Predictive Value of NRAMP1 and HGPX1 Gene Polymorphism for Maintenance BCG Response in Non-muscle-invasive Bladder Cancer.
Identifieur interne : 000045 ( PubMed/Corpus ); précédent : 000044; suivant : 000046Predictive Value of NRAMP1 and HGPX1 Gene Polymorphism for Maintenance BCG Response in Non-muscle-invasive Bladder Cancer.
Auteurs : Claire Lenormand ; Jérôme Couteau ; François-Xavier Nouhaud ; Géraldine Maillet ; Jacqueline Bou ; Françoise Gobet ; Christian PfisterSource :
- Anticancer research [ 1791-7530 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Cation Transport Proteins (genetics), Disease Progression, Disease-Free Survival, Female, Follow-Up Studies, Glutathione Peroxidase (genetics), Humans, Male, Middle Aged, Muscles (microbiology), Muscles (pathology), Mycobacterium bovis (metabolism), Neoplasm Recurrence, Local (genetics), Neoplasm Recurrence, Local (microbiology), Neoplasm Recurrence, Local (pathology), Polymorphism, Genetic (genetics), Retrospective Studies, Urinary Bladder Neoplasms (genetics), Urinary Bladder Neoplasms (microbiology), Urinary Bladder Neoplasms (pathology).
- MESH :
- chemical , genetics : Cation Transport Proteins, Glutathione Peroxidase.
- genetics : Neoplasm Recurrence, Local, Polymorphism, Genetic, Urinary Bladder Neoplasms.
- metabolism : Mycobacterium bovis.
- microbiology : Muscles, Neoplasm Recurrence, Local, Urinary Bladder Neoplasms.
- pathology : Muscles, Neoplasm Recurrence, Local, Urinary Bladder Neoplasms.
- Adult, Aged, Aged, 80 and over, Disease Progression, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
To assess the potential predictive value of natural resistance-associated macrophage protein 1 (NRAMP1) and human glutathione peroxidase 1 (hGPX1) polymorphism in non-muscle-invasive bladder cancer treated with bacillus Calmette-Guerin (BCG) instillation, we conducted an original ancillary multicenter study.
PubMed: 27069153
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Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maillet, Geraldine" sort="Maillet, Geraldine" uniqKey="Maillet G" first="Géraldine" last="Maillet">Géraldine Maillet</name><affiliation><nlm:affiliation>BioTechnology Laboratory, Science and Technology University, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bou, Jacqueline" sort="Bou, Jacqueline" uniqKey="Bou J" first="Jacqueline" last="Bou">Jacqueline Bou</name><affiliation><nlm:affiliation>Department of Genetics, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gobet, Francoise" sort="Gobet, Francoise" uniqKey="Gobet F" first="Françoise" last="Gobet">Françoise Gobet</name><affiliation><nlm:affiliation>Department of Pathology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Christian" sort="Pfister, Christian" uniqKey="Pfister C" first="Christian" last="Pfister">Christian Pfister</name><affiliation><nlm:affiliation>Department of Urology, Rouen University Hospital, Rouen, France Clinical Investigation Center, Inserm 6204, Onco-Urology Group, Rouen, France christian.pfister@chu-rouen.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27069153</idno><idno type="pmid">27069153</idno><idno type="wicri:Area/PubMed/Corpus">000045</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predictive Value of NRAMP1 and HGPX1 Gene Polymorphism for Maintenance BCG Response in Non-muscle-invasive Bladder Cancer.</title><author><name sortKey="Lenormand, Claire" sort="Lenormand, Claire" uniqKey="Lenormand C" first="Claire" last="Lenormand">Claire Lenormand</name><affiliation><nlm:affiliation>Department of Urology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couteau, Jerome" sort="Couteau, Jerome" uniqKey="Couteau J" first="Jérôme" last="Couteau">Jérôme Couteau</name><affiliation><nlm:affiliation>BioTechnology Laboratory, Science and Technology University, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nouhaud, Francois Xavier" sort="Nouhaud, Francois Xavier" uniqKey="Nouhaud F" first="François-Xavier" last="Nouhaud">François-Xavier Nouhaud</name><affiliation><nlm:affiliation>Department of Urology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maillet, Geraldine" sort="Maillet, Geraldine" uniqKey="Maillet G" first="Géraldine" last="Maillet">Géraldine Maillet</name><affiliation><nlm:affiliation>BioTechnology Laboratory, Science and Technology University, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bou, Jacqueline" sort="Bou, Jacqueline" uniqKey="Bou J" first="Jacqueline" last="Bou">Jacqueline Bou</name><affiliation><nlm:affiliation>Department of Genetics, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gobet, Francoise" sort="Gobet, Francoise" uniqKey="Gobet F" first="Françoise" last="Gobet">Françoise Gobet</name><affiliation><nlm:affiliation>Department of Pathology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Christian" sort="Pfister, Christian" uniqKey="Pfister C" first="Christian" last="Pfister">Christian Pfister</name><affiliation><nlm:affiliation>Department of Urology, Rouen University Hospital, Rouen, France Clinical Investigation Center, Inserm 6204, Onco-Urology Group, Rouen, France christian.pfister@chu-rouen.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Anticancer research</title><idno type="eISSN">1791-7530</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cation Transport Proteins (genetics)</term><term>Disease Progression</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Glutathione Peroxidase (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscles (microbiology)</term><term>Muscles (pathology)</term><term>Mycobacterium bovis (metabolism)</term><term>Neoplasm Recurrence, Local (genetics)</term><term>Neoplasm Recurrence, Local (microbiology)</term><term>Neoplasm Recurrence, Local (pathology)</term><term>Polymorphism, Genetic (genetics)</term><term>Retrospective Studies</term><term>Urinary Bladder Neoplasms (genetics)</term><term>Urinary Bladder Neoplasms (microbiology)</term><term>Urinary Bladder Neoplasms (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cation Transport Proteins</term><term>Glutathione Peroxidase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Neoplasm Recurrence, Local</term><term>Polymorphism, Genetic</term><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mycobacterium bovis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Muscles</term><term>Neoplasm Recurrence, Local</term><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Muscles</term><term>Neoplasm Recurrence, Local</term><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the potential predictive value of natural resistance-associated macrophage protein 1 (NRAMP1) and human glutathione peroxidase 1 (hGPX1) polymorphism in non-muscle-invasive bladder cancer treated with bacillus Calmette-Guerin (BCG) instillation, we conducted an original ancillary multicenter study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27069153</PMID><DateCreated><Year>2016</Year><Month>4</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>4</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1791-7530</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Anticancer research</Title><ISOAbbreviation>Anticancer Res.</ISOAbbreviation></Journal><ArticleTitle>Predictive Value of NRAMP1 and HGPX1 Gene Polymorphism for Maintenance BCG Response in Non-muscle-invasive Bladder Cancer.</ArticleTitle><Pagination><MedlinePgn>1737-43</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To assess the potential predictive value of natural resistance-associated macrophage protein 1 (NRAMP1) and human glutathione peroxidase 1 (hGPX1) polymorphism in non-muscle-invasive bladder cancer treated with bacillus Calmette-Guerin (BCG) instillation, we conducted an original ancillary multicenter study.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">We evaluated patients included in the multicenter URO-BCG 4 trial, who received three weekly instillations of one-third dose BCG every 6 months (group I) or two weekly instillations every 3 months (group II) for 3 years. For clinical evaluation we also evaluated tumor recurrence and muscle progression. NRAMP1 and hGPX1 polymorphism analyses were performed on blood DNA. NRAMP1 exon 15 and hGPX1 exon 1c were amplified using Type-it Microsatellite PCR Kit® for multiplex polymerase chain reaction.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">From June 2004 to April 2010, 146 randomized patients were included in this retrospective study. Blood samples were obtained from 107 patients. With 36 months of follow-up, 13.6% of patients had a tumor recurrence and muscle-invasive progression was observed in 4.3% of patients. Concerning NRAMP1 D543N polymorphism, patients with allele A had no tumor recurrence or muscle-invasive progression. No significant difference was observed in gene polymorphism distribution between groups I and II. Moreover, we did not observe any significant association of gene polymorphisms, tumor recurrence or muscle-invasive progression, event time and disease-free survival.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest that no significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time, muscle invasion frequency and disease-free survival, nevertheless, we observed that the NRAMP1 D543N GG genotype group had a shorter time to tumor recurrence.</AbstractText><CopyrightInformation>Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lenormand</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Urology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couteau</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>BioTechnology Laboratory, Science and Technology University, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nouhaud</LastName><ForeName>François-Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Department of Urology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maillet</LastName><ForeName>Géraldine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>BioTechnology Laboratory, Science and Technology University, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bou</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gobet</LastName><ForeName>Françoise</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pathology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfister</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Urology, Rouen University Hospital, Rouen, France Clinical Investigation Center, Inserm 6204, Onco-Urology Group, Rouen, France christian.pfister@chu-rouen.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>Anticancer Res</MedlineTA><NlmUniqueID>8102988</NlmUniqueID><ISSNLinking>0250-7005</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D027682">Cation Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C081134">natural resistance-associated macrophage protein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="C117216">glutathione peroxidase GPX1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber><NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027682" MajorTopicYN="N">Cation Transport Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009132" MajorTopicYN="N">Muscles</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009163" MajorTopicYN="N">Mycobacterium bovis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001749" MajorTopicYN="N">Urinary Bladder Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BGG</Keyword><Keyword MajorTopicYN="N">NRAMP1</Keyword><Keyword MajorTopicYN="N">bladder cancer</Keyword><Keyword MajorTopicYN="N">hGPX1</Keyword><Keyword MajorTopicYN="N">polymorphism</Keyword><Keyword MajorTopicYN="N">recurrence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>1</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27069153</ArticleId><ArticleId 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