Exogenous cortisol enhances aggressive behavior in females, but not in males.
Identifieur interne : 000B61 ( Main/Exploration ); précédent : 000B60; suivant : 000B62Exogenous cortisol enhances aggressive behavior in females, but not in males.
Auteurs : Robina Böhnke [Allemagne] ; Katja Bertsch ; Menno R. Kruk ; Steffen Richter ; Ewald NaumannSource :
- Psychoneuroendocrinology [ 1873-3360 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aggression (drug effects), Female, Humans, Hydrocortisone (pharmacology), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (physiology), Male, Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (physiology), Saliva (chemistry), Sex Factors, Young Adult.
- MESH :
- chemical , pharmacology : Hydrocortisone.
- chemistry : Saliva.
- drug effects : Aggression, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adult, Female, Humans, Male, Sex Factors, Young Adult.
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis plays a major role in the development, elicitation, and enhancement of aggressive behavior in animals. Increasing evidence suggests that this is also true for humans. Here, we report on a study of the role of basal and acute HPA axis activity in a sample of 48 healthy male and female adults. We pharmacologically enhanced cortisol levels and used the Taylor Aggression Paradigm (TAP) to induce and measure aggression (divided into three blocks). Participants either received an oral dose of 20 mg hydrocortisone (cortisol group) or a placebo (placebo group). Half of each group received high or low levels of provocation with the TAP, respectively. Before, we assessed the cortisol awakening response as a trait measure of basal HPA axis activity. Participants in the cortisol group reacted more aggressively in the third block of the TAP compared to the placebo group. Furthermore, gender interacted with treatment: only females, but not males showed enhanced aggressive behavior after cortisol administration. There was no significant difference in males between the placebo and cortisol group. Basal HPA axis activity was negatively related to aggressive behavior, but again only in females and most strongly within the placebo group. This study provides the first evidence for a causal involvement of acute HPA axis activation in aggressive behavior in humans.
DOI: 10.1016/j.psyneuen.2010.01.004
PubMed: 20129738
Affiliations:
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Kruk</name></author><author><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name></author></analytic><series><title level="j">Psychoneuroendocrinology</title><idno type="eISSN">1873-3360</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aggression (drug effects)</term><term>Female</term><term>Humans</term><term>Hydrocortisone (pharmacology)</term><term>Hypothalamo-Hypophyseal System (drug effects)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Male</term><term>Pituitary-Adrenal System (drug effects)</term><term>Pituitary-Adrenal System (physiology)</term><term>Saliva (chemistry)</term><term>Sex Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aggression</term><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Sex Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The hypothalamic-pituitary-adrenal (HPA) axis plays a major role in the development, elicitation, and enhancement of aggressive behavior in animals. Increasing evidence suggests that this is also true for humans. Here, we report on a study of the role of basal and acute HPA axis activity in a sample of 48 healthy male and female adults. We pharmacologically enhanced cortisol levels and used the Taylor Aggression Paradigm (TAP) to induce and measure aggression (divided into three blocks). Participants either received an oral dose of 20 mg hydrocortisone (cortisol group) or a placebo (placebo group). Half of each group received high or low levels of provocation with the TAP, respectively. Before, we assessed the cortisol awakening response as a trait measure of basal HPA axis activity. Participants in the cortisol group reacted more aggressively in the third block of the TAP compared to the placebo group. Furthermore, gender interacted with treatment: only females, but not males showed enhanced aggressive behavior after cortisol administration. There was no significant difference in males between the placebo and cortisol group. Basal HPA axis activity was negatively related to aggressive behavior, but again only in females and most strongly within the placebo group. This study provides the first evidence for a causal involvement of acute HPA axis activation in aggressive behavior in humans.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Bertsch, Katja" sort="Bertsch, Katja" uniqKey="Bertsch K" first="Katja" last="Bertsch">Katja Bertsch</name><name sortKey="Kruk, Menno R" sort="Kruk, Menno R" uniqKey="Kruk M" first="Menno R" last="Kruk">Menno R. Kruk</name><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name><name sortKey="Richter, Steffen" sort="Richter, Steffen" uniqKey="Richter S" first="Steffen" last="Richter">Steffen Richter</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Bohnke, Robina" sort="Bohnke, Robina" uniqKey="Bohnke R" first="Robina" last="Böhnke">Robina Böhnke</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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