Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis
Identifieur interne : 001224 ( Main/Curation ); précédent : 001223; suivant : 001225Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis
Auteurs : Vincent Goëb [France] ; Philippe Dieudé [France] ; Olivier Vittecoq [France] ; Othmane Mejjad [France] ; Jean-François Ménard [France] ; Marlène Thomas [France] ; Danièle Gilbert [France] ; Patrick Boumier [France] ; Sophie Pouplin [France] ; Alain Daragon [France] ; Patrice Fardellone [France] ; François Tron [France] ; François Cornélis [France] ; Xavier Le Loët [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2005.
Abstract
Tumour necrosis factor (TNF)-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). It binds to two receptors, namely TNF receptor (TNFR)I and TNFRII. Several studies have suggested an association between
Url:
DOI: 10.1186/ar1777
PubMed: 16207322
PubMed Central: 1257430
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PMC:1257430Le document en format XML
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196R allele and diagnosis of rheumatoid arthritis</title>
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<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
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<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Dieude, Philippe" sort="Dieude, Philippe" uniqKey="Dieude P" first="Philippe" last="Dieudé">Philippe Dieudé</name>
<affiliation wicri:level="1"><nlm:aff id="I3">GenHotel, University of Evry-Paris VII, Faculty of Lariboisière-Saint Louis, Evry-Genopole and Unité de Génétique clinique, University Hospital of Lariboisière, APHP, Paris, France</nlm:aff>
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<author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean-François" last="Ménard">Jean-François Ménard</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between the <italic>TNFRII </italic>
196R allele and diagnosis of rheumatoid arthritis</title>
<author><name sortKey="Goeb, Vincent" sort="Goeb, Vincent" uniqKey="Goeb V" first="Vincent" last="Goëb">Vincent Goëb</name>
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<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Rouen</settlement>
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<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
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<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Dieude, Philippe" sort="Dieude, Philippe" uniqKey="Dieude P" first="Philippe" last="Dieudé">Philippe Dieudé</name>
<affiliation wicri:level="1"><nlm:aff id="I3">GenHotel, University of Evry-Paris VII, Faculty of Lariboisière-Saint Louis, Evry-Genopole and Unité de Génétique clinique, University Hospital of Lariboisière, APHP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Paris</settlement>
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<author><name sortKey="Vittecoq, Olivier" sort="Vittecoq, Olivier" uniqKey="Vittecoq O" first="Olivier" last="Vittecoq">Olivier Vittecoq</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
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<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Rouen</settlement>
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</affiliation>
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<author><name sortKey="Mejjad, Othmane" sort="Mejjad, Othmane" uniqKey="Mejjad O" first="Othmane" last="Mejjad">Othmane Mejjad</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean-François" last="Ménard">Jean-François Ménard</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Biostatistics Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biostatistics Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas, Marlene" sort="Thomas, Marlene" uniqKey="Thomas M" first="Marlène" last="Thomas">Marlène Thomas</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Daniele" sort="Gilbert, Daniele" uniqKey="Gilbert D" first="Danièle" last="Gilbert">Danièle Gilbert</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boumier, Patrick" sort="Boumier, Patrick" uniqKey="Boumier P" first="Patrick" last="Boumier">Patrick Boumier</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Rheumatology Department, University Hospital of Amiens, Amiens, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Amiens, Amiens</wicri:regionArea>
<placeName><settlement type="city">Amiens</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daragon, Alain" sort="Daragon, Alain" uniqKey="Daragon A" first="Alain" last="Daragon">Alain Daragon</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fardellone, Patrice" sort="Fardellone, Patrice" uniqKey="Fardellone P" first="Patrice" last="Fardellone">Patrice Fardellone</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Rheumatology Department, University Hospital of Amiens, Amiens, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Amiens, Amiens</wicri:regionArea>
<placeName><settlement type="city">Amiens</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tron, Francois" sort="Tron, Francois" uniqKey="Tron F" first="François" last="Tron">François Tron</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornelis, Francois" sort="Cornelis, Francois" uniqKey="Cornelis F" first="François" last="Cornélis">François Cornélis</name>
<affiliation wicri:level="1"><nlm:aff id="I3">GenHotel, University of Evry-Paris VII, Faculty of Lariboisière-Saint Louis, Evry-Genopole and Unité de Génétique clinique, University Hospital of Lariboisière, APHP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>GenHotel, University of Evry-Paris VII, Faculty of Lariboisière-Saint Louis, Evry-Genopole and Unité de Génétique clinique, University Hospital of Lariboisière, APHP, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Loet, Xavier" sort="Le Loet, Xavier" uniqKey="Le Loet X" first="Xavier" last="Le Loët">Xavier Le Loët</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Rheumatology Department, University Hospital of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rheumatology Department, University Hospital of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Inserm U519, IFRMP 23, Faculty of Medicine, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U519, IFRMP 23, Faculty of Medicine, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Arthritis Research & Therapy</title>
<idno type="ISSN">1478-6354</idno>
<idno type="eISSN">1478-6362</idno>
<imprint><date when="2005">2005</date>
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<front><div type="abstract" xml:lang="en"><p>Tumour necrosis factor (TNF)-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). It binds to two receptors, namely TNF receptor (TNFR)I and TNFRII. Several studies have suggested an association between <italic>TNFRII </italic>
196R/R genotype and RA. The objective of the present study was to evaluate the predictive value of the <italic>TNFRII </italic>
196R allele for RA diagnosis and prognosis in a cohort of patients with very early arthritis. We followed up a total of 278 patients recruited from the community, who had swelling of at least two joints that had persisted for longer than 4 weeks but had been evolving for less than 6 months, and who had not received disease-modifying antirheumatic drugs or steroid therapy. At 2 years, patients were classified according to the American College of Rheumatology criteria. All patients were genotyped with respect to <italic>TNFRII </italic>
196M/R polymorphism. Radiographs of hands and feet (read according to the modified Sharp method) and the Health Assessment Questionnaire were used to quantify structural and functional severity. The cohort of 278 patients was found to include 156 and 122 RA and non-RA patients, respectively. The <italic>TNFRII </italic>
196R allele was found to be associated with RA (<italic>P </italic>
= 0.002). However, progression of radiographic severity and Health Assessment Questionnaire scores over 1 year did not differ between carriers of the 196R allele and noncarriers. Our findings suggest that the <italic>TNFRII </italic>
196R allele may be associated with RA diagnosis but that it does not predict early radiographic progression or functional severity in patients with very early, unclassified arthritis.</p>
</div>
</front>
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