Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice.
Identifieur interne : 000E23 ( Main/Merge ); précédent : 000E22; suivant : 000E24Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice.
Auteurs : Ian O. Massé [Canada] ; Sonia Guillemette [Canada] ; Marie-Eve Laramée [Canada] ; Gilles Bronchti [Canada] ; Denis Boire [Canada]Source :
- Brain research [ 1872-6240 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Anophthalmos (pathology), Anophthalmos (physiopathology), Cerebral Cortex (growth & development), Cerebral Cortex (pathology), Cerebral Cortex (physiopathology), Eye Enucleation (adverse effects), Mice, Inbred C57BL, Organ Size, Species Specificity, Thalamic Nuclei (growth & development), Thalamic Nuclei (pathology), Thalamic Nuclei (physiopathology).
- MESH :
- adverse effects : Eye Enucleation.
- growth & development : Cerebral Cortex, Thalamic Nuclei.
- pathology : Anophthalmos, Cerebral Cortex, Thalamic Nuclei.
- physiopathology : Anophthalmos, Cerebral Cortex, Thalamic Nuclei.
- Animals, Mice, Inbred C57BL, Organ Size, Species Specificity.
Abstract
Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J×ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.
DOI: 10.1016/j.brainres.2014.09.025
PubMed: 25242615
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pubmed:25242615Le document en format XML
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Electronic address: denis.boire@uqtr.ca.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7; École d׳optométrie, Université de Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25242615</idno><idno type="pmid">25242615</idno><idno type="doi">10.1016/j.brainres.2014.09.025</idno><idno type="wicri:Area/PubMed/Corpus">000549</idno><idno type="wicri:Area/PubMed/Curation">000549</idno><idno type="wicri:Area/PubMed/Checkpoint">000529</idno><idno type="wicri:Area/Ncbi/Merge">003304</idno><idno type="wicri:Area/Ncbi/Curation">003304</idno><idno type="wicri:Area/Ncbi/Checkpoint">003304</idno><idno type="wicri:Area/Main/Merge">000E23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice.</title><author><name sortKey="Masse, Ian O" sort="Masse, Ian O" uniqKey="Masse I" first="Ian O" last="Massé">Ian O. Massé</name><affiliation wicri:level="1"><nlm:affiliation>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7. Electronic address: ian.masse@uqtr.ca.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Guillemette, Sonia" sort="Guillemette, Sonia" uniqKey="Guillemette S" first="Sonia" last="Guillemette">Sonia Guillemette</name><affiliation wicri:level="1"><nlm:affiliation>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7. Electronic address: sonia.guillemette@uqtr.ca.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Laramee, Marie Eve" sort="Laramee, Marie Eve" uniqKey="Laramee M" first="Marie-Eve" last="Laramée">Marie-Eve Laramée</name><affiliation wicri:level="1"><nlm:affiliation>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7. Electronic address: marieeve.laramee@bio.kuleuven.be.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bronchti, Gilles" sort="Bronchti, Gilles" uniqKey="Bronchti G" first="Gilles" last="Bronchti">Gilles Bronchti</name><affiliation wicri:level="1"><nlm:affiliation>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7. Electronic address: gilles.bronchti@uqtr.ca.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Boire, Denis" sort="Boire, Denis" uniqKey="Boire D" first="Denis" last="Boire">Denis Boire</name><affiliation wicri:level="1"><nlm:affiliation>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7; École d׳optométrie, Université de Montréal, Québec, Canada H3C 3J7. Electronic address: denis.boire@uqtr.ca.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département d׳anatomie, Université du Québec à Trois-Rivières, Québec, Canada G9A 5H7; École d׳optométrie, Université de Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain research</title><idno type="eISSN">1872-6240</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anophthalmos (pathology)</term><term>Anophthalmos (physiopathology)</term><term>Cerebral Cortex (growth & development)</term><term>Cerebral Cortex (pathology)</term><term>Cerebral Cortex (physiopathology)</term><term>Eye Enucleation (adverse effects)</term><term>Mice, Inbred C57BL</term><term>Organ Size</term><term>Species Specificity</term><term>Thalamic Nuclei (growth & development)</term><term>Thalamic Nuclei (pathology)</term><term>Thalamic Nuclei (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Eye Enucleation</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Cerebral Cortex</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Anophthalmos</term><term>Cerebral Cortex</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anophthalmos</term><term>Cerebral Cortex</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice, Inbred C57BL</term><term>Organ Size</term><term>Species Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J×ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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