Anterior Chamber Width Measurement by High-Speed Optical Coherence Tomography
Identifieur interne : 006573 ( Main/Merge ); précédent : 006572; suivant : 006574Anterior Chamber Width Measurement by High-Speed Optical Coherence Tomography
Auteurs : Jason A. Goldsmith [États-Unis] ; Yan Li [États-Unis] ; Maria Regina Chalita [États-Unis] ; Volker Westphal [États-Unis] ; Chetan A. Patil [États-Unis] ; Andrew M. Rollins [États-Unis] ; Joseph A. Izatt [États-Unis] ; David Huang [États-Unis]Source :
- Ophthalmology [ 0161-6420 ] ; 2005.
Abstract
To measure anterior chamber (AC) width and other dimensions relevant to the sizing of phakic intraocular lenses (IOLs) with a high-speed optical coherence tomography (OCT) system.
Cross-sectional observational study.
Both eyes of 20 normal volunteers.
A novel high-speed (4000 axial scans/second) OCT prototype was developed for anterior segment scanning. The system uses long wavelength (1310 nm) for deeper angle penetration, rectangular scanning for undistorted imaging, and short image acquisition time (0.125 seconds) to reduce motion error. Three horizontal cross-sectional OCT images (15.5 mm wide and 6 mm deep) of the anterior segment were obtained from each eye with real-time image display to guide centration on the corneal apex. Image processing software was developed to correct for image warping resulting from index transitions. Anterior chamber dimensions were measured using computer calipers by 3 expert raters (ophthalmologists). Analysis of variance was used to determine interrater, interimage, right versus left eye, and intersubject standard deviation (SD) of OCT measurements.
Anterior chamber width (recess to recess), AC depth, and crystalline lens vault as measured by OCT; external white-to-white (WTW) corneal diameter (CD) as measured by Holladay-Godwin gauge.
The mean AC width was 12.53±0.47 mm (intereye SD), and the mean corneal diameter was 11.78±0.57 mm. Optical coherence tomography measurement of AC width has good repeatability from image to image (SD, 0.134 mm), but there was significant difference between raters (SD, 0.215 mm). Estimation of AC width from WTW CD by linear regression was relatively inaccurate (residual SD, 0.41 mm). The mean AC depth was 2.99±0.323 mm (intereye SD), with repeatability of less than 0.001 mm (interimage SD), and the mean crystalline lens vault was 0.39±0.27 mm with 0.023 mm repeatability.
Reproducible OCT AC biometry was demonstrated using a high-speed OCT prototype. Further improvement in reproducibility may be achieved by automating the measurements with a computer. Direct OCT AC width measurement may improve sizing of angle-supported AC IOLs over conventional estimation by WTW CD. The measurement of AC depth and lens vault also may be useful for other types of phakic AC IOLs.
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DOI: 10.1016/j.ophtha.2004.09.019
PubMed: 15691557
PubMed Central: 1784115
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Goldsmith</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Chalita, Maria Regina" sort="Chalita, Maria Regina" uniqKey="Chalita M" first="Maria Regina" last="Chalita">Maria Regina Chalita</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Westphal, Volker" sort="Westphal, Volker" uniqKey="Westphal V" first="Volker" last="Westphal">Volker Westphal</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Patil, Chetan A" sort="Patil, Chetan A" uniqKey="Patil C" first="Chetan A." last="Patil">Chetan A. Patil</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Rollins, Andrew M" sort="Rollins, Andrew M" uniqKey="Rollins A" first="Andrew M." last="Rollins">Andrew M. Rollins</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Izatt, Joseph A" sort="Izatt, Joseph A" uniqKey="Izatt J" first="Joseph A." last="Izatt">Joseph A. Izatt</name><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Duke University, Durham, North Carolina.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Caroline du Nord</region></placename><wicri:cityArea>Department of Biomedical Engineering, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Huang, David" sort="Huang, David" uniqKey="Huang D" first="David" last="Huang">David Huang</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A5">Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15691557</idno><idno type="pmc">1784115</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784115</idno><idno type="RBID">PMC:1784115</idno><idno type="doi">10.1016/j.ophtha.2004.09.019</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001936</idno><idno type="wicri:Area/Pmc/Curation">001936</idno><idno type="wicri:Area/Pmc/Checkpoint">002584</idno><idno type="wicri:Area/Ncbi/Merge">000688</idno><idno type="wicri:Area/Ncbi/Curation">000688</idno><idno type="wicri:Area/Ncbi/Checkpoint">000688</idno><idno type="wicri:doubleKey">0161-6420:2005:Goldsmith J:anterior:chamber:width</idno><idno type="wicri:Area/Main/Merge">006573</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anterior Chamber Width Measurement by High-Speed Optical Coherence Tomography</title><author><name sortKey="Goldsmith, Jason A" sort="Goldsmith, Jason A" uniqKey="Goldsmith J" first="Jason A." last="Goldsmith">Jason A. Goldsmith</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Chalita, Maria Regina" sort="Chalita, Maria Regina" uniqKey="Chalita M" first="Maria Regina" last="Chalita">Maria Regina Chalita</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Westphal, Volker" sort="Westphal, Volker" uniqKey="Westphal V" first="Volker" last="Westphal">Volker Westphal</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Patil, Chetan A" sort="Patil, Chetan A" uniqKey="Patil C" first="Chetan A." last="Patil">Chetan A. Patil</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Rollins, Andrew M" sort="Rollins, Andrew M" uniqKey="Rollins A" first="Andrew M." last="Rollins">Andrew M. Rollins</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Medicine, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Izatt, Joseph A" sort="Izatt, Joseph A" uniqKey="Izatt J" first="Joseph A." last="Izatt">Joseph A. Izatt</name><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Duke University, Durham, North Carolina.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Caroline du Nord</region></placename><wicri:cityArea>Department of Biomedical Engineering, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Huang, David" sort="Huang, David" uniqKey="Huang D" first="David" last="Huang">David Huang</name><affiliation><nlm:aff id="A1">Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Cole Eye Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation><affiliation><nlm:aff id="A5">Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.</nlm:aff><country xml:lang="fr">États-Unis</country><placename><region type="state">Ohio</region></placename><wicri:cityArea>Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author></analytic><series><title level="j">Ophthalmology</title><idno type="ISSN">0161-6420</idno><idno type="eISSN">1549-4713</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective:</title><p id="P1">To measure anterior chamber (AC) width and other dimensions relevant to the sizing of phakic intraocular lenses (IOLs) with a high-speed optical coherence tomography (OCT) system.</p></sec><sec id="S2"><title>Design:</title><p id="P2">Cross-sectional observational study.</p></sec><sec id="S3"><title>Participants:</title><p id="P3">Both eyes of 20 normal volunteers.</p></sec><sec id="S4"><title>Methods:</title><p id="P4">A novel high-speed (4000 axial scans/second) OCT prototype was developed for anterior segment scanning. The system uses long wavelength (1310 nm) for deeper angle penetration, rectangular scanning for undistorted imaging, and short image acquisition time (0.125 seconds) to reduce motion error. Three horizontal cross-sectional OCT images (15.5 mm wide and 6 mm deep) of the anterior segment were obtained from each eye with real-time image display to guide centration on the corneal apex. Image processing software was developed to correct for image warping resulting from index transitions. Anterior chamber dimensions were measured using computer calipers by 3 expert raters (ophthalmologists). Analysis of variance was used to determine interrater, interimage, right versus left eye, and intersubject standard deviation (SD) of OCT measurements.</p></sec><sec id="S5"><title>Main Outcome Measures:</title><p id="P5">Anterior chamber width (recess to recess), AC depth, and crystalline lens vault as measured by OCT; external white-to-white (WTW) corneal diameter (CD) as measured by Holladay-Godwin gauge.</p></sec><sec id="S6"><title>Results:</title><p id="P6">The mean AC width was 12.53±0.47 mm (intereye SD), and the mean corneal diameter was 11.78±0.57 mm. Optical coherence tomography measurement of AC width has good repeatability from image to image (SD, 0.134 mm), but there was significant difference between raters (SD, 0.215 mm). Estimation of AC width from WTW CD by linear regression was relatively inaccurate (residual SD, 0.41 mm). The mean AC depth was 2.99±0.323 mm (intereye SD), with repeatability of less than 0.001 mm (interimage SD), and the mean crystalline lens vault was 0.39±0.27 mm with 0.023 mm repeatability.</p></sec><sec id="S7"><title>Conclusions:</title><p id="P7">Reproducible OCT AC biometry was demonstrated using a high-speed OCT prototype. Further improvement in reproducibility may be achieved by automating the measurements with a computer. Direct OCT AC width measurement may improve sizing of angle-supported AC IOLs over conventional estimation by WTW CD. The measurement of AC depth and lens vault also may be useful for other types of phakic AC IOLs.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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