HapticV1, Ncbi, Checkpoint, bibRecord, 003235

Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2

Identifieur interne : 003235 ( Ncbi/Checkpoint ); précédent : 003234; suivant : 003236

Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2

Auteurs : Adam B. Goldring [États-Unis] ; Dylan F. Cooke [États-Unis] ; Mary K. L. Baldwin [États-Unis] ; Gregg H. Recanzone [États-Unis] ; Adam G. Gordon [États-Unis] ; Tingrui Pan [États-Unis] ; Scott I. Simon [États-Unis] ; Leah Krubitzer [États-Unis]

Source :

Journal of Neurophysiology [ 0022-3077 ] ; 2014.

RBID : PMC:4233279

Abstract

The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (Macaca mulatta) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (“cool”) and at two time points after deactivation (“rewarm 1,” “rewarm 2”). Although the type of response change observed was variable, for neurons at the recording sites tested >90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233279

DOI: 10.1152/jn.00141.2014
PubMed: 25143537
PubMed Central: 4233279

Affiliations:

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PMC:4233279

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys (<italic>Macaca mulatta</italic>
) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (“cool”) and at two time points after deactivation (“rewarm 1,” “rewarm 2”). Although the type of response change observed was variable, for neurons at the recording sites tested >90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.</p>
</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name>
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<name sortKey="Baldwin, Mary K L" sort="Baldwin, Mary K L" uniqKey="Baldwin M" first="Mary K. L." last="Baldwin">Mary K. L. Baldwin</name>
<name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name>
<name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name>
<name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name>
<name sortKey="Gordon, Adam G" sort="Gordon, Adam G" uniqKey="Gordon A" first="Adam G." last="Gordon">Adam G. Gordon</name>
<name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name>
<name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name>
<name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name>
<name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name>
<name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name>
<name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name>
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Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2

Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2

Source :

Abstract

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Le document en format XML

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