[Multicenter study of sodium alginate in the treatment of regurgitation in infants].
Identifieur interne : 000093 ( Ncbi/Merge ); précédent : 000092; suivant : 000094[Multicenter study of sodium alginate in the treatment of regurgitation in infants].
Auteurs : B. Le Luyer [France] ; J F Mougenot ; L. Mashako ; P. Chapoy ; J P Olives ; A. Morali ; B. Chevallier ; J L Ginies ; C. Dupont ; M. DagorneSource :
- Annales de pediatrie [ 0066-2097 ] ; 1992.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Alginates (administration & dosage), Alginates (adverse effects), Alginates (therapeutic use), Aluminum Hydroxide (administration & dosage), Aluminum Hydroxide (adverse effects), Aluminum Hydroxide (therapeutic use), Bicarbonates (administration & dosage), Bicarbonates (adverse effects), Bicarbonates (therapeutic use), Child, Preschool, Drug Combinations, Endoscopy, Gastrointestinal, Female, France (epidemiology), Gastric Acidity Determination, Gastroesophageal Reflux (diagnosis), Gastroesophageal Reflux (drug therapy), Gastroesophageal Reflux (epidemiology), Humans, Infant, Infant, Newborn, Male, Silicic Acid (administration & dosage), Silicic Acid (adverse effects), Silicic Acid (therapeutic use), Sodium Bicarbonate.
- MESH :
- chemical , administration & dosage : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- chemical , adverse effects : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- chemical , therapeutic use : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- geographic , epidemiology : France.
- diagnosis : Gastroesophageal Reflux.
- drug therapy : Gastroesophageal Reflux.
- epidemiology : Gastroesophageal Reflux.
- Child, Preschool, Drug Combinations, Endoscopy, Gastrointestinal, Female, Gastric Acidity Determination, Humans, Infant, Infant, Newborn, Male, Sodium Bicarbonate.
Abstract
An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.
PubMed: 1485782
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Dagorne</name></author></analytic><series><title level="j">Annales de pediatrie</title><idno type="ISSN">0066-2097</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginates (administration & dosage)</term><term>Alginates (adverse effects)</term><term>Alginates (therapeutic use)</term><term>Aluminum Hydroxide (administration & dosage)</term><term>Aluminum Hydroxide (adverse effects)</term><term>Aluminum Hydroxide (therapeutic use)</term><term>Bicarbonates (administration & dosage)</term><term>Bicarbonates (adverse effects)</term><term>Bicarbonates (therapeutic use)</term><term>Child, Preschool</term><term>Drug Combinations</term><term>Endoscopy, Gastrointestinal</term><term>Female</term><term>France (epidemiology)</term><term>Gastric Acidity Determination</term><term>Gastroesophageal Reflux (diagnosis)</term><term>Gastroesophageal Reflux (drug therapy)</term><term>Gastroesophageal Reflux (epidemiology)</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Silicic Acid (administration & dosage)</term><term>Silicic Acid (adverse effects)</term><term>Silicic Acid (therapeutic use)</term><term>Sodium Bicarbonate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Alginates</term><term>Aluminum Hydroxide</term><term>Bicarbonates</term><term>Silicic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Alginates</term><term>Aluminum Hydroxide</term><term>Bicarbonates</term><term>Silicic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Alginates</term><term>Aluminum Hydroxide</term><term>Bicarbonates</term><term>Silicic Acid</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gastroesophageal Reflux</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gastroesophageal Reflux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Gastroesophageal Reflux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Drug Combinations</term><term>Endoscopy, Gastrointestinal</term><term>Female</term><term>Gastric Acidity Determination</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Sodium Bicarbonate</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1485782</PMID><DateCreated><Year>1993</Year><Month>2</Month><Day>12</Day></DateCreated><DateCompleted><Year>1993</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0066-2097</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>10</Issue><PubDate><Year>1992</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Annales de pediatrie</Title><ISOAbbreviation>Ann Pediatr (Paris)</ISOAbbreviation></Journal><ArticleTitle>[Multicenter study of sodium alginate in the treatment of regurgitation in infants].</ArticleTitle><Pagination><MedlinePgn>635-40</MedlinePgn></Pagination><Abstract><AbstractText>An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.</AbstractText></Abstract><AuthorList CompleteYN="N"><Author ValidYN="Y"><LastName>Le Luyer</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Département de Pédiatrie, Centre Hospitalier, Le Havre.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mougenot</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Mashako</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chapoy</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Olives</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Morali</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Chevallier</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Ginies</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Dupont</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Dagorne</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>FRE</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><VernacularTitle>Etude clinique multicentrique de l'alginate de sodium dans le traitement des régurgitations du nourrisson.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Ann Pediatr (Paris)</MedlineTA><NlmUniqueID>2984696R</NlmUniqueID><ISSNLinking>0066-2097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000464">Alginates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001639">Bicarbonates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>1343-98-2</RegistryNumber><NameOfSubstance UI="D012824">Silicic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>5QB0T2IUN0</RegistryNumber><NameOfSubstance UI="D000536">Aluminum Hydroxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>66220-44-8</RegistryNumber><NameOfSubstance UI="C007829">alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>8MDF5V39QO</RegistryNumber><NameOfSubstance UI="D017693">Sodium Bicarbonate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000464" MajorTopicYN="N">Alginates</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000536" MajorTopicYN="N">Aluminum Hydroxide</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001639" MajorTopicYN="N">Bicarbonates</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016099" MajorTopicYN="N">Endoscopy, Gastrointestinal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005745" MajorTopicYN="N">Gastric Acidity Determination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005764" MajorTopicYN="N">Gastroesophageal Reflux</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012824" MajorTopicYN="N">Silicic Acid</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017693" MajorTopicYN="Y">Sodium Bicarbonate</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1485782</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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