Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape
Identifieur interne : 000535 ( Ncbi/Checkpoint ); précédent : 000534; suivant : 000536Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape
Auteurs : Yasunori Ichihashi [Japon] ; José Antonio Aguilar-Martínez ; Moran Farhi ; Daniel H. Chitwood ; Ravi Kumar ; Lee V. Millon ; Jie Peng ; Julin N. Maloof ; Neelima R. SinhaSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Abstract
Ever since Darwin’s pioneering research, a major challenge in biology has been to understand the genetic basis of morphological evolution. Utilizing the natural variation in leaf morphology between tomato and two related wild species, we identified a gene network module that leads to a dynamic rewiring of interactions in the whole leaf developmental gene regulatory network. Our work experimentally validates the hypothesis that peripheral regions of network, rather than network hubs, are more likely to contribute to evolutionary innovations. Our data also suggest that, likely due to their bottleneck location in the network, the regulation in KNOX homeobox genes was repeatedly manipulated to generate natural variation in leaf shape.
Url:
DOI: 10.1073/pnas.1402835111
PubMed: 24927584
PubMed Central: 4078850
Affiliations:
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Ever since Darwin’s pioneering research, a major challenge in biology has been to understand the genetic basis of morphological evolution. Utilizing the natural variation in leaf morphology between tomato and two related wild species, we identified a gene network module that leads to a dynamic rewiring of interactions in the whole leaf developmental gene regulatory network. Our work experimentally validates the hypothesis that peripheral regions of network, rather than network hubs, are more likely to contribute to evolutionary innovations. Our data also suggest that, likely due to their bottleneck location in the network, the regulation in KNOX homeobox genes was repeatedly manipulated to generate natural variation in leaf shape.</p>
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<name sortKey="Millon, Lee V" sort="Millon, Lee V" uniqKey="Millon L" first="Lee V." last="Millon">Lee V. Millon</name>
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