MALDI TOF imaging mass spectrometry in clinical pathology: a valuable tool for cancer diagnostics (review).
Identifieur interne : 000252 ( Main/Exploration ); précédent : 000251; suivant : 000253MALDI TOF imaging mass spectrometry in clinical pathology: a valuable tool for cancer diagnostics (review).
Auteurs : Jörg Kriegsmann [Allemagne] ; Mark Kriegsmann [Allemagne] ; Rita Casadonte [Allemagne]Source :
- International journal of oncology [ 1791-2423 ] ; 2015.
English descriptors
- KwdEn :
- Biomarkers, Tumor (analysis), Brain (metabolism), Freezing, Humans, Immunohistochemistry (methods), Neoplasms (diagnosis), Neoplasms (metabolism), Neoplasms (pathology), Paraffin Embedding, Pathology, Clinical (methods), Prognosis, Proteins (analysis), Specimen Handling (methods), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods), Tissue Array Analysis, Tissue Fixation (methods).
- MESH :
- chemical , analysis : Biomarkers, Tumor, Proteins.
- diagnosis : Neoplasms.
- metabolism : Brain, Neoplasms.
- methods : Immunohistochemistry, Pathology, Clinical, Specimen Handling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tissue Fixation.
- pathology : Neoplasms.
- Freezing, Humans, Paraffin Embedding, Prognosis, Tissue Array Analysis.
Abstract
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the advantages of mass spectrometry (proteomics), detection of numerous molecules, and spatial resolution in histological tissue sections and cytological preparations. This method allows the detection of proteins, peptides, lipids, carbohydrates or glycoconjugates and small molecules.Formalin-fixed paraffin-embedded tissue can also be investigated by IMS, thus, this method seems to be an ideal tool for cancer diagnostics and biomarker discovery. It may add information to the identification of tumor margins and tumor heterogeneity. The technique allows tumor typing, especially identification of the tumor of origin in metastatic tissue, as well as grading and may provide prognostic information. IMS is a valuable method for the identification of biomarkers and can complement histology, immunohistology and molecular pathology in various fields of histopathological diagnostics, especially with regard to identification and grading of tumors.
DOI: 10.3892/ijo.2014.2788
PubMed: 25482502
Affiliations:
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(review).</title><author><name sortKey="Kriegsmann, Jorg" sort="Kriegsmann, Jorg" uniqKey="Kriegsmann J" first="Jörg" last="Kriegsmann">Jörg Kriegsmann</name><affiliation wicri:level="1"><nlm:affiliation>MVZ for Histology, Cytology and Molecular Diagnostics, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>MVZ for Histology, Cytology and Molecular Diagnostics, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Kriegsmann, Mark" sort="Kriegsmann, Mark" uniqKey="Kriegsmann M" first="Mark" last="Kriegsmann">Mark Kriegsmann</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Pathology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Pathology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Casadonte, Rita" sort="Casadonte, Rita" uniqKey="Casadonte R" first="Rita" last="Casadonte">Rita Casadonte</name><affiliation wicri:level="1"><nlm:affiliation>Proteopath GmbH, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Proteopath GmbH, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of oncology</title><idno type="eISSN">1791-2423</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" 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xml:lang="en"><term>Immunohistochemistry</term><term>Pathology, Clinical</term><term>Specimen Handling</term><term>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</term><term>Tissue Fixation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Freezing</term><term>Humans</term><term>Paraffin Embedding</term><term>Prognosis</term><term>Tissue Array Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the advantages of mass spectrometry (proteomics), detection of numerous molecules, and spatial resolution in histological tissue sections and cytological preparations. This method allows the detection of proteins, peptides, lipids, carbohydrates or glycoconjugates and small molecules.Formalin-fixed paraffin-embedded tissue can also be investigated by IMS, thus, this method seems to be an ideal tool for cancer diagnostics and biomarker discovery. It may add information to the identification of tumor margins and tumor heterogeneity. The technique allows tumor typing, especially identification of the tumor of origin in metastatic tissue, as well as grading and may provide prognostic information. IMS is a valuable method for the identification of biomarkers and can complement histology, immunohistology and molecular pathology in various fields of histopathological diagnostics, especially with regard to identification and grading of tumors.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li></region><settlement><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Kriegsmann, Jorg" sort="Kriegsmann, Jorg" uniqKey="Kriegsmann J" first="Jörg" last="Kriegsmann">Jörg Kriegsmann</name></noRegion><name sortKey="Casadonte, Rita" sort="Casadonte, Rita" uniqKey="Casadonte R" first="Rita" last="Casadonte">Rita Casadonte</name><name sortKey="Kriegsmann, Mark" sort="Kriegsmann, Mark" uniqKey="Kriegsmann M" first="Mark" last="Kriegsmann">Mark Kriegsmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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