Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.
Identifieur interne : 000358 ( PubMed/Corpus ); précédent : 000357; suivant : 000359Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.
Auteurs : Jacob M. Van Laar ; Dominique Farge ; Jacob K. Sont ; Kamran Naraghi ; Zora Marjanovic ; Jérôme Larghero ; Annemie J. Schuerwegh ; Erik W A. Marijt ; Madelon C. Vonk ; Anton V. Schattenberg ; Marco Matucci-Cerinic ; Alexandre E. Voskuyl ; Arjan A. Van De Loosdrecht ; Thomas Daikeler ; Ina Kötter ; Marc Schmalzing ; Thierry Martin ; Bruno Lioure ; Stefan M. Weiner ; Alexander Kreuter ; Christophe Deligny ; Jean-Marc Durand ; Paul Emery ; Klaus P. Machold ; Francoise Sarrot-Reynauld ; Klaus Warnatz ; Daniel F P. Adoue ; Joël Constans ; Hans-Peter Tony ; Nicoletta Del Papa ; Athanasios Fassas ; Andrea Himsel ; David Launay ; Andrea Lo Monaco ; Pierre Philippe ; Isabelle Quéré ; Éric Rich ; Rene Westhovens ; Bridget Griffiths ; Riccardo Saccardi ; Frank H. Van Den Hoogen ; Willem E. Fibbe ; Gérard Socié ; Alois Gratwohl ; Alan TyndallSource :
- JAMA [ 1538-3598 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Autografts, Cyclophosphamide (administration & dosage), Cyclophosphamide (adverse effects), Female, Hematopoietic Stem Cell Transplantation (adverse effects), Humans, Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (adverse effects), Male, Middle Aged, Scleroderma, Diffuse (drug therapy), Survival Analysis.
- MESH :
- chemical , administration & dosage : Cyclophosphamide, Immunosuppressive Agents.
- chemical , adverse effects : Cyclophosphamide, Immunosuppressive Agents.
- adverse effects : Hematopoietic Stem Cell Transplantation.
- drug therapy : Scleroderma, Diffuse.
- Adult, Autografts, Female, Humans, Male, Middle Aged, Survival Analysis.
Abstract
High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials.
DOI: 10.1001/jama.2014.6368
PubMed: 25058083
Links to Exploration step
pubmed:25058083Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.</title><author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name><affiliation><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Farge, Dominique" sort="Farge, Dominique" uniqKey="Farge D" first="Dominique" last="Farge">Dominique Farge</name><affiliation><nlm:affiliation>Internal Medicine and Vascular Disease Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sont, Jacob K" sort="Sont, Jacob K" uniqKey="Sont J" first="Jacob K" last="Sont">Jacob K. Sont</name><affiliation><nlm:affiliation>Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Naraghi, Kamran" sort="Naraghi, Kamran" uniqKey="Naraghi K" first="Kamran" last="Naraghi">Kamran Naraghi</name><affiliation><nlm:affiliation>Department of Rheumatology, The James Cook University Hospital, Middlesbrough, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Marjanovic, Zora" sort="Marjanovic, Zora" uniqKey="Marjanovic Z" first="Zora" last="Marjanovic">Zora Marjanovic</name><affiliation><nlm:affiliation>Service d'Hématologie Clinique et de Thérapie Cellulaire, AP-HP Hôpital Saint-Antoine, Paris 6 University, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Larghero, Jerome" sort="Larghero, Jerome" uniqKey="Larghero J" first="Jérôme" last="Larghero">Jérôme Larghero</name><affiliation><nlm:affiliation>Clinical Investigation Center in Biotherapies and Cell Therapy Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schuerwegh, Annemie J" sort="Schuerwegh, Annemie J" uniqKey="Schuerwegh A" first="Annemie J" last="Schuerwegh">Annemie J. Schuerwegh</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Marijt, Erik W A" sort="Marijt, Erik W A" uniqKey="Marijt E" first="Erik W A" last="Marijt">Erik W A. Marijt</name><affiliation><nlm:affiliation>Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vonk, Madelon C" sort="Vonk, Madelon C" uniqKey="Vonk M" first="Madelon C" last="Vonk">Madelon C. Vonk</name><affiliation><nlm:affiliation>Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schattenberg, Anton V" sort="Schattenberg, Anton V" uniqKey="Schattenberg A" first="Anton V" last="Schattenberg">Anton V. Schattenberg</name><affiliation><nlm:affiliation>Department of Hematology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name><affiliation><nlm:affiliation>Department of Biomedicine, Division of Rheumatology AOUC and Department of Experimental and Clinical Medicine, University of Florence, Florence.</nlm:affiliation></affiliation></author><author><name sortKey="Voskuyl, Alexandre E" sort="Voskuyl, Alexandre E" uniqKey="Voskuyl A" first="Alexandre E" last="Voskuyl">Alexandre E. Voskuyl</name><affiliation><nlm:affiliation>Department of Rheumatology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Loosdrecht, Arjan A" sort="Van De Loosdrecht, Arjan A" uniqKey="Van De Loosdrecht A" first="Arjan A" last="Van De Loosdrecht">Arjan A. Van De Loosdrecht</name><affiliation><nlm:affiliation>Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Daikeler, Thomas" sort="Daikeler, Thomas" uniqKey="Daikeler T" first="Thomas" last="Daikeler">Thomas Daikeler</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kotter, Ina" sort="Kotter, Ina" uniqKey="Kotter I" first="Ina" last="Kötter">Ina Kötter</name><affiliation><nlm:affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schmalzing, Marc" sort="Schmalzing, Marc" uniqKey="Schmalzing M" first="Marc" last="Schmalzing">Marc Schmalzing</name><affiliation><nlm:affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Thierry" sort="Martin, Thierry" uniqKey="Martin T" first="Thierry" last="Martin">Thierry Martin</name><affiliation><nlm:affiliation>Department of Clinical Immunology, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lioure, Bruno" sort="Lioure, Bruno" uniqKey="Lioure B" first="Bruno" last="Lioure">Bruno Lioure</name><affiliation><nlm:affiliation>Service d'Hématologie et d'Oncologie, Unité de Greffe de Cellules Souches Hématopoïétiques, Centre Hospitalier Universitaire Hautepierre, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Weiner, Stefan M" sort="Weiner, Stefan M" uniqKey="Weiner S" first="Stefan M" last="Weiner">Stefan M. Weiner</name><affiliation><nlm:affiliation>2.Medizinische Abteilung Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kreuter, Alexander" sort="Kreuter, Alexander" uniqKey="Kreuter A" first="Alexander" last="Kreuter">Alexander Kreuter</name><affiliation><nlm:affiliation>Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Oberhausen,Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Deligny, Christophe" sort="Deligny, Christophe" uniqKey="Deligny C" first="Christophe" last="Deligny">Christophe Deligny</name><affiliation><nlm:affiliation>Service Médecine Interne, Hôpital Pierre Zobda Quitman, Fort-de France, Martinique.</nlm:affiliation></affiliation></author><author><name sortKey="Durand, Jean Marc" sort="Durand, Jean Marc" uniqKey="Durand J" first="Jean-Marc" last="Durand">Jean-Marc Durand</name><affiliation><nlm:affiliation>Department of Internal Medicine CHU La Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation><nlm:affiliation>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Machold, Klaus P" sort="Machold, Klaus P" uniqKey="Machold K" first="Klaus P" last="Machold">Klaus P. Machold</name><affiliation><nlm:affiliation>Klinische Abteilung für Rheumatologie, Medizinische Universität, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sarrot Reynauld, Francoise" sort="Sarrot Reynauld, Francoise" uniqKey="Sarrot Reynauld F" first="Francoise" last="Sarrot-Reynauld">Francoise Sarrot-Reynauld</name><affiliation><nlm:affiliation>Pôle Pluridisciplinaire de Médecine, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation><nlm:affiliation>Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Adoue, Daniel F P" sort="Adoue, Daniel F P" uniqKey="Adoue D" first="Daniel F P" last="Adoue">Daniel F P. Adoue</name><affiliation><nlm:affiliation>Service Médecine Interne, Centre Hospitalier Universitaire Toulouse.</nlm:affiliation></affiliation></author><author><name sortKey="Constans, Joel" sort="Constans, Joel" uniqKey="Constans J" first="Joël" last="Constans">Joël Constans</name><affiliation><nlm:affiliation>Service Médecine Interne et Médecine Vasculaire, Hôpital St-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tony, Hans Peter" sort="Tony, Hans Peter" uniqKey="Tony H" first="Hans-Peter" last="Tony">Hans-Peter Tony</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University of Würzburg Medical Center, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Del Papa, Nicoletta" sort="Del Papa, Nicoletta" uniqKey="Del Papa N" first="Nicoletta" last="Del Papa">Nicoletta Del Papa</name><affiliation><nlm:affiliation>Day Hospital Reumatologia, Ospedale G. Pini, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fassas, Athanasios" sort="Fassas, Athanasios" uniqKey="Fassas A" first="Athanasios" last="Fassas">Athanasios Fassas</name><affiliation><nlm:affiliation>Department of Hematology, Cell and Gene Therapy Center, George Papanicolaou Hospital, Thessaloniki, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Himsel, Andrea" sort="Himsel, Andrea" uniqKey="Himsel A" first="Andrea" last="Himsel">Andrea Himsel</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Launay, David" sort="Launay, David" uniqKey="Launay D" first="David" last="Launay">David Launay</name><affiliation><nlm:affiliation>Service de Médecine Interne, Hôpital Claude-Huriez, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lo Monaco, Andrea" sort="Lo Monaco, Andrea" uniqKey="Lo Monaco A" first="Andrea" last="Lo Monaco">Andrea Lo Monaco</name><affiliation><nlm:affiliation>Section and Unit of Rheumatology, Department of Medical Sciences, University of Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Philippe, Pierre" sort="Philippe, Pierre" uniqKey="Philippe P" first="Pierre" last="Philippe">Pierre Philippe</name><affiliation><nlm:affiliation>Service de Médecine Interne, Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Quere, Isabelle" sort="Quere, Isabelle" uniqKey="Quere I" first="Isabelle" last="Quéré">Isabelle Quéré</name><affiliation><nlm:affiliation>Department of Internal Medicine, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rich, Eric" sort="Rich, Eric" uniqKey="Rich E" first="Éric" last="Rich">Éric Rich</name><affiliation><nlm:affiliation>Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name><affiliation><nlm:affiliation>Skeletal Biology and Engineering Research Center, Department of Development and Regeneration KU Leuven, Rheumatology, University Hospitals, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Griffiths, Bridget" sort="Griffiths, Bridget" uniqKey="Griffiths B" first="Bridget" last="Griffiths">Bridget Griffiths</name><affiliation><nlm:affiliation>Department of Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Saccardi, Riccardo" sort="Saccardi, Riccardo" uniqKey="Saccardi R" first="Riccardo" last="Saccardi">Riccardo Saccardi</name><affiliation><nlm:affiliation>Department of Hematology, Careggi University Hospital, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Hoogen, Frank H" sort="Van Den Hoogen, Frank H" uniqKey="Van Den Hoogen F" first="Frank H" last="Van Den Hoogen">Frank H. Van Den Hoogen</name><affiliation><nlm:affiliation>Department of Rheumatology, Maartenskliniek, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fibbe, Willem E" sort="Fibbe, Willem E" uniqKey="Fibbe W" first="Willem E" last="Fibbe">Willem E. Fibbe</name><affiliation><nlm:affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation><nlm:affiliation>Hematology/Transplantation, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tyndall, Alan" sort="Tyndall, Alan" uniqKey="Tyndall A" first="Alan" last="Tyndall">Alan Tyndall</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25058083</idno><idno type="pmid">25058083</idno><idno type="doi">10.1001/jama.2014.6368</idno><idno type="wicri:Area/PubMed/Corpus">000358</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000358</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.</title><author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name><affiliation><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Farge, Dominique" sort="Farge, Dominique" uniqKey="Farge D" first="Dominique" last="Farge">Dominique Farge</name><affiliation><nlm:affiliation>Internal Medicine and Vascular Disease Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sont, Jacob K" sort="Sont, Jacob K" uniqKey="Sont J" first="Jacob K" last="Sont">Jacob K. Sont</name><affiliation><nlm:affiliation>Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Naraghi, Kamran" sort="Naraghi, Kamran" uniqKey="Naraghi K" first="Kamran" last="Naraghi">Kamran Naraghi</name><affiliation><nlm:affiliation>Department of Rheumatology, The James Cook University Hospital, Middlesbrough, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Marjanovic, Zora" sort="Marjanovic, Zora" uniqKey="Marjanovic Z" first="Zora" last="Marjanovic">Zora Marjanovic</name><affiliation><nlm:affiliation>Service d'Hématologie Clinique et de Thérapie Cellulaire, AP-HP Hôpital Saint-Antoine, Paris 6 University, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Larghero, Jerome" sort="Larghero, Jerome" uniqKey="Larghero J" first="Jérôme" last="Larghero">Jérôme Larghero</name><affiliation><nlm:affiliation>Clinical Investigation Center in Biotherapies and Cell Therapy Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schuerwegh, Annemie J" sort="Schuerwegh, Annemie J" uniqKey="Schuerwegh A" first="Annemie J" last="Schuerwegh">Annemie J. Schuerwegh</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Marijt, Erik W A" sort="Marijt, Erik W A" uniqKey="Marijt E" first="Erik W A" last="Marijt">Erik W A. Marijt</name><affiliation><nlm:affiliation>Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vonk, Madelon C" sort="Vonk, Madelon C" uniqKey="Vonk M" first="Madelon C" last="Vonk">Madelon C. Vonk</name><affiliation><nlm:affiliation>Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schattenberg, Anton V" sort="Schattenberg, Anton V" uniqKey="Schattenberg A" first="Anton V" last="Schattenberg">Anton V. Schattenberg</name><affiliation><nlm:affiliation>Department of Hematology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name><affiliation><nlm:affiliation>Department of Biomedicine, Division of Rheumatology AOUC and Department of Experimental and Clinical Medicine, University of Florence, Florence.</nlm:affiliation></affiliation></author><author><name sortKey="Voskuyl, Alexandre E" sort="Voskuyl, Alexandre E" uniqKey="Voskuyl A" first="Alexandre E" last="Voskuyl">Alexandre E. Voskuyl</name><affiliation><nlm:affiliation>Department of Rheumatology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van De Loosdrecht, Arjan A" sort="Van De Loosdrecht, Arjan A" uniqKey="Van De Loosdrecht A" first="Arjan A" last="Van De Loosdrecht">Arjan A. Van De Loosdrecht</name><affiliation><nlm:affiliation>Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Daikeler, Thomas" sort="Daikeler, Thomas" uniqKey="Daikeler T" first="Thomas" last="Daikeler">Thomas Daikeler</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kotter, Ina" sort="Kotter, Ina" uniqKey="Kotter I" first="Ina" last="Kötter">Ina Kötter</name><affiliation><nlm:affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schmalzing, Marc" sort="Schmalzing, Marc" uniqKey="Schmalzing M" first="Marc" last="Schmalzing">Marc Schmalzing</name><affiliation><nlm:affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Thierry" sort="Martin, Thierry" uniqKey="Martin T" first="Thierry" last="Martin">Thierry Martin</name><affiliation><nlm:affiliation>Department of Clinical Immunology, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lioure, Bruno" sort="Lioure, Bruno" uniqKey="Lioure B" first="Bruno" last="Lioure">Bruno Lioure</name><affiliation><nlm:affiliation>Service d'Hématologie et d'Oncologie, Unité de Greffe de Cellules Souches Hématopoïétiques, Centre Hospitalier Universitaire Hautepierre, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Weiner, Stefan M" sort="Weiner, Stefan M" uniqKey="Weiner S" first="Stefan M" last="Weiner">Stefan M. Weiner</name><affiliation><nlm:affiliation>2.Medizinische Abteilung Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kreuter, Alexander" sort="Kreuter, Alexander" uniqKey="Kreuter A" first="Alexander" last="Kreuter">Alexander Kreuter</name><affiliation><nlm:affiliation>Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Oberhausen,Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Deligny, Christophe" sort="Deligny, Christophe" uniqKey="Deligny C" first="Christophe" last="Deligny">Christophe Deligny</name><affiliation><nlm:affiliation>Service Médecine Interne, Hôpital Pierre Zobda Quitman, Fort-de France, Martinique.</nlm:affiliation></affiliation></author><author><name sortKey="Durand, Jean Marc" sort="Durand, Jean Marc" uniqKey="Durand J" first="Jean-Marc" last="Durand">Jean-Marc Durand</name><affiliation><nlm:affiliation>Department of Internal Medicine CHU La Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation><nlm:affiliation>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Machold, Klaus P" sort="Machold, Klaus P" uniqKey="Machold K" first="Klaus P" last="Machold">Klaus P. Machold</name><affiliation><nlm:affiliation>Klinische Abteilung für Rheumatologie, Medizinische Universität, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sarrot Reynauld, Francoise" sort="Sarrot Reynauld, Francoise" uniqKey="Sarrot Reynauld F" first="Francoise" last="Sarrot-Reynauld">Francoise Sarrot-Reynauld</name><affiliation><nlm:affiliation>Pôle Pluridisciplinaire de Médecine, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Warnatz, Klaus" sort="Warnatz, Klaus" uniqKey="Warnatz K" first="Klaus" last="Warnatz">Klaus Warnatz</name><affiliation><nlm:affiliation>Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Adoue, Daniel F P" sort="Adoue, Daniel F P" uniqKey="Adoue D" first="Daniel F P" last="Adoue">Daniel F P. Adoue</name><affiliation><nlm:affiliation>Service Médecine Interne, Centre Hospitalier Universitaire Toulouse.</nlm:affiliation></affiliation></author><author><name sortKey="Constans, Joel" sort="Constans, Joel" uniqKey="Constans J" first="Joël" last="Constans">Joël Constans</name><affiliation><nlm:affiliation>Service Médecine Interne et Médecine Vasculaire, Hôpital St-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tony, Hans Peter" sort="Tony, Hans Peter" uniqKey="Tony H" first="Hans-Peter" last="Tony">Hans-Peter Tony</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University of Würzburg Medical Center, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Del Papa, Nicoletta" sort="Del Papa, Nicoletta" uniqKey="Del Papa N" first="Nicoletta" last="Del Papa">Nicoletta Del Papa</name><affiliation><nlm:affiliation>Day Hospital Reumatologia, Ospedale G. Pini, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fassas, Athanasios" sort="Fassas, Athanasios" uniqKey="Fassas A" first="Athanasios" last="Fassas">Athanasios Fassas</name><affiliation><nlm:affiliation>Department of Hematology, Cell and Gene Therapy Center, George Papanicolaou Hospital, Thessaloniki, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Himsel, Andrea" sort="Himsel, Andrea" uniqKey="Himsel A" first="Andrea" last="Himsel">Andrea Himsel</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Launay, David" sort="Launay, David" uniqKey="Launay D" first="David" last="Launay">David Launay</name><affiliation><nlm:affiliation>Service de Médecine Interne, Hôpital Claude-Huriez, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lo Monaco, Andrea" sort="Lo Monaco, Andrea" uniqKey="Lo Monaco A" first="Andrea" last="Lo Monaco">Andrea Lo Monaco</name><affiliation><nlm:affiliation>Section and Unit of Rheumatology, Department of Medical Sciences, University of Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Philippe, Pierre" sort="Philippe, Pierre" uniqKey="Philippe P" first="Pierre" last="Philippe">Pierre Philippe</name><affiliation><nlm:affiliation>Service de Médecine Interne, Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.</nlm:affiliation></affiliation></author><author><name sortKey="Quere, Isabelle" sort="Quere, Isabelle" uniqKey="Quere I" first="Isabelle" last="Quéré">Isabelle Quéré</name><affiliation><nlm:affiliation>Department of Internal Medicine, Montpellier University Hospital, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rich, Eric" sort="Rich, Eric" uniqKey="Rich E" first="Éric" last="Rich">Éric Rich</name><affiliation><nlm:affiliation>Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="Rene" last="Westhovens">Rene Westhovens</name><affiliation><nlm:affiliation>Skeletal Biology and Engineering Research Center, Department of Development and Regeneration KU Leuven, Rheumatology, University Hospitals, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Griffiths, Bridget" sort="Griffiths, Bridget" uniqKey="Griffiths B" first="Bridget" last="Griffiths">Bridget Griffiths</name><affiliation><nlm:affiliation>Department of Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Saccardi, Riccardo" sort="Saccardi, Riccardo" uniqKey="Saccardi R" first="Riccardo" last="Saccardi">Riccardo Saccardi</name><affiliation><nlm:affiliation>Department of Hematology, Careggi University Hospital, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Den Hoogen, Frank H" sort="Van Den Hoogen, Frank H" uniqKey="Van Den Hoogen F" first="Frank H" last="Van Den Hoogen">Frank H. Van Den Hoogen</name><affiliation><nlm:affiliation>Department of Rheumatology, Maartenskliniek, Nijmegen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fibbe, Willem E" sort="Fibbe, Willem E" uniqKey="Fibbe W" first="Willem E" last="Fibbe">Willem E. Fibbe</name><affiliation><nlm:affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation><nlm:affiliation>Hematology/Transplantation, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Tyndall, Alan" sort="Tyndall, Alan" uniqKey="Tyndall A" first="Alan" last="Tyndall">Alan Tyndall</name><affiliation><nlm:affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Autografts</term><term>Cyclophosphamide (administration & dosage)</term><term>Cyclophosphamide (adverse effects)</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation (adverse effects)</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Scleroderma, Diffuse (drug therapy)</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cyclophosphamide</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cyclophosphamide</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Scleroderma, Diffuse</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Autografts</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Survival Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25058083</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>25</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3598</ISSN><JournalIssue CitedMedium="Internet"><Volume>311</Volume><Issue>24</Issue><PubDate><Year>2014</Year><Month>Jun</Month><Day>25</Day></PubDate></JournalIssue><Title>JAMA</Title><ISOAbbreviation>JAMA</ISOAbbreviation></Journal><ArticleTitle>Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.</ArticleTitle><Pagination><MedlinePgn>2490-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jama.2014.6368</ELocationID><Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To compare efficacy and safety of HSCT vs 12 successive monthly intravenous pulses of cyclophosphamide.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">The Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3, multicenter, randomized (1:1), open-label, parallel-group, clinical trial conducted in 10 countries at 29 centers with access to a European Group for Blood and Marrow Transplantation-registered transplant facility. From March 2001 to October 2009, 156 patients with early diffuse cutaneous systemic sclerosis were recruited and followed up until October 31, 2013.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">HSCT vs intravenous pulse cyclophosphamide.</AbstractText><AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">The primary end point was event-free survival, defined as time from randomization until the occurrence of death or persistent major organ failure.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 156 patients were randomly assigned to receive HSCT (n = 79) or cyclophosphamide (n = 77). During a median follow-up of 5.8 years, 53 events occurred: 22 in the HSCT group (19 deaths and 3 irreversible organ failures) and 31 in the control group (23 deaths and 8 irreversible organ failures). During the first year, there were more events in the HSCT group (13 events [16.5%], including 8 treatment-related deaths) than in the control group (8 events [10.4%], with no treatment-related deaths). At 2 years, 14 events (17.7%) had occurred cumulatively in the HSCT group vs 14 events (18.2%) in the control group; at 4 years, 15 events (19%) had occurred cumulatively in the HSCT group vs 20 events (26%) in the control group. Time-varying hazard ratios (modeled with treatment × time interaction) for event-free survival were 0.35 (95% CI, 0.16-0.74) at 2 years and 0.34 (95% CI, 0.16-0.74) at 4 years.</AbstractText><AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Among patients with early diffuse cutaneous systemic sclerosis, HSCT was associated with increased treatment-related mortality in the first year after treatment. However, HCST conferred a significant long-term event-free survival benefit.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">isrctn.org Identifier: ISRCTN54371254.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Laar</LastName><ForeName>Jacob M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farge</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Internal Medicine and Vascular Disease Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sont</LastName><ForeName>Jacob K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naraghi</LastName><ForeName>Kamran</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, The James Cook University Hospital, Middlesbrough, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marjanovic</LastName><ForeName>Zora</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Service d'Hématologie Clinique et de Thérapie Cellulaire, AP-HP Hôpital Saint-Antoine, Paris 6 University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larghero</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clinical Investigation Center in Biotherapies and Cell Therapy Unit, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schuerwegh</LastName><ForeName>Annemie J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marijt</LastName><ForeName>Erik W A</ForeName><Initials>EW</Initials><AffiliationInfo><Affiliation>Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vonk</LastName><ForeName>Madelon C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schattenberg</LastName><ForeName>Anton V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Department of Hematology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matucci-Cerinic</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Division of Rheumatology AOUC and Department of Experimental and Clinical Medicine, University of Florence, Florence.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voskuyl</LastName><ForeName>Alexandre E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, VU University Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Loosdrecht</LastName><ForeName>Arjan A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daikeler</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kötter</LastName><ForeName>Ina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmalzing</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine II, University Hospital, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lioure</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service d'Hématologie et d'Oncologie, Unité de Greffe de Cellules Souches Hématopoïétiques, Centre Hospitalier Universitaire Hautepierre, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiner</LastName><ForeName>Stefan M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>2.Medizinische Abteilung Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kreuter</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Oberhausen,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deligny</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service Médecine Interne, Hôpital Pierre Zobda Quitman, Fort-de France, Martinique.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durand</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine CHU La Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emery</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machold</LastName><ForeName>Klaus P</ForeName><Initials>KP</Initials><AffiliationInfo><Affiliation>Klinische Abteilung für Rheumatologie, Medizinische Universität, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarrot-Reynauld</LastName><ForeName>Francoise</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Pôle Pluridisciplinaire de Médecine, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warnatz</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adoue</LastName><ForeName>Daniel F P</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>Service Médecine Interne, Centre Hospitalier Universitaire Toulouse.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Constans</LastName><ForeName>Joël</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service Médecine Interne et Médecine Vasculaire, Hôpital St-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tony</LastName><ForeName>Hans-Peter</ForeName><Initials>HP</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, University of Würzburg Medical Center, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del Papa</LastName><ForeName>Nicoletta</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Day Hospital Reumatologia, Ospedale G. Pini, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fassas</LastName><ForeName>Athanasios</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Hematology, Cell and Gene Therapy Center, George Papanicolaou Hospital, Thessaloniki, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Himsel</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Launay</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Service de Médecine Interne, Hôpital Claude-Huriez, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lo Monaco</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section and Unit of Rheumatology, Department of Medical Sciences, University of Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Philippe</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service de Médecine Interne, Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quéré</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Montpellier University Hospital, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rich</LastName><ForeName>Éric</ForeName><Initials>É</Initials><AffiliationInfo><Affiliation>Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westhovens</LastName><ForeName>Rene</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Skeletal Biology and Engineering Research Center, Department of Development and Regeneration KU Leuven, Rheumatology, University Hospitals, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffiths</LastName><ForeName>Bridget</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Freeman Hospital, Newcastle upon Tyne, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saccardi</LastName><ForeName>Riccardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Hematology, Careggi University Hospital, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van den Hoogen</LastName><ForeName>Frank H</ForeName><Initials>FH</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Maartenskliniek, Nijmegen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fibbe</LastName><ForeName>Willem E</ForeName><Initials>WE</Initials><AffiliationInfo><Affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Socié</LastName><ForeName>Gérard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hematology/Transplantation, AP-HP Hôpital Saint-Louis, Paris 7 University, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gratwohl</LastName><ForeName>Alois</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Hematology, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyndall</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EBMT/EULAR Scleroderma Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ISRCTN</DataBankName><AccessionNumberList><AccessionNumber>ISRCTN54371254</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>18475</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D017428">Clinical Trial, Phase III</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA</MedlineTA><NlmUniqueID>7501160</NlmUniqueID><ISSNLinking>0098-7484</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>8N3DW7272P</RegistryNumber><NameOfSubstance UI="D003520">Cyclophosphamide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Rheumatol. 2014 Aug;10(8):444</RefSource><PMID Version="1">25023453</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>JAMA. 2014 Nov 5;312(17):1803-4</RefSource><PMID Version="1">25369498</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>JAMA. 2014 Jun 25;311(24):2485-7</RefSource><PMID Version="1">25058081</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>JAMA. 2014 Nov 5;312(17):1803</RefSource><PMID Version="1">25369497</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064592" MajorTopicYN="N">Autografts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003520" MajorTopicYN="N">Cyclophosphamide</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018380" MajorTopicYN="Y">Hematopoietic Stem Cell Transplantation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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