Fatal Propafenone Overdoses: Case Reports and A Review of the Literature
Identifieur interne : 001460 ( Main/Exploration ); précédent : 001459; suivant : 001461Fatal Propafenone Overdoses: Case Reports and A Review of the Literature
Auteurs : Franck Clarot [France] ; Jean Pierre Goullé [France] ; Marlène Horst [France] ; Emmanuelle Vaz [France] ; Christian Lacroix [France] ; Bernard Proust [France]Source :
- Journal of Analytical Toxicology [ 0146-4760 ] ; 2003-11.
Abstract
First synthesized in 1970, propafenone is a frequently used 1C antiarrhythmic drug metabolized into two major metabolites, 5-hydroxypropafenone and norpropafenone. Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients found dead of self-inflicted poisoning where the propafenone blood concentration was very high (one concentration to our knowledge is one of the highest reported in the literature). At autopsy, no evidence of significant pathological disease were found. Propafenone was detected in blood by gas chromatography-mass spectrometry and by high-performance liquid chromatography using a diode-array detector, respectively, as propafenone artifact and propafenone. Blood propafenone concentrations were 4180 ng/mL and 9123 ng/mL. The literature regarding propafenone pharmacokinetic and intoxication is reviewed, and we discuss the low death rate attributed to this drug in contrast to its frequent use.
Url:
DOI: 10.1093/jat/27.8.595
Affiliations:
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Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients found dead of self-inflicted poisoning where the propafenone blood concentration was very high (one concentration to our knowledge is one of the highest reported in the literature). At autopsy, no evidence of significant pathological disease were found. Propafenone was detected in blood by gas chromatography-mass spectrometry and by high-performance liquid chromatography using a diode-array detector, respectively, as propafenone artifact and propafenone. Blood propafenone concentrations were 4180 ng/mL and 9123 ng/mL. The literature regarding propafenone pharmacokinetic and intoxication is reviewed, and we discuss the low death rate attributed to this drug in contrast to its frequent use.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Rouen</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Clarot, Franck" sort="Clarot, Franck" uniqKey="Clarot F" first="Franck" last="Clarot">Franck Clarot</name></noRegion><name sortKey="Clarot, Franck" sort="Clarot, Franck" uniqKey="Clarot F" first="Franck" last="Clarot">Franck Clarot</name><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean Pierre" last="Goullé">Jean Pierre Goullé</name><name sortKey="Horst, Marlene" sort="Horst, Marlene" uniqKey="Horst M" first="Marlène" last="Horst">Marlène Horst</name><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><name sortKey="Proust, Bernard" sort="Proust, Bernard" uniqKey="Proust B" first="Bernard" last="Proust">Bernard Proust</name><name sortKey="Vaz, Emmanuelle" sort="Vaz, Emmanuelle" uniqKey="Vaz E" first="Emmanuelle" last="Vaz">Emmanuelle Vaz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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