A randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck†
Identifieur interne : 000092 ( Main/Merge ); précédent : 000091; suivant : 000093A randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck†
Auteurs : T. Y. Seiwert [États-Unis] ; J. Fayette ; D. Cupissol [France] ; J. M. Del Campo [Espagne] ; P. M. Clement [Belgique] ; R. Hitt [Espagne] ; M. Degardin [France] ; W. Zhang [République populaire de Chine] ; A. Blackman [États-Unis] ; E. Ehrnrooth [Danemark] ; E. E. W. Cohen [États-Unis]Source :
- Annals of Oncology [ 0923-7534 ] ; 2014.
Abstract
Afatinib, an oral irreversible ErbB family blocker, showed comparable activity to cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma in this phase II trial. Further, sequential EGFR/ErbB treatment provided sustained clinical benefit in some patients, suggesting a lack of cross-resistance.
Url:
DOI: 10.1093/annonc/mdu216
PubMed: 24928832
PubMed Central: 4143093
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Y." last="Seiwert">T. Y. Seiwert</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af1"><addr-line>Department of Medicine</addr-line>,<institution>University of Chicago Medical Centre</institution>,<addr-line>Chicago</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fayette, J" sort="Fayette, J" uniqKey="Fayette J" first="J." last="Fayette">J. Fayette</name><affiliation><nlm:aff id="mdu216_af2"><addr-line>Department of Medicine</addr-line>,<institution>Université de Lyon</institution>,<addr-line>Lyon</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cupissol, D" sort="Cupissol, D" uniqKey="Cupissol D" first="D." last="Cupissol">D. Cupissol</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af3"><institution>Institut du Cancer de Montpellier Val d'Aurelle</institution>,<addr-line>Montpellier</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Del Campo, J M" sort="Del Campo, J M" uniqKey="Del Campo J" first="J. M." last="Del Campo">J. M. Del Campo</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af4"><addr-line>Department of Medical Oncology</addr-line>,<institution>Hospital Universitario Vall d'Hebron</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clement, P M" sort="Clement, P M" uniqKey="Clement P" first="P. M." last="Clement">P. M. 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Degardin</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af7"><institution>Centre Oscar Lambret</institution>,<addr-line>Lille</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, W" sort="Zhang, W" uniqKey="Zhang W" first="W." last="Zhang">W. Zhang</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af8"><institution>Boehringer Ingelheim Shanghai Pharmaceuticals Co., Ltd</institution>,<addr-line>Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blackman, A" sort="Blackman, A" uniqKey="Blackman A" first="A." last="Blackman">A. Blackman</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af9"><institution>Boehringer Ingelheim Pharmaceuticals, Inc.</institution>,<addr-line>Ridgefield</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ehrnrooth, E" sort="Ehrnrooth, E" uniqKey="Ehrnrooth E" first="E." last="Ehrnrooth">E. Ehrnrooth</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af10"><institution>Boehringer Ingelheim</institution><addr-line>Danmark A/S</addr-line>,<country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Cohen, E E W" sort="Cohen, E E W" uniqKey="Cohen E" first="E. E. W." last="Cohen">E. E. W. Cohen</name><affiliation wicri:level="1"><nlm:aff id="mdu216_af11"><addr-line>Department of Medicine</addr-line>,<institution>University of California San Diego Moores Cancer Center</institution>,<addr-line>La Jolla</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Afatinib, an oral irreversible ErbB family blocker, showed comparable activity to cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma in this phase II trial. Further, sequential EGFR/ErbB treatment provided sustained clinical benefit in some patients, suggesting a lack of cross-resistance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seiwert, Ty" uniqKey="Seiwert T">TY Seiwert</name></author><author><name sortKey="Salama, Jk" uniqKey="Salama J">JK Salama</name></author><author><name sortKey="Vokes, Ee" uniqKey="Vokes E">EE Vokes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gold, Ka" uniqKey="Gold K">KA Gold</name></author><author><name sortKey="Lee, Hy" uniqKey="Lee H">HY Lee</name></author><author><name sortKey="Kim, Es" uniqKey="Kim E">ES 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sortKey="Song, H" uniqKey="Song H">H Song</name></author><author><name sortKey="Raez, Le" uniqKey="Raez L">LE Raez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soulieres, D" uniqKey="Soulieres D">D Soulieres</name></author><author><name sortKey="Senzer, Nn" uniqKey="Senzer N">NN Senzer</name></author><author><name sortKey="Vokes, Ee" uniqKey="Vokes E">EE Vokes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, Js" uniqKey="Stewart J">JS Stewart</name></author><author><name sortKey="Cohen, Ee" uniqKey="Cohen E">EE Cohen</name></author><author><name sortKey="Licitra, L" uniqKey="Licitra L">L Licitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aaronson, Nk" uniqKey="Aaronson N">NK Aaronson</name></author><author><name sortKey="Ahmedzai, S" uniqKey="Ahmedzai S">S Ahmedzai</name></author><author><name sortKey="Bergman, B" uniqKey="Bergman B">B Bergman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjordal, K" uniqKey="Bjordal K">K Bjordal</name></author><author><name sortKey="Hammerlid, E" uniqKey="Hammerlid E">E Hammerlid</name></author><author><name sortKey="Ahlner Elmqvist, M" uniqKey="Ahlner Elmqvist M">M Ahlner-Elmqvist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeuken, J" uniqKey="Jeuken J">J Jeuken</name></author><author><name sortKey="Sijben, A" uniqKey="Sijben A">A Sijben</name></author><author><name sortKey="Alenda, C" uniqKey="Alenda C">C Alenda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavin, Pt" uniqKey="Lavin P">PT Lavin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karrison, Tg" uniqKey="Karrison T">TG Karrison</name></author><author><name sortKey="Maitland, Ml" uniqKey="Maitland M">ML Maitland</name></author><author><name sortKey="Stadler, Wm" uniqKey="Stadler W">WM Stadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stransky, N" uniqKey="Stransky N">N Stransky</name></author><author><name sortKey="Egloff, Am" uniqKey="Egloff A">AM Egloff</name></author><author><name sortKey="Tward, Ad" uniqKey="Tward A">AD Tward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirsh, V" uniqKey="Hirsh V">V Hirsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Jc" uniqKey="Yang J">JC Yang</name></author><author><name sortKey="Reguart, N" uniqKey="Reguart N">N Reguart</name></author><author><name sortKey="Barinoff, J" uniqKey="Barinoff J">J Barinoff</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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