The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus.
Identifieur interne : 000495 ( Ncbi/Merge ); précédent : 000494; suivant : 000496The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus.
Auteurs : Sawssan Mezghani-Chaari [Tunisie] ; Monia Machreki-Ajmi [Tunisie] ; Gauthier Tremolet [France] ; Kristell Kellner [France] ; Alain Geffard [France] ; Christophe Minier [France] ; Amel Hamza-Chaffai [Tunisie]Source :
- Environmental science and pollution research international [ 1614-7499 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Animals, Bivalvia (drug effects), Bivalvia (metabolism), Endocrine Disruptors (analysis), Endocrine Disruptors (toxicity), Gills (metabolism), Male, Malondialdehyde (analysis), Metals, Heavy (analysis), Oxidative Stress, Reproduction (drug effects), Tunisia, Vitellogenins (analysis), Waste Water (chemistry), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Endocrine Disruptors, Malondialdehyde, Metals, Heavy, Vitellogenins, Water Pollutants, Chemical.
- chemical , chemistry : Waste Water.
- chemical , toxicity : Water Pollutants, Chemical.
- geographic : Tunisia.
- drug effects : Bivalvia, Reproduction.
- metabolism : Bivalvia, Gills.
- chemical , toxicity : Endocrine Disruptors.
- Animals, Male, Oxidative Stress.
Abstract
In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.
DOI: 10.1007/s11356-015-5199-7
PubMed: 26278908
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first="Monia" last="Machreki-Ajmi">Monia Machreki-Ajmi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Tremolet, Gauthier" sort="Tremolet, Gauthier" uniqKey="Tremolet G" first="Gauthier" last="Tremolet">Gauthier Tremolet</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Kellner, Kristell" sort="Kellner, Kristell" uniqKey="Kellner K" first="Kristell" last="Kellner">Kristell Kellner</name><affiliation wicri:level="4"><nlm:affiliation>CNRS INEE-FRE3484 BioMEA, Université de Caen Basse-Normandie, 14032, Caen-Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS INEE-FRE3484 BioMEA, Université de Caen Basse-Normandie, 14032, Caen-Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName></affiliation></author><author><name sortKey="Geffard, Alain" sort="Geffard, Alain" uniqKey="Geffard A" first="Alain" last="Geffard">Alain Geffard</name><affiliation wicri:level="4"><nlm:affiliation>Université de Reims Champagne-Ardenne, UMR-I 02 SEBIO, Campus Moulin de la Housse, B.P. 1039, 51687, REIMS cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Reims Champagne-Ardenne, UMR-I 02 SEBIO, Campus Moulin de la Housse, B.P. 1039, 51687, REIMS cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">REIMS</settlement></placeName><orgName type="university">Université de Reims Champagne-Ardenne</orgName></affiliation></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental science and pollution research international</title><idno type="eISSN">1614-7499</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bivalvia (drug effects)</term><term>Bivalvia (metabolism)</term><term>Endocrine Disruptors (analysis)</term><term>Endocrine Disruptors (toxicity)</term><term>Gills (metabolism)</term><term>Male</term><term>Malondialdehyde (analysis)</term><term>Metals, Heavy (analysis)</term><term>Oxidative Stress</term><term>Reproduction (drug effects)</term><term>Tunisia</term><term>Vitellogenins (analysis)</term><term>Waste Water (chemistry)</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Endocrine Disruptors</term><term>Malondialdehyde</term><term>Metals, Heavy</term><term>Vitellogenins</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Waste Water</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bivalvia</term><term>Reproduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bivalvia</term><term>Gills</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Endocrine Disruptors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Oxidative Stress</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26278908</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1614-7499</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>24</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Environmental science and pollution research international</Title><ISOAbbreviation>Environ Sci Pollut Res Int</ISOAbbreviation></Journal><ArticleTitle>The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus.</ArticleTitle><Pagination><MedlinePgn>19716-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11356-015-5199-7</ELocationID><Abstract><AbstractText>In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mezghani-Chaari</LastName><ForeName>Sawssan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia. mezghani.sawssen@tunet.tn.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre, France. mezghani.sawssen@tunet.tn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machreki-Ajmi</LastName><ForeName>Monia</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tremolet</LastName><ForeName>Gauthier</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kellner</LastName><ForeName>Kristell</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>CNRS INEE-FRE3484 BioMEA, Université de Caen Basse-Normandie, 14032, Caen-Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geffard</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Reims Champagne-Ardenne, UMR-I 02 SEBIO, Campus Moulin de la Housse, B.P. 1039, 51687, REIMS cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minier</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Normandie Université, UMR-I-02 SEBIO, BP 540, 76058, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamza-Chaffai</LastName><ForeName>Amel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Aug</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Environ Sci Pollut Res Int</MedlineTA><NlmUniqueID>9441769</NlmUniqueID><ISSNLinking>0944-1344</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052244">Endocrine Disruptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019216">Metals, Heavy</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014819">Vitellogenins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D062065">Waste Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>4Y8F71G49Q</RegistryNumber><NameOfSubstance UI="D008315">Malondialdehyde</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049872" MajorTopicYN="N">Bivalvia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052244" MajorTopicYN="N">Endocrine Disruptors</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005880" MajorTopicYN="N">Gills</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008315" MajorTopicYN="N">Malondialdehyde</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019216" MajorTopicYN="N">Metals, Heavy</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012098" MajorTopicYN="N">Reproduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014416" MajorTopicYN="N" Type="Geographic">Tunisia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014819" MajorTopicYN="N">Vitellogenins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062065" MajorTopicYN="N">Waste Water</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Androgenic and estrogenic activities</Keyword><Keyword MajorTopicYN="N">Biomarkers</Keyword><Keyword MajorTopicYN="N">Endocrine disruption</Keyword><Keyword MajorTopicYN="N">Municipal wastewater effluents</Keyword><Keyword MajorTopicYN="N">R. decussatus</Keyword><Keyword MajorTopicYN="N">Reproduction</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>5</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>8</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26278908</ArticleId><ArticleId IdType="doi">10.1007/s11356-015-5199-7</ArticleId><ArticleId IdType="pii">10.1007/s11356-015-5199-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Basse-Normandie</li><li>Champagne-Ardenne</li><li>Grand Est</li><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Caen</li><li>Le Havre</li><li>REIMS</li></settlement><orgName><li>Université de Caen Basse-Normandie</li><li>Université de Reims Champagne-Ardenne</li></orgName></list><tree><country name="Tunisie"><noRegion><name sortKey="Mezghani Chaari, Sawssan" sort="Mezghani Chaari, Sawssan" uniqKey="Mezghani Chaari S" first="Sawssan" last="Mezghani-Chaari">Sawssan Mezghani-Chaari</name></noRegion><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Machreki Ajmi, Monia" sort="Machreki Ajmi, Monia" uniqKey="Machreki Ajmi M" first="Monia" last="Machreki-Ajmi">Monia Machreki-Ajmi</name></country><country name="France"><region name="Région Normandie"><name sortKey="Tremolet, Gauthier" sort="Tremolet, Gauthier" uniqKey="Tremolet G" first="Gauthier" last="Tremolet">Gauthier Tremolet</name></region><name sortKey="Geffard, Alain" sort="Geffard, Alain" uniqKey="Geffard A" first="Alain" last="Geffard">Alain Geffard</name><name sortKey="Kellner, Kristell" sort="Kellner, Kristell" uniqKey="Kellner K" first="Kristell" last="Kellner">Kristell Kellner</name><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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