Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory
Identifieur interne : 000951 ( Main/Exploration ); précédent : 000950; suivant : 000952Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory
Auteurs : Kana Okada [Japon] ; Kayo Nishizawa [Japon] ; Tomoko Kobayashi [Japon] ; Shogo Sakata [Japon] ; Kazuto Kobayashi [Japon]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Recognition memory requires processing of various types of information such as objects and locations. Impairment in recognition memory is a prominent feature of amnesia and a symptom of Alzheimer’s disease (AD). Basal forebrain cholinergic neurons contain two major groups, one localized in the medial septum (MS)/vertical diagonal band of Broca (vDB), and the other in the nucleus basalis magnocellularis (NBM). The roles of these cell groups in recognition memory have been debated, and it remains unclear how they contribute to it. We use a genetic cell targeting technique to selectively eliminate cholinergic cell groups and then test spatial and object recognition memory through different behavioural tasks. Eliminating MS/vDB neurons impairs spatial but not object recognition memory in the reference and working memory tasks, whereas NBM elimination undermines only object recognition memory in the working memory task. These impairments are restored by treatment with acetylcholinesterase inhibitors, anti-dementia drugs for AD. Our results highlight that MS/vDB and NBM cholinergic neurons are not only implicated in recognition memory but also have essential roles in different types of recognition memory.
Url:
DOI: 10.1038/srep13158
PubMed: 26246157
PubMed Central: 4526880
Affiliations:
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memory</title><author><name sortKey="Okada, Kana" sort="Okada, Kana" uniqKey="Okada K" first="Kana" last="Okada">Kana Okada</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Behavioural Sciences, Graduate School of Integrated Arts & Sciences, Hiroshima University</institution>, Higashi-Hiroshima 739-8521,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nishizawa, Kayo" sort="Nishizawa, Kayo" uniqKey="Nishizawa K" first="Kayo" last="Nishizawa">Kayo Nishizawa</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine</institution>, Fukushima 960-1295,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kobayashi, Tomoko" sort="Kobayashi, Tomoko" uniqKey="Kobayashi T" first="Tomoko" last="Kobayashi">Tomoko Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine</institution>, Fukushima 960-1295,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sakata, Shogo" sort="Sakata, Shogo" uniqKey="Sakata S" first="Shogo" last="Sakata">Shogo Sakata</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Behavioural Sciences, Graduate School of Integrated Arts & Sciences, Hiroshima University</institution>, Higashi-Hiroshima 739-8521,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kobayashi, Kazuto" sort="Kobayashi, Kazuto" uniqKey="Kobayashi K" first="Kazuto" last="Kobayashi">Kazuto Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine</institution>, Fukushima 960-1295,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Japan Science and Technology Agency, Core Research for Evolutional Science and Technology</institution>, Kawaguchi 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno 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Impairment in recognition memory is a prominent feature of amnesia and a symptom of Alzheimer’s disease (AD). Basal forebrain cholinergic neurons contain two major groups, one localized in the medial septum (MS)/vertical diagonal band of Broca (vDB), and the other in the nucleus basalis magnocellularis (NBM). The roles of these cell groups in recognition memory have been debated, and it remains unclear how they contribute to it. We use a genetic cell targeting technique to selectively eliminate cholinergic cell groups and then test spatial and object recognition memory through different behavioural tasks. Eliminating MS/vDB neurons impairs spatial but not object recognition memory in the reference and working memory tasks, whereas NBM elimination undermines only object recognition memory in the working memory task. These impairments are restored by treatment with acetylcholinesterase inhibitors, anti-dementia drugs for AD. Our results highlight that MS/vDB and NBM cholinergic neurons are not only implicated in recognition memory but also have essential roles in different types of recognition memory.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brown, M W" uniqKey="Brown M">M. W. Brown,</name></author><author><name sortKey="Aggleton, J P" uniqKey="Aggleton J">J. P. Aggleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yonelinas, A P" uniqKey="Yonelinas A">A. P. Yonelinas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warburton, E C" uniqKey="Warburton E">E. C. Warburton</name></author><author><name sortKey="Brown, M W" uniqKey="Brown M">M. W. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Squire, L R" uniqKey="Squire L">L. R. Squire,</name></author><author><name sortKey="Wixted, J T" uniqKey="Wixted J">J. T. 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Lein</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Okada, Kana" sort="Okada, Kana" uniqKey="Okada K" first="Kana" last="Okada">Kana Okada</name></noRegion><name sortKey="Kobayashi, Kazuto" sort="Kobayashi, Kazuto" uniqKey="Kobayashi K" first="Kazuto" last="Kobayashi">Kazuto Kobayashi</name><name sortKey="Kobayashi, Kazuto" sort="Kobayashi, Kazuto" uniqKey="Kobayashi K" first="Kazuto" last="Kobayashi">Kazuto Kobayashi</name><name sortKey="Kobayashi, Tomoko" sort="Kobayashi, Tomoko" uniqKey="Kobayashi T" first="Tomoko" last="Kobayashi">Tomoko Kobayashi</name><name sortKey="Nishizawa, Kayo" sort="Nishizawa, Kayo" uniqKey="Nishizawa K" first="Kayo" last="Nishizawa">Kayo Nishizawa</name><name sortKey="Sakata, Shogo" sort="Sakata, Shogo" uniqKey="Sakata S" first="Shogo" last="Sakata">Shogo Sakata</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|étape= Exploration
|type= RBID
|clé= PMC:4526880
|texte= Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26246157" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |