Upper extremity transplantation: current concepts and challenges in an emerging field
Identifieur interne : 001733 ( Main/Merge ); précédent : 001732; suivant : 001734Upper extremity transplantation: current concepts and challenges in an emerging field
Auteurs : River M. Elliott [États-Unis] ; Scott M. Tintle [États-Unis] ; L. Scott Levin [États-Unis]Source :
- Current Reviews in Musculoskeletal Medicine [ 1935-973X ] ; 2013.
Abstract
Loss of an isolated upper limb is an emotionally and physically devastating event that results in significant impairment. Patients who lose both upper extremities experience profound disability that affects nearly every aspect of their lives. While prosthetics and surgery can eventually provide the single limb amputee with a suitable assisting hand, limited utility, minimal haptic feedback, weight, and discomfort are persistent problems with these techniques that contribute to high rates of prosthetic rejection. Moreover, despite ongoing advances in prosthetic technology, bilateral amputees continue to experience high levels of dependency, disability, and distress. Hand and upper extremity transplantation holds several advantages over prosthetic rehabilitation. The missing limb is replaced with one of similar skin color and size. Sensibility, voluntary motor control, and proprioception are restored to a greater degree, and afford better dexterity and function than prosthetics. The main shortcomings of transplantation include the hazards of immunosuppression, the complications of rejection and its treatment, and high cost. Hand and upper limb transplantation represents the most commonly performed surgery in the growing field of Vascularized Composite Allotransplantation (VCA). As upper limb transplantation and VCA have become more widespread, several important challenges and controversies have emerged. These include: refining indications for transplantation, optimizing immunosuppression, establishing reliable criteria for monitoring, diagnosing, and treating rejection, and standardizing outcome measures. This article will summarize the historical background of hand transplantation and review the current literature and concepts surrounding it.
Url:
DOI: 10.1007/s12178-013-9191-x
PubMed: 24241894
PubMed Central: 4094126
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000900
- to stream Pmc, to step Curation: 000900
- to stream Pmc, to step Checkpoint: 000F17
- to stream PubMed, to step Corpus: 000813
- to stream PubMed, to step Curation: 000813
- to stream PubMed, to step Checkpoint: 000489
- to stream Ncbi, to step Merge: 002A84
- to stream Ncbi, to step Curation: 002A84
- to stream Ncbi, to step Checkpoint: 002A84
Links to Exploration step
PMC:4094126Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Upper extremity transplantation: current concepts and challenges in an emerging field</title>
<author><name sortKey="Elliott, River M" sort="Elliott, River M" uniqKey="Elliott R" first="River M." last="Elliott">River M. Elliott</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">The Curtis National Hand Center, 3333 North Calvert Street, Baltimore, MD 21209 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>The Curtis National Hand Center, 3333 North Calvert Street, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tintle, Scott M" sort="Tintle, Scott M" uniqKey="Tintle S" first="Scott M." last="Tintle">Scott M. Tintle</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, America Building, 19 2nd Floor, Bethesda, MD 20889-5600 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, America Building, 19 2nd Floor, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Levin, L Scott" sort="Levin, L Scott" uniqKey="Levin L" first="L. Scott" last="Levin">L. Scott Levin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24241894</idno>
<idno type="pmc">4094126</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094126</idno>
<idno type="RBID">PMC:4094126</idno>
<idno type="doi">10.1007/s12178-013-9191-x</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000900</idno>
<idno type="wicri:Area/Pmc/Curation">000900</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000F17</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000813</idno>
<idno type="wicri:Area/PubMed/Curation">000813</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000489</idno>
<idno type="wicri:Area/Ncbi/Merge">002A84</idno>
<idno type="wicri:Area/Ncbi/Curation">002A84</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002A84</idno>
<idno type="wicri:doubleKey">1935-973X:2013:Elliott R:upper:extremity:transplantation</idno>
<idno type="wicri:Area/Main/Merge">001733</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Upper extremity transplantation: current concepts and challenges in an emerging field</title>
<author><name sortKey="Elliott, River M" sort="Elliott, River M" uniqKey="Elliott R" first="River M." last="Elliott">River M. Elliott</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">The Curtis National Hand Center, 3333 North Calvert Street, Baltimore, MD 21209 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>The Curtis National Hand Center, 3333 North Calvert Street, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tintle, Scott M" sort="Tintle, Scott M" uniqKey="Tintle S" first="Scott M." last="Tintle">Scott M. Tintle</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, America Building, 19 2nd Floor, Bethesda, MD 20889-5600 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, America Building, 19 2nd Floor, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Levin, L Scott" sort="Levin, L Scott" uniqKey="Levin L" first="L. Scott" last="Levin">L. Scott Levin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Current Reviews in Musculoskeletal Medicine</title>
<idno type="ISSN">1935-973X</idno>
<idno type="eISSN">1935-9748</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Loss of an isolated upper limb is an emotionally and physically devastating event that results in significant impairment. Patients who lose both upper extremities experience profound disability that affects nearly every aspect of their lives. While prosthetics and surgery can eventually provide the single limb amputee with a suitable assisting hand, limited utility, minimal haptic feedback, weight, and discomfort are persistent problems with these techniques that contribute to high rates of prosthetic rejection. Moreover, despite ongoing advances in prosthetic technology, bilateral amputees continue to experience high levels of dependency, disability, and distress. Hand and upper extremity transplantation holds several advantages over prosthetic rehabilitation. The missing limb is replaced with one of similar skin color and size. Sensibility, voluntary motor control, and proprioception are restored to a greater degree, and afford better dexterity and function than prosthetics. The main shortcomings of transplantation include the hazards of immunosuppression, the complications of rejection and its treatment, and high cost. Hand and upper limb transplantation represents the most commonly performed surgery in the growing field of Vascularized Composite Allotransplantation (VCA). As upper limb transplantation and VCA have become more widespread, several important challenges and controversies have emerged. These include: refining indications for transplantation, optimizing immunosuppression, establishing reliable criteria for monitoring, diagnosing, and treating rejection, and standardizing outcome measures. This article will summarize the historical background of hand transplantation and review the current literature and concepts surrounding it.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001733 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001733 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:4094126 |texte= Upper extremity transplantation: current concepts and challenges in an emerging field }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:24241894" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |