Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds.
Identifieur interne : 000082 ( PubMed/Corpus ); précédent : 000081; suivant : 000083Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds.
Auteurs : Diana Alvarez-Mu Oz ; Paolo Indiveri ; Pawel Rostkowski ; Julia Horwood ; Emily Greer ; Christophe Minier ; Nick Pope ; William J. Langston ; Elizabeth M. HillSource :
- Marine pollution bulletin [ 1879-3363 ] ; 2015.
English descriptors
- KwdEn :
- Androgen Antagonists (analysis), Androgen Antagonists (metabolism), Androgen Antagonists (toxicity), Animals, Aquatic Organisms, Bivalvia (physiology), Environmental Monitoring, Estuaries, Female, France, Geologic Sediments (chemistry), Great Britain, Male, Polycyclic Hydrocarbons, Aromatic (analysis), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Androgen Antagonists, Polycyclic Hydrocarbons, Aromatic, Water Pollutants, Chemical.
- chemical , metabolism : Androgen Antagonists, Water Pollutants, Chemical.
- chemical , toxicity : Androgen Antagonists, Water Pollutants, Chemical.
- geographic : France, Great Britain.
- chemistry : Geologic Sediments.
- physiology : Bivalvia.
- Animals, Aquatic Organisms, Environmental Monitoring, Estuaries, Female, Male.
Abstract
This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.
DOI: 10.1016/j.marpolbul.2014.11.014
PubMed: 25496695
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pubmed:25496695Le document en format XML
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Langston</name><affiliation><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hill, Elizabeth M" sort="Hill, Elizabeth M" uniqKey="Hill E" first="Elizabeth M" last="Hill">Elizabeth M. Hill</name><affiliation><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom. 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Langston</name><affiliation><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hill, Elizabeth M" sort="Hill, Elizabeth M" uniqKey="Hill E" first="Elizabeth M" last="Hill">Elizabeth M. Hill</name><affiliation><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom. Electronic address: E.M.Hill@sussex.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Androgen Antagonists (analysis)</term><term>Androgen Antagonists (metabolism)</term><term>Androgen Antagonists (toxicity)</term><term>Animals</term><term>Aquatic Organisms</term><term>Bivalvia (physiology)</term><term>Environmental Monitoring</term><term>Estuaries</term><term>Female</term><term>France</term><term>Geologic Sediments (chemistry)</term><term>Great Britain</term><term>Male</term><term>Polycyclic Hydrocarbons, Aromatic (analysis)</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Androgen Antagonists</term><term>Polycyclic Hydrocarbons, Aromatic</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Androgen Antagonists</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Androgen Antagonists</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term><term>Great Britain</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Geologic Sediments</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bivalvia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Aquatic Organisms</term><term>Environmental Monitoring</term><term>Estuaries</term><term>Female</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25496695</PMID><DateCreated><Year>2015</Year><Month>6</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>6</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3363</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>30</Day></PubDate></JournalIssue><Title>Marine pollution bulletin</Title><ISOAbbreviation>Mar. Pollut. Bull.</ISOAbbreviation></Journal><ArticleTitle>Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds.</ArticleTitle><Pagination><MedlinePgn>590-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.marpolbul.2014.11.014</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0025-326X(14)00766-8</ELocationID><Abstract><AbstractText>This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alvarez-Muñoz</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Indiveri</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rostkowski</LastName><ForeName>Pawel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horwood</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greer</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minier</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, UPRES EA-3222, UFR de Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP 540, 76058 Le Havre Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pope</LastName><ForeName>Nick</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langston</LastName><ForeName>William J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Elizabeth M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom. Electronic address: E.M.Hill@sussex.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>Dec</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mar Pollut Bull</MedlineTA><NlmUniqueID>0260231</NlmUniqueID><ISSNLinking>0025-326X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000726">Androgen Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011084">Polycyclic Hydrocarbons, Aromatic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000726" MajorTopicYN="N">Androgen Antagonists</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059001" MajorTopicYN="N">Aquatic Organisms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049872" MajorTopicYN="N">Bivalvia</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004784" MajorTopicYN="Y">Environmental Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063366" MajorTopicYN="N">Estuaries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019015" MajorTopicYN="N">Geologic Sediments</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006113" MajorTopicYN="N" Type="Geographic">Great Britain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011084" MajorTopicYN="N">Polycyclic Hydrocarbons, Aromatic</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AR-CALUX</Keyword><Keyword MajorTopicYN="N">Anti-androgen</Keyword><Keyword MajorTopicYN="N">Clam</Keyword><Keyword MajorTopicYN="N">Effect-directed analysis</Keyword><Keyword MajorTopicYN="N">Endocrine disruption</Keyword><Keyword MajorTopicYN="N">Sediment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>6</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25496695</ArticleId><ArticleId IdType="pii">S0025-326X(14)00766-8</ArticleId><ArticleId IdType="doi">10.1016/j.marpolbul.2014.11.014</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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