Transoral Robotic Surgery in the HPV Era
Identifieur interne : 000D13 ( Main/Merge ); précédent : 000D12; suivant : 000D14Transoral Robotic Surgery in the HPV Era
Auteurs : Irit Duek [Israël] ; Salem Billan [Israël] ; Moran Amit [Israël] ; Ziv Gil [Israël]Source :
- Rambam Maimonides Medical Journal [ 2076-9172 ] ; 2014.
Abstract
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades mostly due to human papillomavirus (HPV)-related infections. Cancers resulting from HPV infection bear a better prognosis than those that are smoking-related. Because HPV-positive patients are often younger, with lower rates of co-morbid illness and longer overall life expectancies, long-term sequelae of therapy have become an important issue. Treatment of oropharyngeal cancers has typically involved the use of radiation and chemotherapy to avoid the morbidity of open surgery which included mandibulotomy and composite resection. Transoral robotic surgery (TORS) is an emerging treatment option for this disease, avoiding the morbidity of open approaches while providing excellent oncologic and functional outcomes. With overall survival rate at 2 years exceeding 80%, and local failure rate of less than 3%, patients receiving TORS report relatively good health-related quality of life (QOL) scores. The aim of the current review is to provide a summary of the current literature with regard to the oncologic and functional outcomes following treatment of OPSCC with TORS.
Url:
DOI: 10.5041/RMMJ.10144
PubMed: 24808948
PubMed Central: 4011475
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Duek</name><affiliation wicri:level="1"><nlm:aff id="af1-rmmj-5-2-e0010">Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Billan, Salem" sort="Billan, Salem" uniqKey="Billan S" first="Salem" last="Billan">Salem Billan</name><affiliation wicri:level="1"><nlm:aff id="af2-rmmj-5-2-e0010">The Oncology Institute, Rambam Health Care Campus, Haifa, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Oncology Institute, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Amit, Moran" sort="Amit, Moran" uniqKey="Amit M" first="Moran" last="Amit">Moran Amit</name><affiliation wicri:level="1"><nlm:aff id="af1-rmmj-5-2-e0010">Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-rmmj-5-2-e0010">The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Gil, Ziv" sort="Gil, Ziv" uniqKey="Gil Z" first="Ziv" last="Gil">Ziv Gil</name><affiliation wicri:level="1"><nlm:aff id="af1-rmmj-5-2-e0010">Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Otolaryngology Head and Neck Surgery, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-rmmj-5-2-e0010">The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The Laboratory for Applied Cancer Research, the Clinical Research Institute, Rambam Health Care Campus, The Technion, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Rambam Maimonides Medical Journal</title><idno type="eISSN">2076-9172</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has markedly increased over the last three decades mostly due to human papillomavirus (HPV)-related infections. Cancers resulting from HPV infection bear a better prognosis than those that are smoking-related. Because HPV-positive patients are often younger, with lower rates of co-morbid illness and longer overall life expectancies, long-term sequelae of therapy have become an important issue. Treatment of oropharyngeal cancers has typically involved the use of radiation and chemotherapy to avoid the morbidity of open surgery which included mandibulotomy and composite resection. Transoral robotic surgery (TORS) is an emerging treatment option for this disease, avoiding the morbidity of open approaches while providing excellent oncologic and functional outcomes. With overall survival rate at 2 years exceeding 80%, and local failure rate of less than 3%, patients receiving TORS report relatively good health-related quality of life (QOL) scores. The aim of the current review is to provide a summary of the current literature with regard to the oncologic and functional outcomes following treatment of OPSCC with TORS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chaturvedi, Ak" uniqKey="Chaturvedi A">AK Chaturvedi</name></author><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name></author><author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Dt" uniqKey="Lin D">DT Lin</name></author><author><name sortKey="Cohen, Sm" uniqKey="Cohen S">SM Cohen</name></author><author><name sortKey="Coppit, Gl" uniqKey="Coppit G">GL Coppit</name></author><author><name sortKey="Burkey, Bb" uniqKey="Burkey B">BB Burkey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryerson, Ab" uniqKey="Ryerson A">AB Ryerson</name></author><author><name 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sortKey="Rosenthal, El" uniqKey="Rosenthal E">EL Rosenthal</name></author><author><name sortKey="Desmond, Ra" uniqKey="Desmond R">RA Desmond</name></author><author><name sortKey="Magnuson, Js" uniqKey="Magnuson J">JS Magnuson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Almeida, Jr" uniqKey="De Almeida J">JR de Almeida</name></author><author><name sortKey="Byrd, Jk" uniqKey="Byrd J">JK Byrd</name></author><author><name sortKey="Wu, R" uniqKey="Wu R">R Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichols, Ac" uniqKey="Nichols A">AC Nichols</name></author><author><name sortKey="Yoo, J" uniqKey="Yoo J">J Yoo</name></author><author><name sortKey="Hammond, Ja" uniqKey="Hammond J">JA Hammond</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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