Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration
Identifieur interne : 000123 ( Pmc/Checkpoint ); précédent : 000122; suivant : 000124Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration
Auteurs : Erika M. C. D Gata [États-Unis] ; Pierre Magal [France] ; Damien Olivier [France] ; Shigui Ruan [États-Unis] ; Glenn F. Webb [États-Unis]Source :
- Journal of theoretical biology [ 0022-5193 ] ; 2007.
Abstract
Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. To simplify the interpretation and application of the model’s conclusions, a corresponding deterministic model was created, which describes the average behavior of the IBM over a large number of simulations. The integration of these two model systems provides a quantitative analysis of the emergence and spread of antibiotic-resistant bacteria, and demonstrates that early initiation of treatment and minimization of its duration mitigates antibiotic resistance epidemics in hospitals.
Url:
DOI: 10.1016/j.jtbi.2007.08.011
PubMed: 17905310
PubMed Central: 2432019
Affiliations:
- France, États-Unis
- Floride, Haute-Normandie, Massachusetts, Région Normandie, Tennessee
- Cambridge (Massachusetts), Le Havre
- Université Harvard, Université du Havre
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D Gata</name><affiliation wicri:level="4"><nlm:aff id="A1"> Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Mathematics, Université du Havre, 76058 Le Havre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Department of Mathematics, Université du Havre, 76058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name><affiliation wicri:level="4"><nlm:aff id="A3"> Department of Computer Sciences, Université du Havre, 76058 Le Havre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Department of Computer Sciences, Université du Havre, 76058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Mathematics, University of Miami, Coral Gables, FL 33124-4250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Mathematics, University of Miami, Coral Gables, FL 33124-4250</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Webb, Glenn F" sort="Webb, Glenn F" uniqKey="Webb G" first="Glenn F." last="Webb">Glenn F. 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C." last="D Gata">Erika M. C. D Gata</name><affiliation wicri:level="4"><nlm:aff id="A1"> Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Mathematics, Université du Havre, 76058 Le Havre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Department of Mathematics, Université du Havre, 76058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name><affiliation wicri:level="4"><nlm:aff id="A3"> Department of Computer Sciences, Université du Havre, 76058 Le Havre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Department of Computer Sciences, Université du Havre, 76058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Mathematics, University of Miami, Coral Gables, FL 33124-4250, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Mathematics, University of Miami, Coral Gables, FL 33124-4250</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Webb, Glenn F" sort="Webb, Glenn F" uniqKey="Webb G" first="Glenn F." last="Webb">Glenn F. Webb</name><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Mathematics, Vanderbilt University, Nashville, TN 37240</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Journal of theoretical biology</title><idno type="ISSN">0022-5193</idno><idno type="eISSN">1095-8541</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. To simplify the interpretation and application of the model’s conclusions, a corresponding deterministic model was created, which describes the average behavior of the IBM over a large number of simulations. The integration of these two model systems provides a quantitative analysis of the emergence and spread of antibiotic-resistant bacteria, and demonstrates that early initiation of treatment and minimization of its duration mitigates antibiotic resistance epidemics in hospitals.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376342</journal-id><journal-id journal-id-type="pubmed-jr-id">5295</journal-id><journal-id journal-id-type="nlm-ta">J Theor Biol</journal-id><journal-title>Journal of theoretical biology</journal-title><issn pub-type="ppub">0022-5193</issn><issn pub-type="epub">1095-8541</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17905310</article-id><article-id pub-id-type="pmc">2432019</article-id><article-id pub-id-type="doi">10.1016/j.jtbi.2007.08.011</article-id><article-id pub-id-type="manuscript">NIHMS53959</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>D’Agata</surname><given-names>Erika M.C.</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Magal</surname><given-names>Pierre</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Olivier</surname><given-names>Damien</given-names></name><xref rid="A3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Ruan</surname><given-names>Shigui</given-names></name><xref rid="A4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Webb</surname><given-names>Glenn F.</given-names></name><xref rid="A5" ref-type="aff">e</xref></contrib></contrib-group><aff id="A1"><label>a</label> Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA</aff><aff id="A2"><label>b</label> Department of Mathematics, Université du Havre, 76058 Le Havre, France</aff><aff id="A3"><label>c</label> Department of Computer Sciences, Université du Havre, 76058 Le Havre, France</aff><aff id="A4"><label>d</label> Department of Mathematics, University of Miami, Coral Gables, FL 33124-4250, USA</aff><aff id="A5"><label>e</label> Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA</aff><author-notes><corresp id="FN1">*Corresponding author. Tel.: +1 617 667 8127; fax: +1 617 667 7251. E-mail address: <email>edagata@bidmc.harvard.edu</email> (E.M.C. D’Agata)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>25</day><month>8</month><year>2007</year></pub-date><pub-date pub-type="ppub"><day>7</day><month>12</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>6</month><year>2008</year></pub-date><volume>249</volume><issue>3</issue><fpage>487</fpage><lpage>499</lpage><abstract><p id="P1">Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. To simplify the interpretation and application of the model’s conclusions, a corresponding deterministic model was created, which describes the average behavior of the IBM over a large number of simulations. The integration of these two model systems provides a quantitative analysis of the emergence and spread of antibiotic-resistant bacteria, and demonstrates that early initiation of treatment and minimization of its duration mitigates antibiotic resistance epidemics in hospitals.</p></abstract><kwd-group><kwd>Antibiotic-resistant bacteria</kwd><kwd>Individual-based model</kwd><kwd>Differential equation model</kwd><kwd>Basic reproduction number</kwd></kwd-group><contract-num rid="GM1">R01 GM083607-01</contract-num><contract-sponsor id="GM1">National Institute of General Medical Sciences : NIGMS</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Floride</li><li>Haute-Normandie</li><li>Massachusetts</li><li>Région Normandie</li><li>Tennessee</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Le Havre</li></settlement><orgName><li>Université Harvard</li><li>Université du Havre</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="D Gata, Erika M C" sort="D Gata, Erika M C" uniqKey="D Gata E" first="Erika M. C." last="D Gata">Erika M. C. D Gata</name></region><name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name><name sortKey="Webb, Glenn F" sort="Webb, Glenn F" uniqKey="Webb G" first="Glenn F." last="Webb">Glenn F. Webb</name></country><country name="France"><region name="Région Normandie"><name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name></region><name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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