Adaptive robot training for the treatment of incoordination in Multiple Sclerosis
Identifieur interne : 003890 ( Main/Merge ); précédent : 003889; suivant : 003891Adaptive robot training for the treatment of incoordination in Multiple Sclerosis
Auteurs : Elena Vergaro [Italie] ; Valentina Squeri [Italie] ; Giampaolo Brichetto [Italie] ; Maura Casadio [Italie] ; Pietro Morasso [Italie] ; Claudio Solaro [Italie] ; Vittorio Sanguineti [Italie]Source :
- Journal of NeuroEngineering and Rehabilitation [ 1743-0003 ] ; 2010.
Abstract
Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed and tested a robot therapy protocol, aimed at the rehabilitation of incoordination in MS subjects.
Eight subjects with clinically defined MS performed planar reaching movements while grasping the handle of a robotic manipulandum, which generated forces that either reduced (error-reducing, ER) or enhanced (error-enhancing, EE) the curvature of their movements, assessed at the beginning of each session. The protocol was designed to adapt to the individual subjects' impairments, as well as to improvements between sessions (if any). Each subject went through a total of eight training sessions. To compare the effect of the two variants of the training protocol (ER and EE), we used a cross-over design consisting of two blocks of sessions (four ER and four EE; 2 sessions/week), separated by a 2-weeks rest period. The order of application of ER and EE exercises was randomized across subjects. The primary outcome measure was the modification of the Nine Hole Peg Test (NHPT) score. Other clinical scales and movement kinematics were taken as secondary outcomes.
Most subjects revealed a preserved ability to adapt to the robot-generated forces. No significant differences were observed in EE and ER training. However over sessions, subjects exhibited an average 24% decrease in their NHPT score. The other clinical scales showed small improvements for at least some of the subjects. After training, movements became smoother, and their curvature decreased significantly over sessions.
The results point to an improved coordination over sessions and suggest a potential benefit of a short-term, customized, and adaptive robot therapy for MS subjects.
Url:
DOI: 10.1186/1743-0003-7-37
PubMed: 20670420
PubMed Central: 2927907
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002038
- to stream Pmc, to step Curation: 002038
- to stream Pmc, to step Checkpoint: 001F67
- to stream Ncbi, to step Merge: 001638
- to stream Ncbi, to step Curation: 001638
- to stream Ncbi, to step Checkpoint: 001638
Links to Exploration step
PMC:2927907Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adaptive robot training for the treatment of incoordination in Multiple Sclerosis</title><author><name sortKey="Vergaro, Elena" sort="Vergaro, Elena" uniqKey="Vergaro E" first="Elena" last="Vergaro">Elena Vergaro</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Squeri, Valentina" sort="Squeri, Valentina" uniqKey="Squeri V" first="Valentina" last="Squeri">Valentina Squeri</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Brichetto, Giampaolo" sort="Brichetto, Giampaolo" uniqKey="Brichetto G" first="Giampaolo" last="Brichetto">Giampaolo Brichetto</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Via A. De Toni 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Via A. De Toni 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Casadio, Maura" sort="Casadio, Maura" uniqKey="Casadio M" first="Maura" last="Casadio">Maura Casadio</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Morasso, Pietro" sort="Morasso, Pietro" uniqKey="Morasso P" first="Pietro" last="Morasso">Pietro Morasso</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Solaro, Claudio" sort="Solaro, Claudio" uniqKey="Solaro C" first="Claudio" last="Solaro">Claudio Solaro</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, ASL3 Genovese, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, ASL3 Genovese, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Sanguineti, Vittorio" sort="Sanguineti, Vittorio" uniqKey="Sanguineti V" first="Vittorio" last="Sanguineti">Vittorio Sanguineti</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20670420</idno><idno type="pmc">2927907</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927907</idno><idno type="RBID">PMC:2927907</idno><idno type="doi">10.1186/1743-0003-7-37</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002038</idno><idno type="wicri:Area/Pmc/Curation">002038</idno><idno type="wicri:Area/Pmc/Checkpoint">001F67</idno><idno type="wicri:Area/Ncbi/Merge">001638</idno><idno type="wicri:Area/Ncbi/Curation">001638</idno><idno type="wicri:Area/Ncbi/Checkpoint">001638</idno><idno type="wicri:Area/Main/Merge">003890</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adaptive robot training for the treatment of incoordination in Multiple Sclerosis</title><author><name sortKey="Vergaro, Elena" sort="Vergaro, Elena" uniqKey="Vergaro E" first="Elena" last="Vergaro">Elena Vergaro</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Squeri, Valentina" sort="Squeri, Valentina" uniqKey="Squeri V" first="Valentina" last="Squeri">Valentina Squeri</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Brichetto, Giampaolo" sort="Brichetto, Giampaolo" uniqKey="Brichetto G" first="Giampaolo" last="Brichetto">Giampaolo Brichetto</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Via A. De Toni 5, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Via A. De Toni 5, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Casadio, Maura" sort="Casadio, Maura" uniqKey="Casadio M" first="Maura" last="Casadio">Maura Casadio</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Morasso, Pietro" sort="Morasso, Pietro" uniqKey="Morasso P" first="Pietro" last="Morasso">Pietro Morasso</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Solaro, Claudio" sort="Solaro, Claudio" uniqKey="Solaro C" first="Claudio" last="Solaro">Claudio Solaro</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurology, ASL3 Genovese, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, ASL3 Genovese, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Sanguineti, Vittorio" sort="Sanguineti, Vittorio" uniqKey="Sanguineti V" first="Vittorio" last="Sanguineti">Vittorio Sanguineti</name><affiliation wicri:level="1"><nlm:aff id="I1">University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genoa, Department of Informatics, Systems and Telecommunications, Via Opera Pia 13, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Italian Institute of Technology, Via Morego 30, Genoa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology, Via Morego 30, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of NeuroEngineering and Rehabilitation</title><idno type="eISSN">1743-0003</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis (MS) subjects. In this feasibility study, we developed and tested a robot therapy protocol, aimed at the rehabilitation of incoordination in MS subjects.</p></sec><sec><title>Methods</title><p>Eight subjects with clinically defined MS performed planar reaching movements while grasping the handle of a robotic manipulandum, which generated forces that either reduced (error-reducing, ER) or enhanced (error-enhancing, EE) the curvature of their movements, assessed at the beginning of each session. The protocol was designed to adapt to the individual subjects' impairments, as well as to improvements between sessions (if any). Each subject went through a total of eight training sessions. To compare the effect of the two variants of the training protocol (ER and EE), we used a cross-over design consisting of two blocks of sessions (four ER and four EE; 2 sessions/week), separated by a 2-weeks rest period. The order of application of ER and EE exercises was randomized across subjects. The primary outcome measure was the modification of the Nine Hole Peg Test (NHPT) score. Other clinical scales and movement kinematics were taken as secondary outcomes.</p></sec><sec><title>Results</title><p>Most subjects revealed a preserved ability to adapt to the robot-generated forces. No significant differences were observed in EE and ER training. However over sessions, subjects exhibited an average 24% decrease in their NHPT score. The other clinical scales showed small improvements for at least some of the subjects. After training, movements became smoother, and their curvature decreased significantly over sessions.</p></sec><sec><title>Conclusions</title><p>The results point to an improved coordination over sessions and suggest a potential benefit of a short-term, customized, and adaptive robot therapy for MS subjects.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thompson, Aj" uniqKey="Thompson A">AJ Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alusi, Sh" uniqKey="Alusi S">SH Alusi</name></author><author><name sortKey="Worthington, J" uniqKey="Worthington J">J Worthington</name></author><author><name sortKey="Glickman, S" uniqKey="Glickman S">S Glickman</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koch, M" uniqKey="Koch M">M Koch</name></author><author><name sortKey="Mostert, J" uniqKey="Mostert J">J Mostert</name></author><author><name sortKey="Heersema, D" uniqKey="Heersema D">D Heersema</name></author><author><name sortKey="De Keyser, J" uniqKey="De Keyser J">J De Keyser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hallett, M" uniqKey="Hallett M">M Hallett</name></author><author><name sortKey="Berardelli, A" uniqKey="Berardelli A">A Berardelli</name></author><author><name sortKey="Matheson, J" uniqKey="Matheson J">J Matheson</name></author><author><name sortKey="Rothwell, J" uniqKey="Rothwell J">J Rothwell</name></author><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentino, P" uniqKey="Valentino P">P Valentino</name></author><author><name sortKey="Cerasa, A" uniqKey="Cerasa A">A Cerasa</name></author><author><name sortKey="Chiriaco, C" uniqKey="Chiriaco C">C Chiriaco</name></author><author><name sortKey="Nistico, R" uniqKey="Nistico R">R Nistico</name></author><author><name sortKey="Pirritano, D" uniqKey="Pirritano D">D Pirritano</name></author><author><name sortKey="Gioia, M" uniqKey="Gioia M">M Gioia</name></author><author><name sortKey="Lanza, P" uniqKey="Lanza P">P Lanza</name></author><author><name sortKey="Canino, M" uniqKey="Canino M">M Canino</name></author><author><name sortKey="Del Giudice, F" uniqKey="Del Giudice F">F Del Giudice</name></author><author><name sortKey="Gallo, O" uniqKey="Gallo O">O Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastian, Aj" uniqKey="Bastian A">AJ Bastian</name></author><author><name sortKey="Martin, Ta" uniqKey="Martin T">TA Martin</name></author><author><name sortKey="Keating, Jg" uniqKey="Keating J">JG Keating</name></author><author><name sortKey="Thach, Wt" uniqKey="Thach W">WT Thach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Ja" uniqKey="Freeman J">JA Freeman</name></author><author><name sortKey="Langdon, Dw" uniqKey="Langdon D">DW Langdon</name></author><author><name sortKey="Hobart, Jc" uniqKey="Hobart J">JC Hobart</name></author><author><name sortKey="Thompson, Aj" uniqKey="Thompson A">AJ Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Playford, Ed" uniqKey="Playford E">ED Playford</name></author><author><name sortKey="Thompson, Aj" uniqKey="Thompson A">AJ Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rietberg, Mb" uniqKey="Rietberg M">MB Rietberg</name></author><author><name sortKey="Brooks, D" uniqKey="Brooks D">D Brooks</name></author><author><name sortKey="Uitdehaag, Bm" uniqKey="Uitdehaag B">BM Uitdehaag</name></author><author><name sortKey="Kwakkel, G" uniqKey="Kwakkel G">G Kwakkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, F" uniqKey="Khan F">F Khan</name></author><author><name sortKey="Turner Stokes, L" uniqKey="Turner Stokes L">L Turner-Stokes</name></author><author><name sortKey="Ng, L" uniqKey="Ng L">L Ng</name></author><author><name sortKey="Kilpatrick, T" uniqKey="Kilpatrick T">T Kilpatrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mills, R" uniqKey="Mills R">R Mills</name></author><author><name sortKey="Yap, L" uniqKey="Yap L">L Yap</name></author><author><name sortKey="Young, C" uniqKey="Young C">C Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lord, Se" uniqKey="Lord S">SE Lord</name></author><author><name sortKey="Wade, Dt" uniqKey="Wade D">DT Wade</name></author><author><name sortKey="Halligan, Pw" uniqKey="Halligan P">PW Halligan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiles, Cm" uniqKey="Wiles C">CM Wiles</name></author><author><name sortKey="Newcombe, Rg" uniqKey="Newcombe R">RG Newcombe</name></author><author><name sortKey="Fuller, Kj" uniqKey="Fuller K">KJ Fuller</name></author><author><name sortKey="Shaw, S" uniqKey="Shaw S">S Shaw</name></author><author><name sortKey="Furnival Doran, J" uniqKey="Furnival Doran J">J Furnival-Doran</name></author><author><name sortKey="Pickersgill, Tp" uniqKey="Pickersgill T">TP Pickersgill</name></author><author><name sortKey="Morgan, A" uniqKey="Morgan A">A Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armutlu, K" uniqKey="Armutlu K">K Armutlu</name></author><author><name sortKey="Karabudak, R" uniqKey="Karabudak R">R Karabudak</name></author><author><name sortKey="Nurlu, G" uniqKey="Nurlu G">G Nurlu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koch, G" uniqKey="Koch G">G Koch</name></author><author><name sortKey="Rossi, S" uniqKey="Rossi S">S Rossi</name></author><author><name sortKey="Prosperetti, C" uniqKey="Prosperetti C">C Prosperetti</name></author><author><name sortKey="Codeca, C" uniqKey="Codeca C">C Codeca</name></author><author><name sortKey="Monteleone, F" uniqKey="Monteleone F">F Monteleone</name></author><author><name sortKey="Petrosini, L" uniqKey="Petrosini L">L Petrosini</name></author><author><name sortKey="Bernardi, G" uniqKey="Bernardi G">G Bernardi</name></author><author><name sortKey="Centonze, D" uniqKey="Centonze D">D Centonze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quintern, J" uniqKey="Quintern J">J Quintern</name></author><author><name sortKey="Immisch, I" uniqKey="Immisch I">I Immisch</name></author><author><name sortKey="Albrecht, H" uniqKey="Albrecht H">H Albrecht</name></author><author><name sortKey="Pollmann, W" uniqKey="Pollmann W">W Pollmann</name></author><author><name sortKey="Glasauer, S" uniqKey="Glasauer S">S Glasauer</name></author><author><name sortKey="Straube, A" uniqKey="Straube A">A Straube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feys, P" uniqKey="Feys P">P Feys</name></author><author><name sortKey="Helsen, W" uniqKey="Helsen W">W Helsen</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Mooren, D" uniqKey="Mooren D">D Mooren</name></author><author><name sortKey="Albrecht, H" uniqKey="Albrecht H">H Albrecht</name></author><author><name sortKey="Nuttin, B" uniqKey="Nuttin B">B Nuttin</name></author><author><name sortKey="Ketelaer, P" uniqKey="Ketelaer P">P Ketelaer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prange, Gb" uniqKey="Prange G">GB Prange</name></author><author><name sortKey="Jannink, Mj" uniqKey="Jannink M">MJ Jannink</name></author><author><name sortKey="Groothuis Oudshoorn, Cg" uniqKey="Groothuis Oudshoorn C">CG Groothuis-Oudshoorn</name></author><author><name sortKey="Hermens, Hj" uniqKey="Hermens H">HJ Hermens</name></author><author><name sortKey="Ijzerman, Mj" uniqKey="Ijzerman M">MJ Ijzerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, Ac" uniqKey="Lo A">AC Lo</name></author><author><name sortKey="Triche, Ew" uniqKey="Triche E">EW Triche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beer, S" uniqKey="Beer S">S Beer</name></author><author><name sortKey="Aschbacher, B" uniqKey="Aschbacher B">B Aschbacher</name></author><author><name sortKey="Manoglou, D" uniqKey="Manoglou D">D Manoglou</name></author><author><name sortKey="Gamper, E" uniqKey="Gamper E">E Gamper</name></author><author><name sortKey="Kool, J" uniqKey="Kool J">J Kool</name></author><author><name sortKey="Kesselring, J" uniqKey="Kesselring J">J Kesselring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carpinella, I" uniqKey="Carpinella I">I Carpinella</name></author><author><name sortKey="Cattaneo, D" uniqKey="Cattaneo D">D Cattaneo</name></author><author><name sortKey="Abuarqub, S" uniqKey="Abuarqub S">S Abuarqub</name></author><author><name sortKey="Ferrarin, M" uniqKey="Ferrarin M">M Ferrarin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shadmehr, R" uniqKey="Shadmehr R">R Shadmehr</name></author><author><name sortKey="Mussa Ivaldi, Fa" uniqKey="Mussa Ivaldi F">FA Mussa-Ivaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casadio, M" uniqKey="Casadio M">M Casadio</name></author><author><name sortKey="Sanguineti, V" uniqKey="Sanguineti V">V Sanguineti</name></author><author><name sortKey="Morasso, P" uniqKey="Morasso P">P Morasso</name></author><author><name sortKey="Solaro, C" uniqKey="Solaro C">C Solaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leocani, L" uniqKey="Leocani L">L Leocani</name></author><author><name sortKey="Comi, E" uniqKey="Comi E">E Comi</name></author><author><name sortKey="Annovazzi, P" uniqKey="Annovazzi P">P Annovazzi</name></author><author><name sortKey="Rovaris, M" uniqKey="Rovaris M">M Rovaris</name></author><author><name sortKey="Rossi, P" uniqKey="Rossi P">P Rossi</name></author><author><name sortKey="Cursi, M" uniqKey="Cursi M">M Cursi</name></author><author><name sortKey="Comola, M" uniqKey="Comola M">M Comola</name></author><author><name sortKey="Martinelli, V" uniqKey="Martinelli V">V Martinelli</name></author><author><name sortKey="Comi, G" uniqKey="Comi G">G Comi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatzitaki, V" uniqKey="Hatzitaki V">V Hatzitaki</name></author><author><name sortKey="Koudouni, A" uniqKey="Koudouni A">A Koudouni</name></author><author><name sortKey="Orologas, A" uniqKey="Orologas A">A Orologas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Ma" uniqKey="Smith M">MA Smith</name></author><author><name sortKey="Shadmehr, R" uniqKey="Shadmehr R">R Shadmehr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maschke, M" uniqKey="Maschke M">M Maschke</name></author><author><name sortKey="Gomez, Cm" uniqKey="Gomez C">CM Gomez</name></author><author><name sortKey="Ebner, Tj" uniqKey="Ebner T">TJ Ebner</name></author><author><name sortKey="Konczak, J" uniqKey="Konczak J">J Konczak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patton, Jl" uniqKey="Patton J">JL Patton</name></author><author><name sortKey="Mussa Ivaldi, Fa" uniqKey="Mussa Ivaldi F">FA Mussa-Ivaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patton, Jl" uniqKey="Patton J">JL Patton</name></author><author><name sortKey="Stoykov, Me" uniqKey="Stoykov M">ME Stoykov</name></author><author><name sortKey="Kovic, M" uniqKey="Kovic M">M Kovic</name></author><author><name sortKey="Mussa Ivaldi, Fa" uniqKey="Mussa Ivaldi F">FA Mussa-Ivaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Wi" uniqKey="Mcdonald W">WI McDonald</name></author><author><name sortKey="Compston, A" uniqKey="Compston A">A Compston</name></author><author><name sortKey="Edan, G" uniqKey="Edan G">G Edan</name></author><author><name sortKey="Goodkin, D" uniqKey="Goodkin D">D Goodkin</name></author><author><name sortKey="Hartung, Hp" uniqKey="Hartung H">HP Hartung</name></author><author><name sortKey="Lublin, Fd" uniqKey="Lublin F">FD Lublin</name></author><author><name sortKey="Mcfarland, Hf" uniqKey="Mcfarland H">HF McFarland</name></author><author><name sortKey="Paty, Dw" uniqKey="Paty D">DW Paty</name></author><author><name sortKey="Polman, Ch" uniqKey="Polman C">CH Polman</name></author><author><name sortKey="Reingold, Sc" uniqKey="Reingold S">SC Reingold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurtzke, Jf" uniqKey="Kurtzke J">JF Kurtzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sipe, Jc" uniqKey="Sipe J">JC Sipe</name></author><author><name sortKey="Knobler, Rl" uniqKey="Knobler R">RL Knobler</name></author><author><name sortKey="Braheny, Sl" uniqKey="Braheny S">SL Braheny</name></author><author><name sortKey="Rice, Gp" uniqKey="Rice G">GP Rice</name></author><author><name sortKey="Panitch, Hs" uniqKey="Panitch H">HS Panitch</name></author><author><name sortKey="Oldstone, Mb" uniqKey="Oldstone M">MB Oldstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casadio, M" uniqKey="Casadio M">M Casadio</name></author><author><name sortKey="Morasso, Pg" uniqKey="Morasso P">PG Morasso</name></author><author><name sortKey="Sanguineti, V" uniqKey="Sanguineti V">V Sanguineti</name></author><author><name sortKey="Arrichiello, V" uniqKey="Arrichiello V">V Arrichiello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patton, Jl" uniqKey="Patton J">JL Patton</name></author><author><name sortKey="Kovic, M" uniqKey="Kovic M">M Kovic</name></author><author><name sortKey="Mussa Ivaldi, Fa" uniqKey="Mussa Ivaldi F">FA Mussa-Ivaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morasso, P" uniqKey="Morasso P">P Morasso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheidt, Ra" uniqKey="Scheidt R">RA Scheidt</name></author><author><name sortKey="Dingwell, Jb" uniqKey="Dingwell J">JB Dingwell</name></author><author><name sortKey="Mussa Ivaldi, Fa" uniqKey="Mussa Ivaldi F">FA Mussa-Ivaldi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flash, T" uniqKey="Flash T">T Flash</name></author><author><name sortKey="Hogan, N" uniqKey="Hogan N">N Hogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashworth, B" uniqKey="Ashworth B">B Ashworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alusi, Sh" uniqKey="Alusi S">SH Alusi</name></author><author><name sortKey="Worthington, J" uniqKey="Worthington J">J Worthington</name></author><author><name sortKey="Glickman, S" uniqKey="Glickman S">S Glickman</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathiowetz, V" uniqKey="Mathiowetz V">V Mathiowetz</name></author><author><name sortKey="Weber, K" uniqKey="Weber K">K Weber</name></author><author><name sortKey="Kashman, N" uniqKey="Kashman N">N Kashman</name></author><author><name sortKey="Volland, G" uniqKey="Volland G">G Volland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author><author><name sortKey="Findley, Lj" uniqKey="Findley L">LJ Findley</name></author><author><name sortKey="Atchison, P" uniqKey="Atchison P">P Atchison</name></author><author><name sortKey="Behari, M" uniqKey="Behari M">M Behari</name></author><author><name sortKey="Vidailhet, M" uniqKey="Vidailhet M">M Vidailhet</name></author><author><name sortKey="Gresty, M" uniqKey="Gresty M">M Gresty</name></author><author><name sortKey="Rothwell, Jc" uniqKey="Rothwell J">JC Rothwell</name></author><author><name sortKey="Thompson, Pd" uniqKey="Thompson P">PD Thompson</name></author><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teulings, Hl" uniqKey="Teulings H">HL Teulings</name></author><author><name sortKey="Contreras Vidal, Jl" uniqKey="Contreras Vidal J">JL Contreras-Vidal</name></author><author><name sortKey="Stelmach, Ge" uniqKey="Stelmach G">GE Stelmach</name></author><author><name sortKey="Adler, Ch" uniqKey="Adler C">CH Adler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaney, C" uniqKey="Vaney C">C Vaney</name></author><author><name sortKey="Vaney, S" uniqKey="Vaney S">S Vaney</name></author><author><name sortKey="Wade, Dt" uniqKey="Wade D">DT Wade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwid, Sr" uniqKey="Schwid S">SR Schwid</name></author><author><name sortKey="Goodman, Ad" uniqKey="Goodman A">AD Goodman</name></author><author><name sortKey="Mcdermott, Mp" uniqKey="Mcdermott M">MP McDermott</name></author><author><name sortKey="Bever, Cf" uniqKey="Bever C">CF Bever</name></author><author><name sortKey="Cook, Sd" uniqKey="Cook S">SD Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krebs, Hi" uniqKey="Krebs H">HI Krebs</name></author><author><name sortKey="Hogan, N" uniqKey="Hogan N">N Hogan</name></author><author><name sortKey="Aisen, Ml" uniqKey="Aisen M">ML Aisen</name></author><author><name sortKey="Volpe, Bt" uniqKey="Volpe B">BT Volpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krebs, Hi" uniqKey="Krebs H">HI Krebs</name></author><author><name sortKey="Hogan, N" uniqKey="Hogan N">N Hogan</name></author><author><name sortKey="Volpe, Bt" uniqKey="Volpe B">BT Volpe</name></author><author><name sortKey="Aisen, Ml" uniqKey="Aisen M">ML Aisen</name></author><author><name sortKey="Edelstein, L" uniqKey="Edelstein L">L Edelstein</name></author><author><name sortKey="Diels, C" uniqKey="Diels C">C Diels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Ma" uniqKey="Smith M">MA Smith</name></author><author><name sortKey="Ghazizadeh, A" uniqKey="Ghazizadeh A">A Ghazizadeh</name></author><author><name sortKey="Shadmehr, R" uniqKey="Shadmehr R">R Shadmehr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nudo, Rj" uniqKey="Nudo R">RJ Nudo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reinkensmeyer, Dj" uniqKey="Reinkensmeyer D">DJ Reinkensmeyer</name></author><author><name sortKey="Emken, Jl" uniqKey="Emken J">JL Emken</name></author><author><name sortKey="Cramer, Sc" uniqKey="Cramer S">SC Cramer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rocca, Ma" uniqKey="Rocca M">MA Rocca</name></author><author><name sortKey="Colombo, B" uniqKey="Colombo B">B Colombo</name></author><author><name sortKey="Falini, A" uniqKey="Falini A">A Falini</name></author><author><name sortKey="Ghezzi, A" uniqKey="Ghezzi A">A Ghezzi</name></author><author><name sortKey="Martinelli, V" uniqKey="Martinelli V">V Martinelli</name></author><author><name sortKey="Scotti, G" uniqKey="Scotti G">G Scotti</name></author><author><name sortKey="Comi, G" uniqKey="Comi G">G Comi</name></author><author><name sortKey="Filippi, M" uniqKey="Filippi M">M Filippi</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003890 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003890 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:2927907
|texte= Adaptive robot training for the treatment of incoordination in Multiple Sclerosis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:20670420" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |