
<article-title>Blindness alters the microstructure of the ventral but not the dorsal visual stream</article-title>
<source><italic>Brain Structure and Function</italic>
</source>
<year>2015</year>
<fpage>1</fpage>
<lpage>13</lpage>
<pub-id pub-id-type="doi">10.1007/s00429-015-1078-8</pub-id>
<pub-id pub-id-type="pmid">24248427</pub-id>
</element-citation>
</ref>
<ref id="B38"><label>38</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reese</surname>
<given-names>T. G.</given-names>
</name>
<name><surname>Heid</surname>
<given-names>O.</given-names>
</name>
<name><surname>Weisskoff</surname>
<given-names>R. M.</given-names>
</name>
<name><surname>Wedeen</surname>
<given-names>V. J.</given-names>
</name>
</person-group>
<article-title>Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo</article-title>
<source><italic>Magnetic Resonance in Medicine</italic>
</source>
<year>2003</year>
<volume>49</volume>
<issue>1</issue>
<fpage>177</fpage>
<lpage>182</lpage>
<pub-id pub-id-type="doi">10.1002/mrm.10308</pub-id>
<pub-id pub-id-type="other">2-s2.0-0037229177</pub-id>
<pub-id pub-id-type="pmid">12509835</pub-id>
</element-citation>
</ref>
<ref id="B39"><label>39</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andersson</surname>
<given-names>J. L. R.</given-names>
</name>
<name><surname>Skare</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ashburner</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2003</year>
<volume>20</volume>
<issue>2</issue>
<fpage>870</fpage>
<lpage>888</lpage>
<pub-id pub-id-type="doi">10.1016/s1053-8119(03)00336-7</pub-id>
<pub-id pub-id-type="other">2-s2.0-0142074685</pub-id>
<pub-id pub-id-type="pmid">14568458</pub-id>
</element-citation>
</ref>
<ref id="B40"><label>40</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname>
<given-names>S. M.</given-names>
</name>
<name><surname>Jenkinson</surname>
<given-names>M.</given-names>
</name>
<name><surname>Woolrich</surname>
<given-names>M. W.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Advances in functional and structural MR image analysis and implementation as FSL</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2004</year>
<volume>23</volume>
<issue>1</issue>
<fpage>S208</fpage>
<lpage>S219</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2004.07.051</pub-id>
<pub-id pub-id-type="other">2-s2.0-7044260964</pub-id>
<pub-id pub-id-type="pmid">15501092</pub-id>
</element-citation>
</ref>
<ref id="B41"><label>41</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alexander</surname>
<given-names>D. C.</given-names>
</name>
<name><surname>Pierpaoli</surname>
<given-names>C.</given-names>
</name>
<name><surname>Basser</surname>
<given-names>P. J.</given-names>
</name>
<name><surname>Gee</surname>
<given-names>J. C.</given-names>
</name>
</person-group>
<article-title>Spatial transformations of diffusion tensor magnetic resonance images</article-title>
<source><italic>IEEE Transactions on Medical Imaging</italic>
</source>
<year>2001</year>
<volume>20</volume>
<issue>11</issue>
<fpage>1131</fpage>
<lpage>1139</lpage>
<pub-id pub-id-type="doi">10.1109/42.963816</pub-id>
<pub-id pub-id-type="other">2-s2.0-0035498039</pub-id>
<pub-id pub-id-type="pmid">11700739</pub-id>
</element-citation>
</ref>
<ref id="B42"><label>42</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jovicich</surname>
<given-names>J.</given-names>
</name>
<name><surname>Czanner</surname>
<given-names>S.</given-names>
</name>
<name><surname>Greve</surname>
<given-names>D.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2006</year>
<volume>30</volume>
<issue>2</issue>
<fpage>436</fpage>
<lpage>443</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2005.09.046</pub-id>
<pub-id pub-id-type="other">2-s2.0-33645117322</pub-id>
<pub-id pub-id-type="pmid">16300968</pub-id>
</element-citation>
</ref>
<ref id="B43"><label>43</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jones</surname>
<given-names>D. K.</given-names>
</name>
<name><surname>Basser</surname>
<given-names>P. J.</given-names>
</name>
</person-group>
<article-title>‘Squashing peanuts and smashing pumpkins’: how noise distorts diffusion-weighted MR data</article-title>
<source><italic>Magnetic Resonance in Medicine</italic>
</source>
<year>2004</year>
<volume>52</volume>
<issue>5</issue>
<fpage>979</fpage>
<lpage>993</lpage>
<pub-id pub-id-type="doi">10.1002/mrm.20283</pub-id>
<pub-id pub-id-type="other">2-s2.0-7544247899</pub-id>
<pub-id pub-id-type="pmid">15508154</pub-id>
</element-citation>
</ref>
<ref id="B44"><label>44</label>
<element-citation publication-type="confproc"><person-group person-group-type="author"><name><surname>Cook</surname>
<given-names>P. A.</given-names>
</name>
<name><surname>Bai</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Seunarine</surname>
<given-names>K. K.</given-names>
</name>
<name><surname>Hall</surname>
<given-names>M. G.</given-names>
</name>
<name><surname>Parker</surname>
<given-names>G. J.</given-names>
</name>
<name><surname>Alexander</surname>
<given-names>D. C.</given-names>
</name>
</person-group>
<article-title>Camino: open-source diffusion-MRI reconstruction and processing</article-title>
<conf-name>Proceedings in the International Society for Magnetic Resonance in Medicine</conf-name>
<conf-date>May 2006</conf-date>
<fpage>p. 2759</fpage>
</element-citation>
</ref>
<ref id="B45"><label>45</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Behrens</surname>
<given-names>T. E. J.</given-names>
</name>
<name><surname>Woolrich</surname>
<given-names>M. W.</given-names>
</name>
<name><surname>Jenkinson</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Characterization and propagation of uncertainty in diffusion-weighted MR imaging</article-title>
<source><italic>Magnetic Resonance in Medicine</italic>
</source>
<year>2003</year>
<volume>50</volume>
<issue>5</issue>
<fpage>1077</fpage>
<lpage>1088</lpage>
<pub-id pub-id-type="doi">10.1002/mrm.10609</pub-id>
<pub-id pub-id-type="other">2-s2.0-0242353936</pub-id>
<pub-id pub-id-type="pmid">14587019</pub-id>
</element-citation>
</ref>
<ref id="B46"><label>46</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Behrens</surname>
<given-names>T. E. J.</given-names>
</name>
<name><surname>Berg</surname>
<given-names>H. J.</given-names>
</name>
<name><surname>Jbabdi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Rushworth</surname>
<given-names>M. F. S.</given-names>
</name>
<name><surname>Woolrich</surname>
<given-names>M. W.</given-names>
</name>
</person-group>
<article-title>Probabilistic diffusion tractography with multiple fibre orientations: what can we gain?</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2007</year>
<volume>34</volume>
<issue>1</issue>
<fpage>144</fpage>
<lpage>155</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2006.09.018</pub-id>
<pub-id pub-id-type="other">2-s2.0-33751096767</pub-id>
<pub-id pub-id-type="pmid">17070705</pub-id>
</element-citation>
</ref>
<ref id="B47"><label>47</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liptrot</surname>
<given-names>M. G.</given-names>
</name>
<name><surname>Sidaros</surname>
<given-names>K.</given-names>
</name>
<name><surname>Dyrby</surname>
<given-names>T. B.</given-names>
</name>
</person-group>
<article-title>Addressing the path-length-dependency confound in white matter tract segmentation</article-title>
<source><italic>PLoS ONE</italic>
</source>
<year>2014</year>
<volume>9</volume>
<issue>5</issue>
<pub-id pub-id-type="publisher-id">e96247</pub-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0096247</pub-id>
<pub-id pub-id-type="other">2-s2.0-84900445033</pub-id>
</element-citation>
</ref>
<ref id="B48"><label>48</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jenkinson</surname>
<given-names>M.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>A global optimisation method for robust affine registration of brain images</article-title>
<source><italic>Medical Image Analysis</italic>
</source>
<year>2001</year>
<volume>5</volume>
<issue>2</issue>
<fpage>143</fpage>
<lpage>156</lpage>
<pub-id pub-id-type="doi">10.1016/s1361-8415(01)00036-6</pub-id>
<pub-id pub-id-type="other">2-s2.0-0035384136</pub-id>
<pub-id pub-id-type="pmid">11516708</pub-id>
</element-citation>
</ref>
<ref id="B49"><label>49</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jenkinson</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bannister</surname>
<given-names>P.</given-names>
</name>
<name><surname>Brady</surname>
<given-names>M.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Improved optimization for the robust and accurate linear registration and motion correction of brain images</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2002</year>
<volume>17</volume>
<issue>2</issue>
<fpage>825</fpage>
<lpage>841</lpage>
<pub-id pub-id-type="doi">10.1016/S1053-8119(02)91132-8</pub-id>
<pub-id pub-id-type="other">2-s2.0-0036425968</pub-id>
<pub-id pub-id-type="pmid">12377157</pub-id>
</element-citation>
</ref>
<ref id="B50"><label>50</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Andersson</surname>
<given-names>J. L. R.</given-names>
</name>
<name><surname>Jenkinson</surname>
<given-names>M.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Non-linear registration aka spatial normalisation</article-title>
<year>2007</year>
<issue>TR07JA2</issue>
<publisher-name>FMRIB</publisher-name>
</element-citation>
</ref>
<ref id="B51"><label>51</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lilliefors</surname>
<given-names>H. W.</given-names>
</name>
</person-group>
<article-title>On the Kolmogorov-Smirnov test for normality with mean and variance unknown</article-title>
<source><italic>Journal of the American Statistical Association</italic>
</source>
<year>1967</year>
<volume>62</volume>
<issue>318</issue>
<fpage>399</fpage>
<lpage>402</lpage>
</element-citation>
</ref>
<ref id="B52"><label>52</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname>
<given-names>S. M.</given-names>
</name>
<name><surname>Nichols</surname>
<given-names>T. E.</given-names>
</name>
</person-group>
<article-title>Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2009</year>
<volume>44</volume>
<issue>1</issue>
<fpage>83</fpage>
<lpage>98</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2008.03.061</pub-id>
<pub-id pub-id-type="other">2-s2.0-55149112384</pub-id>
<pub-id pub-id-type="pmid">18501637</pub-id>
</element-citation>
</ref>
<ref id="B53"><label>53</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Winkler</surname>
<given-names>A. M.</given-names>
</name>
<name><surname>Ridgway</surname>
<given-names>G. R.</given-names>
</name>
<name><surname>Webster</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>S. M.</given-names>
</name>
<name><surname>Nichols</surname>
<given-names>T. E.</given-names>
</name>
</person-group>
<article-title>Permutation inference for the general linear model</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2014</year>
<volume>92</volume>
<fpage>381</fpage>
<lpage>397</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2014.01.060</pub-id>
<pub-id pub-id-type="other">2-s2.0-84896520627</pub-id>
<pub-id pub-id-type="pmid">24530839</pub-id>
</element-citation>
</ref>
<ref id="B54"><label>54</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Mori</surname>
<given-names>S.</given-names>
</name>
<name><surname>Wakana</surname>
<given-names>S.</given-names>
</name>
<name><surname>Nagae-Poetscher</surname>
<given-names>L. M.</given-names>
</name>
<name><surname>van Zijl</surname>
<given-names>P. C. M.</given-names>
</name>
</person-group>
<source><italic>MRI Atlas of Human White Matter</italic>
</source>
<year>2005</year>
<publisher-loc>Amsterdam, The Netherlands</publisher-loc>
<publisher-name>Elsevier</publisher-name>
</element-citation>
</ref>
<ref id="B55"><label>55</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Catani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Thiebaut de Schotten</surname>
<given-names>M.</given-names>
</name>
</person-group>
<source><italic>Atlas of Human Brain Connections</italic>
</source>
<year>2012</year>
<publisher-name>Oxford University Press</publisher-name>
</element-citation>
</ref>
<ref id="B56"><label>56</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Innocenti</surname>
<given-names>G. M.</given-names>
</name>
<name><surname>Price</surname>
<given-names>D. J.</given-names>
</name>
</person-group>
<article-title>Exuberance in the development of cortical networks</article-title>
<source><italic>Nature Reviews Neuroscience</italic>
</source>
<year>2005</year>
<volume>6</volume>
<issue>12</issue>
<fpage>955</fpage>
<lpage>965</lpage>
<pub-id pub-id-type="doi">10.1038/nrn1790</pub-id>
<pub-id pub-id-type="other">2-s2.0-28644447375</pub-id>
<pub-id pub-id-type="pmid">16288299</pub-id>
</element-citation>
</ref>
<ref id="B57"><label>57</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Innocenti</surname>
<given-names>G. M.</given-names>
</name>
<name><surname>Frost</surname>
<given-names>D. O.</given-names>
</name>
</person-group>
<article-title>The postnatal development of visual callosal connections in the absence of visual experience or of the eyes</article-title>
<source><italic>Experimental Brain Research</italic>
</source>
<year>1980</year>
<volume>39</volume>
<issue>4</issue>
<fpage>365</fpage>
<lpage>375</lpage>
<pub-id pub-id-type="doi">10.1007/bf00239301</pub-id>
<pub-id pub-id-type="other">2-s2.0-0018903939</pub-id>
<pub-id pub-id-type="pmid">7398830</pub-id>
</element-citation>
</ref>
<ref id="B58"><label>58</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Innocenti</surname>
<given-names>G. M.</given-names>
</name>
<name><surname>Frost</surname>
<given-names>D. O.</given-names>
</name>
<name><surname>Illes</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Maturation of visual callosal connections in visually deprived kittens: a challenging critical period</article-title>
<source><italic>Journal of Neuroscience</italic>
</source>
<year>1985</year>
<volume>5</volume>
<issue>2</issue>
<fpage>255</fpage>
<lpage>267</lpage>
<pub-id pub-id-type="other">2-s2.0-0021961901</pub-id>
<pub-id pub-id-type="pmid">3973665</pub-id>
</element-citation>
</ref>
<ref id="B59"><label>59</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bock</surname>
<given-names>A. S.</given-names>
</name>
<name><surname>Saenz</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tungaraza</surname>
<given-names>R.</given-names>
</name>
<name><surname>Boynton</surname>
<given-names>G. M.</given-names>
</name>
<name><surname>Bridge</surname>
<given-names>H.</given-names>
</name>
<name><surname>Fine</surname>
<given-names>I.</given-names>
</name>
</person-group>
<article-title>Visual callosal topography in the absence of retinal input</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2013</year>
<volume>81</volume>
<fpage>325</fpage>
<lpage>334</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2013.05.038</pub-id>
<pub-id pub-id-type="other">2-s2.0-84878873892</pub-id>
<pub-id pub-id-type="pmid">23684881</pub-id>
</element-citation>
</ref>
<ref id="B60"><label>60</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
<name><surname>Liang</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Whole brain functional connectivity in the early blind</article-title>
<source><italic>Brain</italic>
</source>
<year>2007</year>
<volume>130</volume>
<issue>8</issue>
<fpage>2085</fpage>
<lpage>2096</lpage>
<pub-id pub-id-type="doi">10.1093/brain/awm121</pub-id>
<pub-id pub-id-type="other">2-s2.0-34547734497</pub-id>
<pub-id pub-id-type="pmid">17533167</pub-id>
</element-citation>
</ref>
<ref id="B61"><label>61</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leporé</surname>
<given-names>N.</given-names>
</name>
<name><surname>Voss</surname>
<given-names>P.</given-names>
</name>
<name><surname>Lepore</surname>
<given-names>F.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Brain structure changes visualized in early- and late-onset blind subjects</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2010</year>
<volume>49</volume>
<issue>1</issue>
<fpage>134</fpage>
<lpage>140</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2009.07.048</pub-id>
<pub-id pub-id-type="other">2-s2.0-70349976017</pub-id>
<pub-id pub-id-type="pmid">19643183</pub-id>
</element-citation>
</ref>
<ref id="B62"><label>62</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tomaiuolo</surname>
<given-names>F.</given-names>
</name>
<name><surname>Campana</surname>
<given-names>S.</given-names>
</name>
<name><surname>Collins</surname>
<given-names>D. L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Morphometric changes of the corpus callosum in congenital blindness</article-title>
<source><italic>PLoS ONE</italic>
</source>
<year>2014</year>
<volume>9</volume>
<issue>9</issue>
<pub-id pub-id-type="publisher-id">e107871</pub-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0107871</pub-id>
<pub-id pub-id-type="other">2-s2.0-84907584608</pub-id>
</element-citation>
</ref>
<ref id="B63"><label>63</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Caminiti</surname>
<given-names>R.</given-names>
</name>
<name><surname>Carducci</surname>
<given-names>F.</given-names>
</name>
<name><surname>Piervincenzi</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Diameter, length, speed, and conduction delay of callosal axons in macaque monkeys and humans: comparing data from histology and magnetic resonance imaging diffusion tractography</article-title>
<source><italic>Journal of Neuroscience</italic>
</source>
<year>2013</year>
<volume>33</volume>
<issue>36</issue>
<fpage>14501</fpage>
<lpage>14511</lpage>
<pub-id pub-id-type="doi">10.1523/jneurosci.0761-13.2013</pub-id>
<pub-id pub-id-type="other">2-s2.0-84883318400</pub-id>
<pub-id pub-id-type="pmid">24005301</pub-id>
</element-citation>
</ref>
<ref id="B64"><label>64</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname>
<given-names>K. C.</given-names>
</name>
<name><surname>Cheng</surname>
<given-names>J. S.</given-names>
</name>
<name><surname>Fan</surname>
<given-names>S.</given-names>
</name>
<name><surname>Zhou</surname>
<given-names>I. Y.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>E. X.</given-names>
</name>
</person-group>
<article-title>In vivo evaluation of retinal and callosal projections in early postnatal development and plasticity using manganese-enhanced mri and diffusion tensor imaging</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2012</year>
<volume>59</volume>
<issue>3</issue>
<fpage>2274</fpage>
<lpage>2283</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2011.09.055</pub-id>
<pub-id pub-id-type="other">2-s2.0-84855432496</pub-id>
<pub-id pub-id-type="pmid">21985904</pub-id>
</element-citation>
</ref>
<ref id="B65"><label>65</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amedi</surname>
<given-names>A.</given-names>
</name>
<name><surname>Malach</surname>
<given-names>R.</given-names>
</name>
<name><surname>Hendler</surname>
<given-names>T.</given-names>
</name>
<name><surname>Peled</surname>
<given-names>S.</given-names>
</name>
<name><surname>Zohary</surname>
<given-names>E.</given-names>
</name>
</person-group>
<article-title>Visuo-haptic object-related activation in the ventral visual pathway</article-title>
<source><italic>Nature Neuroscience</italic>
</source>
<year>2001</year>
<volume>4</volume>
<issue>3</issue>
<fpage>324</fpage>
<lpage>330</lpage>
<pub-id pub-id-type="doi">10.1038/85201</pub-id>
<pub-id pub-id-type="other">2-s2.0-0035126168</pub-id>
<pub-id pub-id-type="pmid">11224551</pub-id>
</element-citation>
</ref>
<ref id="B66"><label>66</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pietrini</surname>
<given-names>P.</given-names>
</name>
<name><surname>Furey</surname>
<given-names>M. L.</given-names>
</name>
<name><surname>Ricciardi</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Beyond sensory images: object-based representation in the human ventral pathway</article-title>
<source><italic>Proceedings of the National Academy of Sciences of the United States of America</italic>
</source>
<year>2004</year>
<volume>101</volume>
<issue>15</issue>
<fpage>5658</fpage>
<lpage>5663</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0400707101</pub-id>
<pub-id pub-id-type="other">2-s2.0-1842732156</pub-id>
<pub-id pub-id-type="pmid">15064396</pub-id>
</element-citation>
</ref>
<ref id="B67"><label>67</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Poirier</surname>
<given-names>C.</given-names>
</name>
<name><surname>Collignon</surname>
<given-names>O.</given-names>
</name>
<name><surname>Scheiber</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Auditory motion perception activates visual motion areas in early blind subjects</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2006</year>
<volume>31</volume>
<issue>1</issue>
<fpage>279</fpage>
<lpage>285</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2005.11.036</pub-id>
<pub-id pub-id-type="other">2-s2.0-33646587750</pub-id>
<pub-id pub-id-type="pmid">16443376</pub-id>
</element-citation>
</ref>
<ref id="B68"><label>68</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ptito</surname>
<given-names>M.</given-names>
</name>
<name><surname>Matteau</surname>
<given-names>I.</given-names>
</name>
<name><surname>Gjedde</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kupers</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>Recruitment of the middle temporal area by tactile motion in congenital blindness</article-title>
<source><italic>NeuroReport</italic>
</source>
<year>2009</year>
<volume>20</volume>
<issue>6</issue>
<fpage>543</fpage>
<lpage>547</lpage>
<pub-id pub-id-type="doi">10.1097/wnr.0b013e3283279909</pub-id>
<pub-id pub-id-type="other">2-s2.0-67049133262</pub-id>
<pub-id pub-id-type="pmid">19240660</pub-id>
</element-citation>
</ref>
<ref id="B69"><label>69</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renier</surname>
<given-names>L. A.</given-names>
</name>
<name><surname>Anurova</surname>
<given-names>I.</given-names>
</name>
<name><surname>De Volder</surname>
<given-names>A. G.</given-names>
</name>
<name><surname>Carlson</surname>
<given-names>S.</given-names>
</name>
<name><surname>VanMeter</surname>
<given-names>J.</given-names>
</name>
<name><surname>Rauschecker</surname>
<given-names>J. P.</given-names>
</name>
</person-group>
<article-title>Multisensory integration of sounds and vibrotactile stimuli in processing streams for ‘what’ and ‘where’</article-title>
<source><italic>The Journal of Neuroscience</italic>
</source>
<year>2009</year>
<volume>29</volume>
<issue>35</issue>
<fpage>10950</fpage>
<lpage>10960</lpage>
<pub-id pub-id-type="doi">10.1523/jneurosci.0910-09.2009</pub-id>
<pub-id pub-id-type="other">2-s2.0-69749113843</pub-id>
<pub-id pub-id-type="pmid">19726653</pub-id>
</element-citation>
</ref>
<ref id="B70"><label>70</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Collignon</surname>
<given-names>O.</given-names>
</name>
<name><surname>Dormal</surname>
<given-names>G.</given-names>
</name>
<name><surname>Albouy</surname>
<given-names>G.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Impact of blindness onset on the functional organization and the connectivity of the occipital cortex</article-title>
<source><italic>Brain</italic>
</source>
<year>2013</year>
<volume>136</volume>
<issue>9</issue>
<fpage>2769</fpage>
<lpage>2783</lpage>
<pub-id pub-id-type="doi">10.1093/brain/awt176</pub-id>
<pub-id pub-id-type="other">2-s2.0-84883390096</pub-id>
<pub-id pub-id-type="pmid">23831614</pub-id>
</element-citation>
</ref>
<ref id="B71"><label>71</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lasič</surname>
<given-names>S.</given-names>
</name>
<name><surname>Szczepankiewicz</surname>
<given-names>F.</given-names>
</name>
<name><surname>Eriksson</surname>
<given-names>S.</given-names>
</name>
<name><surname>Nilsson</surname>
<given-names>M.</given-names>
</name>
<name><surname>Topgaard</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector</article-title>
<source><italic>Frontiers in Physics</italic>
</source>
<year>2014</year>
<volume>2</volume>
<fpage>1</fpage>
<lpage>14</lpage>
<pub-id pub-id-type="doi">10.3389/fphy.2014.00011</pub-id>
</element-citation>
</ref>
<ref id="B72"><label>72</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Szczepankiewicz</surname>
<given-names>F.</given-names>
</name>
<name><surname>Lasič</surname>
<given-names>S.</given-names>
</name>
<name><surname>van Westen</surname>
<given-names>D.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: applications in healthy volunteers and in brain tumors</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2015</year>
<volume>104</volume>
<fpage>241</fpage>
<lpage>252</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2014.09.057</pub-id>
<pub-id pub-id-type="other">2-s2.0-84908637474</pub-id>
<pub-id pub-id-type="pmid">25284306</pub-id>
</element-citation>
</ref>
<ref id="B73"><label>73</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jespersen</surname>
<given-names>S. N.</given-names>
</name>
<name><surname>Lundell</surname>
<given-names>H.</given-names>
</name>
<name><surname>Sønderby</surname>
<given-names>C. K.</given-names>
</name>
<name><surname>Dyrby</surname>
<given-names>T. B.</given-names>
</name>
</person-group>
<article-title>Commentary on ‘microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientation of order parameter by diffusion MRI with magic-angle spinning of the q-vector’</article-title>
<source><italic>Frontiers of Physics</italic>
</source>
<year>2014</year>
<volume>2, article 28</volume>
<pub-id pub-id-type="doi">10.3389/fphy.2014.00028</pub-id>
</element-citation>
</ref>
<ref id="B74"><label>74</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vos</surname>
<given-names>S. B.</given-names>
</name>
<name><surname>Jones</surname>
<given-names>D. K.</given-names>
</name>
<name><surname>Viergever</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Leemans</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Partial volume effect as a hidden covariate in DTI analyses</article-title>
<source><italic>NeuroImage</italic>
</source>
<year>2011</year>
<volume>55</volume>
<issue>4</issue>
<fpage>1566</fpage>
<lpage>1576</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuroimage.2011.01.048</pub-id>
<pub-id pub-id-type="other">2-s2.0-79952704279</pub-id>
<pub-id pub-id-type="pmid">21262366</pub-id>
</element-citation>
</ref>
<ref id="B75"><label>75</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>D.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>W.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Altered resting-state network connectivity in congenital blind</article-title>
<source><italic>Human Brain Mapping</italic>
</source>
<year>2014</year>
<volume>35</volume>
<issue>6</issue>
<fpage>2573</fpage>
<lpage>2581</lpage>
<pub-id pub-id-type="doi">10.1002/hbm.22350</pub-id>
<pub-id pub-id-type="pmid">24038713</pub-id>
</element-citation>
</ref>
<ref id="B76"><label>76</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Watkins</surname>
<given-names>K. E.</given-names>
</name>
<name><surname>Cowey</surname>
<given-names>A.</given-names>
</name>
<name><surname>Alexander</surname>
<given-names>I.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Language networks in anophthalmia: maintained hierarchy of processing in ‘visual’ cortex</article-title>
<source><italic>Brain</italic>
</source>
<year>2012</year>
<volume>135</volume>
<issue>5</issue>
<fpage>1566</fpage>
<lpage>1577</lpage>
<pub-id pub-id-type="doi">10.1093/brain/aws067</pub-id>
<pub-id pub-id-type="other">2-s2.0-84860602174</pub-id>
<pub-id pub-id-type="pmid">22427328</pub-id>
</element-citation>
</ref>
<ref id="B77"><label>77</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heine</surname>
<given-names>L.</given-names>
</name>
<name><surname>Bahri</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Cavaliere</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Prevalence of increases in functional connectivity in visual, somatosensory and language areas in congenital blindness</article-title>
<source><italic>Frontiers in Neuroanatomy</italic>
</source>
<year>2015</year>
<volume>9, article 86</volume>
<pub-id pub-id-type="doi">10.3389/fnana.2015.00086</pub-id>
</element-citation>
</ref>
<ref id="B78"><label>78</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saygin</surname>
<given-names>Z. M.</given-names>
</name>
<name><surname>Osher</surname>
<given-names>D. E.</given-names>
</name>
<name><surname>Koldewyn</surname>
<given-names>K.</given-names>
</name>
<name><surname>Reynolds</surname>
<given-names>G.</given-names>
</name>
<name><surname>Gabrieli</surname>
<given-names>J. D. E.</given-names>
</name>
<name><surname>Saxe</surname>
<given-names>R. R.</given-names>
</name>
</person-group>
<article-title>Anatomical connectivity patterns predict face selectivity in the fusiform gyrus</article-title>
<source><italic>Nature Neuroscience</italic>
</source>
<year>2012</year>
<volume>15</volume>
<issue>2</issue>
<fpage>321</fpage>
<lpage>327</lpage>
<pub-id pub-id-type="doi">10.1038/nn.3001</pub-id>
<pub-id pub-id-type="other">2-s2.0-84856279673</pub-id>
<pub-id pub-id-type="pmid">22197830</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Statistical parametric maps based on whole-brain anatomical connectivity mapping (ACM) showing voxels where anatomical connectivity is significantly decreased in CB individuals relative to NS (blue voxels): NS > CB individuals (<italic>p</italic>
< 0.05). Alterations are shown to be located mainly in the tract-system of corpus callosum (white arrows). Only voxels surviving the statistical threshold are shown, and <italic>p</italic>
values are based on the threshold-free cluster enhancement and are family-wise error corrected. MNI-coordinates are reported in mm for <italic>x</italic>
-, <italic>y</italic>
-, and <italic>z</italic>
-views. Background image is the FMRIB58_FA template.</p>
</caption>
<graphic xlink:href="NP2016-6029241.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Statistical parametric FA maps showing a relative decrease in regional fractional anisotropy (FA) in CB and LB individuals relative to NS (red-yellow voxels): NS > CB individuals (<italic>p</italic>
< 0.001, (a)) and NS > LB individuals (<italic>p</italic>
< 0.001, (b)). The FA differences are seen in the primary visual pathway indicated by the white arrows and the ventral streams. <italic>p</italic>
values and background image defined as in <xref ref-type="fig" rid="fig1">Figure 1</xref>
.</p>
</caption>
<graphic xlink:href="NP2016-6029241.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Statistical parametric MD and RD maps, showing a relative increase in regional radial diffusivity (RD) and mean diffusivity (MD) in CB and LB individuals relative to NS (red-yellow voxels). (a) shows CB individuals > NS for MD and RD: <italic>p</italic>
< 0.001; (b) shows LB individuals > NS for MD and RD: <italic>p</italic>
< 0.01. The RD and MD increases are accompanying the FA decrease, here illustrated in the primary visual pathway indicated by the white arrows. <italic>p</italic>
values and background image defined as in <xref ref-type="fig" rid="fig1">Figure 1</xref>
.</p>
</caption>
<graphic xlink:href="NP2016-6029241.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Tract ROI statistically significant differences in ACM for NS > CB individuals, voxel-based <italic>p</italic>
<sub>FWE</sub>
< 0.05. Splenium (green arrow) and midbody (light blue arrow) of the corpus callosum (a, b) and the tendency of decreased ACM in the optic radiations (<italic>p</italic>
<sub>uncorrected</sub>
< 0.005, orange arrow) (c). Voxels surviving the statistical threshold are overlaid on the FMRIB58_FA template. No voxels survived the threshold for NS > LB individuals. MNI-coordinates are reported in mm for <italic>x</italic>
-, <italic>y</italic>
-, and <italic>z</italic>
-views.</p>
</caption>
<graphic xlink:href="NP2016-6029241.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Tract ROI statistically significant differences in FA for NS > CB individuals (a, b) and NS > LB individuals (c), voxel-based <italic>p</italic>
<sub>FWE</sub>
< 0.05. Optic radiations (orange arrow), ventral stream (dark blue arrow), right dorsal stream (purple arrow), splenium (green arrow), midbody (light blue arrow), and corticospinal tract (brown arrow). Voxels surviving the statistical threshold are overlaid on the FMRIB58_FA template. MNI-coordinates are reported in mm for <italic>x</italic>
-, <italic>y</italic>
-, and <italic>z</italic>
-views.</p>
</caption>
<graphic xlink:href="NP2016-6029241.005"></graphic>
</fig>
<table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Regions of significantly decreased anatomical connectivity (ACM) in CB compared to NS individuals.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">ACM</th>
<th align="center" rowspan="2" colspan="1"><italic>N</italic>
<sub>voxels</sub>
</th>
<th align="center" rowspan="2" colspan="1"><italic>p</italic>
<sub>FWE-peak</sub>
</th>
<th align="center" rowspan="1" colspan="1">MNI-coordinates</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1">Tract ROI</th>
<th align="center" rowspan="1" colspan="1">(<italic>x</italic>
, <italic>y</italic>
, <italic>z</italic>
)—mm</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">OR <italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">29</td>
<td align="center" rowspan="1" colspan="1">0.002 (uncorr.)</td>
<td align="center" rowspan="1" colspan="1">(36, −64, 2)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">OR <italic>L</italic>
</td>
<td align="center" rowspan="1" colspan="1">11</td>
<td align="center" rowspan="1" colspan="1">0.003 (uncorr.)</td>
<td align="center" rowspan="1" colspan="1">(−28, −68, 4)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">ILF & IFOF <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">SLF <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">Splenium</td>
<td align="center" rowspan="1" colspan="1">24</td>
<td align="center" rowspan="1" colspan="1">0.02</td>
<td align="center" rowspan="1" colspan="1">(−12, −34, 20)</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">18</td>
<td align="center" rowspan="1" colspan="1">0.02</td>
<td align="center" rowspan="1" colspan="1">(±14, −36, 10)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Midbody</td>
<td align="center" rowspan="1" colspan="1">95</td>
<td align="center" rowspan="1" colspan="1">0.02</td>
<td align="center" rowspan="1" colspan="1">(2, −16, 24)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Genu</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CST <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Tract ROI defines the white matter region of interest: optic radiation (OR), inferior longitudinal fasciculus (ILF) and inferior frontooccipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and corticospinal tract (CST). </p>
</fn>
<fn><p><italic>N</italic>
<sub>voxels</sub>
defines the number of voxels surviving the threshold of 0.05. <italic>p</italic>
<sub>FWE-peak</sub>
refers to the <italic>p</italic>
value for the voxel with the largest <italic>t</italic>
-test within a region. Uncorrected <italic>p</italic>
values are given for the OR. MNI-coordinates refer to the coordinates of that voxel in mm. <italic>L</italic>
/<italic>R</italic>
refers to the left and right hemisphere.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label>
<caption><p>Regions of significantly decreased fractional anisotropy (FA) in CB and LB compared to NS individuals.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="3" colspan="1">FA Tract ROI</th>
<th align="center" colspan="3" rowspan="1">CB</th>
<th align="center" colspan="3" rowspan="1">LB</th>
</tr>
<tr><th align="center" rowspan="2" colspan="1"><italic>N</italic>
<sub>voxels</sub>
</th>
<th align="center" rowspan="2" colspan="1"><italic>p</italic>
<sub>FWE-peak</sub>
</th>
<th align="center" rowspan="1" colspan="1">MNI-coordinates</th>
<th align="center" rowspan="2" colspan="1"><italic>N</italic>
<sub>voxels</sub>
</th>
<th align="center" rowspan="2" colspan="1"><italic>p</italic>
<sub>FWE-peak</sub>
</th>
<th align="center" rowspan="1" colspan="1">MNI-coordinates</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">(<italic>x</italic>
, <italic>y</italic>
, <italic>z</italic>
)—mm</th>
<th align="center" rowspan="1" colspan="1">(<italic>x</italic>
, <italic>y</italic>
, <italic>z</italic>
)—mm</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="2" colspan="1">OR <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">151</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(−32, −52, −2)</td>
<td align="center" rowspan="1" colspan="1">74</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(−34, −48, −2)</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">141</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(38, −56, −2)</td>
<td align="center" rowspan="1" colspan="1">86</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(30, −72, 2)</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">ILF & IFOF <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">112</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(−38, −42, −8)</td>
<td align="center" rowspan="1" colspan="1">103</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(−38, −44, −6)</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">79</td>
<td align="center" rowspan="1" colspan="1">0.001</td>
<td align="center" rowspan="1" colspan="1">(36, −44, −4)</td>
<td align="center" rowspan="1" colspan="1">99</td>
<td align="center" rowspan="1" colspan="1"><0.0005</td>
<td align="center" rowspan="1" colspan="1">(44, −24, −14)</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">SLF <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">0.005</td>
<td align="center" rowspan="1" colspan="1">(−42, −18, 26)</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
<td align="center" rowspan="1" colspan="1">—</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">17</td>
<td align="center" rowspan="1" colspan="1">0.001</td>
<td align="center" rowspan="1" colspan="1">(36, −54, 16)</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">0.02</td>
<td align="center" rowspan="1" colspan="1">(40, −14, 24)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Splenium</td>
<td align="center" rowspan="1" colspan="1">303</td>
<td align="center" rowspan="1" colspan="1">0.001</td>
<td align="center" rowspan="1" colspan="1">(2, −34, 8)</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">0.04</td>
<td align="center" rowspan="1" colspan="1">(0, −34, 10)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Midbody</td>
<td align="center" rowspan="1" colspan="1">46</td>
<td align="center" rowspan="1" colspan="1">0.004</td>
<td align="center" rowspan="1" colspan="1">(6, 4, 12)</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">0.05</td>
<td align="center" rowspan="1" colspan="1">(−4, 16, 22)</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Genu</td>
<td align="center" rowspan="1" colspan="1">25</td>
<td align="center" rowspan="1" colspan="1">0.006</td>
<td align="center" rowspan="1" colspan="1">(−6, 20, 12)</td>
<td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">0.05</td>
<td align="center" rowspan="1" colspan="1">(−12, 36, 8)</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">CST <italic>L</italic>
/<italic>R</italic>
</td>
<td align="center" rowspan="1" colspan="1">46</td>
<td align="center" rowspan="1" colspan="1">0.001</td>
<td align="center" rowspan="1" colspan="1">(−20, −16, −10)</td>
<td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">0.03</td>
<td align="center" rowspan="1" colspan="1">(−14, −14, −6)</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">46</td>
<td align="center" rowspan="1" colspan="1">0.001</td>
<td align="center" rowspan="1" colspan="1">(18, −14, 10)</td>
<td align="center" rowspan="1" colspan="1">15</td>
<td align="center" rowspan="1" colspan="1">0.03</td>
<td align="center" rowspan="1" colspan="1">(18, −18, −4)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Abbreviations identical to <xref ref-type="table" rid="tab1">Table 1</xref>
but based on tract ROI differences in FA.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>Danemark</li>
</country>
<region><li>Hovedstaden</li>
</region>
<settlement><li>Copenhague</li>
</settlement>
</list>
<tree><country name="Danemark"><noRegion><name sortKey="Reislev, Nina Linde" sort="Reislev, Nina Linde" uniqKey="Reislev N" first="Nina Linde" last="Reislev">Nina Linde Reislev</name>
</noRegion>
<name sortKey="Dyrby, Tim Bj Rn" sort="Dyrby, Tim Bj Rn" uniqKey="Dyrby T" first="Tim Bj Rn" last="Dyrby">Tim Bj Rn Dyrby</name>
<name sortKey="Kupers, Ron" sort="Kupers, Ron" uniqKey="Kupers R" first="Ron" last="Kupers">Ron Kupers</name>
<name sortKey="Ptito, Maurice" sort="Ptito, Maurice" uniqKey="Ptito M" first="Maurice" last="Ptito">Maurice Ptito</name>
<name sortKey="Reislev, Nina Linde" sort="Reislev, Nina Linde" uniqKey="Reislev N" first="Nina Linde" last="Reislev">Nina Linde Reislev</name>
<name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name>
<name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name>
</country>
<country name="Canada"><noRegion><name sortKey="Ptito, Maurice" sort="Ptito, Maurice" uniqKey="Ptito M" first="Maurice" last="Ptito">Maurice Ptito</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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