Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.
Identifieur interne : 000109 ( PubMed/Curation ); précédent : 000108; suivant : 000110Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.
Auteurs : Jean-Pierre Goullé [France] ; Pascal Le Roux [France] ; Mireille Castanet [France] ; Loïc Mahieu [France] ; Stéphanie Guyet-Job [France] ; Michel Guerbet [France]Source :
- Journal of analytical toxicology [ 1945-2403 ]
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Metals, Heavy.
- chemistry : Plasma.
- methods : Forensic Toxicology.
- Adolescent, Blood Chemical Analysis, Child, Child, Preschool, Female, Humans, Male, Reference Values, Spectrophotometry, Atomic.
Abstract
In recent years, special emphasis has been put on heavy metals. Children are very sensitive to accumulation of metals. Furthermore, as regards elements, the reference values in children are scarce in the literature as it is difficult to obtain the large quantity of blood necessary to analyze many metals by the conventional atomic absorption spectrometry technique. An inductively coupled plasma mass spectrometry (ICP-MS) procedure that uses a reduced sample of 0.3 mL whole blood or plasma is adapted to multielemental determinations. We applied a previously validated technique for adults that simultaneously quantifies 25 elements by ICP-MS in whole blood and 23 in plasma in a series of 99 healthy children ranging from under 5 years to <18 years, without exposure to metal or drug-containing metals. The aims of the study were to compare metallic concentrations according to the age among children and metallic concentration differences between children and adults. The blood and plasma pediatric metallic profile is a practical useful tool for many purposes in clinical toxicology, forensic toxicology and any cases of metal environmental exposure.
DOI: 10.1093/jat/bkv088
PubMed: 26265286
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Analysis</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Forensic Toxicology (methods)</term><term>Humans</term><term>Male</term><term>Metals, Heavy (blood)</term><term>Plasma (chemistry)</term><term>Reference Values</term><term>Spectrophotometry, Atomic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Metals, Heavy</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Forensic Toxicology</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Blood Chemical Analysis</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Reference Values</term><term>Spectrophotometry, Atomic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In recent years, special emphasis has been put on heavy metals. Children are very sensitive to accumulation of metals. Furthermore, as regards elements, the reference values in children are scarce in the literature as it is difficult to obtain the large quantity of blood necessary to analyze many metals by the conventional atomic absorption spectrometry technique. An inductively coupled plasma mass spectrometry (ICP-MS) procedure that uses a reduced sample of 0.3 mL whole blood or plasma is adapted to multielemental determinations. We applied a previously validated technique for adults that simultaneously quantifies 25 elements by ICP-MS in whole blood and 23 in plasma in a series of 99 healthy children ranging from under 5 years to <18 years, without exposure to metal or drug-containing metals. The aims of the study were to compare metallic concentrations according to the age among children and metallic concentration differences between children and adults. The blood and plasma pediatric metallic profile is a practical useful tool for many purposes in clinical toxicology, forensic toxicology and any cases of metal environmental exposure.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26265286</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>31</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1945-2403</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>9</Issue><PubDate><MedlineDate>2015 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Journal of analytical toxicology</Title><ISOAbbreviation>J Anal Toxicol</ISOAbbreviation></Journal><ArticleTitle>Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.</ArticleTitle><Pagination><MedlinePgn>707-13</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jat/bkv088</ELocationID><Abstract><AbstractText>In recent years, special emphasis has been put on heavy metals. Children are very sensitive to accumulation of metals. Furthermore, as regards elements, the reference values in children are scarce in the literature as it is difficult to obtain the large quantity of blood necessary to analyze many metals by the conventional atomic absorption spectrometry technique. An inductively coupled plasma mass spectrometry (ICP-MS) procedure that uses a reduced sample of 0.3 mL whole blood or plasma is adapted to multielemental determinations. We applied a previously validated technique for adults that simultaneously quantifies 25 elements by ICP-MS in whole blood and 23 in plasma in a series of 99 healthy children ranging from under 5 years to <18 years, without exposure to metal or drug-containing metals. The aims of the study were to compare metallic concentrations according to the age among children and metallic concentration differences between children and adults. The blood and plasma pediatric metallic profile is a practical useful tool for many purposes in clinical toxicology, forensic toxicology and any cases of metal environmental exposure.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goullé</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Laboratoire de Toxicologie, ABTE ToxEMAC EA 4651, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen Cedex 1, France Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre Cedex, France jean-pierre.goulle@univ-rouen.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Roux</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service de Pédiatrie, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castanet</LastName><ForeName>Mireille</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Département de Pédiatrie et Centre d'Investigation Clinique-Inserm 204, Hôpitaux de Rouen, 1 rue de Germont, 76031 Rouen Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahieu</LastName><ForeName>Loïc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guyet-Job</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Pédiatrie, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerbet</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire de Toxicologie, ABTE ToxEMAC EA 4651, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen Cedex 1, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Aug</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Anal Toxicol</MedlineTA><NlmUniqueID>7705085</NlmUniqueID><ISSNLinking>0146-4760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019216">Metals, Heavy</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001774" MajorTopicYN="N">Blood Chemical Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053593" MajorTopicYN="N">Forensic Toxicology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019216" MajorTopicYN="N">Metals, Heavy</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="N">Plasma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013054" MajorTopicYN="N">Spectrophotometry, Atomic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26265286</ArticleId><ArticleId IdType="pii">bkv088</ArticleId><ArticleId IdType="doi">10.1093/jat/bkv088</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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