[Semi-invasive necrotic aspergillosis in a child with cystic fibrosis].
Identifieur interne : 000172 ( Ncbi/Merge ); précédent : 000171; suivant : 000173[Semi-invasive necrotic aspergillosis in a child with cystic fibrosis].
Auteurs : A-S Bonnel [France] ; K. Quinque ; P. Le Roux ; B. Le LuyerSource :
- Revue des maladies respiratoires [ 0761-8425 ] ; 2006.
English descriptors
- KwdEn :
- Adolescent, Antifungal Agents (therapeutic use), Aspergillosis (complications), Aspergillosis (diagnosis), Aspergillosis (drug therapy), Aspergillosis (microbiology), Aspergillus fumigatus (cytology), Aspergillus fumigatus (isolation & purification), Bronchoalveolar Lavage, Cystic Fibrosis (complications), Cystic Fibrosis (diagnosis), Cystic Fibrosis (drug therapy), Cystic Fibrosis (microbiology), Female, Humans, Lung Abscess (diagnosis), Lung Abscess (drug therapy), Lung Abscess (etiology), Lung Abscess (microbiology), Pseudomonas aeruginosa (isolation & purification), Staphylococcus aureus (isolation & purification), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antifungal Agents.
- complications : Aspergillosis, Cystic Fibrosis.
- cytology : Aspergillus fumigatus.
- diagnosis : Aspergillosis, Cystic Fibrosis, Lung Abscess.
- drug therapy : Aspergillosis, Cystic Fibrosis, Lung Abscess.
- etiology : Lung Abscess.
- isolation & purification : Aspergillus fumigatus, Pseudomonas aeruginosa, Staphylococcus aureus.
- microbiology : Aspergillosis, Cystic Fibrosis, Lung Abscess.
- Adolescent, Bronchoalveolar Lavage, Female, Humans, Treatment Outcome.
Abstract
Aspergillosis colonisation in cystic fibrosis (CF), usually due to Aspergillus fumigatus (AF), classically presents as allergic bronchopulmonary aspergillosis. However, aspergillus infection can produce a range of manifestations: from minor colonization to an invasive infection.
PubMed: 17127910
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Semi-invasive necrotic aspergillosis in a child with cystic fibrosis].</title><author><name sortKey="Bonnel, A S" sort="Bonnel, A S" uniqKey="Bonnel A" first="A-S" last="Bonnel">A-S Bonnel</name><affiliation wicri:level="1"><nlm:affiliation>CRCM, Département de Pédiatrie, Centre Hospitalier Général Gustave Flaubert, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRCM, Département de Pédiatrie, Centre Hospitalier Général Gustave Flaubert, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Quinque, K" sort="Quinque, K" uniqKey="Quinque K" first="K" last="Quinque">K. Quinque</name></author><author><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name></author><author><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:17127910</idno><idno type="pmid">17127910</idno><idno type="wicri:Area/PubMed/Corpus">000286</idno><idno type="wicri:Area/PubMed/Curation">000286</idno><idno type="wicri:Area/PubMed/Checkpoint">000286</idno><idno type="wicri:Area/Ncbi/Merge">000172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Semi-invasive necrotic aspergillosis in a child with cystic fibrosis].</title><author><name sortKey="Bonnel, A S" sort="Bonnel, A S" uniqKey="Bonnel A" first="A-S" last="Bonnel">A-S Bonnel</name><affiliation wicri:level="1"><nlm:affiliation>CRCM, Département de Pédiatrie, Centre Hospitalier Général Gustave Flaubert, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRCM, Département de Pédiatrie, Centre Hospitalier Général Gustave Flaubert, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Quinque, K" sort="Quinque, K" uniqKey="Quinque K" first="K" last="Quinque">K. Quinque</name></author><author><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name></author><author><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name></author></analytic><series><title level="j">Revue des maladies respiratoires</title><idno type="ISSN">0761-8425</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antifungal Agents (therapeutic use)</term><term>Aspergillosis (complications)</term><term>Aspergillosis (diagnosis)</term><term>Aspergillosis (drug therapy)</term><term>Aspergillosis (microbiology)</term><term>Aspergillus fumigatus (cytology)</term><term>Aspergillus fumigatus (isolation & purification)</term><term>Bronchoalveolar Lavage</term><term>Cystic Fibrosis (complications)</term><term>Cystic Fibrosis (diagnosis)</term><term>Cystic Fibrosis (drug therapy)</term><term>Cystic Fibrosis (microbiology)</term><term>Female</term><term>Humans</term><term>Lung Abscess (diagnosis)</term><term>Lung Abscess (drug therapy)</term><term>Lung Abscess (etiology)</term><term>Lung Abscess (microbiology)</term><term>Pseudomonas aeruginosa (isolation & purification)</term><term>Staphylococcus aureus (isolation & purification)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antifungal Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Aspergillosis</term><term>Cystic Fibrosis</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Aspergillus fumigatus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Aspergillosis</term><term>Cystic Fibrosis</term><term>Lung Abscess</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Aspergillosis</term><term>Cystic Fibrosis</term><term>Lung Abscess</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lung Abscess</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Aspergillus fumigatus</term><term>Pseudomonas aeruginosa</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Aspergillosis</term><term>Cystic Fibrosis</term><term>Lung Abscess</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Bronchoalveolar Lavage</term><term>Female</term><term>Humans</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aspergillosis colonisation in cystic fibrosis (CF), usually due to Aspergillus fumigatus (AF), classically presents as allergic bronchopulmonary aspergillosis. However, aspergillus infection can produce a range of manifestations: from minor colonization to an invasive infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17127910</PMID><DateCreated><Year>2006</Year><Month>11</Month><Day>27</Day></DateCreated><DateCompleted><Year>2007</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0761-8425</ISSN><JournalIssue CitedMedium="Print"><Volume>23</Volume><Issue>4 Pt 1</Issue><PubDate><Year>2006</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Revue des maladies respiratoires</Title><ISOAbbreviation>Rev Mal Respir</ISOAbbreviation></Journal><ArticleTitle>[Semi-invasive necrotic aspergillosis in a child with cystic fibrosis].</ArticleTitle><Pagination><MedlinePgn>343-7</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Aspergillosis colonisation in cystic fibrosis (CF), usually due to Aspergillus fumigatus (AF), classically presents as allergic bronchopulmonary aspergillosis. However, aspergillus infection can produce a range of manifestations: from minor colonization to an invasive infection.</AbstractText><AbstractText Label="CASE REPORT" NlmCategory="METHODS">A 14-year-old CF patient, chronically colonized with Staphylococcus aureus and Pseudomonas aeruginosa, presented with acute right-sided chest pain, a moderate fever and no modification of the sputum. The chest X-ray showed a 5 cm round opacity. Laboratory parameters were WBC 24,500 G/l, CRP 27 mg/l, Total IgE 1527 UI/l, Specific Aspergillus fumigatus IgE 31 UI/l. Bronchoscopy revealed external compression of the middle lobe bronchus with mucopurulent secretions coming from apical segment of the lower lobe. Bronchoalveolar lavage revealed the presence of pseudomonas aeruginosa 103 CFA/ml, staph aureus 107 CFA/ml and one colony of AF. Chest CT scan showed a large necrotic mass with an air-fluid level located in the apical segment of the right lower lobe. Initial therapy with itraconazole and corticosteroid was replaced by voriconazole, caspofungin, metronidazole and linezolide. Treatment was well tolerated and after 8 weeks the chest X-ray appearances had returned to normal.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The possible diagnoses and therapeutic options are discussed. Conventional antifungal treatment with amphotericin B is limited by nephrotoxicity. These newer antifungal agents appear to be effective and well-tolerated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonnel</LastName><ForeName>A-S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>CRCM, Département de Pédiatrie, Centre Hospitalier Général Gustave Flaubert, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quinque</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Le Roux</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Le Luyer</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>FRE</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Aspergillose nécrosante semi invasive chez un enfant de 14 ans atteint de mucoviscidose.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Rev Mal Respir</MedlineTA><NlmUniqueID>8408032</NlmUniqueID><ISSNLinking>0761-8425</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001228" MajorTopicYN="N">Aspergillosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001232" MajorTopicYN="N">Aspergillus fumigatus</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018893" MajorTopicYN="N">Bronchoalveolar Lavage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003550" MajorTopicYN="N">Cystic Fibrosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008169" MajorTopicYN="N">Lung Abscess</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011550" MajorTopicYN="N">Pseudomonas aeruginosa</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>11</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>1</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>11</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17127910</ArticleId><ArticleId IdType="pii">MDOI-RMR-09-2006-23-4-0761-8425-101019-200640421</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name><name sortKey="Quinque, K" sort="Quinque, K" uniqKey="Quinque K" first="K" last="Quinque">K. Quinque</name></noCountry><country name="France"><noRegion><name sortKey="Bonnel, A S" sort="Bonnel, A S" uniqKey="Bonnel A" first="A-S" last="Bonnel">A-S Bonnel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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