[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Identifieur interne : 000410 ( PubMed/Checkpoint ); précédent : 000409; suivant : 000411[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Auteurs : B. Le Luyer [France] ; J F Mougenot ; L. Mashako ; P. Chapoy ; J P Olives ; A. Morali ; B. Chevallier ; J L Ginies ; C. Dupont ; M. DagorneSource :
- Archives francaises de pediatrie [ 0003-9764 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Alginates.
- chemical , pharmacology : Alginates.
- chemical , therapeutic use : Alginates.
- drug therapy : Gastroesophageal Reflux.
- Child, Preschool, Female, Humans, Hydrogen-Ion Concentration, Infant, Infant, Newborn, Male, Reference Values, Suspensions.
Abstract
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
PubMed: 2322080
Affiliations:
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pubmed:2322080Le document en format XML
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<term>Female</term>
<term>Gastroesophageal Reflux (drug therapy)</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Reference Values</term>
<term>Suspensions</term>
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<term>Female</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Infant</term>
<term>Infant, Newborn</term>
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<front><div type="abstract" xml:lang="en">Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.</div>
</front>
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<Title>Archives francaises de pediatrie</Title>
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<ArticleTitle>[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].</ArticleTitle>
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<Abstract><AbstractText>Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.</AbstractText>
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<name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
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