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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Metagenomics and the protein universe</title><author><name sortKey="Godzik, Adam" sort="Godzik, Adam" uniqKey="Godzik A" first="Adam" last="Godzik">Adam Godzik</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21497084</idno><idno type="pmc">3118404</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118404</idno><idno type="RBID">PMC:3118404</idno><idno type="doi">10.1016/j.sbi.2011.03.010</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000324</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Metagenomics and the protein universe</title><author><name sortKey="Godzik, Adam" sort="Godzik, Adam" uniqKey="Godzik A" first="Adam" last="Godzik">Adam Godzik</name></author></analytic><series><title level="j">Current opinion in structural biology</title><idno type="ISSN">0959-440X</idno><idno type="eISSN">1879-033X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Metagenomics sequencing projects have dramatically increased our knowledge of the protein universe and provided over one-half of currently known protein sequences; they have also introduced a much broader phylogenetic diversity into the protein databases. The full analysis of metagenomic datasets is only beginning, but it has already led to the discovery of thousands of new protein families, likely representing novel functions specific to given environments. At the same time, a deeper analysis of such novel families, including experimental structure determination of some representatives, suggests that most of them represent distant homologs of already characterized protein families, and thus most of the protein diversity present in the new environments are due to functional divergence of the known protein families rather than the emergence of new ones.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9107784</journal-id><journal-id journal-id-type="pubmed-jr-id">8602</journal-id><journal-id journal-id-type="nlm-ta">Curr Opin Struct Biol</journal-id><journal-title-group><journal-title>Current opinion in structural biology</journal-title></journal-title-group><issn pub-type="ppub">0959-440X</issn><issn pub-type="epub">1879-033X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21497084</article-id><article-id pub-id-type="pmc">3118404</article-id><article-id pub-id-type="doi">10.1016/j.sbi.2011.03.010</article-id><article-id pub-id-type="manuscript">NIHMS291451</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Metagenomics and the protein universe</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Godzik</surname><given-names>Adam</given-names></name><aff id="A1">Program on Bioinformatics and Systems Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA</aff><email>adam@sanfordburnham.org</email></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>3</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2012</year></pub-date><volume>21</volume><issue>3</issue><fpage>398</fpage><lpage>403</lpage><permissions><copyright-statement>© 2011 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P2">Metagenomics sequencing projects have dramatically increased our knowledge of the protein universe and provided over one-half of currently known protein sequences; they have also introduced a much broader phylogenetic diversity into the protein databases. The full analysis of metagenomic datasets is only beginning, but it has already led to the discovery of thousands of new protein families, likely representing novel functions specific to given environments. At the same time, a deeper analysis of such novel families, including experimental structure determination of some representatives, suggests that most of them represent distant homologs of already characterized protein families, and thus most of the protein diversity present in the new environments are due to functional divergence of the known protein families rather than the emergence of new ones.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of General Medical Sciences : NIGMS</funding-source><award-id>U54 GM094586-01 || GM</award-id></award-group><award-group><funding-source country="United States">National Institute of General Medical Sciences : NIGMS</funding-source><award-id>R01 GM087218-01 || GM</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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