Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).
Identifieur interne : 000112 ( PubMed/Curation ); précédent : 000111; suivant : 000113Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).
Auteurs : Patrizia Maria Carrieri [France] ; Laurent Michel [France] ; Caroline Lions [France] ; Julien Cohen [France] ; Muriel Vray [France] ; Marion Mora [France] ; Fabienne Marcellin [France] ; Bruno Spire [France] ; Alain Morel [France] ; Perrine Roux [France]Source :
- PloS one [ 1932-6203 ] ; 2014.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Methadone.
- geographic : France.
- drug therapy : Opioid-Related Disorders.
- Adult, Female, Humans, Induction Chemotherapy, Male, Primary Health Care.
Abstract
Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.
DOI: 10.1371/journal.pone.0112328
PubMed: 25393311
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Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25393311</idno><idno type="pmid">25393311</idno><idno type="doi">10.1371/journal.pone.0112328</idno><idno type="wicri:Area/PubMed/Corpus">000112</idno><idno type="wicri:Area/PubMed/Curation">000112</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).</title><author><name sortKey="Carrieri, Patrizia Maria" sort="Carrieri, Patrizia Maria" uniqKey="Carrieri P" first="Patrizia Maria" last="Carrieri">Patrizia Maria Carrieri</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Michel, Laurent" sort="Michel, Laurent" uniqKey="Michel L" first="Laurent" last="Michel">Laurent Michel</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, Research Unit 669, Paris, France; Univ Paris-Sud and Univ Paris Descartes, UMR-S0669, Paris, France; Centre Pierre Nicole, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Research Unit 669, Paris, France; Univ Paris-Sud and Univ Paris Descartes, UMR-S0669, Paris, France; Centre Pierre Nicole, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lions, Caroline" sort="Lions, Caroline" uniqKey="Lions C" first="Caroline" last="Lions">Caroline Lions</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Cohen, Julien" sort="Cohen, Julien" uniqKey="Cohen J" first="Julien" last="Cohen">Julien Cohen</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Vray, Muriel" sort="Vray, Muriel" uniqKey="Vray M" first="Muriel" last="Vray">Muriel Vray</name><affiliation wicri:level="1"><nlm:affiliation>Unité de Recherche et d'Expertise en Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche et d'Expertise en Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris</wicri:regionArea></affiliation></author><author><name sortKey="Mora, Marion" sort="Mora, Marion" uniqKey="Mora M" first="Marion" last="Mora">Marion Mora</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Marcellin, Fabienne" sort="Marcellin, Fabienne" uniqKey="Marcellin F" first="Fabienne" last="Marcellin">Fabienne Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Morel, Alain" sort="Morel, Alain" uniqKey="Morel A" first="Alain" last="Morel">Alain Morel</name><affiliation wicri:level="1"><nlm:affiliation>Oppelia, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Oppelia, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Roux, Perrine" sort="Roux, Perrine" uniqKey="Roux P" first="Perrine" last="Roux">Perrine Roux</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>France</term><term>Humans</term><term>Induction Chemotherapy</term><term>Male</term><term>Methadone (therapeutic use)</term><term>Opioid-Related Disorders (drug therapy)</term><term>Primary Health Care</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Methadone</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Opioid-Related Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Induction Chemotherapy</term><term>Male</term><term>Primary Health Care</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25393311</PMID><DateCreated><Year>2014</Year><Month>11</Month><Day>14</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>11</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).</ArticleTitle><Pagination><MedlinePgn>e112328</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0112328</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% non-inferiority hypothesis for PC). Secondary outcomes were abstinence during follow-up, engagement in treatment (i.e. completing the induction period), retention and satisfaction with the explanations provided by the physician. Primary analysis used intention to treat (ITT). Mixed models and the log-rank test were used to assess the arm effect (PC vs. SC) on the course of abstinence and retention, respectively.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the ITT analysis (n = 155 in PC, 66 in SC), which compared the proportions of street-opioid abstinent participants, 85/155 (55%) and 22/66 (33%) of the participants were classified as street-opioid abstinent at M12 in PC and SC, respectively. This ITT analysis showed the non-inferiority of PC (21.5 [7.7; 35.3]). Engagement in treatment and satisfaction with the explanations provided by the physician were significantly higher in PC than SC. Retention in methadone and abstinence during follow-up were comparable in both arms (p = 0.47, p = 0.39, respectively).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Under appropriate conditions, methadone induction in primary care is feasible and acceptable to both physicians and patients. It is as effective as induction in specialized care in reducing street-opioid use and ensuring engagement and retention in treatment for opioid dependence.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">Number Eudract 2008-001338-28; ClinicalTrials.gov: NCT00657397; International Standard Randomized Controlled Trial Number Register ISRCTN31125511.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carrieri</LastName><ForeName>Patrizia Maria</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM, Research Unit 669, Paris, France; Univ Paris-Sud and Univ Paris Descartes, UMR-S0669, Paris, France; Centre Pierre Nicole, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lions</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vray</LastName><ForeName>Muriel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unité de Recherche et d'Expertise en Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mora</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcellin</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spire</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morel</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Oppelia, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roux</LastName><ForeName>Perrine</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM UMR912 (SESSTIM), Marseille, France; Aix Marseille Université, UMR_S912, Marseille, France; ORS PACA, Observatoire Régional de la Santé Provence Alpes Côte d'Azur, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Methaville Study 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One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>UC6VBE7V1Z</RegistryNumber><NameOfSubstance UI="D008691">Methadone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Psychoactive Drugs. 1996 Jul-Sep;28(3):259-65</RefSource><PMID Version="1">8895111</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Epidemiol. 1996 Aug;49(8):949-50</RefSource><PMID Version="1">8699219</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57</RefSource><PMID Version="1">9881538</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 1999 Mar 17;281(11):1000-5</RefSource><PMID Version="1">10086434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Drug 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