How local is the local field potential?
Identifieur interne : 002B44 ( Main/Exploration ); précédent : 002B43; suivant : 002B45How local is the local field potential?
Auteurs : Yoshinao Kajikawa ; Charles E. SchroederSource :
- Neuron [ 0896-6273 ] ; 2011.
Abstract
Local field potentials (LFPs) are of growing importance in neurophysiological investigations. LFPs supplement action potential recordings by indexing activity relevant to EEG, MEG and hemodynamic (fMRI) signals. Recent reports suggest that LFPs reflect activity within very small domains of several hundred microns. We examined this conclusion by comparing LFP, current source density (CSD), and multiunit activity (MUA) signals in macaque auditory cortex. Estimated by frequency tuning bandwidths, these signals' “listening areas” differ systematically with an order of: MUA < CSD < LFP. Computational analyses confirm that observed LFPs receive non-local contributions. Direct measurements indicate passive spread of LFPs to sites more than a centimeter from their origins. These findings appear to be independent of the frequency content of the LFP. Our results challenge the idea that LFP recordings
Url:
DOI: 10.1016/j.neuron.2011.09.029
PubMed: 22153379
PubMed Central: 3240862
Affiliations:
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