A new view on hypocortisolism.
Identifieur interne : 000701 ( PubMed/Corpus ); précédent : 000700; suivant : 000702A new view on hypocortisolism.
Auteurs : Eva Fries ; Judith Hesse ; Juliane Hellhammer ; Dirk H. HellhammerSource :
- Psychoneuroendocrinology [ 0306-4530 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Hydrocortisone.
- physiopathology : Immune System, Stress, Psychological, Sympathetic Nervous System.
- Humans.
Abstract
Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual.
DOI: 10.1016/j.psyneuen.2005.04.006
PubMed: 15950390
Links to Exploration step
pubmed:15950390Le document en format XML
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<author><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name>
<affiliation><nlm:affiliation>Department for Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany.</nlm:affiliation>
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<author><name sortKey="Hesse, Judith" sort="Hesse, Judith" uniqKey="Hesse J" first="Judith" last="Hesse">Judith Hesse</name>
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<author><name sortKey="Hellhammer, Juliane" sort="Hellhammer, Juliane" uniqKey="Hellhammer J" first="Juliane" last="Hellhammer">Juliane Hellhammer</name>
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<author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name>
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<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Hydrocortisone</term>
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<front><div type="abstract" xml:lang="en">Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual.</div>
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<Title>Psychoneuroendocrinology</Title>
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<ArticleTitle>A new view on hypocortisolism.</ArticleTitle>
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<Abstract><AbstractText>Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual.</AbstractText>
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<NumberOfReferences>59</NumberOfReferences>
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