Methemoglobinemie consecutive a l'abus de gel de lidocaïne visqueuse.
Identifieur interne : 000349 ( PubMed/Checkpoint ); précédent : 000348; suivant : 000350Methemoglobinemie consecutive a l'abus de gel de lidocaïne visqueuse.
Auteurs : C. Lacroix [France] ; M. Peureux ; M. Borel ; J. GoulleSource :
- Acta clinica Belgica [ 1784-3286 ] ; 2002.
Abstract
Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1 % following repeated Xylocaine® gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.
DOI: 10.1179/acb.2002.080
PubMed: 24862528
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Borel</name></author><author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:24862528</idno><idno type="pmid">24862528</idno><idno type="doi">10.1179/acb.2002.080</idno><idno type="wicri:Area/PubMed/Corpus">000365</idno><idno type="wicri:Area/PubMed/Curation">000365</idno><idno type="wicri:Area/PubMed/Checkpoint">000365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Methemoglobinemie consecutive a l'abus de gel de lidocaïne visqueuse.</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique Groupe Hospitalier B.P. 24 76083 LE HAVRE CEDEX - FRANCE Tél : 02/32/73/32/24 Fax : 02/32/73/32/38, e-mail : clacroix@ch-havre.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Laboratoire de Pharmacocinétique et de Toxicologie Clinique Groupe Hospitalier B.P. 24 76083 LE HAVRE CEDEX - FRANCE Tél : 02/32/73/32/24 Fax : 02/32/73/32/38</wicri:regionArea></affiliation></author><author><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name></author><author><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name></author><author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name></author></analytic><series><title level="j">Acta clinica Belgica</title><idno type="ISSN">1784-3286</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1 % following repeated Xylocaine® gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24862528</PMID><DateCreated><Year>2014</Year><Month>5</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>05</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>3</Month><Day>7</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1784-3286</ISSN><JournalIssue CitedMedium="Print"><Volume>57 Suppl 1</Volume><PubDate><Year>2002</Year></PubDate></JournalIssue><Title>Acta clinica Belgica</Title><ISOAbbreviation>Acta Clin Belg</ISOAbbreviation></Journal><ArticleTitle>Methemoglobinemie consecutive a l'abus de gel de lidocaïne visqueuse.</ArticleTitle><Pagination><MedlinePgn>58-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1179/acb.2002.080</ELocationID><Abstract><AbstractText>Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1 % following repeated Xylocaine® gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lacroix</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique Groupe Hospitalier B.P. 24 76083 LE HAVRE CEDEX - FRANCE Tél : 02/32/73/32/24 Fax : 02/32/73/32/38, e-mail : clacroix@ch-havre.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peureux</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Borel</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Goulle</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Acta Clin Belg</MedlineTA><NlmUniqueID>0370306</NlmUniqueID><ISSNLinking>1784-3286</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lidocaine,</Keyword><Keyword MajorTopicYN="N">aniline,</Keyword><Keyword MajorTopicYN="N">lidocaïne,</Keyword><Keyword MajorTopicYN="N">metabolism.</Keyword><Keyword MajorTopicYN="N">methemoglobinemia,</Keyword><Keyword MajorTopicYN="N">métabolisme.</Keyword><Keyword MajorTopicYN="N">méthémoglobinémie,</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24862528</ArticleId><ArticleId IdType="doi">10.1179/acb.2002.080</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name></noCountry><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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