In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver.
Identifieur interne : 000078 ( PubMed/Corpus ); précédent : 000077; suivant : 000079In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver.
Auteurs : M. Gerbron ; P. Geraudie ; B. Xuereb ; S. Marie ; C. MinierSource :
- Marine pollution bulletin [ 1879-3363 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Cadmium (metabolism), Cadmium (toxicity), Cyprinidae (physiology), Endocrine Disruptors (metabolism), Endocrine Disruptors (toxicity), Estradiol (metabolism), Estradiol (toxicity), Estrogen Receptor alpha (metabolism), In Vitro Techniques, Liver (metabolism), RNA, Messenger (metabolism), Receptors, Androgen (metabolism), Receptors, Estrogen (metabolism), Toxicity Tests, Vitellogenins (metabolism), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , metabolism : Cadmium, Endocrine Disruptors, Estradiol, Estrogen Receptor alpha, RNA, Messenger, Receptors, Androgen, Receptors, Estrogen, Vitellogenins, Water Pollutants, Chemical.
- chemical , toxicity : Cadmium, Endocrine Disruptors, Estradiol, Water Pollutants, Chemical.
- metabolism : Liver.
- physiology : Cyprinidae.
- Animals, In Vitro Techniques, Toxicity Tests.
Abstract
Cadmium has been reported to exert estrogenic, antiestrogenic or both effects in vertebrate species. To elucidate the endocrine disrupting action of CdCl2, ex vivo and in vivo experiments were performed in roach (Rutilus rutilus). Roach liver explants were exposed to a range of CdCl2 concentrations alone (0.1-50μM) or with an effective concentration (100nM) of 17β-estradiol (E2). In addition, juvenile roach were intraperitoneally injected with CdCl2 (0.1-2.5mg/kg) with or without 1mg E2/kg. Subsequent analysis evaluated the effect of CdCl2 on vitellogenin (VTG) synthesis both at the mRNA and protein level, on estrogen receptors (erα and erβ1) and on androgen receptor (ar) mRNA expression. Ex vivo and in vivo experiments indicated that CdCl2 is strongly anti-estrogenic as, when co-exposed to E2, CdCl2 significantly inhibited VTG production as well as vtg and erα mRNA expressions. Moreover, CdCl2 compromised the E2-mediated induction of the ar mRNA expression in vivo.
DOI: 10.1016/j.marpolbul.2015.03.043
PubMed: 26024563
Links to Exploration step
pubmed:26024563Le document en format XML
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Xuereb</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marie, S" sort="Marie, S" uniqKey="Marie S" first="S" last="Marie">S. Marie</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Minier, C" sort="Minier, C" uniqKey="Minier C" first="C" last="Minier">C. Minier</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26024563</idno><idno type="pmid">26024563</idno><idno type="doi">10.1016/j.marpolbul.2015.03.043</idno><idno type="wicri:Area/PubMed/Corpus">000078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver.</title><author><name sortKey="Gerbron, M" sort="Gerbron, M" uniqKey="Gerbron M" first="M" last="Gerbron">M. Gerbron</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France. Electronic address: marie.gerbron@univ-lehavre.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Geraudie, P" sort="Geraudie, P" uniqKey="Geraudie P" first="P" last="Geraudie">P. Geraudie</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France; Akvaplan Niva as, Fram Centre, 9296 Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Xuereb, B" sort="Xuereb, B" uniqKey="Xuereb B" first="B" last="Xuereb">B. Xuereb</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marie, S" sort="Marie, S" uniqKey="Marie S" first="S" last="Marie">S. Marie</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Minier, C" sort="Minier, C" uniqKey="Minier C" first="C" last="Minier">C. Minier</name><affiliation><nlm:affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cadmium (metabolism)</term><term>Cadmium (toxicity)</term><term>Cyprinidae (physiology)</term><term>Endocrine Disruptors (metabolism)</term><term>Endocrine Disruptors (toxicity)</term><term>Estradiol (metabolism)</term><term>Estradiol (toxicity)</term><term>Estrogen Receptor alpha (metabolism)</term><term>In Vitro Techniques</term><term>Liver (metabolism)</term><term>RNA, Messenger (metabolism)</term><term>Receptors, Androgen (metabolism)</term><term>Receptors, Estrogen (metabolism)</term><term>Toxicity Tests</term><term>Vitellogenins (metabolism)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadmium</term><term>Endocrine Disruptors</term><term>Estradiol</term><term>Estrogen Receptor alpha</term><term>RNA, Messenger</term><term>Receptors, Androgen</term><term>Receptors, Estrogen</term><term>Vitellogenins</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium</term><term>Endocrine Disruptors</term><term>Estradiol</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cyprinidae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>In Vitro Techniques</term><term>Toxicity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cadmium has been reported to exert estrogenic, antiestrogenic or both effects in vertebrate species. To elucidate the endocrine disrupting action of CdCl2, ex vivo and in vivo experiments were performed in roach (Rutilus rutilus). Roach liver explants were exposed to a range of CdCl2 concentrations alone (0.1-50μM) or with an effective concentration (100nM) of 17β-estradiol (E2). In addition, juvenile roach were intraperitoneally injected with CdCl2 (0.1-2.5mg/kg) with or without 1mg E2/kg. Subsequent analysis evaluated the effect of CdCl2 on vitellogenin (VTG) synthesis both at the mRNA and protein level, on estrogen receptors (erα and erβ1) and on androgen receptor (ar) mRNA expression. Ex vivo and in vivo experiments indicated that CdCl2 is strongly anti-estrogenic as, when co-exposed to E2, CdCl2 significantly inhibited VTG production as well as vtg and erα mRNA expressions. Moreover, CdCl2 compromised the E2-mediated induction of the ar mRNA expression in vivo.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26024563</PMID><DateCreated><Year>2015</Year><Month>6</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>6</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3363</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>30</Day></PubDate></JournalIssue><Title>Marine pollution bulletin</Title><ISOAbbreviation>Mar. Pollut. Bull.</ISOAbbreviation></Journal><ArticleTitle>In vitro and in vivo studies of the endocrine disrupting potency of cadmium in roach (Rutilus rutilus) liver.</ArticleTitle><Pagination><MedlinePgn>582-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.marpolbul.2015.03.043</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0025-326X(15)00188-5</ELocationID><Abstract><AbstractText>Cadmium has been reported to exert estrogenic, antiestrogenic or both effects in vertebrate species. To elucidate the endocrine disrupting action of CdCl2, ex vivo and in vivo experiments were performed in roach (Rutilus rutilus). Roach liver explants were exposed to a range of CdCl2 concentrations alone (0.1-50μM) or with an effective concentration (100nM) of 17β-estradiol (E2). In addition, juvenile roach were intraperitoneally injected with CdCl2 (0.1-2.5mg/kg) with or without 1mg E2/kg. Subsequent analysis evaluated the effect of CdCl2 on vitellogenin (VTG) synthesis both at the mRNA and protein level, on estrogen receptors (erα and erβ1) and on androgen receptor (ar) mRNA expression. Ex vivo and in vivo experiments indicated that CdCl2 is strongly anti-estrogenic as, when co-exposed to E2, CdCl2 significantly inhibited VTG production as well as vtg and erα mRNA expressions. Moreover, CdCl2 compromised the E2-mediated induction of the ar mRNA expression in vivo.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gerbron</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France. Electronic address: marie.gerbron@univ-lehavre.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geraudie</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France; Akvaplan Niva as, Fram Centre, 9296 Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xuereb</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marie</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minier</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Ecotoxicology, ULH Normandie Université, SFR SACLE 4116, BP 540, 76058 Le Havre, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>May</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mar Pollut Bull</MedlineTA><NlmUniqueID>0260231</NlmUniqueID><ISSNLinking>0025-326X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052244">Endocrine Disruptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047628">Estrogen Receptor alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011944">Receptors, Androgen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011960">Receptors, Estrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014819">Vitellogenins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>00BH33GNGH</RegistryNumber><NameOfSubstance UI="D002104">Cadmium</NameOfSubstance></Chemical><Chemical><RegistryNumber>4TI98Z838E</RegistryNumber><NameOfSubstance UI="D004958">Estradiol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002104" MajorTopicYN="N">Cadmium</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003530" MajorTopicYN="N">Cyprinidae</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052244" MajorTopicYN="N">Endocrine Disruptors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004958" MajorTopicYN="N">Estradiol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047628" MajorTopicYN="N">Estrogen Receptor alpha</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011944" MajorTopicYN="N">Receptors, Androgen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011960" MajorTopicYN="N">Receptors, Estrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014819" MajorTopicYN="N">Vitellogenins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cadmium</Keyword><Keyword MajorTopicYN="N">Endocrine disruption</Keyword><Keyword MajorTopicYN="N">Liver explants</Keyword><Keyword MajorTopicYN="N">Roach</Keyword><Keyword MajorTopicYN="N">Steroid receptors</Keyword><Keyword MajorTopicYN="N">Vitellogenin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>7</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>3</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>3</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26024563</ArticleId><ArticleId IdType="pii">S0025-326X(15)00188-5</ArticleId><ArticleId IdType="doi">10.1016/j.marpolbul.2015.03.043</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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