Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans
Identifieur interne : 00B125 ( Main/Merge ); précédent : 00B124; suivant : 00B126Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans
Auteurs : Calogero Maria Oddo [Italie] ; Stanisa Raspopovic [Italie, Suisse] ; Fiorenzo Artoni [Italie, Suisse] ; Alberto Mazzoni [Italie] ; Giacomo Spigler [Italie] ; Francesco Petrini [Suisse, Italie] ; Federica Giambattistelli [Italie] ; Fabrizio Vecchio [Italie] ; Francesca Miraglia [Italie] ; Loredana Zollo [Italie] ; Giovanni Di Pino [Italie] ; Domenico Camboni [Italie] ; Maria Chiara Carrozza [Italie] ; Eugenio Guglielmelli [Italie] ; Paolo Maria Rossini [Italie] ; Ugo Faraguna [Italie] ; Silvestro Micera [Italie, Suisse]Source :
- eLife [ 2050-084X ] ; ????.
Abstract
Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents. The MNT process was used to modulate the temporal pattern of electrical spikes delivered to the human median nerve via percutaneous microstimulation in four intact subjects and via implanted intrafascicular stimulation in one transradial amputee. Both approaches allowed the subjects to reliably discriminate spatial coarseness of surfaces as confirmed also by a hybrid neural model of the median nerve. Moreover, MNT-evoked EEG activity showed physiologically plausible responses that were superimposable in time and topography to the ones elicited by a natural mechanical tactile stimulation. These findings can open up novel opportunities for sensory restoration in the next generation of neuro-prosthetic hands.
Url:
DOI: 10.7554/eLife.09148
PubMed: 26952132
PubMed Central: 4798967
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sortKey="Giambattistelli, Federica" sort="Giambattistelli, Federica" uniqKey="Giambattistelli F" first="Federica" last="Giambattistelli">Federica Giambattistelli</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="dept">Institute of Neurology</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vecchio, Fabrizio" sort="Vecchio, Fabrizio" uniqKey="Vecchio F" first="Fabrizio" last="Vecchio">Fabrizio Vecchio</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country 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strict</wicri:regionArea></affiliation></author><author><name sortKey="Camboni, Domenico" sort="Camboni, Domenico" uniqKey="Camboni D" first="Domenico" last="Camboni">Domenico Camboni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carrozza, Maria Chiara" sort="Carrozza, Maria Chiara" uniqKey="Carrozza M" first="Maria Chiara" last="Carrozza">Maria Chiara Carrozza</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guglielmelli, Eugenio" sort="Guglielmelli, Eugenio" uniqKey="Guglielmelli E" first="Eugenio" last="Guglielmelli">Eugenio Guglielmelli</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Laboratory of Biomedical Robotics & Biomicrosystems</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rossini, Paolo Maria" sort="Rossini, Paolo Maria" uniqKey="Rossini P" first="Paolo Maria" last="Rossini">Paolo Maria Rossini</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="dept">Institute of Neurology</institution>,<institution>Catholic University of The Sacred Heart</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faraguna, Ugo" sort="Faraguna, Ugo" uniqKey="Faraguna U" first="Ugo" last="Faraguna">Ugo Faraguna</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Azienda Ospedaliero-Universitaria Pisana</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>IRCCS Stella Maris Foundation</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution content-type="dept">Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia</institution>,<institution>Università di Pisa</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Micera, Silvestro" sort="Micera, Silvestro" uniqKey="Micera S" first="Silvestro" last="Micera">Silvestro Micera</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Center for Neuroprosthetics</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26952132</idno><idno type="pmc">4798967</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798967</idno><idno type="RBID">PMC:4798967</idno><idno type="doi">10.7554/eLife.09148</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000587</idno><idno type="wicri:Area/Pmc/Curation">000587</idno><idno type="wicri:Area/Pmc/Checkpoint">002825</idno><idno type="wicri:Area/Ncbi/Merge">004025</idno><idno type="wicri:Area/Ncbi/Curation">004025</idno><idno type="wicri:Area/Ncbi/Checkpoint">004025</idno><idno type="wicri:Area/Main/Merge">00B125</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans</title><author><name sortKey="Oddo, Calogero Maria" sort="Oddo, Calogero Maria" uniqKey="Oddo C" first="Calogero Maria" last="Oddo">Calogero Maria Oddo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Raspopovic, Stanisa" sort="Raspopovic, Stanisa" uniqKey="Raspopovic S" first="Stanisa" last="Raspopovic">Stanisa Raspopovic</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Center for Neuroprosthetics</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Artoni, Fiorenzo" sort="Artoni, Fiorenzo" uniqKey="Artoni F" first="Fiorenzo" last="Artoni">Fiorenzo Artoni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazzoni, Alberto" sort="Mazzoni, Alberto" uniqKey="Mazzoni A" first="Alberto" last="Mazzoni">Alberto Mazzoni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spigler, Giacomo" sort="Spigler, Giacomo" uniqKey="Spigler G" first="Giacomo" last="Spigler">Giacomo Spigler</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petrini, Francesco" sort="Petrini, Francesco" uniqKey="Petrini F" first="Francesco" last="Petrini">Francesco Petrini</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Center for Neuroprosthetics</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Laboratory of Biomedical Robotics & Biomicrosystems</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giambattistelli, Federica" sort="Giambattistelli, Federica" uniqKey="Giambattistelli F" first="Federica" last="Giambattistelli">Federica Giambattistelli</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="dept">Institute of Neurology</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vecchio, Fabrizio" sort="Vecchio, Fabrizio" uniqKey="Vecchio F" first="Fabrizio" last="Vecchio">Fabrizio Vecchio</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miraglia, Francesca" sort="Miraglia, Francesca" uniqKey="Miraglia F" first="Francesca" last="Miraglia">Francesca Miraglia</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zollo, Loredana" sort="Zollo, Loredana" uniqKey="Zollo L" first="Loredana" last="Zollo">Loredana Zollo</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Laboratory of Biomedical Robotics & Biomicrosystems</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Di Pino, Giovanni" sort="Di Pino, Giovanni" uniqKey="Di Pino G" first="Giovanni" last="Di Pino">Giovanni Di Pino</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Laboratory of Biomedical Robotics & Biomicrosystems</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="dept">Institute of Neurology</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Camboni, Domenico" sort="Camboni, Domenico" uniqKey="Camboni D" first="Domenico" last="Camboni">Domenico Camboni</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carrozza, Maria Chiara" sort="Carrozza, Maria Chiara" uniqKey="Carrozza M" first="Maria Chiara" last="Carrozza">Maria Chiara Carrozza</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guglielmelli, Eugenio" sort="Guglielmelli, Eugenio" uniqKey="Guglielmelli E" first="Eugenio" last="Guglielmelli">Eugenio Guglielmelli</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Laboratory of Biomedical Robotics & Biomicrosystems</institution>,<institution>Università Campus Bio-Medico di Roma</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rossini, Paolo Maria" sort="Rossini, Paolo Maria" uniqKey="Rossini P" first="Paolo Maria" last="Rossini">Paolo Maria Rossini</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Brain Connectivity Laboratory</institution>,<institution>IRCCS San Raffaele Pisana</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="dept">Institute of Neurology</institution>,<institution>Catholic University of The Sacred Heart</institution>,<addr-line>Roma</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faraguna, Ugo" sort="Faraguna, Ugo" uniqKey="Faraguna U" first="Ugo" last="Faraguna">Ugo Faraguna</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Azienda Ospedaliero-Universitaria Pisana</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>IRCCS Stella Maris Foundation</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution content-type="dept">Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia</institution>,<institution>Università di Pisa</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Micera, Silvestro" sort="Micera, Silvestro" uniqKey="Micera S" first="Silvestro" last="Micera">Silvestro Micera</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">The BioRobotics Institute</institution>,<institution>Scuola Superiore Sant'Anna</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Center for Neuroprosthetics</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Bertarelli Foundation Chair in Translational NeuroEngineering, Institute of Bioengineering, School of Engineering</institution>,<institution>École Polytechnique Fédérale de Lausanne</institution>,<addr-line>Lausanne</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents. The MNT process was used to modulate the temporal pattern of electrical spikes delivered to the human median nerve via percutaneous microstimulation in four intact subjects and via implanted intrafascicular stimulation in one transradial amputee. Both approaches allowed the subjects to reliably discriminate spatial coarseness of surfaces as confirmed also by a hybrid neural model of the median nerve. Moreover, MNT-evoked EEG activity showed physiologically plausible responses that were superimposable in time and topography to the ones elicited by a natural mechanical tactile stimulation. These findings can open up novel opportunities for sensory restoration in the next generation of neuro-prosthetic hands.</p><p><bold>DOI:</bold><ext-link ext-link-type="doi" xlink:href="10.7554/eLife.09148.001">http://dx.doi.org/10.7554/eLife.09148.001</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abraira, Ve" uniqKey="Abraira V">VE Abraira</name></author><author><name sortKey="Ginty, Dd" uniqKey="Ginty D">DD Ginty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acar, Za" uniqKey="Acar Z">ZA Acar</name></author><author><name sortKey="Makeig, S" uniqKey="Makeig S">S Makeig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Artoni, F" uniqKey="Artoni F">F Artoni</name></author><author><name sortKey="Menicucci, D" uniqKey="Menicucci D">D Menicucci</name></author><author><name sortKey="Delorme, A" uniqKey="Delorme A">A 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Bramanti</name></author><author><name sortKey="Mecarelli, O" uniqKey="Mecarelli O">O Mecarelli</name></author><author><name sortKey="Rossini, Pm" uniqKey="Rossini P">PM Rossini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Ai" uniqKey="Weber A">AI Weber</name></author><author><name sortKey="Saal, Hp" uniqKey="Saal H">HP Saal</name></author><author><name sortKey="Lieber, Jd" uniqKey="Lieber J">JD Lieber</name></author><author><name sortKey="Cheng, J W" uniqKey="Cheng J">J-W Cheng</name></author><author><name sortKey="Manfredi, Lr" uniqKey="Manfredi L">LR Manfredi</name></author><author><name sortKey="Dammann, Jf" uniqKey="Dammann J">JF Dammann</name></author><author><name sortKey="Bensmaia, Sj" uniqKey="Bensmaia S">SJ Bensmaia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weerasuriya, A" uniqKey="Weerasuriya A">A Weerasuriya</name></author><author><name sortKey="Spangler, Ra" uniqKey="Spangler R">RA Spangler</name></author><author><name sortKey="Rapoport, Si" uniqKey="Rapoport S">SI Rapoport</name></author><author><name sortKey="Taylor, Re" uniqKey="Taylor R">RE Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshioka, T" uniqKey="Yoshioka T">T Yoshioka</name></author><author><name sortKey="Gibb, B" uniqKey="Gibb B">B Gibb</name></author><author><name sortKey="Dorsch, Ak" uniqKey="Dorsch A">AK Dorsch</name></author><author><name sortKey="Hsiao, Ss" uniqKey="Hsiao S">SS Hsiao</name></author><author><name sortKey="Johnson, Ko" uniqKey="Johnson K">KO Johnson</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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