A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.
Identifieur interne : 000350 ( PubMed/Corpus ); précédent : 000349; suivant : 000351A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.
Auteurs : Juliane Hellhammer ; Dominic Vogt ; Nadin Franz ; Ulla Freitas ; David RutenbergSource :
- Lipids in health and disease [ 1476-511X ] ; 2014.
English descriptors
- KwdEn :
- Administration, Oral, Adrenocorticotropic Hormone (blood), Adult, Dietary Supplements, Humans, Hydrocortisone (blood), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (metabolism), Male, Middle Aged, Phosphatidic Acids (administration & dosage), Phosphatidylserines (administration & dosage), Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (metabolism), Plant Extracts (administration & dosage), Soybeans (chemistry), Stress, Psychological (blood), Stress, Psychological (drug therapy), Young Adult.
- MESH :
- chemical , administration & dosage : Phosphatidic Acids, Phosphatidylserines, Plant Extracts.
- chemical , blood : Adrenocorticotropic Hormone, Hydrocortisone.
- blood : Stress, Psychological.
- chemistry : Soybeans.
- drug effects : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- drug therapy : Stress, Psychological.
- metabolism : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Administration, Oral, Adult, Dietary Supplements, Humans, Male, Middle Aged, Young Adult.
Abstract
Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA). Prolonged stress first induces a hyper-activation of the HPAA, which then can be followed by a state of hypo-activation.The aim of this study was to examine effects of an oral supplementation with 400 mg PS & 400 mg PA (PAS 400) per day on the endocrine stress response (ACTH, saliva and serum cortisol) to a psychosocial stressor. A special focus was to analyze subgroups of low versus high chronically stressed subjects as well as to test efficacy of 200 mg PS & 200 mg PA (PAS 200).
DOI: 10.1186/1476-511X-13-121
PubMed: 25081826
Links to Exploration step
pubmed:25081826Le document en format XML
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uniqKey="Freitas U" first="Ulla" last="Freitas">Ulla Freitas</name></author><author><name sortKey="Rutenberg, David" sort="Rutenberg, David" uniqKey="Rutenberg D" first="David" last="Rutenberg">David Rutenberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25081826</idno><idno type="pmid">25081826</idno><idno type="doi">10.1186/1476-511X-13-121</idno><idno type="wicri:Area/PubMed/Corpus">000350</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000350</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.</title><author><name sortKey="Hellhammer, Juliane" sort="Hellhammer, Juliane" uniqKey="Hellhammer J" first="Juliane" last="Hellhammer">Juliane Hellhammer</name><affiliation><nlm:affiliation>Diagnostic Assessment and Clinical Research Organization (Daacro) GmbH & Co, KG, Science Park Trier, Max-Planck-Str, 22, 54296 Trier, Germany. hellhammer@daacro.de.</nlm:affiliation></affiliation></author><author><name sortKey="Vogt, Dominic" sort="Vogt, Dominic" uniqKey="Vogt D" first="Dominic" last="Vogt">Dominic Vogt</name></author><author><name sortKey="Franz, Nadin" sort="Franz, Nadin" uniqKey="Franz N" first="Nadin" last="Franz">Nadin Franz</name></author><author><name sortKey="Freitas, Ulla" sort="Freitas, Ulla" uniqKey="Freitas U" first="Ulla" last="Freitas">Ulla Freitas</name></author><author><name sortKey="Rutenberg, David" sort="Rutenberg, David" uniqKey="Rutenberg D" first="David" last="Rutenberg">David Rutenberg</name></author></analytic><series><title level="j">Lipids in health and disease</title><idno type="eISSN">1476-511X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adrenocorticotropic Hormone (blood)</term><term>Adult</term><term>Dietary Supplements</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hypothalamo-Hypophyseal System (drug effects)</term><term>Hypothalamo-Hypophyseal System (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Phosphatidic Acids (administration & dosage)</term><term>Phosphatidylserines (administration & dosage)</term><term>Pituitary-Adrenal System (drug effects)</term><term>Pituitary-Adrenal System (metabolism)</term><term>Plant Extracts (administration & dosage)</term><term>Soybeans (chemistry)</term><term>Stress, Psychological (blood)</term><term>Stress, Psychological (drug therapy)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Phosphatidic Acids</term><term>Phosphatidylserines</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Dietary Supplements</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA). Prolonged stress first induces a hyper-activation of the HPAA, which then can be followed by a state of hypo-activation.The aim of this study was to examine effects of an oral supplementation with 400 mg PS & 400 mg PA (PAS 400) per day on the endocrine stress response (ACTH, saliva and serum cortisol) to a psychosocial stressor. A special focus was to analyze subgroups of low versus high chronically stressed subjects as well as to test efficacy of 200 mg PS & 200 mg PA (PAS 200).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25081826</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>20</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>05</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1476-511X</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><PubDate><Year>2014</Year><Month>Jul</Month><Day>31</Day></PubDate></JournalIssue><Title>Lipids in health and disease</Title><ISOAbbreviation>Lipids Health Dis</ISOAbbreviation></Journal><ArticleTitle>A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.</ArticleTitle><Pagination><MedlinePgn>121</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1476-511X-13-121</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA). Prolonged stress first induces a hyper-activation of the HPAA, which then can be followed by a state of hypo-activation.The aim of this study was to examine effects of an oral supplementation with 400 mg PS & 400 mg PA (PAS 400) per day on the endocrine stress response (ACTH, saliva and serum cortisol) to a psychosocial stressor. A special focus was to analyze subgroups of low versus high chronically stressed subjects as well as to test efficacy of 200 mg PS & 200 mg PA (PAS 200).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">75 healthy male volunteers were enrolled for this double-blind, placebo-controlled study, stratified by chronic stress level, and randomly allocated to one of three study arms (placebo, PAS 200 and PAS 400 per day, respectively). Study supplementation was administered for 42 days for each participant. Chronic stress was measured with the Trier Inventory for Chronic Stress (TICS), and subgroups of high and low chronic stress were differentiated by median values as provided by the TICS authors. A six week period of supplementation was followed by an acute stress test (Trier Social Stress Test - TSST).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Chronic stress levels and other baseline measures did not differ between treatment groups (all p>0.05). Acute stress was successfully induced by the TSST and resulted in a hyper-responsivity of the HPAA in chronically stressed subjects. Compared to placebo, a supplementation with a daily dose of PAS 400 was effective in normalizing the ACTH (p=0.010), salivary (p=0.043) and serum cortisol responses (p=0.035) to the TSST in chronically high but not in low stressed subjects (all p>0.05). Compared to placebo, supplementation with PAS 200 did not result in any significant differences in these variables (all p>0.05). There were no significant effects of supplementation with PAS on heart rate, pulse transit time, or psychological stress response (all p>0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In chronically stressed subjects, a supplementation with PAS 400 (MemreePlus™) can normalize the hyper-responsivity of the HPAA to an acute stressor.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND"></AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">DRKS-ID: DRKS00005125.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Juliane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Diagnostic Assessment and Clinical Research Organization (Daacro) GmbH & Co, KG, Science Park Trier, Max-Planck-Str, 22, 54296 Trier, Germany. hellhammer@daacro.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogt</LastName><ForeName>Dominic</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Franz</LastName><ForeName>Nadin</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Freitas</LastName><ForeName>Ulla</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Rutenberg</LastName><ForeName>David</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>DRKS</DataBankName><AccessionNumberList><AccessionNumber>DRKS00005125</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lipids Health 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Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010712" MajorTopicYN="N">Phosphatidic Acids</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010718" MajorTopicYN="N">Phosphatidylserines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4237891</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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|clé= pubmed:25081826
|texte= A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
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