Measurement of metformin concentration in erythrocytes: clinical implications.
Identifieur interne : 001484 ( Main/Merge ); précédent : 001483; suivant : 001485Measurement of metformin concentration in erythrocytes: clinical implications.
Auteurs : J-D Lalau [France] ; C. LacroixSource :
- Diabetes, obesity & metabolism [ 1462-8902 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Hypoglycemic Agents, Metformin.
- blood : Diabetes Mellitus, Type 2.
- chemistry : Erythrocytes.
- drug therapy : Diabetes Mellitus, Type 2.
- chemical , therapeutic use : Hypoglycemic Agents, Metformin.
- Adult, Aged, Aged, 80 and over, Humans, Middle Aged.
Abstract
Although pharmacokinetics studies have long suggested a deep compartment for the antidiabetic drug metformin, there is still little information concerning metformin accumulation by individual tissues in man. In the present study, the erythrocyte was chosen to represent this putative deep compartment and metformin concentration in erythrocytes (EM) was compared with that in plasma (PM) to delineate clinical implications.
PubMed: 12630933
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pubmed:12630933Le document en format XML
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