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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology</title><author><name sortKey="Cserni, G" sort="Cserni, G" uniqKey="Cserni G" first="G" last="Cserni">G. Cserni</name><affiliation><nlm:aff id="aff1">Department of Pathology, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</nlm:aff></affiliation></author><author><name sortKey="Amendoeira, I" sort="Amendoeira, I" uniqKey="Amendoeira I" first="I" last="Amendoeira">I. Amendoeira</name><affiliation><nlm:aff id="aff2">Instituto de Patologia et Imunologia Molecular da Universidade do Porto e Serviço de Anatomia Patologica, Hospital S Joaõ, 4200 Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Apostolikas, N" sort="Apostolikas, N" uniqKey="Apostolikas N" first="N" last="Apostolikas">N. Apostolikas</name><affiliation><nlm:aff id="aff3">Department of Pathology, Saint Savas Hospital, 115 22 Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Bellocq, J P" sort="Bellocq, J P" uniqKey="Bellocq J" first="J P" last="Bellocq">J P Bellocq</name><affiliation><nlm:aff id="aff4">Service d’Anatomie Pathologique, Hopital de Hautepierre, F-67098 Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Bianchi, S" sort="Bianchi, S" uniqKey="Bianchi S" first="S" last="Bianchi">S. Bianchi</name><affiliation><nlm:aff id="aff5">Department of Human Pathology and Oncology, University of 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Boecker, W" sort="Boecker, W" uniqKey="Boecker W" first="W" last="Boecker">W. Boecker</name><affiliation><nlm:aff id="aff6">Gerhard-Domagk Institut fur Pathologie, Universitat von Munster, D-48129 Munster, Germany</nlm:aff></affiliation></author><author><name sortKey="Borisch, B" sort="Borisch, B" uniqKey="Borisch B" first="B" last="Borisch">B. Borisch</name><affiliation><nlm:aff id="aff7">Centre Médicale Universitaire, 1211 Genève, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Connolly, C E" sort="Connolly, C E" uniqKey="Connolly C" first="C E" last="Connolly">C E Connolly</name><affiliation><nlm:aff id="aff8">Department of Pathology, Clinical Sciences Institute, University College Hospital, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Decker, T" sort="Decker, T" uniqKey="Decker T" first="T" last="Decker">T. Decker</name><affiliation><nlm:aff id="aff9">Department of Pathology, The Breast Unit, HELIOS Medical Centre, D-13125 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Dervan, P" sort="Dervan, P" uniqKey="Dervan P" first="P" last="Dervan">P. Dervan</name><affiliation><nlm:aff id="aff10">Pathology Department, Mater Hospital, University College Dublin 7, Ireland</nlm:aff></affiliation></author><author><name sortKey="Drijkoningen, M" sort="Drijkoningen, M" uniqKey="Drijkoningen M" first="M" last="Drijkoningen">M. Drijkoningen</name><affiliation><nlm:aff id="aff11">Pathologische Ontleedkunde, University Hospital, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Ellis, I O" sort="Ellis, I O" uniqKey="Ellis I" first="I O" last="Ellis">I O Ellis</name><affiliation><nlm:aff id="aff12">Department of Histopathology, City Hospital, Nottingham NG5 1PB, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Elston, C W" sort="Elston, C W" uniqKey="Elston C" first="C W" last="Elston">C W Elston</name><affiliation><nlm:aff id="aff12">Department of Histopathology, City Hospital, Nottingham NG5 1PB, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Eusebi, V" sort="Eusebi, V" uniqKey="Eusebi V" first="V" last="Eusebi">V. Eusebi</name><affiliation><nlm:aff id="aff13">Sezione Anatomia Patologica M. Malpighi, Universita di Bologna, Ospedale Bellaria, 40139 Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Faverly, D" sort="Faverly, D" uniqKey="Faverly D" first="D" last="Faverly">D. Faverly</name><affiliation><nlm:aff id="aff14">CMP Laboratory, 1070 Bruxelles, Belgium</nlm:aff></affiliation></author><author><name sortKey="Heikkila, P" sort="Heikkila, P" uniqKey="Heikkila P" first="P" last="Heikkila">P. Heikkila</name><affiliation><nlm:aff id="aff15">Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Holland, R" sort="Holland, R" uniqKey="Holland R" first="R" last="Holland">R. Holland</name><affiliation><nlm:aff id="aff16">National Expert & Training Centre for Breast Cancer Screening, Academisch Ziekenhuis Nijmegen, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kerner, H" sort="Kerner, H" uniqKey="Kerner H" first="H" last="Kerner">H. Kerner</name><affiliation><nlm:aff id="aff17">Department of Pathology, Rambam Hospital, 31096 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Kulka, J" sort="Kulka, J" uniqKey="Kulka J" first="J" last="Kulka">J. Kulka</name><affiliation><nlm:aff id="aff18">2nd Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Jacquemier, J" sort="Jacquemier, J" uniqKey="Jacquemier J" first="J" last="Jacquemier">J. Jacquemier</name><affiliation><nlm:aff id="aff19">Institut Paoli Calmettes, 13273 Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Lacerda, M" sort="Lacerda, M" uniqKey="Lacerda M" first="M" last="Lacerda">M. Lacerda</name><affiliation><nlm:aff id="aff20">Laboratorio De Histopatologica, Centro Regional De Oncologia De Coimbra, 3000 Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Martinez Penuela, J" sort="Martinez Penuela, J" uniqKey="Martinez Penuela J" first="J" last="Martinez-Penuela">J. Martinez-Penuela</name><affiliation><nlm:aff id="aff21">Department of Pathology, Hospital de Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="De Miguel, C" sort="De Miguel, C" uniqKey="De Miguel C" first="C" last="De Miguel">C. De Miguel</name><affiliation><nlm:aff id="aff22">Department of Pathology, Hospital Virgen del Camino, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Peterse, J L" sort="Peterse, J L" uniqKey="Peterse J" first="J L" last="Peterse">J L Peterse</name><affiliation><nlm:aff id="aff23">Department of Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rank, F" sort="Rank, F" uniqKey="Rank F" first="F" last="Rank">F. Rank</name><affiliation><nlm:aff id="aff24">Center of Laboratory Medicine and Pathology, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Regitnig, P" sort="Regitnig, P" uniqKey="Regitnig P" first="P" last="Regitnig">P. Regitnig</name><affiliation><nlm:aff id="aff25">Institut fur Pathologie der Karl-Franzens Universitat Graz, A-8036 Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Reiner, A" sort="Reiner, A" uniqKey="Reiner A" first="A" last="Reiner">A. Reiner</name><affiliation><nlm:aff id="aff26">Institute of Pathology, Donauspital, A-1220 Wien, Austria</nlm:aff></affiliation></author><author><name sortKey="Sapino, A" sort="Sapino, A" uniqKey="Sapino A" first="A" last="Sapino">A. Sapino</name><affiliation><nlm:aff id="aff27">Department of Biological Science and Human Oncology, University of Turin, 10126 Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Sigal Zafrani, B" sort="Sigal Zafrani, B" uniqKey="Sigal Zafrani B" first="B" last="Sigal-Zafrani">B. Sigal-Zafrani</name><affiliation><nlm:aff id="aff28">Institut Curie, Section Medicale et Hospitaliere, 75231 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tanous, A M" sort="Tanous, A M" uniqKey="Tanous A" first="A M" last="Tanous">A M Tanous</name><affiliation><nlm:aff id="aff29">Division d’Anatomie Pathologique, Laboratoire National de Santé, 1011 Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Thorstenson, S" sort="Thorstenson, S" uniqKey="Thorstenson S" first="S" last="Thorstenson">S. Thorstenson</name><affiliation><nlm:aff id="aff30">Department of Pathology and Cytology, Kalmar Hospital, S-391 85 Kalmar, Sweden</nlm:aff></affiliation></author><author><name sortKey="Zozaya, E" sort="Zozaya, E" uniqKey="Zozaya E" first="E" last="Zozaya">E. Zozaya</name><affiliation><nlm:aff id="aff21">Department of Pathology, Hospital de Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Fejes, G" sort="Fejes, G" uniqKey="Fejes G" first="G" last="Fejes">G. Fejes</name><affiliation><nlm:aff id="aff31">Department of Informatics, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</nlm:aff></affiliation></author><author><name sortKey="Wells, C A" sort="Wells, C A" uniqKey="Wells C" first="C A" last="Wells">C A Wells</name><affiliation><nlm:aff id="aff32">Department of Histopathology, St Bartholomew’s Hospital Medical School, London EC1A 7BE, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15220360</idno><idno type="pmc">1770358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770358</idno><idno type="RBID">PMC:1770358</idno><idno type="doi">10.1136/jcp.2003.013599</idno><date when="2004">2004</date><idno type="wicri:Area/PubMedCentral/Corpus">000020</idno><idno type="wicri:explorRef" wicri:stream="PubMedCentral" wicri:step="Corpus" wicri:corpus="PMC">000020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology</title><author><name sortKey="Cserni, G" sort="Cserni, G" uniqKey="Cserni G" first="G" last="Cserni">G. Cserni</name><affiliation><nlm:aff id="aff1">Department of Pathology, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</nlm:aff></affiliation></author><author><name sortKey="Amendoeira, I" sort="Amendoeira, I" uniqKey="Amendoeira I" first="I" last="Amendoeira">I. Amendoeira</name><affiliation><nlm:aff id="aff2">Instituto de Patologia et Imunologia Molecular da Universidade do Porto e Serviço de Anatomia Patologica, Hospital S Joaõ, 4200 Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Apostolikas, N" sort="Apostolikas, N" uniqKey="Apostolikas N" first="N" last="Apostolikas">N. Apostolikas</name><affiliation><nlm:aff id="aff3">Department of Pathology, Saint Savas Hospital, 115 22 Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Bellocq, J P" sort="Bellocq, J P" uniqKey="Bellocq J" first="J P" last="Bellocq">J P Bellocq</name><affiliation><nlm:aff id="aff4">Service d’Anatomie Pathologique, Hopital de Hautepierre, F-67098 Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Bianchi, S" sort="Bianchi, S" uniqKey="Bianchi S" first="S" last="Bianchi">S. Bianchi</name><affiliation><nlm:aff id="aff5">Department of Human Pathology and Oncology, University of 50134 Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Boecker, W" sort="Boecker, W" uniqKey="Boecker W" first="W" last="Boecker">W. Boecker</name><affiliation><nlm:aff id="aff6">Gerhard-Domagk Institut fur Pathologie, Universitat von Munster, D-48129 Munster, Germany</nlm:aff></affiliation></author><author><name sortKey="Borisch, B" sort="Borisch, B" uniqKey="Borisch B" first="B" last="Borisch">B. Borisch</name><affiliation><nlm:aff id="aff7">Centre Médicale Universitaire, 1211 Genève, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Connolly, C E" sort="Connolly, C E" uniqKey="Connolly C" first="C E" last="Connolly">C E Connolly</name><affiliation><nlm:aff id="aff8">Department of Pathology, Clinical Sciences Institute, University College Hospital, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Decker, T" sort="Decker, T" uniqKey="Decker T" first="T" last="Decker">T. Decker</name><affiliation><nlm:aff id="aff9">Department of Pathology, The Breast Unit, HELIOS Medical Centre, D-13125 Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Dervan, P" sort="Dervan, P" uniqKey="Dervan P" first="P" last="Dervan">P. Dervan</name><affiliation><nlm:aff id="aff10">Pathology Department, Mater Hospital, University College Dublin 7, Ireland</nlm:aff></affiliation></author><author><name sortKey="Drijkoningen, M" sort="Drijkoningen, M" uniqKey="Drijkoningen M" first="M" last="Drijkoningen">M. Drijkoningen</name><affiliation><nlm:aff id="aff11">Pathologische Ontleedkunde, University Hospital, 3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Ellis, I O" sort="Ellis, I O" uniqKey="Ellis I" first="I O" last="Ellis">I O Ellis</name><affiliation><nlm:aff id="aff12">Department of Histopathology, City Hospital, Nottingham NG5 1PB, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Elston, C W" sort="Elston, C W" uniqKey="Elston C" first="C W" last="Elston">C W Elston</name><affiliation><nlm:aff id="aff12">Department of Histopathology, City Hospital, Nottingham NG5 1PB, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Eusebi, V" sort="Eusebi, V" uniqKey="Eusebi V" first="V" last="Eusebi">V. Eusebi</name><affiliation><nlm:aff id="aff13">Sezione Anatomia Patologica M. Malpighi, Universita di Bologna, Ospedale Bellaria, 40139 Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Faverly, D" sort="Faverly, D" uniqKey="Faverly D" first="D" last="Faverly">D. Faverly</name><affiliation><nlm:aff id="aff14">CMP Laboratory, 1070 Bruxelles, Belgium</nlm:aff></affiliation></author><author><name sortKey="Heikkila, P" sort="Heikkila, P" uniqKey="Heikkila P" first="P" last="Heikkila">P. Heikkila</name><affiliation><nlm:aff id="aff15">Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Holland, R" sort="Holland, R" uniqKey="Holland R" first="R" last="Holland">R. Holland</name><affiliation><nlm:aff id="aff16">National Expert & Training Centre for Breast Cancer Screening, Academisch Ziekenhuis Nijmegen, 6500 HB Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kerner, H" sort="Kerner, H" uniqKey="Kerner H" first="H" last="Kerner">H. Kerner</name><affiliation><nlm:aff id="aff17">Department of Pathology, Rambam Hospital, 31096 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Kulka, J" sort="Kulka, J" uniqKey="Kulka J" first="J" last="Kulka">J. Kulka</name><affiliation><nlm:aff id="aff18">2nd Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Jacquemier, J" sort="Jacquemier, J" uniqKey="Jacquemier J" first="J" last="Jacquemier">J. Jacquemier</name><affiliation><nlm:aff id="aff19">Institut Paoli Calmettes, 13273 Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Lacerda, M" sort="Lacerda, M" uniqKey="Lacerda M" first="M" last="Lacerda">M. Lacerda</name><affiliation><nlm:aff id="aff20">Laboratorio De Histopatologica, Centro Regional De Oncologia De Coimbra, 3000 Coimbra, Portugal</nlm:aff></affiliation></author><author><name sortKey="Martinez Penuela, J" sort="Martinez Penuela, J" uniqKey="Martinez Penuela J" first="J" last="Martinez-Penuela">J. Martinez-Penuela</name><affiliation><nlm:aff id="aff21">Department of Pathology, Hospital de Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="De Miguel, C" sort="De Miguel, C" uniqKey="De Miguel C" first="C" last="De Miguel">C. De Miguel</name><affiliation><nlm:aff id="aff22">Department of Pathology, Hospital Virgen del Camino, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Peterse, J L" sort="Peterse, J L" uniqKey="Peterse J" first="J L" last="Peterse">J L Peterse</name><affiliation><nlm:aff id="aff23">Department of Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Rank, F" sort="Rank, F" uniqKey="Rank F" first="F" last="Rank">F. Rank</name><affiliation><nlm:aff id="aff24">Center of Laboratory Medicine and Pathology, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Regitnig, P" sort="Regitnig, P" uniqKey="Regitnig P" first="P" last="Regitnig">P. Regitnig</name><affiliation><nlm:aff id="aff25">Institut fur Pathologie der Karl-Franzens Universitat Graz, A-8036 Graz, Austria</nlm:aff></affiliation></author><author><name sortKey="Reiner, A" sort="Reiner, A" uniqKey="Reiner A" first="A" last="Reiner">A. Reiner</name><affiliation><nlm:aff id="aff26">Institute of Pathology, Donauspital, A-1220 Wien, Austria</nlm:aff></affiliation></author><author><name sortKey="Sapino, A" sort="Sapino, A" uniqKey="Sapino A" first="A" last="Sapino">A. Sapino</name><affiliation><nlm:aff id="aff27">Department of Biological Science and Human Oncology, University of Turin, 10126 Turin, Italy</nlm:aff></affiliation></author><author><name sortKey="Sigal Zafrani, B" sort="Sigal Zafrani, B" uniqKey="Sigal Zafrani B" first="B" last="Sigal-Zafrani">B. Sigal-Zafrani</name><affiliation><nlm:aff id="aff28">Institut Curie, Section Medicale et Hospitaliere, 75231 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tanous, A M" sort="Tanous, A M" uniqKey="Tanous A" first="A M" last="Tanous">A M Tanous</name><affiliation><nlm:aff id="aff29">Division d’Anatomie Pathologique, Laboratoire National de Santé, 1011 Luxembourg</nlm:aff></affiliation></author><author><name sortKey="Thorstenson, S" sort="Thorstenson, S" uniqKey="Thorstenson S" first="S" last="Thorstenson">S. Thorstenson</name><affiliation><nlm:aff id="aff30">Department of Pathology and Cytology, Kalmar Hospital, S-391 85 Kalmar, Sweden</nlm:aff></affiliation></author><author><name sortKey="Zozaya, E" sort="Zozaya, E" uniqKey="Zozaya E" first="E" last="Zozaya">E. Zozaya</name><affiliation><nlm:aff id="aff21">Department of Pathology, Hospital de Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Fejes, G" sort="Fejes, G" uniqKey="Fejes G" first="G" last="Fejes">G. Fejes</name><affiliation><nlm:aff id="aff31">Department of Informatics, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</nlm:aff></affiliation></author><author><name sortKey="Wells, C A" sort="Wells, C A" uniqKey="Wells C" first="C A" last="Wells">C A Wells</name><affiliation><nlm:aff id="aff32">Department of Histopathology, St Bartholomew’s Hospital Medical School, London EC1A 7BE, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Pathology</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Aims:</bold> To evaluate aspects of the current practice of sentinel lymph node (SLN) pathology in breast cancer via a questionnaire based survey, to recognise major issues that the European guidelines for mammography screening should address in the next revision.</p><p><bold>Methods:</bold> A questionnaire was circulated by mail or electronically by the authors in their respective countries. Replies from pathology units dealing with SLN specimens were evaluated further.</p><p><bold>Results:</bold> Of the 382 respondents, 240 European pathology units were dealing with SLN specimens. Sixty per cent of these units carried out intraoperative assessment, most commonly consisting of frozen sections. Most units slice larger SLNs into pieces and only 12% assess these slices on a single haematoxylin and eosin (HE) stained slide. Seventy one per cent of the units routinely use immunohistochemistry in all cases negative by HE. The terms micrometastasis, submicrometastasis, and isolated tumour cells (ITCs) are used in 93%, 22%, and 71% of units, respectively, but have a rather heterogeneous interpretation. Molecular SLN staging was reported by only 10 units (4%). Most institutions have their own guidelines for SLN processing, but some countries also have well recognised national guidelines.</p><p><bold>Conclusions:</bold> Pathological examination of SLNs throughout Europe varies considerably and is not standardised. The European guidelines should focus on standardising examination. They should recommend techniques that identify metastases > 2 mm as a minimum standard. Uniform reporting of additional findings may also be important, because micrometastases and ITCs may in the future be shown to have clinical relevance.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Pathol</journal-id><journal-id journal-id-type="publisher-id">jclinpath</journal-id><journal-title>Journal of Clinical Pathology</journal-title><issn pub-type="ppub">0021-9746</issn><issn pub-type="epub">1472-4146</issn><publisher><publisher-name>Copyright 2004 Journal of Clinical Pathology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15220360</article-id><article-id pub-id-type="pmc">1770358</article-id><article-id pub-id-type="publisher-id">0570695</article-id><article-id pub-id-type="doi">10.1136/jcp.2003.013599</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cserni</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Amendoeira</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Apostolikas</surname><given-names>N</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bellocq</surname><given-names>J P</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bianchi</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Boecker</surname><given-names>W</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Borisch</surname><given-names>B</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Connolly</surname><given-names>C E</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Decker</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Dervan</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Drijkoningen</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ellis</surname><given-names>I O</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Elston</surname><given-names>C W</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Eusebi</surname><given-names>V</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Faverly</surname><given-names>D</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Heikkila</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Holland</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Kerner</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kulka</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Jacquemier</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Lacerda</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff20">20</xref></contrib><contrib contrib-type="author"><name><surname>Martinez-Penuela</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff21">21</xref></contrib><contrib contrib-type="author"><name><surname>De Miguel</surname><given-names>C</given-names></name><xref ref-type="aff" rid="aff22">22</xref></contrib><contrib contrib-type="author"><name><surname>Peterse</surname><given-names>J L</given-names></name><xref ref-type="aff" rid="aff23">23</xref></contrib><contrib contrib-type="author"><name><surname>Rank</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff24">24</xref></contrib><contrib contrib-type="author"><name><surname>Regitnig</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff25">25</xref></contrib><contrib contrib-type="author"><name><surname>Reiner</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff26">26</xref></contrib><contrib contrib-type="author"><name><surname>Sapino</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff27">27</xref></contrib><contrib contrib-type="author"><name><surname>Sigal-Zafrani</surname><given-names>B</given-names></name><xref ref-type="aff" rid="aff28">28</xref></contrib><contrib contrib-type="author"><name><surname>Tanous</surname><given-names>A M</given-names></name><xref ref-type="aff" rid="aff29">29</xref></contrib><contrib contrib-type="author"><name><surname>Thorstenson</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff30">30</xref></contrib><contrib contrib-type="author"><name><surname>Zozaya</surname><given-names>E</given-names></name><xref ref-type="aff" rid="aff21">21</xref></contrib><contrib contrib-type="author"><name><surname>Fejes</surname><given-names>G</given-names></name><xref ref-type="aff" rid="aff31">31</xref></contrib><contrib contrib-type="author"><name><surname>Wells</surname><given-names>C A</given-names></name><xref ref-type="aff" rid="aff32">32</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Pathology, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</aff><aff id="aff2"><label>2</label>Instituto de Patologia et Imunologia Molecular da Universidade do Porto e Serviço de Anatomia Patologica, Hospital S Joaõ, 4200 Porto, Portugal</aff><aff id="aff3"><label>3</label>Department of Pathology, Saint Savas Hospital, 115 22 Athens, Greece</aff><aff id="aff4"><label>4</label>Service d’Anatomie Pathologique, Hopital de Hautepierre, F-67098 Strasbourg, France</aff><aff id="aff5"><label>5</label>Department of Human Pathology and Oncology, University of 50134 Florence, Italy</aff><aff id="aff6"><label>6</label>Gerhard-Domagk Institut fur Pathologie, Universitat von Munster, D-48129 Munster, Germany</aff><aff id="aff7"><label>7</label>Centre Médicale Universitaire, 1211 Genève, Switzerland</aff><aff id="aff8"><label>8</label>Department of Pathology, Clinical Sciences Institute, University College Hospital, Galway, Ireland</aff><aff id="aff9"><label>9</label>Department of Pathology, The Breast Unit, HELIOS Medical Centre, D-13125 Berlin, Germany</aff><aff id="aff10"><label>10</label>Pathology Department, Mater Hospital, University College Dublin 7, Ireland</aff><aff id="aff11"><label>11</label>Pathologische Ontleedkunde, University Hospital, 3000 Leuven, Belgium</aff><aff id="aff12"><label>12</label>Department of Histopathology, City Hospital, Nottingham NG5 1PB, United Kingdom</aff><aff id="aff13"><label>13</label>Sezione Anatomia Patologica M. Malpighi, Universita di Bologna, Ospedale Bellaria, 40139 Bologna, Italy</aff><aff id="aff14"><label>14</label>CMP Laboratory, 1070 Bruxelles, Belgium</aff><aff id="aff15"><label>15</label>Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland</aff><aff id="aff16"><label>16</label>National Expert & Training Centre for Breast Cancer Screening, Academisch Ziekenhuis Nijmegen, 6500 HB Nijmegen, The Netherlands</aff><aff id="aff17"><label>17</label>Department of Pathology, Rambam Hospital, 31096 Haifa, Israel</aff><aff id="aff18"><label>18</label>2nd Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary</aff><aff id="aff19"><label>19</label>Institut Paoli Calmettes, 13273 Marseille, France</aff><aff id="aff20"><label>20</label>Laboratorio De Histopatologica, Centro Regional De Oncologia De Coimbra, 3000 Coimbra, Portugal</aff><aff id="aff21"><label>21</label>Department of Pathology, Hospital de Navarra, 31008 Pamplona, Spain</aff><aff id="aff22"><label>22</label>Department of Pathology, Hospital Virgen del Camino, 31008 Pamplona, Spain</aff><aff id="aff23"><label>23</label>Department of Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands</aff><aff id="aff24"><label>24</label>Center of Laboratory Medicine and Pathology, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark</aff><aff id="aff25"><label>25</label>Institut fur Pathologie der Karl-Franzens Universitat Graz, A-8036 Graz, Austria</aff><aff id="aff26"><label>26</label>Institute of Pathology, Donauspital, A-1220 Wien, Austria</aff><aff id="aff27"><label>27</label>Department of Biological Science and Human Oncology, University of Turin, 10126 Turin, Italy</aff><aff id="aff28"><label>28</label>Institut Curie, Section Medicale et Hospitaliere, 75231 Paris, France</aff><aff id="aff29"><label>29</label>Division d’Anatomie Pathologique, Laboratoire National de Santé, 1011 Luxembourg</aff><aff id="aff30"><label>30</label>Department of Pathology and Cytology, Kalmar Hospital, S-391 85 Kalmar, Sweden</aff><aff id="aff31"><label>31</label>Department of Informatics, Bács-Kiskun County Teaching Hospital, H-6000 Kecskemét, Hungary</aff><aff id="aff32"><label>32</label>Department of Histopathology, St Bartholomew’s Hospital Medical School, London EC1A 7BE, UK</aff><author-notes><fn><p>Correspondence to:
Dr G Cserni
Bács-Kiskun County Teaching Hospital; Nyíri út 38, H-6000 Kecskemét, Hungary; <email>cserni@freemail.hu</email></p></fn></author-notes><pub-date pub-type="ppub"><month>7</month><year>2004</year></pub-date><volume>57</volume><issue>7</issue><fpage>695</fpage><lpage>701</lpage><history><date date-type="accepted"><day>12</day><month>11</month><year>2003</year></date></history><copyright-statement>Copyright © Copyright 2004 Journal of Clinical Pathology</copyright-statement><copyright-year>2004</copyright-year><abstract><p><bold>Aims:</bold> To evaluate aspects of the current practice of sentinel lymph node (SLN) pathology in breast cancer via a questionnaire based survey, to recognise major issues that the European guidelines for mammography screening should address in the next revision.</p><p><bold>Methods:</bold> A questionnaire was circulated by mail or electronically by the authors in their respective countries. Replies from pathology units dealing with SLN specimens were evaluated further.</p><p><bold>Results:</bold> Of the 382 respondents, 240 European pathology units were dealing with SLN specimens. Sixty per cent of these units carried out intraoperative assessment, most commonly consisting of frozen sections. Most units slice larger SLNs into pieces and only 12% assess these slices on a single haematoxylin and eosin (HE) stained slide. Seventy one per cent of the units routinely use immunohistochemistry in all cases negative by HE. The terms micrometastasis, submicrometastasis, and isolated tumour cells (ITCs) are used in 93%, 22%, and 71% of units, respectively, but have a rather heterogeneous interpretation. Molecular SLN staging was reported by only 10 units (4%). Most institutions have their own guidelines for SLN processing, but some countries also have well recognised national guidelines.</p><p><bold>Conclusions:</bold> Pathological examination of SLNs throughout Europe varies considerably and is not standardised. The European guidelines should focus on standardising examination. They should recommend techniques that identify metastases > 2 mm as a minimum standard. Uniform reporting of additional findings may also be important, because micrometastases and ITCs may in the future be shown to have clinical relevance.</p></abstract><kwd-group><kwd>breast cancer</kwd><kwd>guidelines</kwd><kwd>questionnaire</kwd><kwd>sentinel lymph nodes</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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