Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Identifieur interne : 000050 ( PubMed/Corpus ); précédent : 000049; suivant : 000051Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Auteurs : Bernhard Mlecnik ; Gabriela Bindea ; Helen K. Angell ; Pauline Maby ; Mihaela Angelova ; David Tougeron ; Sarah E. Church ; Lucie Lafontaine ; Maria Fischer ; Tessa Fredriksen ; Maristella Sasso ; Amélie M. Bilocq ; Amos Kirilovsky ; Anna C. Obenauf ; Mohamad Hamieh ; Anne Berger ; Patrick Bruneval ; Jean-Jacques Tuech ; Jean-Christophe Sabourin ; Florence Le Pessot ; Jacques Mauillon ; Arash Rafii ; Pierre Laurent-Puig ; Michael R. Speicher ; Zlatko Trajanoski ; Pierre Michel ; Richard Sesboüe ; Thierry Frebourg ; Franck Pagès ; Viia Valge-Archer ; Jean-Baptiste Latouche ; Jérôme GalonSource :
- Immunity [ 1097-4180 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cells, Cultured, Colorectal Neoplasms (diagnosis), Colorectal Neoplasms (mortality), Cytotoxicity Tests, Immunologic, DNA Mutational Analysis, Female, Frameshift Mutation (genetics), Humans, Immunoassay (methods), Immunologic Memory, Male, Microsatellite Instability, Microsatellite Repeats, Pathology, Molecular (methods), Predictive Value of Tests, Prognosis, Survival Analysis, T-Lymphocyte Subsets (immunology), Th1 Cells (immunology), Transcriptome.
- MESH :
- diagnosis : Colorectal Neoplasms.
- genetics : Frameshift Mutation.
- immunology : T-Lymphocyte Subsets, Th1 Cells.
- methods : Immunoassay, Pathology, Molecular.
- mortality : Colorectal Neoplasms.
- Aged, Aged, 80 and over, Cells, Cultured, Cytotoxicity Tests, Immunologic, DNA Mutational Analysis, Female, Humans, Immunologic Memory, Male, Microsatellite Instability, Microsatellite Repeats, Predictive Value of Tests, Prognosis, Survival Analysis, Transcriptome.
Abstract
Microsatellite instability in colorectal cancer predicts favorable outcomes. However, the mechanistic relationship between microsatellite instability, tumor-infiltrating immune cells, Immunoscore, and their impact on patient survival remains to be elucidated. We found significant differences in mutational patterns, chromosomal instability, and gene expression that correlated with patient microsatellite instability status. A prominent immune gene expression was observed in microsatellite-instable (MSI) tumors, as well as in a subgroup of microsatellite-stable (MSS) tumors. MSI tumors had increased frameshift mutations, showed genetic evidence of immunoediting, had higher densities of Th1, effector-memory T cells, in situ proliferating T cells, and inhibitory PD1-PDL1 cells, had high Immunoscores, and were infiltrated with mutation-specific cytotoxic T cells. Multivariate analysis revealed that Immunoscore was superior to microsatellite instability in predicting patients' disease-specific recurrence and survival. These findings indicate that assessment of the immune status via Immunoscore provides a potent indicator of tumor recurrence beyond microsatellite-instability staging that could be an important guide for immunotherapy strategies.
DOI: 10.1016/j.immuni.2016.02.025
PubMed: 26982367
Links to Exploration step
pubmed:26982367Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.</title><author><name sortKey="Mlecnik, Bernhard" sort="Mlecnik, Bernhard" uniqKey="Mlecnik B" first="Bernhard" last="Mlecnik">Bernhard Mlecnik</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bindea, Gabriela" sort="Bindea, Gabriela" uniqKey="Bindea G" first="Gabriela" last="Bindea">Gabriela Bindea</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Angell, Helen K" sort="Angell, Helen K" uniqKey="Angell H" first="Helen K" last="Angell">Helen K. Angell</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Maby, Pauline" sort="Maby, Pauline" uniqKey="Maby P" first="Pauline" last="Maby">Pauline Maby</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Angelova, Mihaela" sort="Angelova, Mihaela" uniqKey="Angelova M" first="Mihaela" last="Angelova">Mihaela Angelova</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Tougeron, David" sort="Tougeron, David" uniqKey="Tougeron D" first="David" last="Tougeron">David Tougeron</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Church, Sarah E" sort="Church, Sarah E" uniqKey="Church S" first="Sarah E" last="Church">Sarah E. Church</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lafontaine, Lucie" sort="Lafontaine, Lucie" uniqKey="Lafontaine L" first="Lucie" last="Lafontaine">Lucie Lafontaine</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Maria" sort="Fischer, Maria" uniqKey="Fischer M" first="Maria" last="Fischer">Maria Fischer</name><affiliation><nlm:affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Fredriksen, Tessa" sort="Fredriksen, Tessa" uniqKey="Fredriksen T" first="Tessa" last="Fredriksen">Tessa Fredriksen</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sasso, Maristella" sort="Sasso, Maristella" uniqKey="Sasso M" first="Maristella" last="Sasso">Maristella Sasso</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bilocq, Amelie M" sort="Bilocq, Amelie M" uniqKey="Bilocq A" first="Amélie M" last="Bilocq">Amélie M. Bilocq</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kirilovsky, Amos" sort="Kirilovsky, Amos" uniqKey="Kirilovsky A" first="Amos" last="Kirilovsky">Amos Kirilovsky</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Obenauf, Anna C" sort="Obenauf, Anna C" uniqKey="Obenauf A" first="Anna C" last="Obenauf">Anna C. Obenauf</name><affiliation><nlm:affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hamieh, Mohamad" sort="Hamieh, Mohamad" uniqKey="Hamieh M" first="Mohamad" last="Hamieh">Mohamad Hamieh</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Berger, Anne" sort="Berger, Anne" uniqKey="Berger A" first="Anne" last="Berger">Anne Berger</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; Department of General and Digestive Surgery, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bruneval, Patrick" sort="Bruneval, Patrick" uniqKey="Bruneval P" first="Patrick" last="Bruneval">Patrick Bruneval</name><affiliation><nlm:affiliation>Department of Anatomopathology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tuech, Jean Jacques" sort="Tuech, Jean Jacques" uniqKey="Tuech J" first="Jean-Jacques" last="Tuech">Jean-Jacques Tuech</name><affiliation><nlm:affiliation>Department of Digestive Surgery, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sabourin, Jean Christophe" sort="Sabourin, Jean Christophe" uniqKey="Sabourin J" first="Jean-Christophe" last="Sabourin">Jean-Christophe Sabourin</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Pessot, Florence" sort="Le Pessot, Florence" uniqKey="Le Pessot F" first="Florence" last="Le Pessot">Florence Le Pessot</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mauillon, Jacques" sort="Mauillon, Jacques" uniqKey="Mauillon J" first="Jacques" last="Mauillon">Jacques Mauillon</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France; Department of Gastroenterology, Le Havre Hospital, 76600 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rafii, Arash" sort="Rafii, Arash" uniqKey="Rafii A" first="Arash" last="Rafii">Arash Rafii</name><affiliation><nlm:affiliation>Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, 3263 Doha, Qatar.</nlm:affiliation></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:affiliation>UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Speicher, Michael R" sort="Speicher, Michael R" uniqKey="Speicher M" first="Michael R" last="Speicher">Michael R. Speicher</name><affiliation><nlm:affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Trajanoski, Zlatko" sort="Trajanoski, Zlatko" uniqKey="Trajanoski Z" first="Zlatko" last="Trajanoski">Zlatko Trajanoski</name><affiliation><nlm:affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Pierre" sort="Michel, Pierre" uniqKey="Michel P" first="Pierre" last="Michel">Pierre Michel</name><affiliation><nlm:affiliation>Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sesboue, Richard" sort="Sesboue, Richard" uniqKey="Sesboue R" first="Richard" last="Sesboüe">Richard Sesboüe</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Department of Immunology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Valge Archer, Viia" sort="Valge Archer, Viia" uniqKey="Valge Archer V" first="Viia" last="Valge-Archer">Viia Valge-Archer</name><affiliation><nlm:affiliation>Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK; MedImmune, CB21 GGH Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Latouche, Jean Baptiste" sort="Latouche, Jean Baptiste" uniqKey="Latouche J" first="Jean-Baptiste" last="Latouche">Jean-Baptiste Latouche</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address: jerome.galon@crc.jussieu.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26982367</idno><idno type="pmid">26982367</idno><idno type="doi">10.1016/j.immuni.2016.02.025</idno><idno type="wicri:Area/PubMed/Corpus">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.</title><author><name sortKey="Mlecnik, Bernhard" sort="Mlecnik, Bernhard" uniqKey="Mlecnik B" first="Bernhard" last="Mlecnik">Bernhard Mlecnik</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bindea, Gabriela" sort="Bindea, Gabriela" uniqKey="Bindea G" first="Gabriela" last="Bindea">Gabriela Bindea</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Angell, Helen K" sort="Angell, Helen K" uniqKey="Angell H" first="Helen K" last="Angell">Helen K. Angell</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Maby, Pauline" sort="Maby, Pauline" uniqKey="Maby P" first="Pauline" last="Maby">Pauline Maby</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Angelova, Mihaela" sort="Angelova, Mihaela" uniqKey="Angelova M" first="Mihaela" last="Angelova">Mihaela Angelova</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Tougeron, David" sort="Tougeron, David" uniqKey="Tougeron D" first="David" last="Tougeron">David Tougeron</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Church, Sarah E" sort="Church, Sarah E" uniqKey="Church S" first="Sarah E" last="Church">Sarah E. Church</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lafontaine, Lucie" sort="Lafontaine, Lucie" uniqKey="Lafontaine L" first="Lucie" last="Lafontaine">Lucie Lafontaine</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Maria" sort="Fischer, Maria" uniqKey="Fischer M" first="Maria" last="Fischer">Maria Fischer</name><affiliation><nlm:affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Fredriksen, Tessa" sort="Fredriksen, Tessa" uniqKey="Fredriksen T" first="Tessa" last="Fredriksen">Tessa Fredriksen</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sasso, Maristella" sort="Sasso, Maristella" uniqKey="Sasso M" first="Maristella" last="Sasso">Maristella Sasso</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bilocq, Amelie M" sort="Bilocq, Amelie M" uniqKey="Bilocq A" first="Amélie M" last="Bilocq">Amélie M. Bilocq</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kirilovsky, Amos" sort="Kirilovsky, Amos" uniqKey="Kirilovsky A" first="Amos" last="Kirilovsky">Amos Kirilovsky</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Obenauf, Anna C" sort="Obenauf, Anna C" uniqKey="Obenauf A" first="Anna C" last="Obenauf">Anna C. Obenauf</name><affiliation><nlm:affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hamieh, Mohamad" sort="Hamieh, Mohamad" uniqKey="Hamieh M" first="Mohamad" last="Hamieh">Mohamad Hamieh</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Berger, Anne" sort="Berger, Anne" uniqKey="Berger A" first="Anne" last="Berger">Anne Berger</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; Department of General and Digestive Surgery, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bruneval, Patrick" sort="Bruneval, Patrick" uniqKey="Bruneval P" first="Patrick" last="Bruneval">Patrick Bruneval</name><affiliation><nlm:affiliation>Department of Anatomopathology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tuech, Jean Jacques" sort="Tuech, Jean Jacques" uniqKey="Tuech J" first="Jean-Jacques" last="Tuech">Jean-Jacques Tuech</name><affiliation><nlm:affiliation>Department of Digestive Surgery, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sabourin, Jean Christophe" sort="Sabourin, Jean Christophe" uniqKey="Sabourin J" first="Jean-Christophe" last="Sabourin">Jean-Christophe Sabourin</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Pessot, Florence" sort="Le Pessot, Florence" uniqKey="Le Pessot F" first="Florence" last="Le Pessot">Florence Le Pessot</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mauillon, Jacques" sort="Mauillon, Jacques" uniqKey="Mauillon J" first="Jacques" last="Mauillon">Jacques Mauillon</name><affiliation><nlm:affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France; Department of Gastroenterology, Le Havre Hospital, 76600 Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rafii, Arash" sort="Rafii, Arash" uniqKey="Rafii A" first="Arash" last="Rafii">Arash Rafii</name><affiliation><nlm:affiliation>Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, 3263 Doha, Qatar.</nlm:affiliation></affiliation></author><author><name sortKey="Laurent Puig, Pierre" sort="Laurent Puig, Pierre" uniqKey="Laurent Puig P" first="Pierre" last="Laurent-Puig">Pierre Laurent-Puig</name><affiliation><nlm:affiliation>UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Speicher, Michael R" sort="Speicher, Michael R" uniqKey="Speicher M" first="Michael R" last="Speicher">Michael R. Speicher</name><affiliation><nlm:affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Trajanoski, Zlatko" sort="Trajanoski, Zlatko" uniqKey="Trajanoski Z" first="Zlatko" last="Trajanoski">Zlatko Trajanoski</name><affiliation><nlm:affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Pierre" sort="Michel, Pierre" uniqKey="Michel P" first="Pierre" last="Michel">Pierre Michel</name><affiliation><nlm:affiliation>Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sesboue, Richard" sort="Sesboue, Richard" uniqKey="Sesboue R" first="Richard" last="Sesboüe">Richard Sesboüe</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Department of Immunology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Valge Archer, Viia" sort="Valge Archer, Viia" uniqKey="Valge Archer V" first="Viia" last="Valge-Archer">Viia Valge-Archer</name><affiliation><nlm:affiliation>Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK; MedImmune, CB21 GGH Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Latouche, Jean Baptiste" sort="Latouche, Jean Baptiste" uniqKey="Latouche J" first="Jean-Baptiste" last="Latouche">Jean-Baptiste Latouche</name><affiliation><nlm:affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><affiliation><nlm:affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address: jerome.galon@crc.jussieu.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Immunity</title><idno type="eISSN">1097-4180</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cells, Cultured</term><term>Colorectal Neoplasms (diagnosis)</term><term>Colorectal Neoplasms (mortality)</term><term>Cytotoxicity Tests, Immunologic</term><term>DNA Mutational Analysis</term><term>Female</term><term>Frameshift Mutation (genetics)</term><term>Humans</term><term>Immunoassay (methods)</term><term>Immunologic Memory</term><term>Male</term><term>Microsatellite Instability</term><term>Microsatellite Repeats</term><term>Pathology, Molecular (methods)</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Survival Analysis</term><term>T-Lymphocyte Subsets (immunology)</term><term>Th1 Cells (immunology)</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Frameshift Mutation</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>T-Lymphocyte Subsets</term><term>Th1 Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunoassay</term><term>Pathology, Molecular</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cells, Cultured</term><term>Cytotoxicity Tests, Immunologic</term><term>DNA Mutational Analysis</term><term>Female</term><term>Humans</term><term>Immunologic Memory</term><term>Male</term><term>Microsatellite Instability</term><term>Microsatellite Repeats</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Survival Analysis</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microsatellite instability in colorectal cancer predicts favorable outcomes. However, the mechanistic relationship between microsatellite instability, tumor-infiltrating immune cells, Immunoscore, and their impact on patient survival remains to be elucidated. We found significant differences in mutational patterns, chromosomal instability, and gene expression that correlated with patient microsatellite instability status. A prominent immune gene expression was observed in microsatellite-instable (MSI) tumors, as well as in a subgroup of microsatellite-stable (MSS) tumors. MSI tumors had increased frameshift mutations, showed genetic evidence of immunoediting, had higher densities of Th1, effector-memory T cells, in situ proliferating T cells, and inhibitory PD1-PDL1 cells, had high Immunoscores, and were infiltrated with mutation-specific cytotoxic T cells. Multivariate analysis revealed that Immunoscore was superior to microsatellite instability in predicting patients' disease-specific recurrence and survival. These findings indicate that assessment of the immune status via Immunoscore provides a potent indicator of tumor recurrence beyond microsatellite-instability staging that could be an important guide for immunotherapy strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26982367</PMID><DateCreated><Year>2016</Year><Month>3</Month><Day>17</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>3</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-4180</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month><Day>15</Day></PubDate></JournalIssue><Title>Immunity</Title><ISOAbbreviation>Immunity</ISOAbbreviation></Journal><ArticleTitle>Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.</ArticleTitle><Pagination><MedlinePgn>698-711</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.immuni.2016.02.025</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1074-7613(16)30064-4</ELocationID><Abstract><AbstractText>Microsatellite instability in colorectal cancer predicts favorable outcomes. However, the mechanistic relationship between microsatellite instability, tumor-infiltrating immune cells, Immunoscore, and their impact on patient survival remains to be elucidated. We found significant differences in mutational patterns, chromosomal instability, and gene expression that correlated with patient microsatellite instability status. A prominent immune gene expression was observed in microsatellite-instable (MSI) tumors, as well as in a subgroup of microsatellite-stable (MSS) tumors. MSI tumors had increased frameshift mutations, showed genetic evidence of immunoediting, had higher densities of Th1, effector-memory T cells, in situ proliferating T cells, and inhibitory PD1-PDL1 cells, had high Immunoscores, and were infiltrated with mutation-specific cytotoxic T cells. Multivariate analysis revealed that Immunoscore was superior to microsatellite instability in predicting patients' disease-specific recurrence and survival. These findings indicate that assessment of the immune status via Immunoscore provides a potent indicator of tumor recurrence beyond microsatellite-instability staging that could be an important guide for immunotherapy strategies.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mlecnik</LastName><ForeName>Bernhard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bindea</LastName><ForeName>Gabriela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Angell</LastName><ForeName>Helen K</ForeName><Initials>HK</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maby</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Angelova</LastName><ForeName>Mihaela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tougeron</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Church</LastName><ForeName>Sarah E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lafontaine</LastName><ForeName>Lucie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fredriksen</LastName><ForeName>Tessa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasso</LastName><ForeName>Maristella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bilocq</LastName><ForeName>Amélie M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirilovsky</LastName><ForeName>Amos</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obenauf</LastName><ForeName>Anna C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamieh</LastName><ForeName>Mohamad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; Department of General and Digestive Surgery, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruneval</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Anatomopathology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuech</LastName><ForeName>Jean-Jacques</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Digestive Surgery, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabourin</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Pessot</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mauillon</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Anatomopathology, Rouen University Hospital, 76000 Rouen, France; Department of Gastroenterology, Le Havre Hospital, 76600 Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rafii</LastName><ForeName>Arash</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, 3263 Doha, Qatar.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurent-Puig</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Speicher</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, Medical University of Graz, 8010 Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trajanoski</LastName><ForeName>Zlatko</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Biocenter, Division of Bioinformatics, Innsbruck Medical University, 6020 Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sesboüe</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frebourg</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; INSERM, UMRS775, Bases Moléculaires de la Réponse aux Xénobiotiques, 75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagès</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France; Department of Immunology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hopitaux de Paris, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valge-Archer</LastName><ForeName>Viia</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Innovative Medicines and Early Development, Oncology, AstraZeneca, CB4 OWG Cambridge, UK; MedImmune, CB21 GGH Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Latouche</LastName><ForeName>Jean-Baptiste</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>INSERM, U1079, Faculté de Médecine, Université de Rouen and the Institute for Research and Innovation in Biomedecine (IRIB), 76000 Rouen, France; Department of Genetics, Rouen University Hospital, 76000 Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galon</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, 75006 Paris, France; UMRS1138, Université Paris Descartes - Sorbonne Paris Cité, 75006 Paris, France; UMRS1138, Pierre and Marie Curie University (Paris 6) - Sorbonne Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address: jerome.galon@crc.jussieu.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Immunity</MedlineTA><NlmUniqueID>9432918</NlmUniqueID><ISSNLinking>1074-7613</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Immunity. 2016 Mar 15;44(3):525-6</RefSource><PMID Version="1">26982362</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003601" MajorTopicYN="N">Cytotoxicity Tests, Immunologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016368" MajorTopicYN="N">Frameshift Mutation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007118" MajorTopicYN="N">Immunoassay</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="N">Immunologic Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053842" MajorTopicYN="N">Microsatellite Instability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018895" MajorTopicYN="N">Microsatellite Repeats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057089" MajorTopicYN="N">Pathology, Molecular</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016176" MajorTopicYN="N">T-Lymphocyte Subsets</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018417" MajorTopicYN="N">Th1 Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>6</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26982367</ArticleId><ArticleId IdType="pii">S1074-7613(16)30064-4</ArticleId><ArticleId IdType="doi">10.1016/j.immuni.2016.02.025</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000050 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000050 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26982367
|texte= Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26982367" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |