Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology
Identifieur interne : 000637 ( Main/Exploration ); précédent : 000636; suivant : 000638Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology
Auteurs : Vincent Paget [France] ; Mathilde Lechevrel [France] ; Véronique André [France] ; Jérémie Le Goff [France] ; Didier Pottier [France] ; Sylvain Billet [France] ; Guillaume Garçon [France] ; Pirouz Shirali [France] ; François Sichel [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Mutations in the
Url:
DOI: 10.1371/journal.pone.0030921
PubMed: 22319594
PubMed Central: 3272023
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000228
- to stream Pmc, to step Curation: 000226
- to stream Pmc, to step Checkpoint: 000089
- to stream Ncbi, to step Merge: 000307
- to stream Ncbi, to step Curation: 000307
- to stream Ncbi, to step Checkpoint: 000307
- to stream Main, to step Merge: 000637
- to stream Main, to step Curation: 000637
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Benzo<italic>[a]</italic>pyrene, Aflatoxine B<sub>1</sub> and Acetaldehyde Mutational Patterns in <italic>TP53</italic> Gene Using a Functional Assay: Relevance to Human Cancer Aetiology</title><author><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lechevrel, Mathilde" sort="Lechevrel, Mathilde" uniqKey="Lechevrel M" first="Mathilde" last="Lechevrel">Mathilde Lechevrel</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation></author><author><name sortKey="Andre, Veronique" sort="Andre, Veronique" uniqKey="Andre V" first="Véronique" last="André">Véronique André</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Le Goff, Jeremie" sort="Le Goff, Jeremie" uniqKey="Le Goff J" first="Jérémie" last="Le Goff">Jérémie Le Goff</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Pottier, Didier" sort="Pottier, Didier" uniqKey="Pottier D" first="Didier" last="Pottier">Didier Pottier</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Billet, Sylvain" sort="Billet, Sylvain" uniqKey="Billet S" first="Sylvain" last="Billet">Sylvain Billet</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Garcon, Guillaume" sort="Garcon, Guillaume" uniqKey="Garcon G" first="Guillaume" last="Garçon">Guillaume Garçon</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Shirali, Pirouz" sort="Shirali, Pirouz" uniqKey="Shirali P" first="Pirouz" last="Shirali">Pirouz Shirali</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sichel, Francois" sort="Sichel, Francois" uniqKey="Sichel F" first="François" last="Sichel">François Sichel</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22319594</idno><idno type="pmc">3272023</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272023</idno><idno type="RBID">PMC:3272023</idno><idno type="doi">10.1371/journal.pone.0030921</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000228</idno><idno type="wicri:Area/Pmc/Curation">000226</idno><idno type="wicri:Area/Pmc/Checkpoint">000089</idno><idno type="wicri:Area/Ncbi/Merge">000307</idno><idno type="wicri:Area/Ncbi/Curation">000307</idno><idno type="wicri:Area/Ncbi/Checkpoint">000307</idno><idno type="wicri:Area/Main/Merge">000637</idno><idno type="wicri:Area/Main/Curation">000637</idno><idno type="wicri:Area/Main/Exploration">000637</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Benzo<italic>[a]</italic>pyrene, Aflatoxine B<sub>1</sub> and Acetaldehyde Mutational Patterns in <italic>TP53</italic> Gene Using a Functional Assay: Relevance to Human Cancer Aetiology</title><author><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lechevrel, Mathilde" sort="Lechevrel, Mathilde" uniqKey="Lechevrel M" first="Mathilde" last="Lechevrel">Mathilde Lechevrel</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation></author><author><name sortKey="Andre, Veronique" sort="Andre, Veronique" uniqKey="Andre V" first="Véronique" last="André">Véronique André</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Le Goff, Jeremie" sort="Le Goff, Jeremie" uniqKey="Le Goff J" first="Jérémie" last="Le Goff">Jérémie Le Goff</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Pottier, Didier" sort="Pottier, Didier" uniqKey="Pottier D" first="Didier" last="Pottier">Didier Pottier</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Billet, Sylvain" sort="Billet, Sylvain" uniqKey="Billet S" first="Sylvain" last="Billet">Sylvain Billet</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Garcon, Guillaume" sort="Garcon, Guillaume" uniqKey="Garcon G" first="Guillaume" last="Garçon">Guillaume Garçon</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Shirali, Pirouz" sort="Shirali, Pirouz" uniqKey="Shirali P" first="Pirouz" last="Shirali">Pirouz Shirali</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Chimie Environnementale et Interactions sur le Vivant-EA 4492, Université du Littoral Côte d'Opale, Dunkerque</wicri:regionArea><placeName><settlement type="city">Dunkerque</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Université Lille Nord de France, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sichel, Francois" sort="Sichel, Francois" uniqKey="Sichel F" first="François" last="Sichel">François Sichel</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer-EA 1772, Université de Caen Basse-Normandie, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe Régional d'Etudes sur le Cancer, Centre Régional de Lutte Contre le Cancer François Baclesse, Caen</wicri:regionArea><placeName><settlement type="city">Caen</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mutations in the <italic>TP53</italic> gene are the most common alterations in human tumours. <italic>TP53</italic> mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as a fingerprint of aflatoxin B<sub>1</sub> exposure. Likewise G>T transversions in codons 157 and 158 have been related to tobacco exposure in human lung cancers. However, controversies remain about the interpretation of <italic>TP53</italic> mutational pattern in tumours as the fingerprint of genotoxin exposure. By using a functional assay, the Functional Analysis of Separated Alleles in Yeast (FASAY), the present study depicts the mutational pattern of <italic>TP53</italic> in normal human fibroblasts after <italic>in vitro</italic> exposure to well-known carcinogens: benzo<italic>[a]</italic>pyrene, aflatoxin B<sub>1</sub> and acetaldehyde. These <italic>in vitro</italic> patterns of mutations were then compared to those found in human tumours by using the IARC database of <italic>TP53</italic> mutations. The results show that the <italic>TP53</italic> mutational patterns found in human tumours can be only partly ascribed to genotoxin exposure. A complex interplay between the functional impact of the mutations on p53 phenotype and the cancer natural history may affect these patterns. However, our results strongly support that genotoxins exposure plays a major role in the aetiology of the considered cancers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hainaut, P" uniqKey="Hainaut P">P Hainaut</name></author><author><name sortKey="Hollstein, M" uniqKey="Hollstein M">M Hollstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petitjean, A" uniqKey="Petitjean A">A Petitjean</name></author><author><name sortKey="Mathe, E" uniqKey="Mathe E">E Mathe</name></author><author><name sortKey="Kato, S" uniqKey="Kato S">S Kato</name></author><author><name sortKey="Ishioka, C" uniqKey="Ishioka C">C Ishioka</name></author><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, Jl" uniqKey="Luo J">JL Luo</name></author><author><name sortKey="Tong, Wm" uniqKey="Tong W">WM Tong</name></author><author><name sortKey="Yoon, Jh" uniqKey="Yoon J">JH Yoon</name></author><author><name sortKey="Hergenhahn, M" uniqKey="Hergenhahn M">M Hergenhahn</name></author><author><name sortKey="Koomagi, R" uniqKey="Koomagi R">R Koomagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfeifer, Gp" uniqKey="Pfeifer G">GP Pfeifer</name></author><author><name sortKey="Denissenko, Mf" uniqKey="Denissenko M">MF Denissenko</name></author><author><name sortKey="Olivier, M" uniqKey="Olivier M">M Olivier</name></author><author><name sortKey="Tretyakova, N" uniqKey="Tretyakova N">N Tretyakova</name></author><author><name sortKey="Hecht, Ss" uniqKey="Hecht S">SS Hecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smela, Me" uniqKey="Smela M">ME Smela</name></author><author><name sortKey="Currier, Ss" uniqKey="Currier S">SS Currier</name></author><author><name sortKey="Bailey, Ea" uniqKey="Bailey E">EA Bailey</name></author><author><name sortKey="Essigmann, Jm" uniqKey="Essigmann J">JM Essigmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arlt, Vm" uniqKey="Arlt V">VM Arlt</name></author><author><name sortKey="Stiborova, M" uniqKey="Stiborova M">M Stiborová</name></author><author><name sortKey="Vom Brocke, J" uniqKey="Vom Brocke J">J vom Brocke</name></author><author><name sortKey="Sim Es, Ml" uniqKey="Sim Es M">ML Simões</name></author><author><name sortKey="Lord, Gm" uniqKey="Lord G">GM Lord</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Besaratinia, A" uniqKey="Besaratinia A">A Besaratinia</name></author><author><name sortKey="Pfeifer, Gp" uniqKey="Pfeifer G">GP Pfeifer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bitton, A" uniqKey="Bitton A">A Bitton</name></author><author><name sortKey="Neuman, Md" uniqKey="Neuman M">MD Neuman</name></author><author><name sortKey="Barnoya, J" uniqKey="Barnoya J">J Barnoya</name></author><author><name sortKey="Glantz, Sa" uniqKey="Glantz S">SA Glantz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Jx" uniqKey="Chen J">JX Chen</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author><author><name sortKey="West, M" uniqKey="West M">M West</name></author><author><name sortKey="Tang, Ms" uniqKey="Tang M">MS Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Ms" uniqKey="Tang M">MS Tang</name></author><author><name sortKey="Zheng, Jb" uniqKey="Zheng J">JB Zheng</name></author><author><name sortKey="Denissenko, Mf" uniqKey="Denissenko M">MF Denissenko</name></author><author><name sortKey="Pfeifer, Gp" uniqKey="Pfeifer G">GP Pfeifer</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoon, J" uniqKey="Yoon J">J Yoon</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author><author><name sortKey="Pfeifer, Gp" uniqKey="Pfeifer G">GP Pfeifer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dearth, Lr" uniqKey="Dearth L">LR Dearth</name></author><author><name sortKey="Qian, H" uniqKey="Qian H">H Qian</name></author><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Baroni, Te" uniqKey="Baroni T">TE Baroni</name></author><author><name sortKey="Zeng, J" uniqKey="Zeng J">J Zeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishioka, C" uniqKey="Ishioka C">C Ishioka</name></author><author><name sortKey="Frebourg, T" uniqKey="Frebourg T">T Frebourg</name></author><author><name sortKey="Yan, Yx" uniqKey="Yan Y">YX Yan</name></author><author><name sortKey="Vidal, M" uniqKey="Vidal M">M Vidal</name></author><author><name sortKey="Friend, Sh" uniqKey="Friend S">SH Friend</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flaman, Jm" uniqKey="Flaman J">JM Flaman</name></author><author><name sortKey="Frebourg, T" uniqKey="Frebourg T">T Frebourg</name></author><author><name sortKey="Moreau, V" uniqKey="Moreau V">V Moreau</name></author><author><name sortKey="Charbonnier, F" uniqKey="Charbonnier F">F Charbonnier</name></author><author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paget, V" uniqKey="Paget V">V Paget</name></author><author><name sortKey="Lechevrel, M" uniqKey="Lechevrel M">M Lechevrel</name></author><author><name sortKey="Sichel, F" uniqKey="Sichel F">F Sichel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paget, V" uniqKey="Paget V">V Paget</name></author><author><name sortKey="Sichel, F" uniqKey="Sichel F">F Sichel</name></author><author><name sortKey="Garon, D" uniqKey="Garon D">D Garon</name></author><author><name sortKey="Lechevrel, M" uniqKey="Lechevrel M">M Lechevrel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scudiero, Da" uniqKey="Scudiero D">DA Scudiero</name></author><author><name sortKey="Shoemaker, Rh" uniqKey="Shoemaker R">RH Shoemaker</name></author><author><name sortKey="Paull, Kd" uniqKey="Paull K">KD Paull</name></author><author><name sortKey="Monks, A" uniqKey="Monks A">A Monks</name></author><author><name sortKey="Tierney, S" uniqKey="Tierney S">S Tierney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Mv" uniqKey="Reddy M">MV Reddy</name></author><author><name sortKey="Randerath, K" uniqKey="Randerath K">K Randerath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Goff, J" uniqKey="Le Goff J">J Le Goff</name></author><author><name sortKey="Andre, V" uniqKey="Andre V">V André</name></author><author><name sortKey="Lebailly, P" uniqKey="Lebailly P">P Lebailly</name></author><author><name sortKey="Pottier, D" uniqKey="Pottier D">D Pottier</name></author><author><name sortKey="Perin, F" uniqKey="Perin F">F Périn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Divi, Rl" uniqKey="Divi R">RL Divi</name></author><author><name sortKey="Beland, Fa" uniqKey="Beland F">FA Beland</name></author><author><name sortKey="Fu, Pp" uniqKey="Fu P">PP Fu</name></author><author><name sortKey="Von Tungeln, Ls" uniqKey="Von Tungeln L">LS Von Tungeln</name></author><author><name sortKey="Schoket, B" uniqKey="Schoket B">B Schoket</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Ym" uniqKey="Shen Y">YM Shen</name></author><author><name sortKey="Troxel, Ab" uniqKey="Troxel A">AB Troxel</name></author><author><name sortKey="Vedantam, S" uniqKey="Vedantam S">S Vedantam</name></author><author><name sortKey="Penning, Tm" uniqKey="Penning T">TM Penning</name></author><author><name sortKey="Field, J" uniqKey="Field J">J Field</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olivier, M" uniqKey="Olivier M">M Olivier</name></author><author><name sortKey="Eeles, R" uniqKey="Eeles R">R Eeles</name></author><author><name sortKey="Hollstein, M" uniqKey="Hollstein M">M Hollstein</name></author><author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name></author><author><name sortKey="Harris, Cc" uniqKey="Harris C">CC Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Sc" uniqKey="Cheng S">SC Cheng</name></author><author><name sortKey="Hilton, Bd" uniqKey="Hilton B">BD Hilton</name></author><author><name sortKey="Roman, Jm" uniqKey="Roman J">JM Roman</name></author><author><name sortKey="Dipple, A" uniqKey="Dipple A">A Dipple</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schurter, Ej" uniqKey="Schurter E">EJ Schurter</name></author><author><name sortKey="Yeh, Hj" uniqKey="Yeh H">HJ Yeh</name></author><author><name sortKey="Sayer, Jm" uniqKey="Sayer J">JM Sayer</name></author><author><name sortKey="Lakshman, Mk" uniqKey="Lakshman M">MK Lakshman</name></author><author><name sortKey="Yagi, H" uniqKey="Yagi H">H Yagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, Hj" uniqKey="Yeh H">HJ Yeh</name></author><author><name sortKey="Sayer, Jm" uniqKey="Sayer J">JM Sayer</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Altieri, As" uniqKey="Altieri A">AS Altieri</name></author><author><name sortKey="Byrd, Ra" uniqKey="Byrd R">RA Byrd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penning, Tm" uniqKey="Penning T">TM Penning</name></author><author><name sortKey="Burczynski, Me" uniqKey="Burczynski M">ME Burczynski</name></author><author><name sortKey="Hung, Cf" uniqKey="Hung C">CF Hung</name></author><author><name sortKey="Mccoull, Kd" uniqKey="Mccoull K">KD McCoull</name></author><author><name sortKey="Palackal, Nt" uniqKey="Palackal N">NT Palackal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shou, M" uniqKey="Shou M">M Shou</name></author><author><name sortKey="Harvey, Rg" uniqKey="Harvey R">RG Harvey</name></author><author><name sortKey="Penning, Tm" uniqKey="Penning T">TM Penning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balu, N" uniqKey="Balu N">N Balu</name></author><author><name sortKey="Padgett, Wt" uniqKey="Padgett W">WT Padgett</name></author><author><name sortKey="Lambert, Gr" uniqKey="Lambert G">GR Lambert</name></author><author><name sortKey="Swank, Ae" uniqKey="Swank A">AE Swank</name></author><author><name sortKey="Richard, Am" uniqKey="Richard A">AM Richard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denissenko, Mf" uniqKey="Denissenko M">MF Denissenko</name></author><author><name sortKey="Pao, A" uniqKey="Pao A">A Pao</name></author><author><name sortKey="Tang, M" uniqKey="Tang M">M Tang</name></author><author><name sortKey="Pfeifer, Gp" uniqKey="Pfeifer G">GP Pfeifer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Le" uniqKey="Smith L">LE Smith</name></author><author><name sortKey="Denissenko, Mf" uniqKey="Denissenko M">MF Denissenko</name></author><author><name sortKey="Bennett, Wp" uniqKey="Bennett W">WP Bennett</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Amin, S" uniqKey="Amin S">S Amin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Sj" uniqKey="Wei S">SJ Wei</name></author><author><name sortKey="Chang, Rl" uniqKey="Chang R">RL Chang</name></author><author><name sortKey="Bhachech, N" uniqKey="Bhachech N">N Bhachech</name></author><author><name sortKey="Cui, Xx" uniqKey="Cui X">XX Cui</name></author><author><name sortKey="Merkler, Ka" uniqKey="Merkler K">KA Merkler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hakura, A" uniqKey="Hakura A">A Hakura</name></author><author><name sortKey="Tsutsui, Y" uniqKey="Tsutsui Y">Y Tsutsui</name></author><author><name sortKey="Sonoda, J" uniqKey="Sonoda J">J Sonoda</name></author><author><name sortKey="Tsukidate, K" uniqKey="Tsukidate K">K Tsukidate</name></author><author><name sortKey="Mikami, T" uniqKey="Mikami T">T Mikami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoon, Jh" uniqKey="Yoon J">JH Yoon</name></author><author><name sortKey="Smith, Le" uniqKey="Smith L">LE Smith</name></author><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name></author><author><name sortKey="Tang, M" uniqKey="Tang M">M Tang</name></author><author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aoki, Y" uniqKey="Aoki Y">Y Aoki</name></author><author><name sortKey="Hashimoto, Ah" uniqKey="Hashimoto A">AH Hashimoto</name></author><author><name sortKey="Amanuma, K" uniqKey="Amanuma K">K Amanuma</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M Matsumoto</name></author><author><name sortKey="Hiyoshi, K" uniqKey="Hiyoshi K">K Hiyoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Braithwaite, E" uniqKey="Braithwaite E">E Braithwaite</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author><author><name sortKey="Geacintov, Ne" uniqKey="Geacintov N">NE Geacintov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Muehlbauer, Kr" uniqKey="Muehlbauer K">KR Muehlbauer</name></author><author><name sortKey="Schmeiser, Hh" uniqKey="Schmeiser H">HH Schmeiser</name></author><author><name sortKey="Hergenhahn, M" uniqKey="Hergenhahn M">M Hergenhahn</name></author><author><name sortKey="Belharazem, D" uniqKey="Belharazem D">D Belharazem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reinbold, M" uniqKey="Reinbold M">M Reinbold</name></author><author><name sortKey="Luo, Jl" uniqKey="Luo J">JL Luo</name></author><author><name sortKey="Nedelko, T" uniqKey="Nedelko T">T Nedelko</name></author><author><name sortKey="Jerchow, B" uniqKey="Jerchow B">B Jerchow</name></author><author><name sortKey="Murphy, Me" uniqKey="Murphy M">ME Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggeri, B" uniqKey="Ruggeri B">B Ruggeri</name></author><author><name sortKey="Dirado, M" uniqKey="Dirado M">M DiRado</name></author><author><name sortKey="Zhang, Sy" uniqKey="Zhang S">SY Zhang</name></author><author><name sortKey="Bauer, B" uniqKey="Bauer B">B Bauer</name></author><author><name sortKey="Goodrow, T" uniqKey="Goodrow T">T Goodrow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Culp, Sj" uniqKey="Culp S">SJ Culp</name></author><author><name sortKey="Warbritton, Ar" uniqKey="Warbritton A">AR Warbritton</name></author><author><name sortKey="Smith, Ba" uniqKey="Smith B">BA Smith</name></author><author><name sortKey="Li, Ee" uniqKey="Li E">EE Li</name></author><author><name sortKey="Beland, Fa" uniqKey="Beland F">FA Beland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussain, Sp" uniqKey="Hussain S">SP Hussain</name></author><author><name sortKey="Schwank, J" uniqKey="Schwank J">J Schwank</name></author><author><name sortKey="Staib, F" uniqKey="Staib F">F Staib</name></author><author><name sortKey="Wang, Xw" uniqKey="Wang X">XW Wang</name></author><author><name sortKey="Harris, Cc" uniqKey="Harris C">CC Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baan, R" uniqKey="Baan R">R Baan</name></author><author><name sortKey="Straif, K" uniqKey="Straif K">K Straif</name></author><author><name sortKey="Grosse, Y" uniqKey="Grosse Y">Y Grosse</name></author><author><name sortKey="Secretan, B" uniqKey="Secretan B">B Secretan</name></author><author><name sortKey="El Ghissassi, F" uniqKey="El Ghissassi F">F El Ghissassi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohn, S" uniqKey="Sohn S">S Sohn</name></author><author><name sortKey="Jaitovitch Groisman, I" uniqKey="Jaitovitch Groisman I">I Jaitovitch-Groisman</name></author><author><name sortKey="Benlimame, N" uniqKey="Benlimame N">N Benlimame</name></author><author><name sortKey="Galipeau, J" uniqKey="Galipeau J">J Galipeau</name></author><author><name sortKey="Batist, G" uniqKey="Batist G">G Batist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pleasance, Ed" uniqKey="Pleasance E">ED Pleasance</name></author><author><name sortKey="Stephens, Pj" uniqKey="Stephens P">PJ Stephens</name></author><author><name sortKey="O Meara, S" uniqKey="O Meara S">S O'Meara</name></author><author><name sortKey="Mcbride, Dj" uniqKey="Mcbride D">DJ McBride</name></author><author><name sortKey="Meynert, A" uniqKey="Meynert A">A Meynert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li></region><settlement><li>Caen</li><li>Dunkerque</li><li>Lille</li></settlement><orgName><li>Université de Caen Basse-Normandie</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name></noRegion><name sortKey="Andre, Veronique" sort="Andre, Veronique" uniqKey="Andre V" first="Véronique" last="André">Véronique André</name><name sortKey="Andre, Veronique" sort="Andre, Veronique" uniqKey="Andre V" first="Véronique" last="André">Véronique André</name><name sortKey="Billet, Sylvain" sort="Billet, Sylvain" uniqKey="Billet S" first="Sylvain" last="Billet">Sylvain Billet</name><name sortKey="Billet, Sylvain" sort="Billet, Sylvain" uniqKey="Billet S" first="Sylvain" last="Billet">Sylvain Billet</name><name sortKey="Garcon, Guillaume" sort="Garcon, Guillaume" uniqKey="Garcon G" first="Guillaume" last="Garçon">Guillaume Garçon</name><name sortKey="Garcon, Guillaume" sort="Garcon, Guillaume" uniqKey="Garcon G" first="Guillaume" last="Garçon">Guillaume Garçon</name><name sortKey="Le Goff, Jeremie" sort="Le Goff, Jeremie" uniqKey="Le Goff J" first="Jérémie" last="Le Goff">Jérémie Le Goff</name><name sortKey="Le Goff, Jeremie" sort="Le Goff, Jeremie" uniqKey="Le Goff J" first="Jérémie" last="Le Goff">Jérémie Le Goff</name><name sortKey="Lechevrel, Mathilde" sort="Lechevrel, Mathilde" uniqKey="Lechevrel M" first="Mathilde" last="Lechevrel">Mathilde Lechevrel</name><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name><name sortKey="Paget, Vincent" sort="Paget, Vincent" uniqKey="Paget V" first="Vincent" last="Paget">Vincent Paget</name><name sortKey="Pottier, Didier" sort="Pottier, Didier" uniqKey="Pottier D" first="Didier" last="Pottier">Didier Pottier</name><name sortKey="Pottier, Didier" sort="Pottier, Didier" uniqKey="Pottier D" first="Didier" last="Pottier">Didier Pottier</name><name sortKey="Shirali, Pirouz" sort="Shirali, Pirouz" uniqKey="Shirali P" first="Pirouz" last="Shirali">Pirouz Shirali</name><name sortKey="Shirali, Pirouz" sort="Shirali, Pirouz" uniqKey="Shirali P" first="Pirouz" last="Shirali">Pirouz Shirali</name><name sortKey="Sichel, Francois" sort="Sichel, Francois" uniqKey="Sichel F" first="François" last="Sichel">François Sichel</name><name sortKey="Sichel, Francois" sort="Sichel, Francois" uniqKey="Sichel F" first="François" last="Sichel">François Sichel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000637 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000637 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3272023
|texte= Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22319594" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |