The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.
Identifieur interne : 000A19 ( Ncbi/Merge ); précédent : 000A18; suivant : 000A20The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.
Auteurs : Iris L. Maas [Allemagne] ; Sandra Nolte [Australie] ; Otto B. Walter [Allemagne] ; Thomas Berger [Suisse] ; Martin Hautzinger [Allemagne] ; Fritz Hohagen [Allemagne] ; Wolfgang Lutz [Allemagne] ; Björn Meyer [Royaume-Uni] ; Johanna Schröder [Allemagne] ; Christina Sp Th [Allemagne] ; Jan Philipp Klein [Allemagne] ; Steffen Moritz [Allemagne] ; Matthias Rose [États-Unis]Source :
- Journal of clinical epidemiology [ 1878-5921 ] ; 2016.
Abstract
To compare treatment effect estimates obtained from a regression discontinuity (RD) design with results from an actual randomized controlled trial (RCT).
DOI: 10.1016/j.jclinepi.2016.11.008
PubMed: 27865902
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Maas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nolte, Sandra" sort="Nolte, Sandra" uniqKey="Nolte S" first="Sandra" last="Nolte">Sandra Nolte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125</wicri:regionArea><wicri:noRegion>Victoria 3125</wicri:noRegion></affiliation></author><author><name sortKey="Walter, Otto B" sort="Walter, Otto B" uniqKey="Walter O" first="Otto B" last="Walter">Otto B. Walter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Berger, Thomas" sort="Berger, Thomas" uniqKey="Berger T" first="Thomas" last="Berger">Thomas Berger</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, Bern 3012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, Bern 3012</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Schleichstrasse 4, Tübingen 72074, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Schleichstrasse 4, Tübingen 72074</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Hohagen, Fritz" sort="Hohagen, Fritz" uniqKey="Hohagen F" first="Fritz" last="Hohagen">Fritz Hohagen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Lutz, Wolfgang" sort="Lutz, Wolfgang" uniqKey="Lutz W" first="Wolfgang" last="Lutz">Wolfgang Lutz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, University of Trier, Trier 54286, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, University of Trier, Trier 54286</wicri:regionArea><wicri:noRegion>54286</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Meyer, Bjorn" sort="Meyer, Bjorn" uniqKey="Meyer B" first="Björn" last="Meyer">Björn Meyer</name><affiliation wicri:level="1"><nlm:affiliation>GAIA AG, Gertigstrasse 12-14, Hamburg 22303, Germany; Department of Psychology, City University London, Northampton Square, London EC1V 0HB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GAIA AG, Gertigstrasse 12-14, Hamburg 22303, Germany; Department of Psychology, City University London, Northampton Square, London EC1V 0HB</wicri:regionArea><wicri:noRegion>London EC1V 0HB</wicri:noRegion></affiliation></author><author><name sortKey="Schroder, Johanna" sort="Schroder, Johanna" uniqKey="Schroder J" first="Johanna" last="Schröder">Johanna Schröder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Sp Th, Christina" sort="Sp Th, Christina" uniqKey="Sp Th C" first="Christina" last="Sp Th">Christina Sp Th</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Jan Philipp" sort="Klein, Jan Philipp" uniqKey="Klein J" first="Jan Philipp" last="Klein">Jan Philipp Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Moritz, Steffen" sort="Moritz, Steffen" uniqKey="Moritz S" first="Steffen" last="Moritz">Steffen Moritz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Rose, Matthias" sort="Rose, Matthias" uniqKey="Rose M" first="Matthias" last="Rose">Matthias Rose</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Outcomes Measurement Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address: matthias.rose@charite.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Outcomes Measurement Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27865902</idno><idno type="pmid">27865902</idno><idno type="doi">10.1016/j.jclinepi.2016.11.008</idno><idno type="wicri:Area/PubMed/Corpus">000051</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000051</idno><idno type="wicri:Area/PubMed/Curation">000051</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000051</idno><idno type="wicri:Area/PubMed/Checkpoint">000051</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000051</idno><idno type="wicri:Area/Ncbi/Merge">000A19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.</title><author><name sortKey="Maas, Iris L" sort="Maas, Iris L" uniqKey="Maas I" first="Iris L" last="Maas">Iris L. Maas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nolte, Sandra" sort="Nolte, Sandra" uniqKey="Nolte S" first="Sandra" last="Nolte">Sandra Nolte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125</wicri:regionArea><wicri:noRegion>Victoria 3125</wicri:noRegion></affiliation></author><author><name sortKey="Walter, Otto B" sort="Walter, Otto B" uniqKey="Walter O" first="Otto B" last="Walter">Otto B. Walter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Berger, Thomas" sort="Berger, Thomas" uniqKey="Berger T" first="Thomas" last="Berger">Thomas Berger</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, Bern 3012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, Bern 3012</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Schleichstrasse 4, Tübingen 72074, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Schleichstrasse 4, Tübingen 72074</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Hohagen, Fritz" sort="Hohagen, Fritz" uniqKey="Hohagen F" first="Fritz" last="Hohagen">Fritz Hohagen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Lutz, Wolfgang" sort="Lutz, Wolfgang" uniqKey="Lutz W" first="Wolfgang" last="Lutz">Wolfgang Lutz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, University of Trier, Trier 54286, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, University of Trier, Trier 54286</wicri:regionArea><wicri:noRegion>54286</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Meyer, Bjorn" sort="Meyer, Bjorn" uniqKey="Meyer B" first="Björn" last="Meyer">Björn Meyer</name><affiliation wicri:level="1"><nlm:affiliation>GAIA AG, Gertigstrasse 12-14, Hamburg 22303, Germany; Department of Psychology, City University London, Northampton Square, London EC1V 0HB, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GAIA AG, Gertigstrasse 12-14, Hamburg 22303, Germany; Department of Psychology, City University London, Northampton Square, London EC1V 0HB</wicri:regionArea><wicri:noRegion>London EC1V 0HB</wicri:noRegion></affiliation></author><author><name sortKey="Schroder, Johanna" sort="Schroder, Johanna" uniqKey="Schroder J" first="Johanna" last="Schröder">Johanna Schröder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Sp Th, Christina" sort="Sp Th, Christina" uniqKey="Sp Th C" first="Christina" last="Sp Th">Christina Sp Th</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Jan Philipp" sort="Klein, Jan Philipp" uniqKey="Klein J" first="Jan Philipp" last="Klein">Jan Philipp Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538</wicri:regionArea><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>23538</wicri:noRegion><wicri:noRegion>Lübeck 23538</wicri:noRegion></affiliation></author><author><name sortKey="Moritz, Steffen" sort="Moritz, Steffen" uniqKey="Moritz S" first="Steffen" last="Moritz">Steffen Moritz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Rose, Matthias" sort="Rose, Matthias" uniqKey="Rose M" first="Matthias" last="Rose">Matthias Rose</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Outcomes Measurement Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address: matthias.rose@charite.de.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Outcomes Measurement Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Journal of clinical epidemiology</title><idno type="eISSN">1878-5921</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To compare treatment effect estimates obtained from a regression discontinuity (RD) design with results from an actual randomized controlled trial (RCT).</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27865902</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>01</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5921</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Nov</Month><Day>16</Day></PubDate></JournalIssue><Title>Journal of clinical epidemiology</Title><ISOAbbreviation>J Clin Epidemiol</ISOAbbreviation></Journal><ArticleTitle>The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0895-4356(16)30682-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jclinepi.2016.11.008</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To compare treatment effect estimates obtained from a regression discontinuity (RD) design with results from an actual randomized controlled trial (RCT).</AbstractText><AbstractText Label="STUDY DESIGN AND SETTING" NlmCategory="METHODS">Data from an RCT (EVIDENT), which studied the effect of an Internet intervention on depressive symptoms measured with the Patient Health Questionnaire (PHQ-9), were used to perform an RD analysis, in which treatment allocation was determined by a cutoff value at baseline (PHQ-9 = 10). A linear regression model was fitted to the data, selecting participants above the cutoff who had received the intervention (n = 317) and control participants below the cutoff (n = 187). Outcome was PHQ-9 sum score 12 weeks after baseline. Robustness of the effect estimate was studied; the estimate was compared with the RCT treatment effect.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The final regression model showed a regression coefficient of -2.29 [95% confidence interval (CI): -3.72 to -.85] compared with a treatment effect found in the RCT of -1.57 (95% CI: -2.07 to -1.07).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Although the estimates obtained from two designs are not equal, their confidence intervals overlap, suggesting that an RD design can be a valid alternative for RCTs. This finding is particularly important for situations where an RCT may not be feasible or ethical as is often the case in clinical research settings.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maas</LastName><ForeName>Iris L</ForeName><Initials>IL</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolte</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walter</LastName><ForeName>Otto B</ForeName><Initials>OB</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, Bern 3012, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hautzinger</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Schleichstrasse 4, Tübingen 72074, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hohagen</LastName><ForeName>Fritz</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lutz</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Trier, Trier 54286, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Björn</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>GAIA AG, Gertigstrasse 12-14, Hamburg 22303, Germany; Department of Psychology, City University London, Northampton Square, London EC1V 0HB, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schröder</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Späth</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>Jan Philipp</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Lübeck University, Ratzeburger Allee 160, Lübeck 23538, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moritz</LastName><ForeName>Steffen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Outcomes Measurement Science, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address: matthias.rose@charite.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Epidemiol</MedlineTA><NlmUniqueID>8801383</NlmUniqueID><ISSNLinking>0895-4356</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Causal inference</Keyword><Keyword MajorTopicYN="N">Depression</Keyword><Keyword MajorTopicYN="N">Nonrandom group assignment</Keyword><Keyword MajorTopicYN="N">PHQ-9</Keyword><Keyword MajorTopicYN="N">Randomized controlled trials</Keyword><Keyword MajorTopicYN="N">Regression discontinuity design</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27865902</ArticleId><ArticleId IdType="pii">S0895-4356(16)30682-5</ArticleId><ArticleId IdType="doi">10.1016/j.jclinepi.2016.11.008</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Berlin</li><li>Canton de Berne</li><li>District de Tübingen</li><li>Hambourg</li><li>Massachusetts</li><li>Rhénanie-Palatinat</li></region><settlement><li>Berlin</li><li>Berne</li><li>Hambourg</li><li>Trèves (Allemagne)</li><li>Tübingen</li></settlement><orgName><li>Université de Berne</li><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Maas, Iris L" sort="Maas, Iris L" uniqKey="Maas I" first="Iris L" last="Maas">Iris L. Maas</name></region><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><name sortKey="Hohagen, Fritz" sort="Hohagen, Fritz" uniqKey="Hohagen F" first="Fritz" last="Hohagen">Fritz Hohagen</name><name sortKey="Klein, Jan Philipp" sort="Klein, Jan Philipp" uniqKey="Klein J" first="Jan Philipp" last="Klein">Jan Philipp Klein</name><name sortKey="Lutz, Wolfgang" sort="Lutz, Wolfgang" uniqKey="Lutz W" first="Wolfgang" last="Lutz">Wolfgang Lutz</name><name sortKey="Moritz, Steffen" sort="Moritz, Steffen" uniqKey="Moritz S" first="Steffen" last="Moritz">Steffen Moritz</name><name sortKey="Schroder, Johanna" sort="Schroder, Johanna" uniqKey="Schroder J" first="Johanna" last="Schröder">Johanna Schröder</name><name sortKey="Sp Th, Christina" sort="Sp Th, Christina" uniqKey="Sp Th C" first="Christina" last="Sp Th">Christina Sp Th</name><name sortKey="Walter, Otto B" sort="Walter, Otto B" uniqKey="Walter O" first="Otto B" last="Walter">Otto B. Walter</name></country><country name="Australie"><noRegion><name sortKey="Nolte, Sandra" sort="Nolte, Sandra" uniqKey="Nolte S" first="Sandra" last="Nolte">Sandra Nolte</name></noRegion></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Berger, Thomas" sort="Berger, Thomas" uniqKey="Berger T" first="Thomas" last="Berger">Thomas Berger</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Meyer, Bjorn" sort="Meyer, Bjorn" uniqKey="Meyer B" first="Björn" last="Meyer">Björn Meyer</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Rose, Matthias" sort="Rose, Matthias" uniqKey="Rose M" first="Matthias" last="Rose">Matthias Rose</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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