Analysis of eight glycols in serum using LC-ESI-MS-MS.
Identifieur interne : 000431 ( Ncbi/Merge ); précédent : 000430; suivant : 000432Analysis of eight glycols in serum using LC-ESI-MS-MS.
Auteurs : Laurent Imbert [France] ; Elodie Saussereau [France] ; Christian Lacroix [France]Source :
- Journal of analytical toxicology [ 1945-2403 ]
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Butylene Glycols, Ethylene Glycol, Ethylene Glycols, Glycols, Propylene Glycols.
- chemical , metabolism : Polyethylene Glycols.
- methods : Chromatography, Liquid, Tandem Mass Spectrometry.
- Humans, Limit of Detection, Reproducibility of Results.
Abstract
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.
DOI: 10.1093/jat/bku100
PubMed: 25187402
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76083 Le Havre cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of analytical toxicology</title><idno type="eISSN">1945-2403</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Butylene Glycols (blood)</term><term>Chromatography, Liquid (methods)</term><term>Ethylene Glycol (blood)</term><term>Ethylene Glycols (blood)</term><term>Glycols (blood)</term><term>Humans</term><term>Limit of Detection</term><term>Polyethylene Glycols (metabolism)</term><term>Propylene Glycols (blood)</term><term>Reproducibility of Results</term><term>Tandem Mass Spectrometry (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Butylene Glycols</term><term>Ethylene Glycol</term><term>Ethylene Glycols</term><term>Glycols</term><term>Propylene Glycols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Polyethylene Glycols</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Liquid</term><term>Tandem Mass Spectrometry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Limit of Detection</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25187402</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1945-2403</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>9</Issue><PubDate><MedlineDate>2014 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Journal of analytical toxicology</Title><ISOAbbreviation>J Anal Toxicol</ISOAbbreviation></Journal><ArticleTitle>Analysis of eight glycols in serum using LC-ESI-MS-MS.</ArticleTitle><Pagination><MedlinePgn>676-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jat/bku100</ELocationID><Abstract><AbstractText>A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters were tested: linearity, repeatability and intermediate precision, limits of detection and quantification, carry over and ion suppression. Limits of detection were between 0.18 and 1.1 mg/L, and limits of quantification were between 0.4 and 2.3 mg/L. Separation of isomers was possible either chromatographically or by selecting specific multiple reaction monitoring transitions. This method could be a useful tool in case of suspected intoxication with antifreeze agents, solvents, dietary supplements or some medical drug compounds.</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Imbert</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France laurent.imbert@ch-havre.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saussereau</LastName><ForeName>Elodie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacroix</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pharmacokinetic and Toxicology Unit, Hospital Group of Le Havre, BP 24, 76083 Le Havre cedex, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>Sep</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Anal Toxicol</MedlineTA><NlmUniqueID>7705085</NlmUniqueID><ISSNLinking>0146-4760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002072">Butylene Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005026">Ethylene Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006018">Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011409">Propylene Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>30IQX730WE</RegistryNumber><NameOfSubstance UI="D011092">Polyethylene Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>3P5SU53360</RegistryNumber><NameOfSubstance UI="C028914">triethylene glycol</NameOfSubstance></Chemical><Chemical><RegistryNumber>513-85-9</RegistryNumber><NameOfSubstance UI="C026978">2,3-butylene glycol</NameOfSubstance></Chemical><Chemical><RegistryNumber>5965N8W85T</RegistryNumber><NameOfSubstance UI="C041787">1,3-propanediol</NameOfSubstance></Chemical><Chemical><RegistryNumber>61BR964293</RegistryNumber><NameOfSubstance UI="C013484">diethylene glycol</NameOfSubstance></Chemical><Chemical><RegistryNumber>7XOO2LE6G3</RegistryNumber><NameOfSubstance UI="C039681">1,4-butanediol</NameOfSubstance></Chemical><Chemical><RegistryNumber>FC72KVT52F</RegistryNumber><NameOfSubstance UI="D019855">Ethylene Glycol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002072" MajorTopicYN="N">Butylene Glycols</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002853" MajorTopicYN="N">Chromatography, Liquid</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019855" MajorTopicYN="N">Ethylene Glycol</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005026" MajorTopicYN="N">Ethylene Glycols</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006018" MajorTopicYN="N">Glycols</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName 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sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><name sortKey="Saussereau, Elodie" sort="Saussereau, Elodie" uniqKey="Saussereau E" first="Elodie" last="Saussereau">Elodie Saussereau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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