Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device.
Identifieur interne : 000039 ( Ncbi/Merge ); précédent : 000038; suivant : 000040Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device.
Auteurs : J C Dubus [France] ; C. Marguet ; A. Deschildre ; L. Mely ; P. Le Roux ; J. Brouard ; L. HuiartSource :
- Allergy [ 0105-4538 ] ; 2001.
English descriptors
- KwdEn :
- Administration, Inhalation, Adolescent, Adrenal Cortex Hormones (administration & dosage), Adrenal Cortex Hormones (adverse effects), Age Factors, Asthma (drug therapy), Chi-Square Distribution, Child, Child, Preschool, Cross-Sectional Studies, Drug Eruptions (etiology), Female, Humans, Infant, Male, Mouth Diseases (chemically induced), Nebulizers and Vaporizers, Prospective Studies, Respiratory Tract Diseases (chemically induced), Surveys and Questionnaires.
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones.
- chemical , adverse effects : Adrenal Cortex Hormones.
- chemically induced : Mouth Diseases, Respiratory Tract Diseases.
- drug therapy : Asthma.
- etiology : Drug Eruptions.
- Administration, Inhalation, Adolescent, Age Factors, Chi-Square Distribution, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Male, Nebulizers and Vaporizers, Prospective Studies, Surveys and Questionnaires.
Abstract
The objective was to investigate the local side-effects of inhaled corticosteroids (ICS) in daily life in asthmatic children, particularly the younger ones, by an observational prospective cross-sectional cohort study.
PubMed: 11576072
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pubmed:11576072Le document en format XML
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Marguet</name></author><author><name sortKey="Deschildre, A" sort="Deschildre, A" uniqKey="Deschildre A" first="A" last="Deschildre">A. Deschildre</name></author><author><name sortKey="Mely, L" sort="Mely, L" uniqKey="Mely L" first="L" last="Mely">L. Mely</name></author><author><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name></author><author><name sortKey="Brouard, J" sort="Brouard, J" uniqKey="Brouard J" first="J" last="Brouard">J. Brouard</name></author><author><name sortKey="Huiart, L" sort="Huiart, L" uniqKey="Huiart L" first="L" last="Huiart">L. Huiart</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11576072</idno><idno type="pmid">11576072</idno><idno type="wicri:Area/PubMed/Corpus">000372</idno><idno type="wicri:Area/PubMed/Curation">000372</idno><idno type="wicri:Area/PubMed/Checkpoint">000372</idno><idno type="wicri:Area/Ncbi/Merge">000039</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device.</title><author><name sortKey="Dubus, J C" sort="Dubus, J C" uniqKey="Dubus J" first="J C" last="Dubus">J C Dubus</name><affiliation wicri:level="1"><nlm:affiliation>Services de Pédiatrie, CHU Timone-Enfants, Marseille, Hôpital Charles Nicolle (Rouen), Hôpital Jeanne de Flandres (Lille), Hôpital du Havre (Le Havre), CH Côte de Nâcre (Caen), INSERM U379, Institut Paoli-Calmette, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Services de Pédiatrie, CHU Timone-Enfants, Marseille, Hôpital Charles Nicolle (Rouen), Hôpital Jeanne de Flandres (Lille), Hôpital du Havre (Le Havre), CH Côte de Nâcre (Caen), INSERM U379, Institut Paoli-Calmette, Marseille</wicri:regionArea><placeName><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Marguet, C" sort="Marguet, C" uniqKey="Marguet C" first="C" last="Marguet">C. Marguet</name></author><author><name sortKey="Deschildre, A" sort="Deschildre, A" uniqKey="Deschildre A" first="A" last="Deschildre">A. Deschildre</name></author><author><name sortKey="Mely, L" sort="Mely, L" uniqKey="Mely L" first="L" last="Mely">L. Mely</name></author><author><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name></author><author><name sortKey="Brouard, J" sort="Brouard, J" uniqKey="Brouard J" first="J" last="Brouard">J. Brouard</name></author><author><name sortKey="Huiart, L" sort="Huiart, L" uniqKey="Huiart L" first="L" last="Huiart">L. Huiart</name></author></analytic><series><title level="j">Allergy</title><idno type="ISSN">0105-4538</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation</term><term>Adolescent</term><term>Adrenal Cortex Hormones (administration & dosage)</term><term>Adrenal Cortex Hormones (adverse effects)</term><term>Age Factors</term><term>Asthma (drug therapy)</term><term>Chi-Square Distribution</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Drug Eruptions (etiology)</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Mouth Diseases (chemically induced)</term><term>Nebulizers and Vaporizers</term><term>Prospective Studies</term><term>Respiratory Tract Diseases (chemically induced)</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Mouth Diseases</term><term>Respiratory Tract Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug Eruptions</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Inhalation</term><term>Adolescent</term><term>Age Factors</term><term>Chi-Square Distribution</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Nebulizers and Vaporizers</term><term>Prospective Studies</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective was to investigate the local side-effects of inhaled corticosteroids (ICS) in daily life in asthmatic children, particularly the younger ones, by an observational prospective cross-sectional cohort study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11576072</PMID><DateCreated><Year>2001</Year><Month>9</Month><Day>28</Day></DateCreated><DateCompleted><Year>2001</Year><Month>11</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0105-4538</ISSN><JournalIssue CitedMedium="Print"><Volume>56</Volume><Issue>10</Issue><PubDate><Year>2001</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Allergy</Title><ISOAbbreviation>Allergy</ISOAbbreviation></Journal><ArticleTitle>Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device.</ArticleTitle><Pagination><MedlinePgn>944-8</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The objective was to investigate the local side-effects of inhaled corticosteroids (ICS) in daily life in asthmatic children, particularly the younger ones, by an observational prospective cross-sectional cohort study.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Asthmatic children (n=639, 75.9+/-48.9 months, 61.3% boys), treated with beclomethasone dipropionate (BDP) (721.0+/-287.3 microg per day) or budesonide (BUD) (835.5+/-684.9 microg per day) for at least 1 month, were recruited at the time of a scheduled visit. Local side-effects were researched by questionnaire (cough during inhalation, hoarseness, dysphonia, and thirsty feeling) and clinical examination (perioral dermatitis, oral candidiasis, and tongue hypertrophy).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Exactly 63.3% of the children aged under 6 years and 59.5% of the older ones reported one local side-effect. Cough (39.7%) was dependent on young age, use of BDP, and mainly use of spacer device, with an OR of 4.7 (95% CI: 2.7-8.2). Thirsty feeling (21.9%) and hoarseness (14.1%) occurred in children using ICS and long-acting beta2-agonists. Dysphonia (11.1%) was favored by high doses of BDP and BUD, and by inhalation from spacer devices or nebulizers. No factor favored oral candidiasis (10.7%). Perioral dermatitis (2.9%) and tongue hypertrophy (0.1%) were associated with nebulization.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Local side-effects of ICS are common in asthmatic children of all ages, and the device used constitutes the most influential factor.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dubus</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Services de Pédiatrie, CHU Timone-Enfants, Marseille, Hôpital Charles Nicolle (Rouen), Hôpital Jeanne de Flandres (Lille), Hôpital du Havre (Le Havre), CH Côte de Nâcre (Caen), INSERM U379, Institut Paoli-Calmette, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marguet</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Deschildre</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mely</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Le Roux</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Brouard</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Huiart</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><CollectiveName>Réseau de Recherche Clinique en Pneumonologie Pédiatrique</CollectiveName></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Allergy</MedlineTA><NlmUniqueID>7804028</NlmUniqueID><ISSNLinking>0105-4538</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Allergy. 2001 Oct;56(10):925-7</RefSource><PMID Version="1">11576069</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000280" MajorTopicYN="N">Administration, Inhalation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003875" MajorTopicYN="N">Drug Eruptions</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009059" MajorTopicYN="N">Mouth Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009330" MajorTopicYN="N">Nebulizers and Vaporizers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012140" MajorTopicYN="N">Respiratory Tract Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>9</Month><Day>29</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>11</Month><Day>3</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>9</Month><Day>29</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11576072</ArticleId><ArticleId IdType="pii">all100</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><settlement><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Brouard, J" sort="Brouard, J" uniqKey="Brouard J" first="J" last="Brouard">J. Brouard</name><name sortKey="Deschildre, A" sort="Deschildre, A" uniqKey="Deschildre A" first="A" last="Deschildre">A. Deschildre</name><name sortKey="Huiart, L" sort="Huiart, L" uniqKey="Huiart L" first="L" last="Huiart">L. Huiart</name><name sortKey="Le Roux, P" sort="Le Roux, P" uniqKey="Le Roux P" first="P" last="Le Roux">P. Le Roux</name><name sortKey="Marguet, C" sort="Marguet, C" uniqKey="Marguet C" first="C" last="Marguet">C. Marguet</name><name sortKey="Mely, L" sort="Mely, L" uniqKey="Mely L" first="L" last="Mely">L. Mely</name></noCountry><country name="France"><noRegion><name sortKey="Dubus, J C" sort="Dubus, J C" uniqKey="Dubus J" first="J C" last="Dubus">J C Dubus</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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