Panton-Valentine Leukocidin-Positive and Toxic Shock Syndrome Toxin 1-Positive Methicillin-Resistant Staphylococcus aureus: a French Multicenter Prospective Study in 2008▿
Identifieur interne : 000175 ( Pmc/Curation ); précédent : 000174; suivant : 000176Panton-Valentine Leukocidin-Positive and Toxic Shock Syndrome Toxin 1-Positive Methicillin-Resistant Staphylococcus aureus: a French Multicenter Prospective Study in 2008▿
Auteurs : Jérôme Robert ; Anne Tristan ; Laurent Cavalié ; Jean-Winoc Decousser ; Michèle Bes ; Jerome Etienne ; Frédéric LaurentSource :
- Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2011.
Abstract
The epidemiology of community-acquired methicillin-resistant
Url:
DOI: 10.1128/AAC.01221-10
PubMed: 21220529
PubMed Central: 3067161
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: a French Multicenter Prospective Study in 2008<xref ref-type="fn" rid="fn1">▿</xref>
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<author><name sortKey="Robert, Jerome" sort="Robert, Jerome" uniqKey="Robert J" first="Jérôme" last="Robert">Jérôme Robert</name>
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<author><name sortKey="Tristan, Anne" sort="Tristan, Anne" uniqKey="Tristan A" first="Anne" last="Tristan">Anne Tristan</name>
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<author><name sortKey="Cavalie, Laurent" sort="Cavalie, Laurent" uniqKey="Cavalie L" first="Laurent" last="Cavalié">Laurent Cavalié</name>
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<author><name sortKey="Decousser, Jean Winoc" sort="Decousser, Jean Winoc" uniqKey="Decousser J" first="Jean-Winoc" last="Decousser">Jean-Winoc Decousser</name>
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<author><name sortKey="Bes, Michele" sort="Bes, Michele" uniqKey="Bes M" first="Michèle" last="Bes">Michèle Bes</name>
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<author><name sortKey="Etienne, Jerome" sort="Etienne, Jerome" uniqKey="Etienne J" first="Jerome" last="Etienne">Jerome Etienne</name>
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<author><name sortKey="Laurent, Frederic" sort="Laurent, Frederic" uniqKey="Laurent F" first="Frédéric" last="Laurent">Frédéric Laurent</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Panton-Valentine Leukocidin-Positive and Toxic Shock Syndrome Toxin 1-Positive Methicillin-Resistant <italic>Staphylococcus aureus</italic>
: a French Multicenter Prospective Study in 2008<xref ref-type="fn" rid="fn1">▿</xref>
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<author><name sortKey="Robert, Jerome" sort="Robert, Jerome" uniqKey="Robert J" first="Jérôme" last="Robert">Jérôme Robert</name>
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<author><name sortKey="Tristan, Anne" sort="Tristan, Anne" uniqKey="Tristan A" first="Anne" last="Tristan">Anne Tristan</name>
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<author><name sortKey="Cavalie, Laurent" sort="Cavalie, Laurent" uniqKey="Cavalie L" first="Laurent" last="Cavalié">Laurent Cavalié</name>
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<author><name sortKey="Decousser, Jean Winoc" sort="Decousser, Jean Winoc" uniqKey="Decousser J" first="Jean-Winoc" last="Decousser">Jean-Winoc Decousser</name>
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<author><name sortKey="Bes, Michele" sort="Bes, Michele" uniqKey="Bes M" first="Michèle" last="Bes">Michèle Bes</name>
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<author><name sortKey="Etienne, Jerome" sort="Etienne, Jerome" uniqKey="Etienne J" first="Jerome" last="Etienne">Jerome Etienne</name>
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<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
<idno type="eISSN">1098-6596</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p>The epidemiology of community-acquired methicillin-resistant <italic>Staphylococcus aureus</italic>
(CA-MRSA) differs from country to country. We assess the features of the ST80 European clone, which is the most prevalent PVL-positive CA-MRSA clone in Europe, and the TSST-1 ST5 clone that was recently described in France. In 2008, all MRSA strains susceptible to fluoroquinolones and gentamicin and resistant to fusidic acid that were isolated in 104 French laboratories were characterized using <italic>agr</italic>
alleles, <italic>spa</italic>
typing, and the staphylococcal cassette chromosome <italic>mec</italic>
element and PCR profiling of 21 toxin genes. Three phenotypes were defined: (i) kanamycin resistant, associated with the ST80 clone; (ii) kanamycin and tobramycin resistant, associated with the ST5 clone; and (iii) aminoglycoside susceptible, which was less frequently associated with the ST5 clone. Among the 7,253 MRSA strains isolated, 91 (1.3%) were ST80 CA-MRSA (89 phenotype 1) and 190 (2.6%) were ST5 CA-MRSA (146 phenotype 2, 42 phenotype 3). Compared to the latter, ST80 CA-MRSAs were more likely to be community acquired (80% versus 46%) and found in young patients (median age, 26.0 years versus 49.5 years) with deep cutaneous infections (48% versus 6%). They were less likely to be tetracycline susceptible (22% versus 85%) and to be isolated from respiratory infections (6% versus 27%). The TSST-1 ST5 clone has rapidly emerged in France and has become even more prevalent than the ST80 European clone, whose prevalence has remained stable. The epidemiological and clinical patterns of the two clones differ drastically. Given the low prevalence of both among all staphylococcal infections, no modification of antibiotic recommendations is required yet.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id>
<journal-id journal-id-type="publisher-id">aac</journal-id>
<journal-title-group><journal-title>Antimicrobial Agents and Chemotherapy</journal-title>
</journal-title-group>
<issn pub-type="ppub">0066-4804</issn>
<issn pub-type="epub">1098-6596</issn>
<publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21220529</article-id>
<article-id pub-id-type="pmc">3067161</article-id>
<article-id pub-id-type="publisher-id">1221-10</article-id>
<article-id pub-id-type="doi">10.1128/AAC.01221-10</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Epidemiology and Surveillance</subject>
</subj-group>
</article-categories>
<title-group><article-title>Panton-Valentine Leukocidin-Positive and Toxic Shock Syndrome Toxin 1-Positive Methicillin-Resistant <italic>Staphylococcus aureus</italic>
: a French Multicenter Prospective Study in 2008<xref ref-type="fn" rid="fn1">▿</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Robert</surname>
<given-names>Jérôme</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tristan</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cavalié</surname>
<given-names>Laurent</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Decousser</surname>
<given-names>Jean-Winoc</given-names>
</name>
<xref ref-type="aff" rid="aff1">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bes</surname>
<given-names>Michèle</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Etienne</surname>
<given-names>Jerome</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laurent</surname>
<given-names>Frédéric</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><collab>on behalf of ONERBA (Observatoire National de l'Epidémiologie de la Résistance Bactérienne aux Antibiotiques)</collab>
</contrib>
</contrib-group>
<aff id="aff1">Bactériologie-Hygiène, EA 1541, UFR de Médecine Pierre et Marie Curie (Paris 6), Site Pitié-Salpêtrière, AP-HP, Paris, France,<label>1</label>
French National Reference Centre for Staphylococci, University of Lyon, Inserm U851, Faculté de Médecine Lyon Est, Lyon, France,<label>2</label>
Bactériologie-Hygiène, Institut Fédératif de Biologie, Toulouse, France,<label>3</label>
Bactériologie-Hygiène, CHU Antoine Béclère, APHP, Clamart, France<label>4</label>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Mailing address: Bactériologie-Hygiène, UFR de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, 91 Bd de l'hôpital, 75634 Paris Cedex 13, France. Phone: (33) 1 40 77 97 46. Fax: (33) 1 45 82 75 77. E-mail: <email>jerome.robert@psl.aphp.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>1</month>
<year>2011</year>
</pub-date>
<volume>55</volume>
<issue>4</issue>
<fpage>1734</fpage>
<lpage>1739</lpage>
<history><date date-type="received"><day>5</day>
<month>9</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>29</day>
<month>10</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>3</day>
<month>1</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2011, American Society for Microbiology</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:href="zac00411001734.pdf"></self-uri>
<abstract><p>The epidemiology of community-acquired methicillin-resistant <italic>Staphylococcus aureus</italic>
(CA-MRSA) differs from country to country. We assess the features of the ST80 European clone, which is the most prevalent PVL-positive CA-MRSA clone in Europe, and the TSST-1 ST5 clone that was recently described in France. In 2008, all MRSA strains susceptible to fluoroquinolones and gentamicin and resistant to fusidic acid that were isolated in 104 French laboratories were characterized using <italic>agr</italic>
alleles, <italic>spa</italic>
typing, and the staphylococcal cassette chromosome <italic>mec</italic>
element and PCR profiling of 21 toxin genes. Three phenotypes were defined: (i) kanamycin resistant, associated with the ST80 clone; (ii) kanamycin and tobramycin resistant, associated with the ST5 clone; and (iii) aminoglycoside susceptible, which was less frequently associated with the ST5 clone. Among the 7,253 MRSA strains isolated, 91 (1.3%) were ST80 CA-MRSA (89 phenotype 1) and 190 (2.6%) were ST5 CA-MRSA (146 phenotype 2, 42 phenotype 3). Compared to the latter, ST80 CA-MRSAs were more likely to be community acquired (80% versus 46%) and found in young patients (median age, 26.0 years versus 49.5 years) with deep cutaneous infections (48% versus 6%). They were less likely to be tetracycline susceptible (22% versus 85%) and to be isolated from respiratory infections (6% versus 27%). The TSST-1 ST5 clone has rapidly emerged in France and has become even more prevalent than the ST80 European clone, whose prevalence has remained stable. The epidemiological and clinical patterns of the two clones differ drastically. Given the low prevalence of both among all staphylococcal infections, no modification of antibiotic recommendations is required yet.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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