The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria
Identifieur interne : 000D45 ( Main/Exploration ); précédent : 000D44; suivant : 000D46The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria
Auteurs : Erika M. C. D'Agata [États-Unis] ; Myrielle Dupont-Rouzeyrol [France] ; Pierre Magal [France] ; Damien Olivier [France] ; Shigui Ruan [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2008.
Abstract
The emergence and ongoing spread of antimicrobial-resistant bacteria is a major public health threat. Infections caused by antimicrobial-resistant bacteria are associated with substantially higher rates of morbidity and mortality compared to infections caused by antimicrobial-susceptible bacteria. The emergence and spread of these bacteria is complex and requires incorporating numerous interrelated factors which clinical studies cannot adequately address.
A model is created which incorporates several key factors contributing to the emergence and spread of resistant bacteria including the effects of the immune system, acquisition of resistance genes and antimicrobial exposure. The model identifies key strategies which would limit the emergence of antimicrobial-resistant bacterial strains. Specifically, the simulations show that early initiation of antimicrobial therapy and combination therapy with two antibiotics prevents the emergence of resistant bacteria, whereas shorter courses of therapy and sequential administration of antibiotics promote the emergence of resistant strains.
The principal findings suggest that (i) shorter lengths of antibiotic therapy and early interruption of antibiotic therapy provide an advantage for the resistant strains, (ii) combination therapy with two antibiotics prevents the emergence of resistance strains in contrast to sequential antibiotic therapy, and (iii) early initiation of antibiotics is among the most important factors preventing the emergence of resistant strains. These findings provide new insights into strategies aimed at optimizing the administration of antimicrobials for the treatment of infections and the prevention of the emergence of antimicrobial resistance.
Url:
DOI: 10.1371/journal.pone.0004036
PubMed: 19112501
PubMed Central: 2603320
Affiliations:
- France, États-Unis
- Floride, Haute-Normandie, Massachusetts, Région Normandie
- Le Havre
- Université du Havre
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000154
- to stream Pmc, to step Curation: 000152
- to stream Pmc, to step Checkpoint: 000119
- to stream Ncbi, to step Merge: 000222
- to stream Ncbi, to step Curation: 000222
- to stream Ncbi, to step Checkpoint: 000222
- to stream Main, to step Merge: 000D56
- to stream Main, to step Curation: 000D45
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria</title>
<author><name sortKey="D Agata, Erika M C" sort="D Agata, Erika M C" uniqKey="D Agata E" first="Erika M. C." last="D'Agata">Erika M. C. D'Agata</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dupont Rouzeyrol, Myrielle" sort="Dupont Rouzeyrol, Myrielle" uniqKey="Dupont Rouzeyrol M" first="Myrielle" last="Dupont-Rouzeyrol">Myrielle Dupont-Rouzeyrol</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Laboratoire d'Ecotoxicologie des Milieux Aquatiques, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Ecotoxicologie des Milieux Aquatiques, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Laboratoire de Mathématiques Appliquées, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Mathématiques Appliquées, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name>
<affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Mathematics, University of Miami, Coral Gables, Florida, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mathematics, University of Miami, Coral Gables, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19112501</idno>
<idno type="pmc">2603320</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603320</idno>
<idno type="RBID">PMC:2603320</idno>
<idno type="doi">10.1371/journal.pone.0004036</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000154</idno>
<idno type="wicri:Area/Pmc/Curation">000152</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000119</idno>
<idno type="wicri:Area/Ncbi/Merge">000222</idno>
<idno type="wicri:Area/Ncbi/Curation">000222</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000222</idno>
<idno type="wicri:Area/Main/Merge">000D56</idno>
<idno type="wicri:Area/Main/Curation">000D45</idno>
<idno type="wicri:Area/Main/Exploration">000D45</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria</title>
<author><name sortKey="D Agata, Erika M C" sort="D Agata, Erika M C" uniqKey="D Agata E" first="Erika M. C." last="D'Agata">Erika M. C. D'Agata</name>
<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dupont Rouzeyrol, Myrielle" sort="Dupont Rouzeyrol, Myrielle" uniqKey="Dupont Rouzeyrol M" first="Myrielle" last="Dupont-Rouzeyrol">Myrielle Dupont-Rouzeyrol</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Laboratoire d'Ecotoxicologie des Milieux Aquatiques, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Ecotoxicologie des Milieux Aquatiques, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Laboratoire de Mathématiques Appliquées, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Mathématiques Appliquées, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes, Université du Havre, Le Havre, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes, Université du Havre, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
<orgName type="university">Université du Havre</orgName>
<placeName><settlement type="city">Le Havre</settlement>
<region type="region" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name>
<affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Mathematics, University of Miami, Coral Gables, Florida, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mathematics, University of Miami, Coral Gables, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Backgroud</title>
<p>The emergence and ongoing spread of antimicrobial-resistant bacteria is a major public health threat. Infections caused by antimicrobial-resistant bacteria are associated with substantially higher rates of morbidity and mortality compared to infections caused by antimicrobial-susceptible bacteria. The emergence and spread of these bacteria is complex and requires incorporating numerous interrelated factors which clinical studies cannot adequately address.</p>
</sec>
<sec><title>Methods/Principal Findings</title>
<p>A model is created which incorporates several key factors contributing to the emergence and spread of resistant bacteria including the effects of the immune system, acquisition of resistance genes and antimicrobial exposure. The model identifies key strategies which would limit the emergence of antimicrobial-resistant bacterial strains. Specifically, the simulations show that early initiation of antimicrobial therapy and combination therapy with two antibiotics prevents the emergence of resistant bacteria, whereas shorter courses of therapy and sequential administration of antibiotics promote the emergence of resistant strains.</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>The principal findings suggest that (i) shorter lengths of antibiotic therapy and early interruption of antibiotic therapy provide an advantage for the resistant strains, (ii) combination therapy with two antibiotics prevents the emergence of resistance strains in contrast to sequential antibiotic therapy, and (iii) early initiation of antibiotics is among the most important factors preventing the emergence of resistant strains. These findings provide new insights into strategies aimed at optimizing the administration of antimicrobials for the treatment of infections and the prevention of the emergence of antimicrobial resistance.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Haute-Normandie</li>
<li>Massachusetts</li>
<li>Région Normandie</li>
</region>
<settlement><li>Le Havre</li>
</settlement>
<orgName><li>Université du Havre</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="D Agata, Erika M C" sort="D Agata, Erika M C" uniqKey="D Agata E" first="Erika M. C." last="D'Agata">Erika M. C. D'Agata</name>
</region>
<name sortKey="Ruan, Shigui" sort="Ruan, Shigui" uniqKey="Ruan S" first="Shigui" last="Ruan">Shigui Ruan</name>
</country>
<country name="France"><noRegion><name sortKey="Dupont Rouzeyrol, Myrielle" sort="Dupont Rouzeyrol, Myrielle" uniqKey="Dupont Rouzeyrol M" first="Myrielle" last="Dupont-Rouzeyrol">Myrielle Dupont-Rouzeyrol</name>
</noRegion>
<name sortKey="Magal, Pierre" sort="Magal, Pierre" uniqKey="Magal P" first="Pierre" last="Magal">Pierre Magal</name>
<name sortKey="Olivier, Damien" sort="Olivier, Damien" uniqKey="Olivier D" first="Damien" last="Olivier">Damien Olivier</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/France |area= LeHavreV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2603320 |texte= The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19112501" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LeHavreV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |