Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.
Identifieur interne : 000204 ( PubMed/Corpus ); précédent : 000203; suivant : 000205Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.
Auteurs : Perrine Geraudie ; Nathalie Hinfray ; Marie Gerbron ; Jean-Marc Porcher ; François Brion ; Christophe MinierSource :
- Aquatic toxicology (Amsterdam, Netherlands) [ 1879-1514 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Aromatase (metabolism), Biomarkers (metabolism), Brain (drug effects), Brain (enzymology), Cyprinidae (metabolism), Disorders of Sex Development (chemically induced), Endocrine Disruptors (toxicity), Environmental Exposure (adverse effects), Estradiol (metabolism), Female, Male, Ovary (drug effects), Ovary (physiology), Seasons, Sexual Maturation (drug effects), Testosterone (analogs & derivatives), Testosterone (metabolism), Vitellogenins (metabolism), Water Pollution, Chemical (adverse effects).
- MESH :
- chemical , analogs & derivatives : Testosterone.
- chemical , metabolism : Aromatase, Biomarkers, Estradiol, Testosterone, Vitellogenins.
- adverse effects : Environmental Exposure, Water Pollution, Chemical.
- chemically induced : Disorders of Sex Development.
- drug effects : Brain, Ovary, Sexual Maturation.
- enzymology : Brain.
- metabolism : Cyprinidae.
- physiology : Ovary.
- chemical , toxicity : Endocrine Disruptors.
- Animals, Female, Male, Seasons.
Abstract
P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg(-1)min(-1) in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20-50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.
DOI: 10.1016/j.aquatox.2011.07.009
PubMed: 21820384
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sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="François" last="Brion">François Brion</name></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21820384</idno><idno type="pmid">21820384</idno><idno type="doi">10.1016/j.aquatox.2011.07.009</idno><idno type="wicri:Area/PubMed/Corpus">000204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.</title><author><name sortKey="Geraudie, Perrine" sort="Geraudie, Perrine" uniqKey="Geraudie P" first="Perrine" last="Geraudie">Perrine Geraudie</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, EA3222, University of Le Havre, BP 540, 76058 Le Havre, France. perrine.maltret@univ-lehavre.fr</nlm:affiliation></affiliation></author><author><name sortKey="Hinfray, Nathalie" sort="Hinfray, Nathalie" uniqKey="Hinfray N" first="Nathalie" last="Hinfray">Nathalie Hinfray</name></author><author><name sortKey="Gerbron, Marie" sort="Gerbron, Marie" uniqKey="Gerbron M" first="Marie" last="Gerbron">Marie Gerbron</name></author><author><name sortKey="Porcher, Jean Marc" sort="Porcher, Jean Marc" uniqKey="Porcher J" first="Jean-Marc" last="Porcher">Jean-Marc Porcher</name></author><author><name sortKey="Brion, Francois" sort="Brion, Francois" uniqKey="Brion F" first="François" last="Brion">François Brion</name></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></author></analytic><series><title level="j">Aquatic toxicology (Amsterdam, Netherlands)</title><idno type="eISSN">1879-1514</idno><imprint><date when="2011" 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xml:lang="en"><term>Testosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aromatase</term><term>Biomarkers</term><term>Estradiol</term><term>Testosterone</term><term>Vitellogenins</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term><term>Water Pollution, Chemical</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Disorders of Sex Development</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Ovary</term><term>Sexual Maturation</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cyprinidae</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Ovary</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Endocrine Disruptors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Seasons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg(-1)min(-1) in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20-50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21820384</PMID><DateCreated><Year>2011</Year><Month>11</Month><Day>2</Day></DateCreated><DateCompleted><Year>2012</Year><Month>07</Month><Day>27</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1514</ISSN><JournalIssue CitedMedium="Internet"><Volume>105</Volume><Issue>3-4</Issue><PubDate><Year>2011</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Aquatic toxicology (Amsterdam, Netherlands)</Title><ISOAbbreviation>Aquat. Toxicol.</ISOAbbreviation></Journal><ArticleTitle>Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): seasonal variations and impact of environmental contaminants.</ArticleTitle><Pagination><MedlinePgn>378-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.aquatox.2011.07.009</ELocationID><Abstract><AbstractText>P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg(-1)min(-1) in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20-50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Geraudie</LastName><ForeName>Perrine</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, EA3222, University of Le Havre, BP 540, 76058 Le Havre, France. perrine.maltret@univ-lehavre.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hinfray</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Gerbron</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Porcher</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Brion</LastName><ForeName>François</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Minier</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>Jul</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Aquat Toxicol</MedlineTA><NlmUniqueID>8500246</NlmUniqueID><ISSNLinking>0166-445X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052244">Endocrine Disruptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014819">Vitellogenins</NameOfSubstance></Chemical><Chemical><RegistryNumber>3XMK78S47O</RegistryNumber><NameOfSubstance UI="D013739">Testosterone</NameOfSubstance></Chemical><Chemical><RegistryNumber>4TI98Z838E</RegistryNumber><NameOfSubstance 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UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010053" MajorTopicYN="N">Ovary</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="Y">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012741" MajorTopicYN="N">Sexual Maturation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013739" MajorTopicYN="N">Testosterone</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014819" 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