Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual–haptic crossmodal working memory
Identifieur interne : 003571 ( Ncbi/Merge ); précédent : 003570; suivant : 003572Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual–haptic crossmodal working memory
Auteurs : Liping Wang [République populaire de Chine] ; Xianchun Li [République populaire de Chine] ; Steven S. Hsiao ; Fred A. Lenz ; Mark Bodner [États-Unis] ; Yong-Di Zhou ; Joaquín M. FusterSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Eye Movements (physiology), Female, Macaca mulatta (physiology), Macaca mulatta (psychology), Male, Memory, Short-Term (physiology), Neurons (physiology), Photic Stimulation, Physical Stimulation, Prefrontal Cortex (physiology), Task Performance and Analysis, Time Factors, Touch Perception (physiology), Visual Perception (physiology).
- MESH :
- physiology : Eye Movements, Macaca mulatta, Memory, Short-Term, Neurons, Prefrontal Cortex, Touch Perception, Visual Perception.
- psychology : Macaca mulatta.
- Animals, Female, Male, Photic Stimulation, Physical Stimulation, Task Performance and Analysis, Time Factors.
Abstract
Neural activity was recorded from the dorsolateral prefrontal cortex (DLPFC) when a monkey performed visuo–haptic crossmodal and haptic–haptic unimodal delayed matching-to-sample (cue) tasks. Results indicate that neural networks in the DLPFC function sequentially in the crossmodal task from visual stimulus encoding and crossmodal information transferring between visual and tactile stimuli to the behavioral action. Our findings may clarify the neural mechanisms by which the cerebral cortex stores information in working memory, a cognitive function of prime importance in the coordination of behavior, speech, and reasoning.
Url:
DOI: 10.1073/pnas.1410130112
PubMed: 25540412
PubMed Central: 4299181
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Hsiao</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Neuroscience,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21205;</nlm:aff></affiliation></author><author><name sortKey="Lenz, Fred A" sort="Lenz, Fred A" uniqKey="Lenz F" first="Fred A." last="Lenz">Fred A. Lenz</name><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff6"><institution>MIND Research Institute</institution>, Irvine, CA 92617</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Yong Di" sort="Zhou, Yong Di" uniqKey="Zhou Y" first="Yong-Di" last="Zhou">Yong-Di Zhou</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Fuster, Joaquin M" sort="Fuster, Joaquin M" uniqKey="Fuster J" first="Joaquín M." last="Fuster">Joaquín M. Fuster</name><affiliation><nlm:aff id="aff7">Semel Institute for Neuroscience and Human Behavior,<institution>University of California, Los Angeles</institution>,<addr-line>CA</addr-line> 90024</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Eye Movements (physiology)</term><term>Female</term><term>Macaca mulatta (physiology)</term><term>Macaca mulatta (psychology)</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Neurons (physiology)</term><term>Photic Stimulation</term><term>Physical Stimulation</term><term>Prefrontal Cortex (physiology)</term><term>Task Performance and Analysis</term><term>Time Factors</term><term>Touch Perception (physiology)</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Eye Movements</term><term>Macaca mulatta</term><term>Memory, Short-Term</term><term>Neurons</term><term>Prefrontal Cortex</term><term>Touch Perception</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Photic Stimulation</term><term>Physical Stimulation</term><term>Task Performance and Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Neural activity was recorded from the dorsolateral prefrontal cortex (DLPFC) when a monkey performed visuo–haptic crossmodal and haptic–haptic unimodal delayed matching-to-sample (cue) tasks. Results indicate that neural networks in the DLPFC function sequentially in the crossmodal task from visual stimulus encoding and crossmodal information transferring between visual and tactile stimuli to the behavioral action. Our findings may clarify the neural mechanisms by which the cerebral cortex stores information in working memory, a cognitive function of prime importance in the coordination of behavior, speech, and reasoning.</p></div></front></TEI><double pmid="25540412"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual–haptic crossmodal working memory</title><author><name sortKey="Wang, Liping" sort="Wang, Liping" uniqKey="Wang L" first="Liping" last="Wang">Liping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science,<institution>East China Normal University</institution>, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xianchun" sort="Li, Xianchun" uniqKey="Li X" first="Xianchun" last="Li">Xianchun Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science,<institution>East China Normal University</institution>, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsiao, Steven S" sort="Hsiao, Steven S" uniqKey="Hsiao S" first="Steven S." last="Hsiao">Steven S. Hsiao</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Neuroscience,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21205;</nlm:aff></affiliation></author><author><name sortKey="Lenz, Fred A" sort="Lenz, Fred A" uniqKey="Lenz F" first="Fred A." last="Lenz">Fred A. Lenz</name><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff6"><institution>MIND Research Institute</institution>, Irvine, CA 92617</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Yong Di" sort="Zhou, Yong Di" uniqKey="Zhou Y" first="Yong-Di" last="Zhou">Yong-Di Zhou</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Fuster, Joaquin M" sort="Fuster, Joaquin M" uniqKey="Fuster J" first="Joaquín M." last="Fuster">Joaquín M. Fuster</name><affiliation><nlm:aff id="aff7">Semel Institute for Neuroscience and Human Behavior,<institution>University of California, Los Angeles</institution>,<addr-line>CA</addr-line> 90024</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25540412</idno><idno type="pmc">4299181</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299181</idno><idno type="RBID">PMC:4299181</idno><idno type="doi">10.1073/pnas.1410130112</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001556</idno><idno type="wicri:Area/Pmc/Curation">001556</idno><idno type="wicri:Area/Pmc/Checkpoint">000D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual–haptic crossmodal working memory</title><author><name sortKey="Wang, Liping" sort="Wang, Liping" uniqKey="Wang L" first="Liping" last="Wang">Liping Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science,<institution>East China Normal University</institution>, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xianchun" sort="Li, Xianchun" uniqKey="Li X" first="Xianchun" last="Li">Xianchun Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science,<institution>East China Normal University</institution>, Shanghai 200062,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hsiao, Steven S" sort="Hsiao, Steven S" uniqKey="Hsiao S" first="Steven S." last="Hsiao">Steven S. Hsiao</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Neuroscience,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21205;</nlm:aff></affiliation></author><author><name sortKey="Lenz, Fred A" sort="Lenz, Fred A" uniqKey="Lenz F" first="Fred A." last="Lenz">Fred A. Lenz</name><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff6"><institution>MIND Research Institute</institution>, Irvine, CA 92617</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Yong Di" sort="Zhou, Yong Di" uniqKey="Zhou Y" first="Yong-Di" last="Zhou">Yong-Di Zhou</name><affiliation><nlm:aff id="aff3">Krieger Mind/Brain Institute,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21218;</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Department of Neurosurgery,<institution>Johns Hopkins University</institution>, Baltimore,<addr-line>MD</addr-line> 21287;</nlm:aff></affiliation></author><author><name sortKey="Fuster, Joaquin M" sort="Fuster, Joaquin M" uniqKey="Fuster J" first="Joaquín M." last="Fuster">Joaquín M. Fuster</name><affiliation><nlm:aff id="aff7">Semel Institute for Neuroscience and Human Behavior,<institution>University of California, Los Angeles</institution>,<addr-line>CA</addr-line> 90024</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Neural activity was recorded from the dorsolateral prefrontal cortex (DLPFC) when a monkey performed visuo–haptic crossmodal and haptic–haptic unimodal delayed matching-to-sample (cue) tasks. Results indicate that neural networks in the DLPFC function sequentially in the crossmodal task from visual stimulus encoding and crossmodal information transferring between visual and tactile stimuli to the behavioral action. Our findings may clarify the neural mechanisms by which the cerebral cortex stores information in working memory, a cognitive function of prime importance in the coordination of behavior, speech, and reasoning.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual-haptic crossmodal working memory.</title><author><name sortKey="Wang, Liping" sort="Wang, Liping" uniqKey="Wang L" first="Liping" last="Wang">Liping Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062, China;</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062</wicri:regionArea><wicri:noRegion>Shanghai 200062</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xianchun" sort="Li, Xianchun" uniqKey="Li X" first="Xianchun" last="Li">Xianchun Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China;</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062</wicri:regionArea><wicri:noRegion>Shanghai 200062</wicri:noRegion></affiliation></author><author><name sortKey="Hsiao, Steven S" sort="Hsiao, Steven S" uniqKey="Hsiao S" first="Steven S" last="Hsiao">Steven S. Hsiao</name><affiliation wicri:level="2"><nlm:affiliation>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neuroscience, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lenz, Fred A" sort="Lenz, Fred A" uniqKey="Lenz F" first="Fred A" last="Lenz">Fred A. Lenz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurosurgery, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><affiliation wicri:level="2"><nlm:affiliation>MIND Research Institute, Irvine, CA 92617; and.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>MIND Research Institute, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Yong Di" sort="Zhou, Yong Di" uniqKey="Zhou Y" first="Yong-Di" last="Zhou">Yong-Di Zhou</name><affiliation wicri:level="3"><nlm:affiliation>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287; yzhou12@jhmi.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neurosurgery, Johns Hopkins University, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fuster, Joaquin M" sort="Fuster, Joaquin M" uniqKey="Fuster J" first="Joaquín M" last="Fuster">Joaquín M. Fuster</name><affiliation wicri:level="2"><nlm:affiliation>Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90024.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25540412</idno><idno type="pmid">25540412</idno><idno type="doi">10.1073/pnas.1410130112</idno><idno type="wicri:Area/PubMed/Corpus">000457</idno><idno type="wicri:Area/PubMed/Curation">000457</idno><idno type="wicri:Area/PubMed/Checkpoint">000382</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual-haptic crossmodal working memory.</title><author><name sortKey="Wang, Liping" sort="Wang, Liping" uniqKey="Wang L" first="Liping" last="Wang">Liping Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062, China;</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062</wicri:regionArea><wicri:noRegion>Shanghai 200062</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xianchun" sort="Li, Xianchun" uniqKey="Li X" first="Xianchun" last="Li">Xianchun Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China;</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Brain Functional Genomics (Ministry of Education & Science and Technology Commission of Shanghai Municipality), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062</wicri:regionArea><wicri:noRegion>Shanghai 200062</wicri:noRegion></affiliation></author><author><name sortKey="Hsiao, Steven S" sort="Hsiao, Steven S" uniqKey="Hsiao S" first="Steven S" last="Hsiao">Steven S. Hsiao</name><affiliation wicri:level="2"><nlm:affiliation>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neuroscience, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Lenz, Fred A" sort="Lenz, Fred A" uniqKey="Lenz F" first="Fred A" last="Lenz">Fred A. Lenz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287;</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurosurgery, Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name><affiliation wicri:level="2"><nlm:affiliation>MIND Research Institute, Irvine, CA 92617; and.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>MIND Research Institute, Irvine</wicri:cityArea></affiliation></author><author><name sortKey="Zhou, Yong Di" sort="Zhou, Yong Di" uniqKey="Zhou Y" first="Yong-Di" last="Zhou">Yong-Di Zhou</name><affiliation wicri:level="3"><nlm:affiliation>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287; yzhou12@jhmi.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218; Department of Neurosurgery, Johns Hopkins University, Baltimore</wicri:regionArea><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fuster, Joaquin M" sort="Fuster, Joaquin M" uniqKey="Fuster J" first="Joaquín M" last="Fuster">Joaquín M. Fuster</name><affiliation wicri:level="2"><nlm:affiliation>Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90024.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Eye Movements (physiology)</term><term>Female</term><term>Macaca mulatta (physiology)</term><term>Macaca mulatta (psychology)</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Neurons (physiology)</term><term>Photic Stimulation</term><term>Physical Stimulation</term><term>Prefrontal Cortex (physiology)</term><term>Task Performance and Analysis</term><term>Time Factors</term><term>Touch Perception (physiology)</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Eye Movements</term><term>Macaca mulatta</term><term>Memory, Short-Term</term><term>Neurons</term><term>Prefrontal Cortex</term><term>Touch Perception</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Photic Stimulation</term><term>Physical Stimulation</term><term>Task Performance and Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies have shown that neurons of monkey dorsolateral prefrontal cortex (DLPFC) integrate information across modalities and maintain it throughout the delay period of working-memory (WM) tasks. However, the mechanisms of this temporal integration in the DLPFC are still poorly understood. In the present study, to further elucidate the role of the DLPFC in crossmodal WM, we trained monkeys to perform visuo-haptic (VH) crossmodal and haptic-haptic (HH) unimodal WM tasks. The neuronal activity recorded in the DLPFC in the delay period of both tasks indicates that the early-delay differential activity probably is related to the encoding of sample information with different strengths depending on task modality, that the late-delay differential activity reflects the associated (modality-independent) action component of haptic choice in both tasks (that is, the anticipation of the behavioral choice and/or active recall and maintenance of sample information for subsequent action), and that the sustained whole-delay differential activity likely bridges and integrates the sensory and action components. In addition, the VH late-delay differential activity was significantly diminished when the haptic choice was not required. Taken together, the results show that, in addition to the whole-delay differential activity, DLPFC neurons also show early- and late-delay differential activities. These previously unidentified findings indicate that DLPFC is capable of (i) holding the coded sample information (e.g., visual or tactile information) in the early-delay activity, (ii) retrieving the abstract information (orientations) of the sample (whether the sample has been haptic or visual) and holding it in the late-delay activity, and (iii) preparing for behavioral choice acting on that abstract information.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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