Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.
Identifieur interne : 000080 ( PubMed/Curation ); précédent : 000079; suivant : 000081Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.
Auteurs : Corina M. Ciocan [Royaume-Uni] ; Elena Cubero-Leon [Royaume-Uni] ; William J. Langston [Royaume-Uni] ; Nick Pope [Royaume-Uni] ; Keith Cornelius [Royaume-Uni] ; E M Hill [Royaume-Uni] ; Diana Alvarez-Munoz [Royaume-Uni] ; Paolo Indiveri [Royaume-Uni] ; Adelaide Lerebours [Royaume-Uni] ; Christophe Minier [France] ; Jeanette M. Rotchell [Royaume-Uni]Source :
- Marine pollution bulletin [ 1879-3363 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Biomarkers (metabolism), Bivalvia (genetics), Bivalvia (metabolism), Disorders of Sex Development, Environment, Environmental Monitoring (methods), Female, Gene Expression (drug effects), Gene Expression (physiology), Humans, Male, Testis (metabolism), Transcriptome, Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Water Pollutants, Chemical.
- chemical , metabolism : Biomarkers, Water Pollutants, Chemical.
- drug effects : Gene Expression.
- genetics : Bivalvia.
- metabolism : Bivalvia, Testis.
- methods : Environmental Monitoring.
- physiology : Gene Expression.
- chemical , toxicity : Water Pollutants, Chemical.
- Animals, Disorders of Sex Development, Environment, Female, Humans, Male, Transcriptome.
Abstract
Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.
DOI: 10.1016/j.marpolbul.2015.02.019
PubMed: 25746199
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Rotchell</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom. Electronic address: J.Rotchell@Hull.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25746199</idno><idno type="pmid">25746199</idno><idno type="doi">10.1016/j.marpolbul.2015.02.019</idno><idno type="wicri:Area/PubMed/Corpus">000080</idno><idno type="wicri:Area/PubMed/Curation">000080</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.</title><author><name sortKey="Ciocan, Corina M" sort="Ciocan, Corina M" uniqKey="Ciocan C" first="Corina M" last="Ciocan">Corina M. Ciocan</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, United Kingdom; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, United Kingdom; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Cubero Leon, Elena" sort="Cubero Leon, Elena" uniqKey="Cubero Leon E" first="Elena" last="Cubero-Leon">Elena Cubero-Leon</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J" last="Langston">William J. Langston</name><affiliation wicri:level="1"><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB</wicri:regionArea></affiliation></author><author><name sortKey="Pope, Nick" sort="Pope, Nick" uniqKey="Pope N" first="Nick" last="Pope">Nick Pope</name><affiliation wicri:level="1"><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB</wicri:regionArea></affiliation></author><author><name sortKey="Cornelius, Keith" sort="Cornelius, Keith" uniqKey="Cornelius K" first="Keith" last="Cornelius">Keith Cornelius</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Hill, E M" sort="Hill, E M" uniqKey="Hill E" first="E M" last="Hill">E M Hill</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Alvarez Munoz, Diana" sort="Alvarez Munoz, Diana" uniqKey="Alvarez Munoz D" first="Diana" last="Alvarez-Munoz">Diana Alvarez-Munoz</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Indiveri, Paolo" sort="Indiveri, Paolo" uniqKey="Indiveri P" first="Paolo" last="Indiveri">Paolo Indiveri</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea></affiliation></author><author><name sortKey="Lerebours, Adelaide" sort="Lerebours, Adelaide" uniqKey="Lerebours A" first="Adelaide" last="Lerebours">Adelaide Lerebours</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Institute of Marine Sciences, University of Portsmouth, Ferry Road, Eastney, Portsmouth PO4 9LY, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences, Institute of Marine Sciences, University of Portsmouth, Ferry Road, Eastney, Portsmouth PO4 9LY</wicri:regionArea></affiliation></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre</wicri:regionArea></affiliation></author><author><name sortKey="Rotchell, Jeanette M" sort="Rotchell, Jeanette M" uniqKey="Rotchell J" first="Jeanette M" last="Rotchell">Jeanette M. Rotchell</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom. Electronic address: J.Rotchell@Hull.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX</wicri:regionArea></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers (metabolism)</term><term>Bivalvia (genetics)</term><term>Bivalvia (metabolism)</term><term>Disorders of Sex Development</term><term>Environment</term><term>Environmental Monitoring (methods)</term><term>Female</term><term>Gene Expression (drug effects)</term><term>Gene Expression (physiology)</term><term>Humans</term><term>Male</term><term>Testis (metabolism)</term><term>Transcriptome</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bivalvia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bivalvia</term><term>Testis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Environmental Monitoring</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disorders of Sex Development</term><term>Environment</term><term>Female</term><term>Humans</term><term>Male</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25746199</PMID><DateCreated><Year>2015</Year><Month>6</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>6</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3363</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>30</Day></PubDate></JournalIssue><Title>Marine pollution bulletin</Title><ISOAbbreviation>Mar. Pollut. Bull.</ISOAbbreviation></Journal><ArticleTitle>Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.</ArticleTitle><Pagination><MedlinePgn>610-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.marpolbul.2015.02.019</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0025-326X(15)00109-5</ELocationID><Abstract><AbstractText>Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ciocan</LastName><ForeName>Corina M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, United Kingdom; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cubero-Leon</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langston</LastName><ForeName>William J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pope</LastName><ForeName>Nick</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cornelius</LastName><ForeName>Keith</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>E M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alvarez-Munoz</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Indiveri</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerebours</LastName><ForeName>Adelaide</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Institute of Marine Sciences, University of Portsmouth, Ferry Road, Eastney, Portsmouth PO4 9LY, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minier</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rotchell</LastName><ForeName>Jeanette M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom. Electronic address: J.Rotchell@Hull.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Mar</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mar Pollut Bull</MedlineTA><NlmUniqueID>0260231</NlmUniqueID><ISSNLinking>0025-326X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049872" MajorTopicYN="N">Bivalvia</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012734" MajorTopicYN="N">Disorders of Sex Development</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004777" MajorTopicYN="N">Environment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004784" MajorTopicYN="N">Environmental Monitoring</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013737" MajorTopicYN="N">Testis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Clams</Keyword><Keyword MajorTopicYN="N">English Channel</Keyword><Keyword MajorTopicYN="N">Gene expression</Keyword><Keyword MajorTopicYN="N">Intersex</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>6</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>1</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>2</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25746199</ArticleId><ArticleId IdType="pii">S0025-326X(15)00109-5</ArticleId><ArticleId IdType="doi">10.1016/j.marpolbul.2015.02.019</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.
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