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[Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].

Identifieur interne : 000263 ( PubMed/Curation ); précédent : 000262; suivant : 000264

[Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].

Auteurs : I. Jennesseaux [France] ; D. Carre-Gislard ; P. Bravard

Source :

RBID : pubmed:18342096

English descriptors

Abstract

Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers.

DOI: 10.1016/j.annder.2007.06.008
PubMed: 18342096

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pubmed:18342096

Le document en format XML

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<title xml:lang="en">[Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].</title>
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<name sortKey="Jennesseaux, I" sort="Jennesseaux, I" uniqKey="Jennesseaux I" first="I" last="Jennesseaux">I. Jennesseaux</name>
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<nlm:affiliation>Service de dermatologie, centre hospitalier Jacques-Monod, B.P. 24, 76083 Le Havre cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de dermatologie, centre hospitalier Jacques-Monod, B.P. 24, 76083 Le Havre cedex</wicri:regionArea>
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<name sortKey="Carre Gislard, D" sort="Carre Gislard, D" uniqKey="Carre Gislard D" first="D" last="Carre-Gislard">D. Carre-Gislard</name>
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<name sortKey="Bravard, P" sort="Bravard, P" uniqKey="Bravard P" first="P" last="Bravard">P. Bravard</name>
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<nlm:affiliation>Service de dermatologie, centre hospitalier Jacques-Monod, B.P. 24, 76083 Le Havre cedex, France.</nlm:affiliation>
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<term>Anti-Arrhythmia Agents (adverse effects)</term>
<term>Cicatrix (pathology)</term>
<term>Conjunctivitis (chemically induced)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Nicorandil (adverse effects)</term>
<term>Pacemaker, Artificial</term>
<term>Skin Ulcer (chemically induced)</term>
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<term>Anti-Arrhythmia Agents</term>
<term>Nicorandil</term>
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<term>Conjunctivitis</term>
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<div type="abstract" xml:lang="en">Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers.</div>
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<Year>2008</Year>
<Month>Feb</Month>
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<Title>Annales de dermatologie et de venereologie</Title>
<ISOAbbreviation>Ann Dermatol Venereol</ISOAbbreviation>
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<ArticleTitle>[Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">An 86-year-old woman presented ulceration on a pacemaker implantation scar despite complete initial wound healing. Nicorandil had been initiated three months earlier. None of the usual causes of ulceration of a pacemaker scar were seen. Complete and permanent wound-healing was achieved 12 days after discontinuation of nicorandil.</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This is the first reported case of cutaneous ulceration on a vulnerable area of skin ascribable to high-dose nicorandil.</AbstractText>
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