Differentiation of prostatitis and prostate cancer using the Prostate Imaging-Reporting and Data System (PI-RADS).
Identifieur interne : 000114 ( PubMed/Corpus ); précédent : 000113; suivant : 000115Differentiation of prostatitis and prostate cancer using the Prostate Imaging-Reporting and Data System (PI-RADS).
Auteurs : Michael Meier-Schroers ; Guido Kukuk ; Karsten Wolter ; Georges Decker ; Stefan Fischer ; Christian Marx ; Frank Traeber ; Alois Martin Sprinkart ; Wolfgang Block ; Hans Heinz Schild ; Winfried WillinekSource :
- European journal of radiology [ 1872-7727 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Contrast Media, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Humans, Image Enhancement, Magnetic Resonance Imaging (methods), Magnetic Resonance Spectroscopy, Male, Prostatic Neoplasms (diagnostic imaging), Prostatic Neoplasms (pathology), Prostatitis (diagnostic imaging), Radiology Information Systems, Reproducibility of Results.
- MESH :
- chemical : Contrast Media.
- diagnostic imaging : Prostatic Neoplasms, Prostatitis.
- methods : Magnetic Resonance Imaging.
- pathology : Prostatic Neoplasms.
- Aged, Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Humans, Image Enhancement, Magnetic Resonance Spectroscopy, Male, Radiology Information Systems, Reproducibility of Results.
Abstract
To determine if prostate cancer (PCa) and prostatitis can be differentiated by using PI-RADS.
DOI: 10.1016/j.ejrad.2016.04.014
PubMed: 27235878
Links to Exploration step
pubmed:27235878Le document en format XML
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Electronic address: guido.kukuk@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Wolter, Karsten" sort="Wolter, Karsten" uniqKey="Wolter K" first="Karsten" last="Wolter">Karsten Wolter</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: karsten.wolter@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Decker, Georges" sort="Decker, Georges" uniqKey="Decker G" first="Georges" last="Decker">Georges Decker</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: georges.decker@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Stefan" sort="Fischer, Stefan" uniqKey="Fischer S" first="Stefan" last="Fischer">Stefan Fischer</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: stefan.fischer@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Marx, Christian" sort="Marx, Christian" uniqKey="Marx C" first="Christian" last="Marx">Christian Marx</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: christian.marx@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Traeber, Frank" sort="Traeber, Frank" uniqKey="Traeber F" first="Frank" last="Traeber">Frank Traeber</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: frank.traeber@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Sprinkart, Alois Martin" sort="Sprinkart, Alois Martin" uniqKey="Sprinkart A" first="Alois Martin" last="Sprinkart">Alois Martin Sprinkart</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: sprinkart@uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Block, Wolfgang" sort="Block, Wolfgang" uniqKey="Block W" first="Wolfgang" last="Block">Wolfgang Block</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str 25, 53127 Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schild, Hans Heinz" sort="Schild, Hans Heinz" uniqKey="Schild H" first="Hans Heinz" last="Schild">Hans Heinz Schild</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: hans.schild@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Willinek, Winfried" sort="Willinek, Winfried" uniqKey="Willinek W" first="Winfried" last="Willinek">Winfried Willinek</name><affiliation><nlm:affiliation>Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Hospital of the Barmherzige Brüder Trier, Nordallee 1, 54292 Trier, Germany. Electronic address: w.willinek@bk-trier.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27235878</idno><idno type="pmid">27235878</idno><idno type="doi">10.1016/j.ejrad.2016.04.014</idno><idno type="wicri:Area/PubMed/Corpus">000114</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000114</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differentiation of prostatitis and prostate cancer using the Prostate Imaging-Reporting and Data System (PI-RADS).</title><author><name sortKey="Meier Schroers, Michael" sort="Meier Schroers, Michael" uniqKey="Meier Schroers M" first="Michael" last="Meier-Schroers">Michael Meier-Schroers</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: michael.meier@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Kukuk, Guido" sort="Kukuk, Guido" uniqKey="Kukuk G" first="Guido" last="Kukuk">Guido Kukuk</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: guido.kukuk@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Wolter, Karsten" sort="Wolter, Karsten" uniqKey="Wolter K" first="Karsten" last="Wolter">Karsten Wolter</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: karsten.wolter@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Decker, Georges" sort="Decker, Georges" uniqKey="Decker G" first="Georges" last="Decker">Georges Decker</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: georges.decker@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Stefan" sort="Fischer, Stefan" uniqKey="Fischer S" first="Stefan" last="Fischer">Stefan Fischer</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: stefan.fischer@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Marx, Christian" sort="Marx, Christian" uniqKey="Marx C" first="Christian" last="Marx">Christian Marx</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: christian.marx@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Traeber, Frank" sort="Traeber, Frank" uniqKey="Traeber F" first="Frank" last="Traeber">Frank Traeber</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: frank.traeber@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Sprinkart, Alois Martin" sort="Sprinkart, Alois Martin" uniqKey="Sprinkart A" first="Alois Martin" last="Sprinkart">Alois Martin Sprinkart</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: sprinkart@uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Block, Wolfgang" sort="Block, Wolfgang" uniqKey="Block W" first="Wolfgang" last="Block">Wolfgang Block</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str 25, 53127 Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schild, Hans Heinz" sort="Schild, Hans Heinz" uniqKey="Schild H" first="Hans Heinz" last="Schild">Hans Heinz Schild</name><affiliation><nlm:affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: hans.schild@ukb.uni-bonn.de.</nlm:affiliation></affiliation></author><author><name sortKey="Willinek, Winfried" sort="Willinek, Winfried" uniqKey="Willinek W" first="Winfried" last="Willinek">Winfried Willinek</name><affiliation><nlm:affiliation>Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Hospital of the Barmherzige Brüder Trier, Nordallee 1, 54292 Trier, Germany. Electronic address: w.willinek@bk-trier.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of radiology</title><idno type="eISSN">1872-7727</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Contrast Media</term><term>Diagnosis, Differential</term><term>Diffusion Magnetic Resonance Imaging</term><term>Humans</term><term>Image Enhancement</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Prostatic Neoplasms (diagnostic imaging)</term><term>Prostatic Neoplasms (pathology)</term><term>Prostatitis (diagnostic imaging)</term><term>Radiology Information Systems</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Contrast Media</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Prostatic Neoplasms</term><term>Prostatitis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Diffusion Magnetic Resonance Imaging</term><term>Humans</term><term>Image Enhancement</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Radiology Information Systems</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine if prostate cancer (PCa) and prostatitis can be differentiated by using PI-RADS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27235878</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>29</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7727</ISSN><JournalIssue CitedMedium="Internet"><Volume>85</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>European journal of radiology</Title><ISOAbbreviation>Eur J Radiol</ISOAbbreviation></Journal><ArticleTitle>Differentiation of prostatitis and prostate cancer using the Prostate Imaging-Reporting and Data System (PI-RADS).</ArticleTitle><Pagination><MedlinePgn>1304-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejrad.2016.04.014</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0720-048X(16)30135-8</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To determine if prostate cancer (PCa) and prostatitis can be differentiated by using PI-RADS.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">3T MR images of 68 patients with 85 cancer suspicious lesions were analyzed. The findings were correlated with histopathology. T2w imaging (T2WI), diffusion weighted imaging (DWI), dynamic contrast enhancement (DCE), and MR-Spectroscopy (MRS) were acquired. Every lesion was given a single PI-RADS score for each parameter, as well as a sum score and a PI-RADS v2 score. Furthermore, T2-morphology, ADC-value, perfusion type, citrate/choline-level, and localization were evaluated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">44 of 85 lesions showed PCa (51.8%), 21 chronic prostatitis (24.7%), and 20 other benign tissue such as hyperplasia or fibromuscular tissue (23.5%). The single PI-RADS score for T2WI, DWI, DCE, as well as the aggregated score including and not including MRS, and the PI-RADS v2-score were all significantly higher for PCa than for prostatitis or other tissue (p<0.001). The single PI-RADS score for MRS and the PI-RADS sum score including MRS were significantly higher for prostatitis than for other tissue (p=0.029 and p=0.020), whereas the other parameters were not different. Prostatitis usually presented borderline pathological PI-RADS scores, showed restricted diffusion with ADC≥900mm(2)/s in 100% of cases, was more often indistinctly hypointense on T2WI (66.7%), and localized in the transitional zone (57.1%). An ADC≥900mm(2)/s achieved the highest predictive value for prostatitis (AUC=0.859).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Prostatitis can be differentiated from PCa using PI-RADS, since all available parameters are more distinct in cases of cancer. However, there is significant overlap between prostatitis and other benign findings, thus PI-RADS is only suitable to a limited extent for the primary assessment of prostatitis. Restricted diffusion with ADC≥900mm(2)/s is believed to be a good indicator for prostatitis. MRS can help to distinguish between prostatitis and other tissue.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meier-Schroers</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: michael.meier@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kukuk</LastName><ForeName>Guido</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: guido.kukuk@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolter</LastName><ForeName>Karsten</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: karsten.wolter@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Decker</LastName><ForeName>Georges</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: georges.decker@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: stefan.fischer@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marx</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: christian.marx@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traeber</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: frank.traeber@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sprinkart</LastName><ForeName>Alois Martin</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: sprinkart@uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Block</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str 25, 53127 Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schild</LastName><ForeName>Hans Heinz</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. Electronic address: hans.schild@ukb.uni-bonn.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willinek</LastName><ForeName>Winfried</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Hospital of the Barmherzige Brüder Trier, Nordallee 1, 54292 Trier, Germany. Electronic address: w.willinek@bk-trier.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Eur J Radiol</MedlineTA><NlmUniqueID>8106411</NlmUniqueID><ISSNLinking>0720-048X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003287" MajorTopicYN="N">Contrast Media</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D038524" MajorTopicYN="N">Diffusion Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007089" MajorTopicYN="N">Image Enhancement</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011471" MajorTopicYN="N">Prostatic Neoplasms</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011472" MajorTopicYN="N">Prostatitis</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011873" MajorTopicYN="Y">Radiology Information Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">PI-RADS</Keyword><Keyword MajorTopicYN="N">Prostate</Keyword><Keyword MajorTopicYN="N">Prostate cancer</Keyword><Keyword MajorTopicYN="N">Prostatitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>04</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27235878</ArticleId><ArticleId IdType="pii">S0720-048X(16)30135-8</ArticleId><ArticleId IdType="doi">10.1016/j.ejrad.2016.04.014</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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