Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis
Identifieur interne : 003C47 ( Ncbi/Checkpoint ); précédent : 003C46; suivant : 003C48Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis
Auteurs : Nicola Santoro [États-Unis] ; Sonia Caprio [États-Unis] ; Ariel E. Feldstein [États-Unis]Source :
- Clinical lipidology [ 1758-4299 ] ; 2013.
Abstract
The rising prevalence of obesity in the last few decades has been accompanied by an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of liver pathology from isolated hepatic steatosis to steatohepatitis and advanced fibrosis. Dietary habits characterized by consumption of high-caloric, lipid-rich diets play a major role in the development of NAFLD. Recent studies have uncovered the importance of certain components of the diet. In this review, we will focus on the growing evidence for a central role of n-6 polyunsaturated fatty acids. We will discuss novel findings linking oxidative stress and increased production of reactive oxygen species in the liver to oxidation of n-6 polyunsaturated fatty acids and production of specific lipid oxidation metabolites. In particular, we will highlight the potential role of these metabolites as noninvasive markers to diagnose and monitor the extent of liver damage in patients with NAFLD.
Url:
DOI: 10.2217/clp.13.39
PubMed: 26405460
PubMed Central: 4578804
Affiliations:
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Feldstein</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pediatrics, University of California San Diego, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26405460</idno><idno type="pmc">4578804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578804</idno><idno type="RBID">PMC:4578804</idno><idno type="doi">10.2217/clp.13.39</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001811</idno><idno type="wicri:Area/Pmc/Curation">001811</idno><idno type="wicri:Area/Pmc/Checkpoint">001101</idno><idno type="wicri:Area/Ncbi/Merge">003C47</idno><idno type="wicri:Area/Ncbi/Curation">003C47</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis</title><author><name sortKey="Santoro, Nicola" sort="Santoro, Nicola" uniqKey="Santoro N" first="Nicola" last="Santoro">Nicola Santoro</name><affiliation wicri:level="2"><nlm:aff id="A1">Yale University, Pediatrics, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Pediatrics, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Caprio, Sonia" sort="Caprio, Sonia" uniqKey="Caprio S" first="Sonia" last="Caprio">Sonia Caprio</name><affiliation wicri:level="2"><nlm:aff id="A1">Yale University, Pediatrics, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Pediatrics, New Haven, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Feldstein, Ariel E" sort="Feldstein, Ariel E" uniqKey="Feldstein A" first="Ariel E." last="Feldstein">Ariel E. Feldstein</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pediatrics, University of California San Diego, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Clinical lipidology</title><idno type="ISSN">1758-4299</idno><idno type="eISSN">1758-4302</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The rising prevalence of obesity in the last few decades has been accompanied by an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of liver pathology from isolated hepatic steatosis to steatohepatitis and advanced fibrosis. Dietary habits characterized by consumption of high-caloric, lipid-rich diets play a major role in the development of NAFLD. Recent studies have uncovered the importance of certain components of the diet. In this review, we will focus on the growing evidence for a central role of n-6 polyunsaturated fatty acids. We will discuss novel findings linking oxidative stress and increased production of reactive oxygen species in the liver to oxidation of n-6 polyunsaturated fatty acids and production of specific lipid oxidation metabolites. In particular, we will highlight the potential role of these metabolites as noninvasive markers to diagnose and monitor the extent of liver damage in patients with NAFLD.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Santoro, Nicola" sort="Santoro, Nicola" uniqKey="Santoro N" first="Nicola" last="Santoro">Nicola Santoro</name></region><name sortKey="Caprio, Sonia" sort="Caprio, Sonia" uniqKey="Caprio S" first="Sonia" last="Caprio">Sonia Caprio</name><name sortKey="Feldstein, Ariel E" sort="Feldstein, Ariel E" uniqKey="Feldstein A" first="Ariel E." last="Feldstein">Ariel E. Feldstein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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