LeHavreV1, Main, Exploration, bibRecord, 001F97

Phenobarbital in hair and drug monitoring

Identifieur interne : 001F97 ( Main/Exploration ); précédent : 001F96; suivant : 001F98

Phenobarbital in hair and drug monitoring

Auteurs : J. P. Goullé [France] ; J. Noyon [France] ; A. Layet [France] ; N. F. Rapoport [France] ; Y. Vaschalde [France] ; Y. Pignier [France] ; D. Bouige [France] ; F. Jouen [France]

Source :

Forensic Science International [ 0379-0738 ] ; 1995.

RBID : ISTEX:8CE78042B51F2D01CAAEBA50DC8D4C8F572A4886

English descriptors

KwdEn :
- Adult, Drug Monitoring (methods), Epilepsy (drug therapy), Female, Gas Chromatography-Mass Spectrometry, Hair (chemistry), Humans, Male, Middle Aged, Phenobarbital (analysis), Phenobarbital (blood), Phenobarbital (therapeutic use).
MESH :
- chemical , analysis : Phenobarbital.
- chemical , blood : Phenobarbital.
- chemistry : Hair.
- drug therapy : Epilepsy.
- methods : Drug Monitoring.
- chemical , therapeutic use : Phenobarbital.
- Adult, Female, Gas Chromatography-Mass Spectrometry, Humans, Male, Middle Aged.

Abstract

Phenobarbital analysis was performed in vertex hair of patients by gas chromatography mass spectrometry (GC/MS). After washing with dichloromethane, about 250 mg were ground to dust in a ball mill. A 50-mg sample was stirred mechanically for 10 min with 3 ml of NH4Cl HCl buffer (pH 2.0) containing phenobarbital D5. A solid phase extraction was performed (extrelut Merck) and elution was achieved with chloroform/isopropanol/n-heptane (50:17:33; v v). A full scan (40–240 uma) acquisition was realized by GC/MS with an ion trap (ITD 700 Finnigan) using a DB5-MS chromatographic column. Quantification was achieved by integrating dominants ions (phenobarbital, 204; phenobarbital D5, 209). Compared to serum, hair concentrates phenobarbital during anti-epileptic therapy (average value 36.4 ng/mg, n = 40 vs. 18.7 mg/l, n = 23). A group correlation exists between phenobarbital in hair and phenobarbital in serum, and between phenobarbital in hair and clinic observation in some typical cases. Phenobarbital in hair yields good information over a long period, especially when blood collection has not been made, when clinical disorders are observed on long-term therapeutic observance.

Url:

https://api.istex.fr/document/8CE78042B51F2D01CAAEBA50DC8D4C8F572A4886/fulltext/pdf

DOI: 10.1016/0379-0738(94)01619-G

Affiliations:

Le document en format XML

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<author><name sortKey="Layet, A" sort="Layet, A" uniqKey="Layet A" first="A." last="Layet">A. Layet</name>
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<author><name sortKey="Pignier, Y" sort="Pignier, Y" uniqKey="Pignier Y" first="Y." last="Pignier">Y. Pignier</name>
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<author><name sortKey="Bouige, D" sort="Bouige, D" uniqKey="Bouige D" first="D." last="Bouige">D. Bouige</name>
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<front><div type="abstract" xml:lang="en">Phenobarbital analysis was performed in vertex hair of patients by gas chromatography mass spectrometry (GC/MS). After washing with dichloromethane, about 250 mg were ground to dust in a ball mill. A 50-mg sample was stirred mechanically for 10 min with 3 ml of NH4Cl HCl buffer (pH 2.0) containing phenobarbital D5. A solid phase extraction was performed (extrelut Merck) and elution was achieved with chloroform/isopropanol/n-heptane (50:17:33; v v). A full scan (40–240 uma) acquisition was realized by GC/MS with an ion trap (ITD 700 Finnigan) using a DB5-MS chromatographic column. Quantification was achieved by integrating dominants ions (phenobarbital, 204; phenobarbital D5, 209). Compared to serum, hair concentrates phenobarbital during anti-epileptic therapy (average value 36.4 ng/mg, n = 40 vs. 18.7 mg/l, n = 23). A group correlation exists between phenobarbital in hair and phenobarbital in serum, and between phenobarbital in hair and clinic observation in some typical cases. Phenobarbital in hair yields good information over a long period, especially when blood collection has not been made, when clinical disorders are observed on long-term therapeutic observance.</div>
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Phenobarbital in hair and drug monitoring

Phenobarbital in hair and drug monitoring

Source :

English descriptors

Abstract

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