Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay
Identifieur interne : 000A40 ( Main/Merge ); précédent : 000A39; suivant : 000A41Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay
Auteurs : Julian-Dario Rembe [Allemagne] ; Julia K. Böhm [Allemagne] ; Carolin Fromm-Dornieden [Allemagne] ; Nadine Sch Fer [Allemagne] ; Marc Maegele [Allemagne] ; Matthias Fröhlich [Allemagne] ; Ewa K. Stuermer [Allemagne]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2015.
Abstract
Due to demographical changes the number of elderly patients depending on oral anticoagulation is expected to rise. Prolonged bleeding times in case of traumatic injuries represent the drawback of these medications, not only in major trauma, but also in superficial wounds. Therefore, dressings capable of accelerating coagulation onset and shortening bleeding times are desirable for these patients.
The hemostatic potential and physical properties of different types of superficial wound dressings (standard wound pad, two alginates, chitosan, collagen (Lyostypt®), oxidized cellulose, and QuikClot®) were assessed in vitro. For this purpose the clotting times of blood under the influence of the named hemostatics from healthy volunteers were compared with Marcumar® or ASS® treated patients. For that, a newly developed coagulation assay based on spectrophotometric extinction measurements of thrombin activity was used.
The fastest coagulation onset was observed for oxidized cellulose (Ø 2.47 min), Lantor alginate-
All tested specimens seem to induce clotting independently from the administered type of oral anticoagulant, providing the possibility to neglect the disadvantage in clotting times arising from anticoagulation on a local basis. QuikClot®, oxidized cellulose and unexpectedly alginate-
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DOI: 10.1186/s12967-015-0740-5
PubMed: 26620128
PubMed Central: 4666077
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Böhm</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Fromm Dornieden, Carolin" sort="Fromm Dornieden, Carolin" uniqKey="Fromm Dornieden C" first="Carolin" last="Fromm-Dornieden">Carolin Fromm-Dornieden</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Sch Fer, Nadine" sort="Sch Fer, Nadine" uniqKey="Sch Fer N" first="Nadine" last="Sch Fer">Nadine Sch Fer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Maegele, Marc" sort="Maegele, Marc" uniqKey="Maegele M" first="Marc" last="Maegele">Marc Maegele</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Frohlich, Matthias" sort="Frohlich, Matthias" uniqKey="Frohlich M" first="Matthias" last="Fröhlich">Matthias Fröhlich</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Stuermer, Ewa K" sort="Stuermer, Ewa K" uniqKey="Stuermer E" first="Ewa K." last="Stuermer">Ewa K. Stuermer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26620128</idno><idno type="pmc">4666077</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666077</idno><idno type="RBID">PMC:4666077</idno><idno type="doi">10.1186/s12967-015-0740-5</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000867</idno><idno type="wicri:Area/Pmc/Curation">000867</idno><idno type="wicri:Area/Pmc/Checkpoint">000689</idno><idno type="wicri:Area/Ncbi/Merge">003D98</idno><idno type="wicri:Area/Ncbi/Curation">003D98</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D98</idno><idno type="wicri:Area/Main/Merge">000A40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay</title><author><name sortKey="Rembe, Julian Dario" sort="Rembe, Julian Dario" uniqKey="Rembe J" first="Julian-Dario" last="Rembe">Julian-Dario Rembe</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Bohm, Julia K" sort="Bohm, Julia K" uniqKey="Bohm J" first="Julia K." last="Böhm">Julia K. Böhm</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Fromm Dornieden, Carolin" sort="Fromm Dornieden, Carolin" uniqKey="Fromm Dornieden C" first="Carolin" last="Fromm-Dornieden">Carolin Fromm-Dornieden</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Sch Fer, Nadine" sort="Sch Fer, Nadine" uniqKey="Sch Fer N" first="Nadine" last="Sch Fer">Nadine Sch Fer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Maegele, Marc" sort="Maegele, Marc" uniqKey="Maegele M" first="Marc" last="Maegele">Marc Maegele</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Frohlich, Matthias" sort="Frohlich, Matthias" uniqKey="Frohlich M" first="Matthias" last="Fröhlich">Matthias Fröhlich</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Traumatology, Orthopaedic Surgery and Sports Traumatology, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Stuermer, Ewa K" sort="Stuermer, Ewa K" uniqKey="Stuermer E" first="Ewa K." last="Stuermer">Ewa K. Stuermer</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Due to demographical changes the number of elderly patients depending on oral anticoagulation is expected to rise. Prolonged bleeding times in case of traumatic injuries represent the drawback of these medications, not only in major trauma, but also in superficial wounds. Therefore, dressings capable of accelerating coagulation onset and shortening bleeding times are desirable for these patients.</p></sec><sec><title>Methods</title><p>The hemostatic potential and physical properties of different types of superficial wound dressings (standard wound pad, two alginates, chitosan, collagen (Lyostypt<sup>®</sup>), oxidized cellulose, and QuikClot<sup>®</sup>) were assessed in vitro. For this purpose the clotting times of blood under the influence of the named hemostatics from healthy volunteers were compared with Marcumar<sup>®</sup> or ASS<sup>®</sup> treated patients. For that, a newly developed coagulation assay based on spectrophotometric extinction measurements of thrombin activity was used.</p></sec><sec><title>Results</title><p>The fastest coagulation onset was observed for oxidized cellulose (Ø 2.47 min), Lantor alginate-<sc>l</sc> (Ø 2.50 min) and QuikClot<sup>®</sup> (Ø 3.01 min). Chitosan (Ø 5.32 min) and the collagen Lyostypt<sup>®</sup> (Ø 7.59 min) induced clotting comparatively late. Regarding physical parameters, QuikClot<sup>®</sup> showed the lowest absorption capacity and speed while chitosan and both alginates achieved the highest. While oxidized cellulose displayed the best clotting times, unfortunately it also revealed low absorption capacity.</p></sec><sec><title>Conclusions</title><p>All tested specimens seem to induce clotting independently from the administered type of oral anticoagulant, providing the possibility to neglect the disadvantage in clotting times arising from anticoagulation on a local basis. QuikClot<sup>®</sup>, oxidized cellulose and unexpectedly alginate-<sc>l</sc> were superior to chitosan and Lyostypt<sup>®</sup>. Due to its additional well-known positive effect on wound healing alginate-<sc>l</sc> should be considered for further investigations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wattigney, Wa" uniqKey="Wattigney W">WA Wattigney</name></author><author><name sortKey="Mensah, Ga" uniqKey="Mensah G">GA Mensah</name></author><author><name sortKey="Croft, Jb" uniqKey="Croft J">JB Croft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyasaka, Y" uniqKey="Miyasaka Y">Y Miyasaka</name></author><author><name sortKey="Barnes, Me" uniqKey="Barnes M">ME Barnes</name></author><author><name sortKey="Gersh, Bj" uniqKey="Gersh B">BJ Gersh</name></author><author><name sortKey="Cha, Ss" uniqKey="Cha S">SS Cha</name></author><author><name sortKey="Bailey, Kr" uniqKey="Bailey K">KR Bailey</name></author><author><name sortKey="Abhayaratna, Wp" uniqKey="Abhayaratna W">WP 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Vahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steenfos, Hh" uniqKey="Steenfos H">HH Steenfos</name></author><author><name sortKey="Agren, Ms" uniqKey="Agren M">MS Agren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenyvesi, T" uniqKey="Fenyvesi T">T Fenyvesi</name></author><author><name sortKey="Jorg, I" uniqKey="Jorg I">I Jörg</name></author><author><name sortKey="Weiss, C" uniqKey="Weiss C">C Weiss</name></author><author><name sortKey="Harenberg, J" uniqKey="Harenberg J">J Harenberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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